⚠ Provisional — human review required. Tiers are computationally assigned. Per OSMF Grading Methodology §5, every Tier 1/2 entry must be verified against the source paper before publication.
🧬 MCAS

Therapeutic Agents
MCAS

Evidence-graded candidate agents from the OSMF discovery pipeline. Click any source count to see linked trial and paper references.

145Agents
0Tier 1 (LC RCT)
55Tier 2 (Related RCT)
2443Source entries
Evidence tiers: T1 — RCT in LC/PASC/PACVS T2 — RCT in related condition T3 — Observational in LC T4 — Case series T5 — Case report T6 — Mechanistic / preclinical
145 agents
5-mg Desloratadine
T2
T2 — RCT in related condition
MCAS
12 sources
  • T6INDIRECT 25397904 ↗H1-antihistamines for chronic spontaneous urticaria
  • T6INDIRECT 37024900 ↗The efficacy and safety of high-dose nonsedating antihistamines in chronic spontaneous urticaria: a
  • T2 12968983 ↗Twenty-four-hour activity and consistency of activity of levocetirizine and desloratadine in the ski
  • T2 17324243 ↗Desloratadine dose selection in children aged 6 months to 2 years: comparison of population pharmaco
  • T6 32400125 ↗The KAAACI/KDA Evidence-Based Practice Guidelines for Chronic Spontaneous Urticaria in Korean Adults
  • T6 28289538 ↗Effectiveness and safety of antihistamines up to fourfold or higher in treatment of chronic spontane
  • T6INDIRECT 30944690 ↗Vitamin D supplements improve urticaria symptoms and quality of life in chronic spontaneous urticari
  • T6INDIRECT 30402619 ↗Hyperresponsiveness to antihistamines in spontaneous urticaria and heat urticaria
  • T6INDIRECT 25346784 ↗Vitamin d supplements improve urticaria symptoms and quality of life in chronic spontaneous urticari
  • T4 PMC4101696 ↗Abstracts of the XX World Allergy CongressTM 2007 December 2–6, 2007, Bangkok, Thailand
  • T6 19915710 ↗Impact of Desloratadine on Symptoms and Quality of Life in Subjects with Chronic Idiopathic Urticari
  • T6 32467688 ↗The effect of levocetirizine and montelukast on clinical symptoms, serum level and skin expression o
Allogeneic Hematopoietic Stem Cell Transplantation
T2
T2 — RCT in related condition
MCAS
19 sources
  • T6INDIRECT 28644114 ↗Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation
  • T6INDIRECT 28694687 ↗Efficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese
  • T6INDIRECT 34748627 ↗COVID-19 in vaccinated adult patients with hematological malignancies: preliminary results from EPIC
  • T6INDIRECT 34608129 ↗Real-world experience of CPX-351 as first-line treatment for patients with acute myeloid leukemia
  • T6INDIRECT 35640224 ↗Efficacy and safety of avapritinib in previously treated patients with advanced systemic mastocytosi
  • T2 31132454 ↗Noninfectious Neurologic Complications after Allogeneic Hematopoietic Stem Cell Transplantation
  • T6INDIRECT 23935024 ↗Alternative donor hematopoietic stem cell transplantation for mature lymphoid malignancies after red
  • T6INDIRECT 30922329 ↗Genetic polymorphisms of histone methyltransferase SETD2 predicts prognosis and chemotherapy respons
  • T6 27834397 ↗The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia
  • T6 28484466 ↗The ST2/IL-33 Axis in Immune Cells during Inflammatory Diseases
  • T6INDIRECT 25964669 ↗How I treat hypereosinophilic syndromes
  • T6INDIRECT 23023713 ↗Pathogenesis of follicular lymphoma
  • T6INDIRECT 34774343 ↗A review of FLT3 inhibitors in acute myeloid leukemia
  • T6INDIRECT 31547472 ↗CD123 as a Therapeutic Target in the Treatment of Hematological Malignancies
  • T6INDIRECT 31723789 ↗Diagnosis and Treatment of Chronic Myelomonocytic Leukemias in Adults: Recommendations From the Euro
  • T6INDIRECT 25796139 ↗Measuring therapeutic response in chronic graft-versus-host disease. National Institutes of Health c
  • T6 28031180 ↗Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts
  • T6 24136165 ↗The genetic basis of myelodysplasia and its clinical relevance
  • T6 29619379 ↗Eosinophils from Physiology to Disease: A Comprehensive Review
Allogeneic hematopoietic stem cell transplantation
T2
T2 — RCT in related condition
MCAS
20 sources
  • T6 NCT01384513 ↗A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Mali
  • T6INDIRECT 28644114 ↗Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation
  • T6INDIRECT 28694687 ↗Efficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese
  • T6INDIRECT 34748627 ↗COVID-19 in vaccinated adult patients with hematological malignancies: preliminary results from EPIC
  • T6INDIRECT 34608129 ↗Real-world experience of CPX-351 as first-line treatment for patients with acute myeloid leukemia
  • T6INDIRECT 35640224 ↗Efficacy and safety of avapritinib in previously treated patients with advanced systemic mastocytosi
  • T2 31132454 ↗Noninfectious Neurologic Complications after Allogeneic Hematopoietic Stem Cell Transplantation
  • T6INDIRECT 23935024 ↗Alternative donor hematopoietic stem cell transplantation for mature lymphoid malignancies after red
  • T6INDIRECT 30922329 ↗Genetic polymorphisms of histone methyltransferase SETD2 predicts prognosis and chemotherapy respons
  • T6 27834397 ↗The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia
  • T6 28484466 ↗The ST2/IL-33 Axis in Immune Cells during Inflammatory Diseases
  • T6INDIRECT 25964669 ↗How I treat hypereosinophilic syndromes
  • T6INDIRECT 23023713 ↗Pathogenesis of follicular lymphoma
  • T6INDIRECT 34774343 ↗A review of FLT3 inhibitors in acute myeloid leukemia
  • T6INDIRECT 31547472 ↗CD123 as a Therapeutic Target in the Treatment of Hematological Malignancies
  • T6INDIRECT 31723789 ↗Diagnosis and Treatment of Chronic Myelomonocytic Leukemias in Adults: Recommendations From the Euro
  • T6INDIRECT 25796139 ↗Measuring therapeutic response in chronic graft-versus-host disease. National Institutes of Health c
  • T6 28031180 ↗Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts
  • T6 24136165 ↗The genetic basis of myelodysplasia and its clinical relevance
  • T6 29619379 ↗Eosinophils from Physiology to Disease: A Comprehensive Review
Anakinra
T2
T2 — RCT in related condition
MCAS
25 sources
  • T6INDIRECT 31749986 ↗Efficacy and safety of topical and systemic medications: a systematic literature review informing th
  • T6INDIRECT 37487610 ↗The 2022 EULAR/ACR points to consider at the early stages of diagnosis and management of suspected h
  • T6INDIRECT 37486733 ↗The 2022 EULAR/ACR Points to Consider at the Early Stages of Diagnosis and Management of Suspected H
  • T6INDIRECT 35359659 ↗Targeting Inflammatory Mediators in Epilepsy: A Systematic Review of Its Molecular Basis and Clinica
  • T6INDIRECT 35350578 ↗Immunomodulating Therapies in Acute Myocarditis and Recurrent/Acute Pericarditis
  • T6INDIRECT 35563242 ↗Liver Injury in COVID-19 Patients with Drugs as Causatives: A Systematic Review of 996 DILI Cases Pu
  • T6INDIRECT 38139057 ↗The Effects of Periodontal Treatment on Rheumatoid Arthritis and of Anti-Rheumatic Drugs on Periodon
  • T2 29141858 ↗Interleukin-1 Blockade in Recently Decompensated Systolic Heart Failure: Results From REDHART (Recen
  • T6INDIRECT 38849829 ↗Dapagliflozin reduces systemic inflammation in patients with type 2 diabetes without known heart fai
  • T6INDIRECT 23087179 ↗Sustained efficacy of the monoclonal anti-interleukin-1 beta antibody canakinumab in a 9-month trial
  • T6INDIRECT 24275598 ↗Treating inflammation by blocking interleukin-1 in humans
  • T6INDIRECT 32107531 ↗Pediatric hemophagocytic lymphohistiocytosis
  • T6INDIRECT 32803422 ↗Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a com
  • T6INDIRECT 20643990 ↗Narrative review: the systemic capillary leak syndrome
  • T6INDIRECT 33867315 ↗The immune response to SARS-CoV-2 and COVID-19 immunopathology - Current perspectives
  • T6INDIRECT 35606650 ↗Pyoderma Gangrenosum: An Updated Literature Review on Established and Emerging Pharmacological Treat
  • T6INDIRECT 29259713 ↗The etiopathogenesis of atopic dermatitis: barrier disruption, immunological derangement, and prurit
  • T6 26121197 ↗Inflammasomes: mechanism of action, role in disease, and therapeutics
  • T6 31676858 ↗TIM3 comes of age as an inhibitory receptor
  • T6 18982161 ↗The cytokine network in asthma and chronic obstructive pulmonary disease
  • T6 25625584 ↗NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflamm
  • T6 32376392 ↗Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventio
  • T6 29764485 ↗The role of inflammation in the development of epilepsy
  • T6 30774631 ↗The Immunology of Macrophage Activation Syndrome
  • T6 22889225 ↗The inflammation highway: metabolism accelerates inflammatory traffic in obesity
Barzolvolimab
T2
T2 — RCT in related condition
MCAS
15 sources
  • T6INDIRECT 40520797 ↗Clinical efficacy and safety of acupuncture in the treatment for chronic spontaneous urticaria: a sy
  • T2 40415544 ↗Anti-KIT Barzolvolimab for Chronic Spontaneous Urticaria
  • T6 39158477 ↗Therapeutic monoclonal antibodies in allergy: Targeting IgE, cytokine, and alarmin pathways
  • T6 38345154 ↗Prurigo nodularis: new insights into pathogenesis and novel therapeutics
  • T6 37717255 ↗Chronic Prurigo Including Prurigo Nodularis: New Insights and Treatments
  • T6 37887317 ↗Mechanistic Insights into Eosinophilic Esophagitis: Therapies Targeting Pathophysiological Mechanism
  • T6 38077377 ↗Molecular mechanisms of pruritus in prurigo nodularis
  • T6INDIRECT 37894846 ↗Current and Novel Therapies for Eosinophilic Gastrointestinal Diseases
  • T6INDIRECT 38135920 ↗Review article: Emerging insights into the epidemiology, pathophysiology, diagnostic and therapeutic
  • T6INDIRECT 37386330 ↗Current and Emerging Therapies for Chronic Spontaneous Urticaria: A Narrative Review
  • T6INDIRECT 38791201 ↗Prurigo Nodularis: Pathogenesis and the Horizon of Potential Therapeutics
  • T6INDIRECT 39028396 ↗New insights into chronic inducible urticaria
  • T6 38630620 ↗Mast cells: a novel therapeutic avenue for cardiovascular diseases?
  • T6 38289515 ↗Cellular and Molecular Mechanisms of Mast Cells in Atherosclerotic Plaque Progression and Destabiliz
  • T6 37376140 ↗Frenemies in the Microenvironment: Harnessing Mast Cells for Cancer Immunotherapy
Best supportive care
T2
T2 — RCT in related condition
MCAS
24 sources
  • T2 NCT05449444 ↗Masitinib for the Treatment of Severe Mast Cell Activation Syndrome
  • T6 26462910 ↗Biomarkers of severe dengue disease - a review
  • T6 31216696 ↗Multidisciplinary Challenges in Mastocytosis and How to Address with Personalized Medicine Approache
  • T6 32663575 ↗Tackling the cytokine storm in COVID-19, challenges and hopes
  • T6 34382298 ↗Tissue factor and its procoagulant activity on cancer-associated thromboembolism in pancreatic cance
  • T6 34289787 ↗Avapritinib for Systemic Mastocytosis
  • T6INDIRECT 34660314 ↗Molecular Pathogenesis of Chronic Myelomonocytic Leukemia and Potential Molecular Targets for Treatm
  • T6INDIRECT 26179201 ↗Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with ad
  • T6INDIRECT 38320129 ↗Avapritinib versus Placebo in Indolent Systemic Mastocytosis
  • T6INDIRECT 28550021 ↗Effects of continuous positive airway pressure on neurocognitive architecture and function in patien
  • T6INDIRECT 42319518 ↗Psychometric evaluation of the Mastocytosis Symptom Severity Daily Diary (MS2D2) in adults with nona
  • T6 34054126 ↗Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
  • T6 26391154 ↗Targeted therapy in cancer
  • T6 33685604 ↗Biologics for Treatment of Atopic Dermatitis: Current Status and Future Prospect
  • T6 21125679 ↗The GIST paradigm: lessons for other kinase-driven cancers
  • T6 23829867 ↗Phase II study of personalized peptide vaccination for refractory bone and soft tissue sarcoma patie
  • T6INDIRECT 33672766 ↗Thrombocytopenia in Virus Infections
  • T6INDIRECT 27843641 ↗ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016
  • T6INDIRECT 24135408 ↗Novel agents for multiple myeloma to overcome resistance in phase III clinical trials
  • T6INDIRECT 32462367 ↗Revolutions in treatment options in gastrointestinal stromal tumours (GISTs): the latest updates
  • T6INDIRECT 34178645 ↗Perspectives on Immunotherapy of Metastatic Colorectal Cancer
  • T6INDIRECT 34295668 ↗International consensus on severe lung cancer-the first edition
  • T6INDIRECT 30327374 ↗The mutational landscape of accelerated- and blast-phase myeloproliferative neoplasms impacts patien
  • T6 24605265 ↗Trial Watch: Tumor-targeting monoclonal antibodies in cancer therapy
Bilastin
T2
T2 — RCT in related condition
MCAS
5 sources
  • T2 39351222 ↗Efficacy and safety of switching to bilastine, an H1-antihistamine, in patients with refractory chro
  • T6 33785991 ↗Expertenkonsensus zu praxisrelevanten Aspekten bei der Behandlung der chronischen Urtikaria
  • T6 28035215 ↗The role and choice criteria of antihistamines in allergy management - expert opinion
  • T6 37626727 ↗Chronic Urticaria Biomarkers IL-6, ESR and CRP in Correlation with Disease Severity and Patient Qual
  • T6 40745660 ↗2024 CSACI Annual Scientific Meeting Book of Abstracts
Brentuximab vedotin
T2
T2 — RCT in related condition
MCAS
20 sources
  • T6 NCT01807598 ↗Brentuximab Vedotin in Treating Patients With Advanced Systemic Mastocytosis or Mast Cell Leukemia
  • T2 28010897 ↗Brentuximab vedotin for treatment of non-Hodgkin lymphomas: A systematic review
  • T6INDIRECT 40422524 ↗Patient-Reported Outcome Measures (PROMS) in Lymphoma
  • T6INDIRECT 42068413 ↗Prevalence of antibody drug conjugated-induced nausea and vomiting (ADCINV) in patients with cancer
  • T6INDIRECT 34904799 ↗Polatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma
  • T6INDIRECT 26109102 ↗Epigenetic therapy overcomes treatment resistance in T cell prolymphocytic leukemia
  • T6INDIRECT 35640224 ↗Efficacy and safety of avapritinib in previously treated patients with advanced systemic mastocytosi
  • T6 33657296 ↗Diffuse Large B-Cell Lymphoma
  • T6 26679767 ↗Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive
  • T6 28885612 ↗Understanding CD30 biology and therapeutic targeting: a historical perspective providing insight int
  • T6 28254862 ↗Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the
  • T6INDIRECT 35790816 ↗Efficacy of avapritinib versus best available therapy in the treatment of advanced systemic mastocyt
  • T5 26994848 ↗Treatment of CD30-positive systemic mastocytosis with brentuximab vedotin
  • T6INDIRECT 29844705 ↗Severe cutaneous adverse reactions induced by targeted anticancer therapies and immunotherapies
  • T6INDIRECT 32522746 ↗Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies
  • T6INDIRECT 29052609 ↗Neuro-ophthalmic side effects of molecularly targeted cancer drugs
  • T6 26654227 ↗Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell l
  • T6 35217782 ↗New treatment strategies for advanced-stage gastrointestinal stromal tumours
  • T6 30677473 ↗Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposit
  • T6 33291602 ↗Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes
CT-P39
T2
T2 — RCT in related condition
MCAS
17 sources
  • T2 39785096 ↗CT-P39 Compared With Reference Omalizumab in Chronic Spontaneous Urticaria: Results From a Double-Bl
  • T6 40074986 ↗Update on the Treatment of Chronic Spontaneous Urticaria
  • T6 33289684 ↗Immune Response to <i>Borrelia</i>: Lessons from Lyme Disease Spirochetes
  • T6 23790098 ↗Bell's palsy and sudden deafness associated with Rickettsia spp. infection in Sweden. A retrospectiv
  • T6 36434739 ↗Pharmacokinetic equivalence of CT-P39 and reference omalizumab in healthy individuals: A randomised,
  • T6INDIRECT 42128382 ↗Targeting immune dysregulation in chronic spontaneous urticaria: beyond antihistamines
  • T6INDIRECT 41809769 ↗Treatments and Targets to Achieve Disease Control in Chronic Spontaneous Urticaria: Current and Emer
  • T4 PMC5103240 ↗6th International Symposium on Molecular Allergology (ISMA)
  • T4 PMC7159569 ↗Abstracts: Poster session
  • T4 PMC11627186 ↗ACNP 63rd Annual Meeting: Poster Abstracts P1-P304
  • T4 PMC11535630 ↗OA20 Differentiating Lupus Nephritis from Pre-eclampsia-A Diagnostic Dilemma
  • T4 PMC7917173 ↗Abstracts of the 87th Annual Meeting of the German Society for Experimental and Clinical Pharmacolog
  • T6 36839989 ↗Drugging Hijacked Kinase Pathways in Pediatric Oncology: Opportunities and Current Scenario
  • T6 41654334 ↗Systemic Treatments for Chronic Spontaneous Urticaria: Anti-IgE and Beyond
  • T6 41270830 ↗Emerging IgE and non-IgE targeted therapies for chronic urticaria
  • T6 1633419 ↗Oncogenes and cell proliferation
  • T6 40747638 ↗Biologic and small molecule therapies in chronic spontaneous urticaria: an update
Clemastine
T2
T2 — RCT in related condition
MCAS
21 sources
  • T6INDIRECT 25397904 ↗H1-antihistamines for chronic spontaneous urticaria
  • T6INDIRECT 33206207 ↗Histamine receptors and COVID-19
  • T6INDIRECT 17253584 ↗H1-antihistamines for the treatment of anaphylaxis with and without shock
  • T6INDIRECT 23450580 ↗Oral H1 antihistamines as monotherapy for eczema
  • T6INDIRECT 28342911 ↗Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis
  • T2 2874958 ↗Terfenadine in chronic urticaria: a comparison with clemastine and placebo
  • T6INDIRECT 1715267 ↗Acrivastine. A review of its pharmacological properties and therapeutic efficacy in allergic rhiniti
  • T2 2650586 ↗Clinical evaluation of ketotifen for chronic urticaria: multicenter double-blind comparative study w
  • T6 29949830 ↗Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis
  • T6 33204386 ↗World allergy organization anaphylaxis guidance 2020
  • T6INDIRECT 28965641 ↗Severe Delayed Drug Reactions: Role of Genetics and Viral Infections
  • T6INDIRECT 36983108 ↗Bone Cement and Its Anesthetic Complications: A Narrative Review
  • T6INDIRECT 32128023 ↗IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position p
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6INDIRECT 23452057 ↗Characterization of different courses of atopic dermatitis in adolescent and adult patients
  • T6INDIRECT 23282578 ↗H1 antihistamines: current status and future directions
  • T6INDIRECT 26120521 ↗Guideline for acute therapy and management of anaphylaxis: S2 Guideline of the German Society for Al
  • T6 30007465 ↗Hereditary Alpha Tryptasemia: Genotyping and Associated Clinical Features
  • T6 35744757 ↗Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Patho
  • T6 30965592 ↗The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines i
  • T6 33657648 ↗Allergenic components of the mRNA-1273 vaccine for COVID-19: Possible involvement of polyethylene gl
Cyclophosphamide
T2
T2 — RCT in related condition
RegisteredME/CFSMCASPOTS
70 sources
  • T2 NCT02444091 ↗Cyclophosphamide in Myalgic Encephalopathy/ Chronic Fatigue Syndrome (ME/CFS)
  • T6 NCT01384513 ↗A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Mali
  • T6REGISTERED-ONLY NCT03779854 ↗Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults
  • T6INDIRECT 21491378 ↗Interventions for preventing oral mucositis for patients with cancer receiving treatment
  • T6INDIRECT 20687070 ↗Interventions for treating oral mucositis for patients with cancer receiving treatment
  • T6INDIRECT 36103991 ↗Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 d
  • T6INDIRECT 36228963 ↗Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline patho
  • T6INDIRECT 23599118 ↗Topical interleukin 1 receptor antagonist for treatment of dry eye disease: a randomized clinical tr
  • T6INDIRECT 15471655 ↗Course of fatigue in women receiving chemotherapy and/or radiotherapy for early stage breast cancer
  • T6INDIRECT 26844275 ↗Radiation-induced CD8 T-lymphocyte Apoptosis as a Predictor of Breast Fibrosis After Radiotherapy: R
  • T6 2683611 ↗Biology of natural killer cells
  • T6 10515901 ↗Q fever
  • T6 32762681 ↗Natural killer cells in cancer biology and therapy
  • T6 19375665 ↗Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity
  • T6 9560217 ↗Bax directly induces release of cytochrome c from isolated mitochondria
  • T6INDIRECT 20548096 ↗Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-
  • T6INDIRECT 34904799 ↗Polatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma
  • T2 30901302 ↗Randomized Phase III Trial of Ibrutinib and Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristin
  • T6INDIRECT 36542826 ↗Lisocabtagene maraleucel as second-line therapy for large B-cell lymphoma: primary analysis of the p
  • T6INDIRECT 30184451 ↗Rituximab plus Lenalidomide in Advanced Untreated Follicular Lymphoma
  • T6INDIRECT 25046337 ↗Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who rema
  • T6INDIRECT 30811293 ↗First-Line Treatment of Patients With Indolent Non-Hodgkin Lymphoma or Mantle-Cell Lymphoma With Ben
  • T6INDIRECT 20431041 ↗Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and l
  • T6INDIRECT 25154820 ↗Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effect
  • T6INDIRECT 25842160 ↗Circulating tumour DNA and CT monitoring in patients with untreated diffuse large B-cell lymphoma: a
  • T6INDIRECT 34542573 ↗Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephaliti
  • T6INDIRECT 26561338 ↗Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy
  • T6INDIRECT 29217664 ↗Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Re
  • T6INDIRECT 29271481 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 30361325 ↗DUET: A Phase 2 Study Evaluating the Efficacy and Safety of Sparsentan in Patients with FSGS
  • T6INDIRECT 32244252 ↗Daratumumab plus CyBorD for patients with newly diagnosed AL amyloidosis: safety run-in results of A
  • T6INDIRECT 1739631 ↗Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)
  • T6INDIRECT 8774401 ↗Intravenous immunoglobulin treatment in paraneoplastic neurological syndromes with antineuronal auto
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 17655751 ↗Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis
  • T6INDIRECT 24247168 ↗Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer
  • T6INDIRECT 29523094 ↗Pediatric multiple sclerosis: a review
  • T6INDIRECT 29186062 ↗Viral Oncology: Molecular Biology and Pathogenesis
  • T6INDIRECT 23452057 ↗Characterization of different courses of atopic dermatitis in adolescent and adult patients
  • T6 34630027 ↗Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy
  • T6 22544865 ↗Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action,
  • T6 25315420 ↗Autoimmune encephalopathies
  • T6 29344421 ↗Anti-Aging Implications of <i>Astragalus Membranaceus</i> (Huangqi): A Well-Known Chinese Tonic
  • T6INDIRECT 28242845 ↗Focal Segmental Glomerulosclerosis
  • T6INDIRECT 33649022 ↗Autoimmune encephalitis: proposed best practice recommendations for diagnosis and acute management
  • T6INDIRECT 32106302 ↗Overview of Castleman disease
  • T6INDIRECT 28213891 ↗Opioids and the immune system - friend or foe
  • T6INDIRECT 35215786 ↗<i>Herpes zoster</i>: A Review of Clinical Manifestations and Management
  • T6INDIRECT 29915719 ↗Past, Present, and Future of Rituximab-The World's First Oncology Monoclonal Antibody Therapy
  • T6INDIRECT 27777266 ↗A Proposal for a Serology-Based Approach to Membranous Nephropathy
  • T6 32433595 ↗Interaction between microbiota and immunity in health and disease
  • T6 32934330 ↗Exploring the NK cell platform for cancer immunotherapy
  • T6 37169756 ↗Angiogenic signaling pathways and anti-angiogenic therapy for cancer
  • T6 19597008 ↗Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis
  • T6 26228647 ↗Colchicine--Update on mechanisms of action and therapeutic uses
  • T6 32376392 ↗Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventio
  • T6 28550082 ↗Primary Membranous Nephropathy
  • T6 33657296 ↗Diffuse Large B-Cell Lymphoma
  • T6INDIRECT 30049614 ↗Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex ence
  • T6INDIRECT 24462240 ↗Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a c
  • T6INDIRECT 24703753 ↗A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder assoc
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 24423978 ↗Adrenocortical carcinoma
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 32792490 ↗Podocytopathies
  • T6 34988090 ↗Treatment of Inflammatory Bowel Disease: A Comprehensive Review
  • T6 24323045 ↗Autophagy and human diseases
Dapsone
T2
T2 — RCT in related condition
MCAS
22 sources
  • T6INDIRECT 25919144 ↗Interventions for rosacea
  • T6INDIRECT 22972085 ↗Systemic interventions for recurrent aphthous stomatitis (mouth ulcers)
  • T6INDIRECT 32176310 ↗A Systematic Review of Drug-Induced Pemphigoid
  • T6INDIRECT 21812866 ↗Urban legends: recurrent aphthous stomatitis
  • T6INDIRECT 37189381 ↗Dupilumab in Inflammatory Skin Diseases: A Systematic Review
  • T6INDIRECT 34431983 ↗Evaluation of Pharmacologic Treatments for H1 Antihistamine-Refractory Chronic Spontaneous Urticaria
  • T6INDIRECT 30879003 ↗Effects of an Oral CRTh2 Antagonist (AZD1981) on Eosinophil Activity and Symptoms in Chronic Spontan
  • T2 25213055 ↗Double-blind placebo-controlled trial of dapsone in antihistamine refractory chronic idiopathic urti
  • T6INDIRECT 19330244 ↗Systemic treatment in severe cases of recurrent aphthous stomatitis: an open trial
  • T6INDIRECT 18484427 ↗Urticaria unresponsive to antihistaminic treatment: an open study of therapeutic options based on hi
  • T6INDIRECT 17655751 ↗Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis
  • T6INDIRECT 30558872 ↗Antibiotic allergy
  • T6INDIRECT 11788573 ↗The non-H pylori helicobacters: their expanding role in gastrointestinal and systemic diseases
  • T6INDIRECT 26254049 ↗Evolving models of the immunopathogenesis of T cell-mediated drug allergy: The role of host, pathoge
  • T6INDIRECT 28832953 ↗Colchicine: an ancient drug with novel applications
  • T6INDIRECT 35606650 ↗Pyoderma Gangrenosum: An Updated Literature Review on Established and Emerging Pharmacological Treat
  • T6INDIRECT 31513026 ↗Celiac Disease: Extraintestinal Manifestations and Associated Conditions
  • T6INDIRECT 27866580 ↗Eosinophilia
  • T6 24310318 ↗Dapsone in dermatology and beyond
  • T6 30573342 ↗Controversies in drug allergy: Testing for delayed reactions
  • T6 10987697 ↗Practice guidelines for the management of community-acquired pneumonia in adults. Infectious Disease
  • T6 16437620 ↗Extraintestinal manifestations in inflammatory bowel disease
Deferasirox
T2
T2 — RCT in related condition
MCAS
20 sources
  • T2 19187278 ↗Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with
  • T6 30347635 ↗New Perspectives in Iron Chelation Therapy for the Treatment of Neurodegenerative Diseases
  • T6 25079860 ↗Acute interstitial nephritis - a reappraisal and update
  • T6 19951979 ↗Tailoring iron chelation by iron intake and serum ferritin: the prospective EPIC study of deferasiro
  • T6 28121072 ↗Current Status of Companion and Complementary Diagnostics: Strategic Considerations for Development
  • T6INDIRECT 30805232 ↗Mucormycotic Osteomyelitis Involving the Maxilla: A Rare Case Report and Review of the Literature
  • T6INDIRECT 36046774 ↗Efficacy of CRISPR-Based Gene Editing in a Sickle Cell Disease Patient as Measured through the Eye
  • T6INDIRECT 36278522 ↗Acute Promyelocytic Leukemia in a Woman with Thalassemia Intermedia: Case Report and Review of Liter
  • T6INDIRECT 38928368 ↗Copper, Iron, Cadmium, and Arsenic, All Generated in the Universe: Elucidating Their Environmental I
  • T6INDIRECT 28919773 ↗Sickle cell retinopathy: improving care with a multidisciplinary approach
  • T6INDIRECT 35079682 ↗Dilemmas in the Management of Osteoporosis in Younger Adults
  • T6INDIRECT 36588206 ↗Rhino-orbito-cerebral mucormycosis and its resurgence during COVID-19 pandemic: A review
  • T6INDIRECT 19898904 ↗High-affinity alphavbeta3 integrin targeted optical probe as a new imaging biomarker for early ather
  • T6 22300258 ↗Non-systemic drugs: a critical review
  • T6 31474092 ↗Proximal renal tubular acidosis with and without Fanconi syndrome
  • T6 28149844 ↗Companion diagnostics-a tool to improve pharmacotherapy
  • T6 33143139 ↗Iron Assimilation during Emerging Infections Caused by Opportunistic Fungi with emphasis on Mucorale
  • T6 39596504 ↗Drug Repurposing for Cancer Treatment: A Comprehensive Review
  • T6 33919446 ↗Different Approaches in Therapy Aiming to Stabilize an Unstable Atherosclerotic Plaque
  • T6 22924125 ↗Health-Related Quality of Life, Treatment Satisfaction, Adherence and Persistence in β-Thalassemia a
Denosumab
T2
T2 — RCT in related condition
MCAS
28 sources
  • T6 NCT03401060 ↗Interest of Denosumab Treatment in Osteoporosis Associated to Systemic Mastocytosis
  • T6INDIRECT 35628390 ↗Meta-Analysis of Two Human RNA-seq Datasets to Determine Periodontitis Diagnostic Biomarkers and Dru
  • T6INDIRECT 40965250 ↗Association of body mass index and bone mineral density in postmenopausal women: a systematic review
  • T6INDIRECT 40485004 ↗Implant Survival in Patient Populations With a Mean Age of 65-75 Years Compared to Older Cohorts: A
  • T6INDIRECT 27706804 ↗Bisphosphonates for steroid-induced osteoporosis
  • T6INDIRECT 38820458 ↗Increased Prevalence of Periapical Lesions in Osteoporosis Patients: A Systematic Review
  • T2 40309441 ↗Efficacy and safety of abaloparatide, denosumab, teriparatide, oral bisphosphonates, and intravenous
  • T6INDIRECT 31482156 ↗Are drug-related dental management cautions in Lexicomp Online for Dentistry evidence-based? A syste
  • T2 40612431 ↗The efficacy and safety of denosumab, risedronate, alendronate and teriparatide to treat male osteop
  • T2 42181204 ↗Comparative efficacy and safety of odanacatib, abaloparatide, denosumab, teriparatide, and bisphosph
  • T6INDIRECT 33123580 ↗Combined Administration of Bisphosphonates, Chemotherapeutic Agents, and/or Targeted Drugs Increases
  • T5 32373677 ↗Rebound-associated vertebral fractures may occur in sequential time points following denosumab disco
  • T6INDIRECT 24766381 ↗Osteoporosis prevention, screening, and treatment: a review
  • T6INDIRECT 27132234 ↗Pharmacological treatment options for mast cell activation disease
  • T6INDIRECT 24044484 ↗Mastocytosis: update on pharmacotherapy and future directions
  • T6INDIRECT 39596206 ↗Primary Osteoporosis Induced by Androgen and Estrogen Deficiency: The Molecular and Cellular Perspec
  • T6INDIRECT 28131128 ↗Premenopausal Osteoporosis
  • T6INDIRECT 36292765 ↗Hereditary Metabolic Bone Diseases: A Review of Pathogenesis, Diagnosis and Management
  • T6INDIRECT 21224201 ↗American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the d
  • T6 25810047 ↗Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma
  • T6 32844416 ↗Current understanding of periodontal disease pathogenesis and targets for host-modulation therapy
  • T6 21753790 ↗Advances in sarcoma genomics and new therapeutic targets
  • T6 36012730 ↗Current Status of the Diagnosis and Management of Osteoporosis
  • T6 25971649 ↗Management of endocrine disease: Secondary osteoporosis: pathophysiology and management
  • T6 26150706 ↗Epidemiology and management of osteoporosis in the People's Republic of China: current perspectives
  • T6 30324412 ↗European guidance for the diagnosis and management of osteoporosis in postmenopausal women
  • T6 23079689 ↗European guidance for the diagnosis and management of osteoporosis in postmenopausal women
  • T6 25182228 ↗Clinician's Guide to Prevention and Treatment of Osteoporosis
FSD201
T2
T2 — RCT in related condition
WithdrawnMCAS
1 source
  • T2WITHDRAWN NCT05652907 ↗Safety and Efficacy of FSD201 for the Treatment of Chronic Pain Associated With Idiopathic MCAS (MCA
Ferrous Sulfate
T2
T2 — RCT in related condition
MCAS
18 sources
  • T6INDIRECT 40611956 ↗Impact of &lt;i&gt;Helicobacter pylori&lt;/i&gt; infection on iron deficiency anemia in children: a
  • T6INDIRECT 22870245 ↗Exercise training prevents oxidative stress and ubiquitin-proteasome system overactivity and reverse
  • T2 34782532 ↗Comparison of efficacy & safety of iron polymaltose complex & ferrous ascorbate with ferrous sulphat
  • T6INDIRECT 22858697 ↗Iron supplementation reduces the erosive potential of a cola drink on enamel and dentin in situ
  • T6 32655238 ↗Indian National Association for the Study of the Liver Consensus Statement on Acute Liver Failure (P
  • T6 38928368 ↗Copper, Iron, Cadmium, and Arsenic, All Generated in the Universe: Elucidating Their Environmental I
  • T6 25266247 ↗Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task fo
  • T6 32614911 ↗Detecting rare diseases in electronic health records using machine learning and knowledge engineerin
  • T6 38290531 ↗Investigating intestinal mast cell dynamics during acute heat stress in growing pigs
  • T6INDIRECT 26134967 ↗Pseudomelanosis of the stomach and duodenum: an uncommon endoscopic finding
  • T6INDIRECT 28480101 ↗Cervical Necrotizing Fasciitis: A Potentially Fatal Disease with Varied Etiology
  • T6INDIRECT 25889707 ↗Valsalva retinopathy in pregnancy: a case report
  • T6INDIRECT 22593635 ↗Pruritus in the elderly: clinical approaches to the improvement of quality of life
  • T6INDIRECT 28397154 ↗Abstracts from the 2017 Society of General Internal Medicine Annual Meeting
  • T6 39596504 ↗Drug Repurposing for Cancer Treatment: A Comprehensive Review
  • T6 36978841 ↗Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Liter
  • T6 40137174 ↗Diverse Physiological Roles of Kynurenine Pathway Metabolites: Updated Implications for Health and D
  • T6 22184416 ↗Alkyl hydroperoxide reductase is required for Helicobacter cinaedi intestinal colonization and survi
Fludarabine
T2
T2 — RCT in related condition
RegisteredWithdrawnMCASPOTS
42 sources
  • T6WITHDRAWN NCT01773395 ↗GVAX vs. Placebo for MDS/AML After Allo HSCT
  • T6 NCT01384513 ↗A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Mali
  • T6REGISTERED-ONLY NCT03779854 ↗Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults
  • T6INDIRECT 36542826 ↗Lisocabtagene maraleucel as second-line therapy for large B-cell lymphoma: primary analysis of the p
  • T2 12393618 ↗Fludarabine, mitoxantrone, dexamethasone (FND) compared with an alternating triple therapy (ATT) reg
  • T6INDIRECT 25154820 ↗Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effect
  • T2 8648382 ↗Fludarabine, mitoxantrone, and dexamethasone: an effective new regimen for indolent lymphoma
  • T6INDIRECT 38659046 ↗Long-term remission and survival in patients with relapsed or refractory multiple myeloma after trea
  • T2 15741224 ↗Myelodysplasia and acute myeloid leukemia following therapy for indolent lymphoma with fludarabine,
  • T6 32934330 ↗Exploring the NK cell platform for cancer immunotherapy
  • T6 11229815 ↗The CD40/CD154 receptor/ligand dyad
  • T6 29915719 ↗Past, Present, and Future of Rituximab-The World's First Oncology Monoclonal Antibody Therapy
  • T6 24859366 ↗Activity of SL-401, a targeted therapy directed to interleukin-3 receptor, in blastic plasmacytoid d
  • T6INDIRECT 37756687 ↗Toxicity profiles of antibody-drug conjugates for anticancer treatment: a systematic review and meta
  • T6INDIRECT 28971751 ↗Anti-CD 19 and anti-CD 20 CAR-modified T cells for B-cell malignancies: a systematic review and meta
  • T6INDIRECT 29217664 ↗Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Re
  • T6INDIRECT 19263294 ↗Prolonged myelosuppression with clofarabine in the treatment of patients with relapsed or refractory
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6 33895845 ↗2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral A
  • T6 31210940 ↗European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gl
  • T6 22308288 ↗CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 a
  • T6 22762314 ↗Eltrombopag and improved hematopoiesis in refractory aplastic anemia
  • T6INDIRECT 30705099 ↗IgG4-related disease: what a hematologist needs to know
  • T6INDIRECT 34774343 ↗A review of FLT3 inhibitors in acute myeloid leukemia
  • T6INDIRECT 29844705 ↗Severe cutaneous adverse reactions induced by targeted anticancer therapies and immunotherapies
  • T6INDIRECT 32522746 ↗Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies
  • T6INDIRECT 33875812 ↗Transplant-associated thrombotic microangiopathy: theoretical considerations and a practical approac
  • T6INDIRECT 29475724 ↗A gene-expression profiling score for prediction of outcome in patients with follicular lymphoma: a
  • T6 19099185 ↗Mcl-1 is a potential therapeutic target in multiple types of cancer
  • T6 22075983 ↗BCL2A1: the underdog in the BCL2 family
  • T6 24975478 ↗Getting Syk: spleen tyrosine kinase as a therapeutic target
  • T6 23060872 ↗Immune dysregulation, polyendocrinopathy, enteropathy, x-linked syndrome: a paradigm of immunodefici
  • T6INDIRECT 30348186 ↗Anti-BCMA CAR-T cells for treatment of plasma cell dyscrasia: case report on POEMS syndrome and mult
  • T6INDIRECT 34134525 ↗Recognition, Prevention, and Management of Arrhythmias and Autonomic Disorders in Cardio-Oncology: A
  • T6INDIRECT 37345050 ↗The Black Hole: CAR T Cell Therapy in AML
  • T6INDIRECT 25124015 ↗Noninvasive imaging of cardiovascular injury related to the treatment of cancer
  • T6 30130469 ↗Iron and Cancer
  • T6 28174091 ↗Inhibitors of cyclin-dependent kinases as cancer therapeutics
  • T6 25561510 ↗Advances in anticancer immunotoxin therapy
  • T6 26566663 ↗The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel th
  • T6 26391778 ↗Cancer-treatment-induced neurotoxicity--focus on newer treatments
Ganciclovir
T2
T2 — RCT in related condition
MCAS
21 sources
  • T6INDIRECT 35563242 ↗Liver Injury in COVID-19 Patients with Drugs as Causatives: A Systematic Review of 996 DILI Cases Pu
  • T6INDIRECT 22895957 ↗Antivirals for idiopathic sudden sensorineural hearing loss
  • T6INDIRECT 16236177 ↗A multicenter trial of the efficacy and safety of tigecycline versus imipenem/cilastatin in patients
  • T6INDIRECT 26037730 ↗Acupuncture for the sequelae of Bell's palsy: a randomized controlled trial
  • T6INDIRECT 38587846 ↗Intravesical Interferon Therapy vs Hyaluronic Acid for Pain Among Female Individuals With Interstiti
  • T6INDIRECT 21388554 ↗Acupuncture for sequelae of Bell's palsy: a randomized controlled trial protocol
  • T2 25563312 ↗Clinical efficacy of oral ganciclovir for prophylaxis and treatment of recurrent herpes simplex kera
  • T6INDIRECT 39506756 ↗Therapeutic effects of acyclovir and acyclovir-clobetasol nanofibers vs. cream formulation for recur
  • T6 35215786 ↗<i>Herpes zoster</i>: A Review of Clinical Manifestations and Management
  • T6 33219338 ↗Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease
  • T6INDIRECT 35343828 ↗Salivary gland function, development, and regeneration
  • T6INDIRECT 21277939 ↗Mucins in the pathogenesis of breast cancer: implications in diagnosis, prognosis and therapy
  • T6INDIRECT 32778962 ↗Repurposing of Kinase Inhibitors for Treatment of COVID-19
  • T6INDIRECT 32522746 ↗Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies
  • T6INDIRECT 32963819 ↗Ocular Findings in COVID-19 Patients: A Review of Direct Manifestations and Indirect Effects on the
  • T6INDIRECT 33485845 ↗Systemic diseases and the cornea
  • T6 11842096 ↗Natural and pharmacological regulation of telomerase
  • T6 39326415 ↗Mechanisms of long COVID and the path toward therapeutics
  • T6 36899952 ↗Pathogenesis Underlying Neurological Manifestations of Long COVID Syndrome and Potential Therapeutic
  • T6 15085193 ↗Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial fa
  • T6 24138883 ↗Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection
Granisetron
T2
T2 — RCT in related condition
MCAS
20 sources
  • T6 NCT00186628 ↗Phase 2 Trial of Prophylactic Rituximab Therapy for Prevention of CGVHD
  • T6INDIRECT 38103150 ↗Pharmacological Treatments of Temporomandibular Disorders: A Systematic Review Including a Network M
  • T6INDIRECT 37455197 ↗Pharmacological agents for prevention of pruritus in women undergoing Caesarean delivery with neurax
  • T6INDIRECT 32546683 ↗A comprehensive map of disease networks and molecular drug discoveries for glaucoma
  • T2 11197756 ↗Immediate effects of the serotonin antagonist granisetron on temporomandibular joint pain in patient
  • T6INDIRECT 37288512 ↗The effect of pharyngeal packing on gastric volume in patients undergoing nasal surgery: a randomise
  • T6INDIRECT 22733017 ↗Amyloidosis of the gastrointestinal tract: a 13-year, single-center, referral experience
  • T6 33370241 ↗International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydrox
  • T6 29844705 ↗Severe cutaneous adverse reactions induced by targeted anticancer therapies and immunotherapies
  • T6 35964548 ↗Optimizing treatment management of trastuzumab deruxtecan in clinical practice of breast cancer
  • T6 28240194 ↗Brain and Gut CRF Signaling: Biological Actions and Role in the Gastrointestinal Tract
  • T6INDIRECT 21767775 ↗Pruritus: management algorithms and experimental therapies
  • T6INDIRECT 20137004 ↗Emesis in dogs: a review
  • T6INDIRECT 24251966 ↗Exploring the link between pholcodine exposure and neuromuscular blocking agent anaphylaxis
  • T6INDIRECT 23403690 ↗Mechanisms, causes, investigation and management of vomiting disorders in cats: a literature review
  • T6 35145413 ↗Current Treatment Options and Therapeutic Insights for Gastrointestinal Dysmotility and Functional G
  • T6 38516587 ↗Indole-containing pharmaceuticals: targets, pharmacological activities, and SAR studies
  • T6 32696221 ↗Enhancement of skin permeability with thermal ablation techniques: concept to commercial products
  • T6 37933613 ↗Pyrazole: an emerging privileged scaffold in drug discovery
  • T6 26635531 ↗Gastrointestinal Parasites and the Neural Control of Gut Functions
H1 antihistamines
T2
T2 — RCT in related condition
MCAS
26 sources
  • T6INDIRECT 30427977 ↗Benefits and Harms of Omalizumab Treatment in Adolescent and Adult Patients With Chronic Idiopathic
  • T6INDIRECT 29392757 ↗Chronic spontaneous urticaria in children - a systematic review on interventions and comorbidities
  • T2 25046337 ↗Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who rema
  • T6INDIRECT 28435464 ↗Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of F
  • T6INDIRECT 28069279 ↗Masitinib for treatment of severely symptomatic indolent systemic mastocytosis: a randomised, placeb
  • T6INDIRECT 34750553 ↗Fenebrutinib in H<sub>1</sub> antihistamine-refractory chronic spontaneous urticaria: a randomized p
  • T6INDIRECT 15086698 ↗Impact of hydroxychloroquine therapy on chronic urticaria: chronic autoimmune urticaria study and ev
  • T6INDIRECT 19453774 ↗The use of a responder analysis to identify clinically meaningful differences in chronic urticaria p
  • T6INDIRECT 28160338 ↗H1-antihistamine-refractory chronic spontaneous urticaria: it's worse than we thought - first result
  • T6INDIRECT 6114712 ↗Combined H1 and H2 antihistamine therapy in chronic urticaria
  • T6INDIRECT 32196678 ↗Eleven faces of coronavirus disease 2019
  • T6INDIRECT 32436290 ↗EAACI Allergen Immunotherapy User's Guide
  • T6INDIRECT 21668033 ↗Diagnosis and treatment of cutaneous mastocytosis in children: practical recommendations
  • T6INDIRECT 31256161 ↗Why the 20% + 2 Tryptase Formula Is a Diagnostic Gold Standard for Severe Systemic Mast Cell Activat
  • T6INDIRECT 32128023 ↗IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position p
  • T6INDIRECT 26525001 ↗2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6INDIRECT 23452057 ↗Characterization of different courses of atopic dermatitis in adolescent and adult patients
  • T6 26779180 ↗Mast Cell: A Multi-Functional Master Cell
  • T6 30150993 ↗The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hu
  • T6 28780941 ↗The pathophysiology of anaphylaxis
  • T6 29949830 ↗Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis
  • T6 33204386 ↗World allergy organization anaphylaxis guidance 2020
  • T6 24679069 ↗Sublingual immunotherapy: World Allergy Organization position paper 2013 update
  • T6 21134576 ↗Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAI
  • T6 23268454 ↗World allergy organization guidelines for the assessment and management of anaphylaxis
High Dose Vitamin D3
T2
T2 — RCT in related condition
MCAS
18 sources
  • T2 32895648 ↗Prenatal or Childhood Serum Levels of Vitamin D and Dental Caries in Paediatric Patients: A Systemat
  • T2 40745339 ↗Chronic urticaria and vitamin D supplementations: a systematic review
  • T6INDIRECT 40205160 ↗Do clinical caries-preventive interventions applied to expectant mothers affect caries-related param
  • T2 24507460 ↗Beneficial role for supplemental vitamin D3 treatment in chronic urticaria: a randomized study
  • T2 35774395 ↗High Dose Intramuscular Vitamin D3 Supplementation Impacts the Gut Microbiota of Patients With <i>Cl
  • T6 34445803 ↗The Impact of Vitamin D on Skin Aging
  • T6 31632510 ↗Vitamin D and alopecia areata: possible roles in pathogenesis and potential implications for therapy
  • T6 27014952 ↗Vitamin D in atopic dermatitis, chronic urticaria and allergic contact dermatitis
  • T6 37560437 ↗Scientific opinion on the tolerable upper intake level for vitamin D, including the derivation of a
  • T6 32503654 ↗Does a ketogenic diet as an adjuvant therapy for drug treatment enhance chemotherapy sensitivity and
  • T5 30944690 ↗Vitamin D supplements improve urticaria symptoms and quality of life in chronic spontaneous urticari
  • T4 40681996 ↗Vitamin D and skin disorders: bridging molecular insights to clinical innovations
  • T4 30534360 ↗Relationship between vitamin D and chronic spontaneous urticaria: a systematic review
  • T4 25346784 ↗Vitamin d supplements improve urticaria symptoms and quality of life in chronic spontaneous urticari
  • T6 25976440 ↗A 60-year-old woman with recurrent episodes of flushing, urticaria, and angioedema
  • T6 40551736 ↗Cholecalciferol (vitamin D3): efficacy, safety, and implications in public health
  • T6 39796035 ↗Skin Disorders and Osteoporosis: Unraveling the Interplay Between Vitamin D, Microbiota, and Epigene
  • T6 41846928 ↗Vitamin D&lt;sub&gt;3&lt;/sub&gt; as an immunomodulatory agent: molecular mechanisms, clinical trans
Hydrocortisone
T2
T2 — RCT in related condition
MCAS
26 sources
  • T6 NCT00186628 ↗Phase 2 Trial of Prophylactic Rituximab Therapy for Prevention of CGVHD
  • T6INDIRECT 25420283 ↗Hypersensitivity reactions to intravenous iron: guidance for risk minimization and management
  • T6INDIRECT 25900167 ↗High-Dose Corticosteroid Use and Risk of Hip Osteonecrosis: Meta-Analysis and Systematic Literature
  • T6INDIRECT 12804509 ↗Physiotherapy interventions for shoulder pain
  • T6INDIRECT 21812866 ↗Urban legends: recurrent aphthous stomatitis
  • T6INDIRECT 28192644 ↗Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery
  • T6INDIRECT 26132597 ↗Topical tacrolimus for atopic dermatitis
  • T6INDIRECT 23936562 ↗Immune response to snake envenoming and treatment with antivenom; complement activation, cytokine pr
  • T6INDIRECT 23041624 ↗T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
  • T2 7865982 ↗Low-dose hydrocortisone infusion attenuates the systemic inflammatory response syndrome. The Phospho
  • T6 19560575 ↗Intestinal barrier function: molecular regulation and disease pathogenesis
  • T6INDIRECT 23939821 ↗Key role of CRF in the skin stress response system
  • T6INDIRECT 32803422 ↗Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a com
  • T6INDIRECT 21277939 ↗Mucins in the pathogenesis of breast cancer: implications in diagnosis, prognosis and therapy
  • T6INDIRECT 24813302 ↗Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of a
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6INDIRECT 23452057 ↗Characterization of different courses of atopic dermatitis in adolescent and adult patients
  • T6INDIRECT 19143700 ↗Suspected anaphylactic reactions associated with anaesthesia
  • T6 11229815 ↗The CD40/CD154 receptor/ligand dyad
  • T6 33961029 ↗Congenital Adrenal Hyperplasia-Current Insights in Pathophysiology, Diagnostics, and Management
  • T6 33204386 ↗World allergy organization anaphylaxis guidance 2020
  • T6 30449684 ↗Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids
  • T6 19926814 ↗Early weaning stress impairs development of mucosal barrier function in the porcine intestine
  • T6 24531552 ↗Bitter and sweet taste receptors regulate human upper respiratory innate immunity
  • T6 24153250 ↗Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans
  • T6 28346442 ↗Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
IV Dexamethasone
T2
T2 — RCT in related condition
MCAS
17 sources
  • T2 25793707 ↗Effect of intravenous sodium valproate vs dexamethasone on acute migraine headache: a double blind r
  • T6INDIRECT 41223203 ↗Analgesic effectiveness of wound infiltration with bupivacaine versus a mixture of bupivacaine and t
  • T6INDIRECT 21119866 ↗Suspected systemic calcinosis and calciphylaxis in 5 horses
  • T6 20886011 ↗Hypersensitivity reactions associated with platinum antineoplastic agents: a systematic review
  • T6 34096653 ↗Mucormycosis in patients with COVID-19: A cross-sectional descriptive multicentre study from Iran
  • T6 22927730 ↗Current options for the treatment of optic neuritis
  • T6INDIRECT 33834172 ↗Prolonged Anaphylaxis to Pfizer Coronavirus Disease 2019 Vaccine: A Case Report and Mechanism of Act
  • T6INDIRECT 36817292 ↗Hypocomplementemic Urticarial Vasculitis Syndrome Masquerading as Systemic Lupus Erythematosus: A Ca
  • T6INDIRECT 30899622 ↗Anaphylaxis Induced by Sugammadex in a Patient with Papillary Serous Carcinoma of the Uterine Adnexa
  • T6INDIRECT 32725471 ↗Abstracts from the 2020 Annual Meeting of the Society of General Internal Medicine
  • T6INDIRECT 28397154 ↗Abstracts from the 2017 Society of General Internal Medicine Annual Meeting
  • T6 38690390 ↗Ocular involvement in oral vesiculobullous diseases: A review on reported cases in the literature
  • T6 32745248 ↗Abstracts from the European Academy of Allergy and Clinical Immunology Congress, 26-30 May 2018, Mun
  • T6 27114361 ↗Abstracts from the 2016 Society of General Internal Medicine Annual Meeting
  • T6 35252582 ↗Main Abstracts
  • T6 35295545 ↗Premedications for Cancer Therapies: A Primer for the Hematology/Oncology Provider
  • T6 34828527 ↗State of the Art in Hepatic Dysfunction in Pregnancy
Ligelizumab
T2
T2 — RCT in related condition
MCAS
24 sources
  • T6INDIRECT 34431983 ↗Evaluation of Pharmacologic Treatments for H1 Antihistamine-Refractory Chronic Spontaneous Urticaria
  • T6INDIRECT 34695599 ↗Impact of Pharmacological Treatments for Chronic Spontaneous Urticaria with an Inadequate Response t
  • T6INDIRECT 37572360 ↗Interventions for bullous pemphigoid
  • T2 25200415 ↗Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-Ig
  • T6INDIRECT 34750553 ↗Fenebrutinib in H<sub>1</sub> antihistamine-refractory chronic spontaneous urticaria: a randomized p
  • T2 38008109 ↗Efficacy and safety of ligelizumab in adults and adolescents with chronic spontaneous urticaria: res
  • T2 37492920 ↗Ligelizumab in adolescents with chronic spontaneous urticaria: Results of a dedicated phase 2b rando
  • T6INDIRECT 40415544 ↗Anti-KIT Barzolvolimab for Chronic Spontaneous Urticaria
  • T6INDIRECT 37545503 ↗Anti-interleukin 4 receptor α antibody for the treatment of Chinese bullous pemphigoid patients with
  • T6 35667749 ↗Autoimmune chronic spontaneous urticaria
  • T6INDIRECT 29259713 ↗The etiopathogenesis of atopic dermatitis: barrier disruption, immunological derangement, and prurit
  • T6INDIRECT 28097159 ↗IgE-Related Chronic Diseases and Anti-IgE-Based Treatments
  • T6INDIRECT 31636640 ↗The Intersection of IgE Autoantibodies and Eosinophilia in the Pathogenesis of Bullous Pemphigoid
  • T6INDIRECT 30882368 ↗The use of biologics for immune modulation in allergic disease
  • T6INDIRECT 32421085 ↗Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in
  • T6INDIRECT 30021447 ↗Biologics in Chronic Rhinosinusitis: An Update and Thoughts for Future Directions
  • T6INDIRECT 37190096 ↗Mast Cells as a Target-A Comprehensive Review of Recent Therapeutic Approaches
  • T6INDIRECT 27826958 ↗Personalized Medicine in Allergy
  • T6 36928371 ↗The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment
  • T6 32929378 ↗Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precisi
  • T6 39962262 ↗Type 2 immunity in allergic diseases
  • T6 33807098 ↗Pruritus as a Distinctive Feature of Type 2 Inflammation
  • T6 32224621 ↗Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020
  • T6 35469840 ↗KIT as a master regulator of the mast cell lineage
Low Dose Vitamin D3
T2
T2 — RCT in related condition
MCAS
2 sources
  • T2 35268051 ↗Vitamin D Supplementation and Sleep: A Systematic Review and Meta-Analysis of Intervention Studies
  • T6 30534360 ↗Relationship between vitamin D and chronic spontaneous urticaria: a systematic review
Masitinib /kg/day
T2
T2 — RCT in related condition
MCAS
1 source
  • T2 NCT05449444 ↗Masitinib for the Treatment of Severe Mast Cell Activation Syndrome
Methotrexate
T2
T2 — RCT in related condition
RegisteredWithdrawnMCASPOTS
51 sources
  • T6WITHDRAWN NCT01773395 ↗GVAX vs. Placebo for MDS/AML After Allo HSCT
  • T6REGISTERED-ONLY NCT03779854 ↗Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults
  • T2 21855836 ↗Systematic review and meta-analysis of methotrexate use and risk of cardiovascular disease
  • T6INDIRECT 31046809 ↗Long-term safety of secukinumab in patients with moderate-to-severe plaque psoriasis, psoriatic arth
  • T6INDIRECT 25046337 ↗Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who rema
  • T6INDIRECT 30943337 ↗Benralizumab for &lt;i&gt;PDGFRA&lt;/i&gt;-Negative Hypereosinophilic Syndrome
  • T6INDIRECT 30343531 ↗Efficacy and Safety of Ixekizumab in the Treatment of Radiographic Axial Spondyloarthritis: Sixteen-
  • T6INDIRECT 35671774 ↗Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor
  • T6INDIRECT 28435464 ↗Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of F
  • T6INDIRECT 25154820 ↗Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effect
  • T6INDIRECT 25789989 ↗A pilot study of omalizumab in eosinophilic esophagitis
  • T6 35732831 ↗The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 34542573 ↗Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephaliti
  • T6INDIRECT 28816346 ↗Homocysteine-lowering interventions for preventing cardiovascular events
  • T6INDIRECT 30019766 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30521670 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 26561338 ↗Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy
  • T6INDIRECT 27382171 ↗Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid a
  • T6INDIRECT 1739631 ↗Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)
  • T6INDIRECT 17965121 ↗Synovial tissue response to rituximab: mechanism of action and identification of biomarkers of respo
  • T6INDIRECT 17655751 ↗Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis
  • T6INDIRECT 24275598 ↗Treating inflammation by blocking interleukin-1 in humans
  • T6INDIRECT 32107531 ↗Pediatric hemophagocytic lymphohistiocytosis
  • T6INDIRECT 33077936 ↗Kinase inhibition in autoimmunity and inflammation
  • T6INDIRECT 35215786 ↗<i>Herpes zoster</i>: A Review of Clinical Manifestations and Management
  • T6INDIRECT 29915719 ↗Past, Present, and Future of Rituximab-The World's First Oncology Monoclonal Antibody Therapy
  • T6INDIRECT 24366648 ↗Diagnosis and management of Neuro-Behçet's disease: international consensus recommendations
  • T6INDIRECT 23109216 ↗Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for p
  • T6 34824210 ↗The JAK/STAT signaling pathway: from bench to clinic
  • T6 21303899 ↗International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of ad
  • T6 18758473 ↗Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
  • T6 25287861 ↗Calcitonin gene-related peptide: physiology and pathophysiology
  • T6 24587990 ↗Oxidative stress, prooxidants, and antioxidants: the interplay
  • T6 38311623 ↗Extracellular vesicles as tools and targets in therapy for diseases
  • T6 37169756 ↗Angiogenic signaling pathways and anti-angiogenic therapy for cancer
  • T6INDIRECT 30218025 ↗Mechanisms, biomarkers and targets for adult-onset Still's disease
  • T6INDIRECT 35655306 ↗Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine
  • T6INDIRECT 31954495 ↗Diagnosis and management of toxicities of immune checkpoint inhibitors in hepatocellular carcinoma
  • T6INDIRECT 34655433 ↗Chemotherapy-Induced Peripheral Neuropathy: Epidemiology, Pathomechanisms and Treatment
  • T6INDIRECT 24672257 ↗Chemotherapy-induced peripheral neuropathy in adults: a comprehensive update of the literature
  • T6INDIRECT 31485575 ↗Clinical Manifestations, Diagnosis, and Treatment of Sarcoidosis
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6 37919282 ↗Smart nanoparticles for cancer therapy
  • T6 34988090 ↗Treatment of Inflammatory Bowel Disease: A Comprehensive Review
  • T6 32213941 ↗Chemical Constituents and Pharmacological Activities of Garlic (<i>Allium sativum</i> L.): A Review
  • T6 29163522 ↗The Vagus Nerve in the Neuro-Immune Axis: Implications in the Pathology of the Gastrointestinal Trac
  • T6 31633216 ↗Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
  • T6 25182228 ↗Clinician's Guide to Prevention and Treatment of Osteoporosis
  • T6 35478046 ↗The clinician's guide to prevention and treatment of osteoporosis
Music Therapy
T2
T2 — RCT in related condition
MCAS
22 sources
  • T6INDIRECT 35968291 ↗Rhythmic auditory stimulation promotes gait recovery in Parkinson's patients: A systematic review an
  • T2 37735362 ↗A systematic review and network meta-analysis of virtual reality, audiovisuals and music interventio
  • T6INDIRECT 22978561 ↗Ending homelessness among people with mental illness: the At Home/Chez Soi randomized trial of a Hou
  • T2 30545420 ↗Music therapy intervention in cardiac autonomic modulation, anxiety, and depression in mothers of pr
  • T6INDIRECT 27769226 ↗The effectiveness of a Housing First adaptation for ethnic minority groups: findings of a pragmatic
  • T6INDIRECT 23031406 ↗Moving from rhetoric to reality: adapting Housing First for homeless individuals with mental illness
  • T2 32401941 ↗Effect of music at 432 Hz and 440 Hz on dental anxiety and salivary cortisol levels in patients unde
  • T6INDIRECT 25887511 ↗Effectiveness and cost-effectiveness of cognitive adaptation training as a nursing intervention in l
  • T6INDIRECT 32399126 ↗Effects of Rhythmic Sensory Stimulation on Ehlers-Danlos Syndrome: A Pilot Study
  • T6 27843641 ↗ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016
  • T6INDIRECT 35401253 ↗Psychological Interventions for Young People With Psychotic Disorders: A Systematic Review
  • T6INDIRECT 39428602 ↗Ketamine and Esketamine in Clinical Trials: FDA-Approved and Emerging Indications, Trial Trends With
  • T6INDIRECT 34444622 ↗An Integrative Review of Recovery Services to Improve the Lives of Adults Living with Severe Mental
  • T6INDIRECT 41009795 ↗Advances in Psoriasis Research: Decoding Immune Circuits and Developing Novel Therapies
  • T6INDIRECT 30240102 ↗Abstracts from the 50th Congress of the International Society of Paediatric Oncology (SIOP) Kyoto, J
  • T6INDIRECT 40726475 ↗11th European Stroke Organisation Conference Abstracts - 21-23 May 2025, Helsinki, Finland
  • T6 39273008 ↗Gut-Brain Axis: Role of Microbiome, Metabolomics, Hormones, and Stress in Mental Health Disorders
  • T6 36674580 ↗Alzheimer's Disease-Biochemical and Psychological Background for Diagnosis and Treatment
  • T6 40792123 ↗The China Alzheimer Report 2025
  • T6 30993550 ↗Update in Neurocritical Care: a summary of the 2018 Paris international conference of the French Soc
  • T6 30588066 ↗Vaso-occlusive crisis in sickle cell disease: current paradigm on pain management
  • T6 26541397 ↗Methods of reducing pain during bone marrow biopsy: a narrative review
Ophthalmological examination
T2
T2 — RCT in related condition
MCAS
28 sources
  • T2 NCT04978740 ↗Ocular and Palpebral Manifestations of Mastocytosis (MOOMA)
  • T6 30242621 ↗Latest Clinical Approaches in the Ocular Management of Cystinosis: A Review of Current Practice and
  • T6 30965123 ↗Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host di
  • T6 33928457 ↗Effects of acute alcohol consumption on neuronal activity and cerebral vasomotor response
  • T6 29977446 ↗Neurologic Complications of Acute Posterior Multifocal Placoid Pigment Epitheliopathy: A Case Series
  • T6 32722267 ↗Evaluation of Subchronic Oral Dose Toxicity of Freeze-Dried Skimmed Powder of <i>Zophobas atratus</i
  • T6INDIRECT 25919144 ↗Interventions for rosacea
  • T6INDIRECT 27373108 ↗COGAN'S SYNDROME
  • T6INDIRECT 38407686 ↗Visual outcomes and patient satisfaction after bilateral implantation of an enhanced monofocal intra
  • T6INDIRECT 24429379 ↗Impact of patient access to Internet health records on glaucoma medication: randomized controlled tr
  • T6INDIRECT 32059021 ↗Evaluating the cost-consequence of a standardized strategy for the etiological diagnosis of uveitis
  • T6INDIRECT 28866675 ↗SAVE-AMD: Safety of VEGF Inhibitors in Age-Related Macular Degeneration
  • T6INDIRECT 27388951 ↗Choroidal and macular thickness changes in type 1 diabetes mellitus patients without diabetic retino
  • T6 35186126 ↗Hydroxychloroquine in systemic lupus erythematosus: overview of current knowledge
  • T6 27895936 ↗Neovascular glaucoma: a review
  • T6 27769587 ↗Deep Retinal Layer Microvasculature Dropout Detected by the Optical Coherence Tomography Angiography
  • T6INDIRECT 33270751 ↗Retinal changes in COVID-19 hospitalized cases
  • T6INDIRECT 32735134 ↗Papillophlebitis in a COVID-19 patient: Inflammation and hypercoagulable state
  • T6INDIRECT 33249111 ↗Optical coherence tomography angiography analysis of the retina in patients recovered from COVID-19:
  • T6INDIRECT 25775251 ↗The ophthalmic branch of the Gutenberg Health Study: study design, cohort profile and self-reported
  • T6INDIRECT 37886027 ↗GEMA 5.3. Spanish Guideline on the Management of Asthma
  • T6INDIRECT 33961108 ↗Reduced macular vessel density in COVID-19 patients with and without associated thrombotic events us
  • T6 34830247 ↗Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eye
  • T6 30967901 ↗Risks and risk management in modern multiple sclerosis immunotherapeutic treatment
  • T6 34370174 ↗Ocular toxoplasmosis: a review of the current diagnostic and therapeutic approaches
  • T6 33372616 ↗French recommendations for the management of systemic necrotizing vasculitides (polyarteritis nodosa
  • T6 22117835 ↗Proteomic analysis of saliva: a unique tool to distinguish primary Sjögren's syndrome from secondary
  • T6 25387009 ↗Ophthalmological features of Parkinson disease
QGE031
T2
T2 — RCT in related condition
MCAS
17 sources
  • T6INDIRECT 41251748 ↗Efficacy and safety of different doses of ligelizumab in patients with chronic spontaneous urticaria
  • T6INDIRECT 37572360 ↗Interventions for bullous pemphigoid
  • T2 25200415 ↗Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-Ig
  • T6 33685604 ↗Biologics for Treatment of Atopic Dermatitis: Current Status and Future Prospect
  • T6 38101757 ↗Feast for thought: A comprehensive review of food allergy 2021-2023
  • T6 26621973 ↗Anti-IgE treatment, airway inflammation and remodelling in severe allergic asthma: current knowledge
  • T6 27864548 ↗From IgE to Omalizumab
  • T6INDIRECT 28097159 ↗IgE-Related Chronic Diseases and Anti-IgE-Based Treatments
  • T6INDIRECT 31636640 ↗The Intersection of IgE Autoantibodies and Eosinophilia in the Pathogenesis of Bullous Pemphigoid
  • T6INDIRECT 30882368 ↗The use of biologics for immune modulation in allergic disease
  • T6INDIRECT 33628747 ↗Anti-IgE for the Treatment of Chronic Urticaria
  • T6INDIRECT 28078079 ↗Looking forward to new targeted treatments for chronic spontaneous urticaria
  • T6INDIRECT 31494233 ↗Current and emerging treatments for chronic spontaneous urticaria
  • T6INDIRECT 34456900 ↗Novel Approaches in the Inhibition of IgE-Induced Mast Cell Reactivity in Food Allergy
  • T6INDIRECT 31172716 ↗Emerging Therapies in Chronic Spontaneous Urticaria
  • T6 32086776 ↗The Role of Mast Cells in IgE-Independent Lung Diseases
  • T6 36652536 ↗Allergy: Mechanistic insights into new methods of prevention and therapy
Remibrutinib
T2
T2 — RCT in related condition
MCAS
27 sources
  • T6INDIRECT 40696933 ↗Manual acupuncture for the treatment of chronic spontaneous urticaria: a systematic review and meta-
  • T6INDIRECT 40663028 ↗Comparative efficacy and safety of biologics and systemic immunomodulatory treatments for chronic ur
  • T6INDIRECT 40520797 ↗Clinical efficacy and safety of acupuncture in the treatment for chronic spontaneous urticaria: a sy
  • T2 36096203 ↗Remibrutinib, a novel BTK inhibitor, demonstrates promising efficacy and safety in chronic spontaneo
  • T2 40043237 ↗Remibrutinib in Chronic Spontaneous Urticaria
  • T6INDIRECT 40266575 ↗Rilzabrutinib in Antihistamine-Refractory Chronic Spontaneous Urticaria: The RILECSU Phase 2 Randomi
  • T6INDIRECT 38308655 ↗Targeting histamine receptor 4 in cholinergic urticaria with izuforant (LEO 152020): results from a
  • T2 41115533 ↗Remibrutinib in chronic spontaneous urticaria: 52-week results from two phase 3 studies
  • T6 35667749 ↗Autoimmune chronic spontaneous urticaria
  • T6 32224621 ↗Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020
  • T6INDIRECT 38492772 ↗Bruton's tyrosine kinase inhibition for the treatment of allergic disorders
  • T6INDIRECT 37386330 ↗Current and Emerging Therapies for Chronic Spontaneous Urticaria: A Narrative Review
  • T6INDIRECT 39028396 ↗New insights into chronic inducible urticaria
  • T6INDIRECT 40532792 ↗Current and future landscape of Bruton tyrosine kinase inhibitors in allergy
  • T6INDIRECT 39598410 ↗Therapies for Chronic Spontaneous Urticaria: Present and Future Developments
  • T6INDIRECT 36776192 ↗Biologicals in Treatment of Chronic Urticaria: A Narrative Review
  • T6INDIRECT 35956071 ↗Monoclonal Antibodies in Treating Chronic Spontaneous Urticaria: New Drugs for an Old Disease
  • T6INDIRECT 39932658 ↗Clinical and Pathophysiological Tangles Between Allergy and Autoimmunity: Deconstructing an Old Dich
  • T6 36183125 ↗BTK inhibitors in the treatment of hematological malignancies and inflammatory diseases: mechanisms
  • T6 38101757 ↗Feast for thought: A comprehensive review of food allergy 2021-2023
  • T6 36251242 ↗New Mechanistic Advances in FcεRI-Mast Cell-Mediated Allergic Signaling
  • T6 32401033 ↗A Fast and Clean BTK Inhibitor
  • T6 38630620 ↗Mast cells: a novel therapeutic avenue for cardiovascular diseases?
  • T6 36430941 ↗Human Lung Mast Cells: Therapeutic Implications in Asthma
  • T6 34778053 ↗Clinical Trials of the BTK Inhibitors Ibrutinib and Acalabrutinib in Human Diseases Beyond B Cell Ma
  • T6 35175630 ↗Bruton's tyrosine kinase inhibition-An emerging therapeutic strategy in immune-mediated dermatologic
  • T6 38141832 ↗BTK signaling-a crucial link in the pathophysiology of chronic spontaneous urticaria
Rilzabrutinib
T2
T2 — RCT in related condition
MCAS
20 sources
  • T6INDIRECT 37572360 ↗Interventions for bullous pemphigoid
  • T6INDIRECT 40520797 ↗Clinical efficacy and safety of acupuncture in the treatment for chronic spontaneous urticaria: a sy
  • T2 40266575 ↗Rilzabrutinib in Antihistamine-Refractory Chronic Spontaneous Urticaria: The RILECSU Phase 2 Randomi
  • T6 36183125 ↗BTK inhibitors in the treatment of hematological malignancies and inflammatory diseases: mechanisms
  • T6 37188939 ↗Protein kinases: drug targets for immunological disorders
  • T6 35175630 ↗Bruton's tyrosine kinase inhibition-An emerging therapeutic strategy in immune-mediated dermatologic
  • T6 38474348 ↗Eosinophilic Asthma: Pathophysiology and Therapeutic Horizons
  • T6 33674445 ↗Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibi
  • T6 40838448 ↗Immunosuppressants for IgG4-related disease
  • T6INDIRECT 38492772 ↗Bruton's tyrosine kinase inhibition for the treatment of allergic disorders
  • T6INDIRECT 37386330 ↗Current and Emerging Therapies for Chronic Spontaneous Urticaria: A Narrative Review
  • T6INDIRECT 39028396 ↗New insights into chronic inducible urticaria
  • T6INDIRECT 40532792 ↗Current and future landscape of Bruton tyrosine kinase inhibitors in allergy
  • T6INDIRECT 39598410 ↗Therapies for Chronic Spontaneous Urticaria: Present and Future Developments
  • T6INDIRECT 35956071 ↗Monoclonal Antibodies in Treating Chronic Spontaneous Urticaria: New Drugs for an Old Disease
  • T6INDIRECT 39932658 ↗Clinical and Pathophysiological Tangles Between Allergy and Autoimmunity: Deconstructing an Old Dich
  • T6 36903645 ↗Bruton's Tyrosine Kinase Inhibitors (BTKIs): Review of Preclinical Studies and Evaluation of Clinica
  • T6 35290608 ↗Autoimmune Neurological Disorders with IgG4 Antibodies: a Distinct Disease Spectrum with Unique IgG4
  • T6 36140335 ↗The NF-κB Pharmacopeia: Novel Strategies to Subdue an Intractable Target
  • T6 38141832 ↗BTK signaling-a crucial link in the pathophysiology of chronic spontaneous urticaria
Rituximab
T2
T2 — RCT in related condition
MCAS
22 sources
  • T2 20548096 ↗Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-
  • T6INDIRECT 34904799 ↗Polatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma
  • T2 30901302 ↗Randomized Phase III Trial of Ibrutinib and Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristin
  • T6INDIRECT 36542826 ↗Lisocabtagene maraleucel as second-line therapy for large B-cell lymphoma: primary analysis of the p
  • T2 30184451 ↗Rituximab plus Lenalidomide in Advanced Untreated Follicular Lymphoma
  • T2 30811293 ↗First-Line Treatment of Patients With Indolent Non-Hodgkin Lymphoma or Mantle-Cell Lymphoma With Ben
  • T6INDIRECT 25154820 ↗Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effect
  • T6INDIRECT 25842160 ↗Circulating tumour DNA and CT monitoring in patients with untreated diffuse large B-cell lymphoma: a
  • T6 34054126 ↗Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
  • T6 32934330 ↗Exploring the NK cell platform for cancer immunotherapy
  • T6INDIRECT 24275598 ↗Treating inflammation by blocking interleukin-1 in humans
  • T6INDIRECT 28242845 ↗Focal Segmental Glomerulosclerosis
  • T6INDIRECT 33649022 ↗Autoimmune encephalitis: proposed best practice recommendations for diagnosis and acute management
  • T6INDIRECT 32107531 ↗Pediatric hemophagocytic lymphohistiocytosis
  • T6INDIRECT 32106302 ↗Overview of Castleman disease
  • T6INDIRECT 33219338 ↗Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease
  • T4 29915719 ↗Past, Present, and Future of Rituximab-The World's First Oncology Monoclonal Antibody Therapy
  • T6INDIRECT 27777266 ↗A Proposal for a Serology-Based Approach to Membranous Nephropathy
  • T6 33046850 ↗Myocarditis and inflammatory cardiomyopathy: current evidence and future directions
  • T6 32376392 ↗Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventio
  • T6 28550082 ↗Primary Membranous Nephropathy
  • T6 33657296 ↗Diffuse Large B-Cell Lymphoma
Sample collection
T2
T2 — RCT in related condition
RegisteredMCAS
37 sources
  • T2REGISTERED-ONLY NCT07655375 ↗Study Evaluating the Effect of UCB8600 on Mast Cell Activation in the Human Gut
  • T6INDIRECT 34470661 ↗Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histologica
  • T6INDIRECT 24101698 ↗Enhancement of vasoreactivity and cognition by intranasal insulin in type 2 diabetes
  • T6INDIRECT 9516894 ↗Increased urinary excretion of LTE4 after exercise and attenuation of exercise-induced bronchospasm
  • T6INDIRECT 29228964 ↗Effects of a multi-strain probiotic supplement for 12 weeks in circulating endotoxin levels and card
  • T6INDIRECT 23936562 ↗Immune response to snake envenoming and treatment with antivenom; complement activation, cytokine pr
  • T6INDIRECT 30914378 ↗Integrative analysis of the intestinal metabolome of childhood asthma
  • T6INDIRECT 28342911 ↗Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis
  • T6INDIRECT 33147277 ↗Bone marrow microenvironments that contribute to patient outcomes in newly diagnosed multiple myelom
  • T6INDIRECT 25527564 ↗Episodic angioedema with eosinophilia (Gleich syndrome) is a multilineage cell cycling disorder
  • T6INDIRECT 33675817 ↗Peanut diversity and specific activity are the dominant IgE characteristics for effector cell activa
  • T6 34248921 ↗Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Con
  • T6 34308300 ↗Characterizing long COVID in an international cohort: 7 months of symptoms and their impact
  • T6INDIRECT 26459294 ↗Meta-analysis derived atopic dermatitis (MADAD) transcriptome defines a robust AD signature highligh
  • T6INDIRECT 26110030 ↗Clinical and diagnostic utility of saliva as a non-invasive diagnostic fluid: 
a systematic review
  • T6INDIRECT 21829582 ↗Intestinal microbiota in healthy adults: temporal analysis reveals individual and common core and re
  • T6INDIRECT 30145102 ↗The impact of Helicobacter pylori infection, eradication therapy and probiotic supplementation on gu
  • T6INDIRECT 16621965 ↗Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to trea
  • T6INDIRECT 25842160 ↗Circulating tumour DNA and CT monitoring in patients with untreated diffuse large B-cell lymphoma: a
  • T6INDIRECT 28924229 ↗Variations in oral microbiota associated with oral cancer
  • T6INDIRECT 18765957 ↗Multicenter approach to recurrent acute and chronic pancreatitis in the United States: the North Ame
  • T6INDIRECT 14557297 ↗Current perspectives on ophthalmic mycoses
  • T6INDIRECT 28401256 ↗Immune-mediated cytokine storm and its role in severe dengue
  • T6INDIRECT 27881403 ↗Irritable bowel syndrome: a gut microbiota-related disorder?
  • T6INDIRECT 20643990 ↗Narrative review: the systemic capillary leak syndrome
  • T6INDIRECT 19010417 ↗Biomarkers of Alzheimer's disease
  • T6INDIRECT 27863252 ↗The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
  • T6INDIRECT 22552007 ↗EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal,
  • T6INDIRECT 32010645 ↗The Oral Microbiota May Have Influence on Oral Cancer
  • T6 21304480 ↗Epidemiology of Alzheimer disease
  • T6 31110428 ↗Oral microbiome: Unveiling the fundamentals
  • T6 32473127 ↗Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed
  • T6 10987697 ↗Practice guidelines for the management of community-acquired pneumonia in adults. Infectious Disease
  • T6 32404436 ↗TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes
  • T6 32470396 ↗Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alteratio
  • T6 15326289 ↗Identification and proteomic profiling of exosomes in human urine
  • T6 22698087 ↗Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils
Xolair
T2
T2 — RCT in related condition
MCAS
21 sources
  • T6INDIRECT 29650949 ↗Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement
  • T6INDIRECT 25200415 ↗Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-Ig
  • T6INDIRECT 28435464 ↗Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of F
  • T2 30654196 ↗Efficacy and Safety of Omalizumab (Xolair) for Cholinergic Urticaria in Patients Unresponsive to a D
  • T6INDIRECT 39785096 ↗CT-P39 Compared With Reference Omalizumab in Chronic Spontaneous Urticaria: Results From a Double-Bl
  • T6INDIRECT 23041624 ↗T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
  • T6INDIRECT 24176117 ↗A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic pa
  • T6INDIRECT 17765756 ↗Anti-IgE treatment of eosinophil-associated gastrointestinal disorders
  • T6INDIRECT 25789989 ↗A pilot study of omalizumab in eosinophilic esophagitis
  • T6 18650915 ↗The development of allergic inflammation
  • T6INDIRECT 25754717 ↗Biologic therapies targeting eosinophils: current status and future prospects
  • T6INDIRECT 31636640 ↗The Intersection of IgE Autoantibodies and Eosinophilia in the Pathogenesis of Bullous Pemphigoid
  • T6INDIRECT 28725969 ↗Mastocytosis: from a Molecular Point of View
  • T6INDIRECT 32421085 ↗Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in
  • T6INDIRECT 27334777 ↗Guideline of Chronic Urticaria Beyond
  • T6INDIRECT 35987486 ↗Safety of Biologics for Atopic Diseases During Pregnancy
  • T6INDIRECT 23452057 ↗Characterization of different courses of atopic dermatitis in adolescent and adult patients
  • T6INDIRECT 24532966 ↗Omalizumab, an anti-immunoglobulin E antibody: state of the art
  • T6 24531552 ↗Bitter and sweet taste receptors regulate human upper respiratory innate immunity
  • T6 33811184 ↗SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-de
  • T6 32224621 ↗Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020
avapritinib (KIT/PDGFRA inhibitor)
T2
T2 — RCT in related condition
MCAS
23 sources
  • T2 35114819 ↗Indirect treatment comparisons of avapritinib versus midostaurin for patients with advanced systemic
  • T2 38320129 ↗Avapritinib versus Placebo in Indolent Systemic Mastocytosis
  • T2 35640224 ↗Efficacy and safety of avapritinib in previously treated patients with advanced systemic mastocytosi
  • T6 34054126 ↗Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
  • T6 37169756 ↗Angiogenic signaling pathways and anti-angiogenic therapy for cancer
  • T6 32929378 ↗Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precisi
  • T6 37849038 ↗Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer
  • T6 36130297 ↗Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia
  • T6 34873347 ↗Safety and efficacy of avapritinib in advanced systemic mastocytosis: the phase 1 EXPLORER trial
  • T6 32804590 ↗Switch Control Inhibition of KIT and PDGFRA in Patients With Advanced Gastrointestinal Stromal Tumor
  • T4 35790816 ↗Efficacy of avapritinib versus best available therapy in the treatment of advanced systemic mastocyt
  • T6INDIRECT 34322383 ↗Early and Next-Generation KIT/PDGFRA Kinase Inhibitors and the Future of Treatment for Advanced Gast
  • T6INDIRECT 31372066 ↗Novel approaches to treating advanced systemic mastocytosis
  • T6INDIRECT 32462367 ↗Revolutions in treatment options in gastrointestinal stromal tumours (GISTs): the latest updates
  • T6INDIRECT 36980652 ↗Hepatotoxicity of Small Molecule Protein Kinase Inhibitors for Cancer
  • T6INDIRECT 33804174 ↗Response Criteria in Advanced Systemic Mastocytosis: Evolution in the Era of KIT Inhibitors
  • T6INDIRECT 38851398 ↗Mast cell activation syndrome: Current understanding and research needs
  • T6INDIRECT 35544644 ↗CancerVar: An artificial intelligence-empowered platform for clinical interpretation of somatic muta
  • T6 39138146 ↗Therapeutic advances of targeting receptor tyrosine kinases in cancer
  • T6 36254250 ↗Small molecule inhibitors targeting the cancers
  • T6 36849435 ↗Molecular and functional imaging in cancer-targeted therapy: current applications and future directi
  • T6 35217782 ↗New treatment strategies for advanced-stage gastrointestinal stromal tumours
  • T6 30884251 ↗Recent advances in our understanding of mast cell activation - or should it be mast cell mediator di
benralizumab (anti-IL-5Rα)
T2
T2 — RCT in related condition
MCAS
27 sources
  • T6INDIRECT 37189381 ↗Dupilumab in Inflammatory Skin Diseases: A Systematic Review
  • T6INDIRECT 35316551 ↗A systematic review on mucocutaneous presentations after COVID-19 vaccination and expert recommendat
  • T6INDIRECT 35350578 ↗Immunomodulating Therapies in Acute Myocarditis and Recurrent/Acute Pericarditis
  • T6INDIRECT 37658939 ↗Vernal Keratoconjunctivitis: A Systematic Review
  • T2 30943337 ↗Benralizumab for &lt;i&gt;PDGFRA&lt;/i&gt;-Negative Hypereosinophilic Syndrome
  • T2 30658649 ↗Modulation of blood inflammatory markers by benralizumab in patients with eosinophilic airway diseas
  • T2 38367194 ↗Benralizumab does not elicit therapeutic effect in patients with chronic spontaneous urticaria: resu
  • T2 32997916 ↗Benralizumab for Chronic Spontaneous Urticaria
  • T6 34824210 ↗The JAK/STAT signaling pathway: from bench to clinic
  • T6 28689842 ↗Asthma Exacerbations: Pathogenesis, Prevention, and Treatment
  • T6INDIRECT 25964669 ↗How I treat hypereosinophilic syndromes
  • T6INDIRECT 34519063 ↗Advances and highlights in biomarkers of allergic diseases
  • T6INDIRECT 29682504 ↗Targeting the Interleukin-5 Pathway for Treatment of Eosinophilic Conditions Other than Asthma
  • T6INDIRECT 31836530 ↗Approaches and Challenges to Management of Pediatric and Adult Patients With Eosinophilic Esophagiti
  • T6INDIRECT 32522746 ↗Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies
  • T6INDIRECT 35496822 ↗The emerging roles of eosinophils: Implications for the targeted treatment of eosinophilic-associate
  • T6INDIRECT 25754717 ↗Biologic therapies targeting eosinophils: current status and future prospects
  • T6INDIRECT 31239747 ↗Eosinophilic gastroenteritis: diagnosis and clinical perspectives
  • T6 28713812 ↗The Biology of Eosinophils and Their Role in Asthma
  • T6 28910134 ↗Eosinophilic and Noneosinophilic Asthma
  • T6 29733746 ↗The "less-is-more" in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced anti
  • T6 36964157 ↗Pathogenesis of allergic diseases and implications for therapeutic interventions
  • T6 29619379 ↗Eosinophils from Physiology to Disease: A Comprehensive Review
  • T6 36928371 ↗The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment
  • T6 32893900 ↗Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma
  • T6 34473358 ↗Endotypes of chronic rhinosinusitis: Relationships to disease phenotypes, pathogenesis, clinical fin
  • T6 35923421 ↗Type 2 inflammation in asthma and other airway diseases
bilastine (H1 antihistamine)
T2
T2 — RCT in related condition
MCAS
21 sources
  • T6INDIRECT 25397904 ↗H1-antihistamines for chronic spontaneous urticaria
  • T6INDIRECT 33665200 ↗Skin Manifestations in COVID-19 Patients: Are They Indicators for Disease Severity? A Systematic Rev
  • T6INDIRECT 35316551 ↗A systematic review on mucocutaneous presentations after COVID-19 vaccination and expert recommendat
  • T6INDIRECT 32986289 ↗Management of urticaria in COVID-19 patients: A systematic review
  • T6INDIRECT 33030434 ↗Efficacy and Safety of Up-dosing Antihistamines in Chronic Spontaneous Urticaria: A Systematic Revie
  • T6INDIRECT 24472058 ↗Night-time sedating H1 -antihistamine increases daytime somnolence but not treatment efficacy in chr
  • T2 26918853 ↗Safety and tolerability of bilastine 10 mg administered for 12 weeks in children with allergic disea
  • T2 32618048 ↗Effectiveness, safety, and tolerability of bilastine 20 mg vs levocetirizine 5 mg for the treatment
  • T6INDIRECT 39785096 ↗CT-P39 Compared With Reference Omalizumab in Chronic Spontaneous Urticaria: Results From a Double-Bl
  • T6 22035879 ↗Histamine and H1-antihistamines: celebrating a century of progress
  • T6INDIRECT 29527019 ↗Consensus Statement for the Diagnosis and Treatment of Urticaria: A 2017 Update
  • T6INDIRECT 32128023 ↗IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position p
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6INDIRECT 23282382 ↗Diagnosis and treatment of urticaria and angioedema: a worldwide perspective
  • T6INDIRECT 23282578 ↗H1 antihistamines: current status and future directions
  • T6 36964157 ↗Pathogenesis of allergic diseases and implications for therapeutic interventions
  • T6 35463011 ↗Allergic Rhinitis: A Clinical and Pathophysiological Overview
  • T6 30805711 ↗Translational Preclinical Pharmacologic Disease Models for Ophthalmic Drug Development
  • T6 37601647 ↗Immunologic, genetic, and ecological interplay of factors involved in allergic diseases
  • T6 35879928 ↗Current and Future Strategies for the Diagnosis and Treatment of the Alpha-Gal Syndrome (AGS)
  • T6 30924425 ↗Chronic Urticaria: An Overview of Treatment and Recent Patents
canakinumab (anti-IL-1β)
T2
T2 — RCT in related condition
MCAS
25 sources
  • T6INDIRECT 34394107 ↗Serum C-Reactive Protein and Periodontitis: A Systematic Review and Meta-Analysis
  • T6INDIRECT 35359659 ↗Targeting Inflammatory Mediators in Epilepsy: A Systematic Review of Its Molecular Basis and Clinica
  • T6INDIRECT 35350578 ↗Immunomodulating Therapies in Acute Myocarditis and Recurrent/Acute Pericarditis
  • T6INDIRECT 34431983 ↗Evaluation of Pharmacologic Treatments for H1 Antihistamine-Refractory Chronic Spontaneous Urticaria
  • T6INDIRECT 29141858 ↗Interleukin-1 Blockade in Recently Decompensated Systolic Heart Failure: Results From REDHART (Recen
  • T6INDIRECT 22875601 ↗Treatment with the interleukin-17A-blocking antibody secukinumab does not interfere with the efficac
  • T2 32827729 ↗Canakinumab Lacks Efficacy in Treating Adult Patients with Moderate to Severe Chronic Spontaneous Ur
  • T2 23087179 ↗Sustained efficacy of the monoclonal anti-interleukin-1 beta antibody canakinumab in a 9-month trial
  • T6INDIRECT 27663070 ↗Gevokizumab in the Treatment of Autoimmune Non-necrotizing Anterior Scleritis: Results of a Phase I/
  • T6INDIRECT 34096620 ↗Mediterranean fever gene variants modify clinical phenotypes of idiopathic multi-centric Castleman d
  • T6INDIRECT 24275598 ↗Treating inflammation by blocking interleukin-1 in humans
  • T6INDIRECT 33867315 ↗The immune response to SARS-CoV-2 and COVID-19 immunopathology - Current perspectives
  • T6INDIRECT 35606650 ↗Pyoderma Gangrenosum: An Updated Literature Review on Established and Emerging Pharmacological Treat
  • T6INDIRECT 32522746 ↗Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies
  • T6INDIRECT 36941354 ↗Clonal haematopoiesis and dysregulation of the immune system
  • T6INDIRECT 25905009 ↗Schnitzler's syndrome: lessons from 281 cases
  • T6INDIRECT 33073244 ↗Imperfect storm: is interleukin-33 the Achilles heel of COVID-19?
  • T6INDIRECT 25758134 ↗Tolerance and efficacy of off-label anti-interleukin-1 treatments in France: a nationwide survey
  • T6 26121197 ↗Inflammasomes: mechanism of action, role in disease, and therapeutics
  • T6 25625584 ↗NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflamm
  • T6 32376392 ↗Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventio
  • T6 30774631 ↗The Immunology of Macrophage Activation Syndrome
  • T6 30042333 ↗Interleukin-1 Beta-A Friend or Foe in Malignancies?
  • T6 34298011 ↗Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, ch
  • T6 30670444 ↗The central role of inflammatory signaling in the pathogenesis of myelodysplastic syndromes
cannabidiol (CBD)
T2
T2 — RCT in related condition
MCAS
25 sources
  • T6INDIRECT 31981369 ↗Interventions for chronic pruritus of unknown origin
  • T6INDIRECT 41408255 ↗Effectiveness of 0.1% triamcinolone acetonide compared with those of other therapies for minor recur
  • T6INDIRECT 39067455 ↗The role of fibrosis in endometriosis: a systematic review
  • T6INDIRECT 36742321 ↗Dupilumab for the treatment of prurigo nodularis: A systematic review
  • T6INDIRECT 39899062 ↗The Effects of Cannabinoids on Ischemic Stroke-Associated Neuroinflammation: A Systematic Review
  • T6INDIRECT 40873582 ↗The role of TGF-β superfamily in endometriosis: a systematic review
  • T6INDIRECT 32678452 ↗Effect of Inhaled Cannabis for Pain in Adults With Sickle Cell Disease: A Randomized Clinical Trial
  • T6INDIRECT 36837393 ↗Hemp Seed Oil in Association with β-Caryophyllene, Myrcene and Ginger Extract as a Nutraceutical Int
  • T6INDIRECT 41730291 ↗Colchicine in patients with chronic inflammatory cardiomyopathy: rationale and design of the CMP-MYT
  • T2 41635790 ↗Efficacy, pharmacokinetics and safety of liposomal synthetic cannabidiol injected subcutaneously in
  • T6INDIRECT 34625019 ↗Inflammatory complications of CGRP monoclonal antibodies: a case series
  • T6INDIRECT 32316328 ↗A Guide to Targeting the Endocannabinoid System in Drug Design
  • T6INDIRECT 34512404 ↗A Review of the Potential Use of Pinene and Linalool as Terpene-Based Medicines for Brain Health: Di
  • T6INDIRECT 31396087 ↗Palmitoylethanolamide (PEA) as a Potential Therapeutic Agent in Alzheimer's Disease
  • T6INDIRECT 35102560 ↗Cannabis-related allergies: An international overview and consensus recommendations
  • T6INDIRECT 35215320 ↗Cannabis-Based Products for the Treatment of Skin Inflammatory Diseases: A Timely Review
  • T6INDIRECT 33810493 ↗Topical Treatments and Their Molecular/Cellular Mechanisms in Patients with Peripheral Neuropathic P
  • T6 25407511 ↗Intestinal permeability--a new target for disease prevention and therapy
  • T6 33046850 ↗Myocarditis and inflammatory cardiomyopathy: current evidence and future directions
  • T6 25796370 ↗Endocannabinoid signaling at the periphery: 50 years after THC
  • T6 33718398 ↗Oxidative Stress in Non-alcoholic Fatty Liver Disease. An Updated Mini Review
  • T6 21420431 ↗Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system
  • T6 36928371 ↗The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment
  • T6 21062421 ↗TRPV channels and vascular function
  • T6 7724569 ↗Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and
desloratadine (H1 antihistamine)
T2
T2 — RCT in related condition
MCAS
24 sources
  • T6INDIRECT 27237730 ↗Updosing nonsedating antihistamines in patients with chronic spontaneous urticaria: a systematic rev
  • T6INDIRECT 30427977 ↗Benefits and Harms of Omalizumab Treatment in Adolescent and Adult Patients With Chronic Idiopathic
  • T6INDIRECT 19001265 ↗Intralymphatic allergen administration renders specific immunotherapy faster and safer: a randomized
  • T6INDIRECT 25046337 ↗Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who rema
  • T2 20226302 ↗The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficu
  • T6INDIRECT 15947280 ↗Inflammatory basis of exercise-induced bronchoconstriction
  • T6INDIRECT 34750553 ↗Fenebrutinib in H<sub>1</sub> antihistamine-refractory chronic spontaneous urticaria: a randomized p
  • T2 11277962 ↗Once-daily desloratadine improves the signs and symptoms of chronic idiopathic urticaria: a randomiz
  • T6INDIRECT 10831005 ↗Fexofenadine HCl is safe and effective for treatment of chronic idiopathic urticaria
  • T6INDIRECT 28160338 ↗H1-antihistamine-refractory chronic spontaneous urticaria: it's worse than we thought - first result
  • T6INDIRECT 15577865 ↗Rhinosinusitis: establishing definitions for clinical research and patient care
  • T6INDIRECT 33821570 ↗Delivery of oligonucleotide-based therapeutics: challenges and opportunities
  • T6INDIRECT 15577816 ↗Rhinosinusitis: Establishing definitions for clinical research and patient care
  • T6INDIRECT 29431216 ↗Mast cell-neural interactions contribute to pain and itch
  • T6INDIRECT 37630231 ↗Malondialdehyde as a Potential Oxidative Stress Marker for Allergy-Oriented Diseases: An Update
  • T6INDIRECT 27861988 ↗Mechanisms of action that contribute to efficacy of omalizumab in chronic spontaneous urticaria
  • T6INDIRECT 32128023 ↗IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position p
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6 23334570 ↗A review on anti-inflammatory activity of monoterpenes
  • T6 21460831 ↗TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch
  • T6 14660743 ↗Mast cells are required for experimental oral allergen-induced diarrhea
  • T6 31027996 ↗Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic I
  • T6 21134576 ↗Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAI
  • T6 23268454 ↗World allergy organization guidelines for the assessment and management of anaphylaxis
dexamethasone
T2
T2 — RCT in related condition
MCAS
26 sources
  • T6 NCT04681105 ↗Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological Malig
  • T6 32678530 ↗Dexamethasone in Hospitalized Patients with Covid-19.
  • T6INDIRECT 37056675 ↗The crucial role and mechanism of insulin resistance in metabolic disease
  • T6INDIRECT 33937212 ↗Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics
  • T6INDIRECT 19960229 ↗The role of chemotherapy in the management of newly diagnosed brain metastases: a systematic review
  • T6INDIRECT 36542826 ↗Lisocabtagene maraleucel as second-line therapy for large B-cell lymphoma: primary analysis of the p
  • T6INDIRECT 25154820 ↗Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effect
  • T6INDIRECT 25042748 ↗Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a
  • T2 8648382 ↗Fludarabine, mitoxantrone, and dexamethasone: an effective new regimen for indolent lymphoma
  • T6INDIRECT 22733017 ↗Amyloidosis of the gastrointestinal tract: a 13-year, single-center, referral experience
  • T6 34054126 ↗Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
  • T6 33657296 ↗Diffuse Large B-Cell Lymphoma
  • T6INDIRECT 24275598 ↗Treating inflammation by blocking interleukin-1 in humans
  • T6INDIRECT 32107531 ↗Pediatric hemophagocytic lymphohistiocytosis
  • T6INDIRECT 14557297 ↗Current perspectives on ophthalmic mycoses
  • T6INDIRECT 34039409 ↗The landscape of bispecific T cell engager in cancer treatment
  • T6INDIRECT 25279127 ↗Dry eye: an inflammatory ocular disease
  • T6INDIRECT 32184554 ↗The Evolving Treatment of Diabetic Retinopathy
  • T6INDIRECT 33867315 ↗The immune response to SARS-CoV-2 and COVID-19 immunopathology - Current perspectives
  • T6INDIRECT 24813302 ↗Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of a
  • T6 37169756 ↗Angiogenic signaling pathways and anti-angiogenic therapy for cancer
  • T6 21766791 ↗Resolvins and protectins in inflammation resolution
  • T6 29411111 ↗Functional morphology of the blood-brain barrier in health and disease
  • T6 25686754 ↗The role of inflammation in perinatal brain injury
  • T6 19601838 ↗The roles of antimicrobial peptides in innate host defense
  • T6 15109499 ↗Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal
dupilumab (anti-IL-4/IL-13)
T2
T2 — RCT in related condition
MCAS
26 sources
  • T6INDIRECT 26459294 ↗Meta-analysis derived atopic dermatitis (MADAD) transcriptome defines a robust AD signature highligh
  • T2 37189381 ↗Dupilumab in Inflammatory Skin Diseases: A Systematic Review
  • T6INDIRECT 35275399 ↗Strategies for using topical corticosteroids in children and adults with eczema
  • T6INDIRECT 35316551 ↗A systematic review on mucocutaneous presentations after COVID-19 vaccination and expert recommendat
  • T6INDIRECT 37658939 ↗Vernal Keratoconjunctivitis: A Systematic Review
  • T6INDIRECT 29650949 ↗Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement
  • T2 38431226 ↗Dupilumab in patients with chronic spontaneous urticaria (LIBERTY-CSU CUPID): Two randomized, double
  • T2 33611847 ↗Efficacy of dupilumab in patients with a history of prior sinus surgery for chronic rhinosinusitis w
  • T6 34824210 ↗The JAK/STAT signaling pathway: from bench to clinic
  • T6 27795547 ↗Food allergy: immune mechanisms, diagnosis and immunotherapy
  • T6INDIRECT 34519063 ↗Advances and highlights in biomarkers of allergic diseases
  • T6INDIRECT 29114938 ↗Immune response patterns in non-communicable inflammatory skin diseases
  • T6INDIRECT 29374516 ↗The vicious cycle of itch and anxiety
  • T6INDIRECT 29259713 ↗The etiopathogenesis of atopic dermatitis: barrier disruption, immunological derangement, and prurit
  • T6INDIRECT 31836530 ↗Approaches and Challenges to Management of Pediatric and Adult Patients With Eosinophilic Esophagiti
  • T6INDIRECT 32522746 ↗Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies
  • T6INDIRECT 35373533 ↗International consensus statement on allergy and rhinology: Olfaction
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6 28910134 ↗Eosinophilic and Noneosinophilic Asthma
  • T6 36964157 ↗Pathogenesis of allergic diseases and implications for therapeutic interventions
  • T6 31869278 ↗Physiology and Pathophysiology of Itch
  • T6 36428114 ↗Novel insights into atopic dermatitis
  • T6 29619379 ↗Eosinophils from Physiology to Disease: A Comprehensive Review
  • T6 34473358 ↗Endotypes of chronic rhinosinusitis: Relationships to disease phenotypes, pathogenesis, clinical fin
  • T6 35923421 ↗Type 2 inflammation in asthma and other airway diseases
  • T6 31838750 ↗Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα antibody, is required to broadly inhibit t
fexofenadine (H1 antihistamine)
T2
T2 — RCT in related condition
MCAS
20 sources
  • T6INDIRECT 35742951 ↗IL-31: State of the Art for an Inflammation-Oriented Interleukin
  • T6INDIRECT 37189381 ↗Dupilumab in Inflammatory Skin Diseases: A Systematic Review
  • T6INDIRECT 33206207 ↗Histamine receptors and COVID-19
  • T2 10831005 ↗Fexofenadine HCl is safe and effective for treatment of chronic idiopathic urticaria
  • T2 10417497 ↗A double-blind, placebo-controlled investigation of the effects of fexofenadine, loratadine and prom
  • T6INDIRECT 24472058 ↗Night-time sedating H1 -antihistamine increases daytime somnolence but not treatment efficacy in chr
  • T6INDIRECT 12968983 ↗Twenty-four-hour activity and consistency of activity of levocetirizine and desloratadine in the ski
  • T6INDIRECT 17765756 ↗Anti-IgE treatment of eosinophil-associated gastrointestinal disorders
  • T6 26779180 ↗Mast Cell: A Multi-Functional Master Cell
  • T6 29949830 ↗Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis
  • T6INDIRECT 32571129 ↗Diagnosis & management of alpha-gal syndrome: lessons from 2,500 patients
  • T6INDIRECT 26755686 ↗Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside
  • T6INDIRECT 24262698 ↗Mastocytosis
  • T6INDIRECT 32128023 ↗IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position p
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6INDIRECT 23452057 ↗Characterization of different courses of atopic dermatitis in adolescent and adult patients
  • T6INDIRECT 15870014 ↗In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation
  • T6 36964157 ↗Pathogenesis of allergic diseases and implications for therapeutic interventions
  • T6 33105588 ↗Perivascular Inflammation in Pulmonary Arterial Hypertension
  • T6 23734637 ↗The role of histamine in neurogenic inflammation
imatinib (tyrosine kinase inhibitor)
T2
T2 — RCT in related condition
MCAS
22 sources
  • T2 28514613 ↗KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma
  • T6INDIRECT 30943337 ↗Benralizumab for &lt;i&gt;PDGFRA&lt;/i&gt;-Negative Hypereosinophilic Syndrome
  • T6INDIRECT 28069279 ↗Masitinib for treatment of severely symptomatic indolent systemic mastocytosis: a randomised, placeb
  • T2 12932387 ↗Imatinib for systemic mast-cell disease
  • T6INDIRECT 31922567 ↗The Molecular Analysis for Therapy Choice (NCI-MATCH) Trial: Lessons for Genomic Trial Design
  • T6 35732831 ↗The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid
  • T6 18483217 ↗Role of platelet-derived growth factors in physiology and medicine
  • T6 25810047 ↗Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma
  • T6 22834835 ↗Functions of S100 proteins
  • T6 25266247 ↗Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task fo
  • T6INDIRECT 17655751 ↗Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis
  • T6INDIRECT 18684881 ↗Mast cells and mastocytosis
  • T6INDIRECT 29431216 ↗Mast cell-neural interactions contribute to pain and itch
  • T6INDIRECT 34684008 ↗Improving Curcumin Bioavailability: Current Strategies and Future Perspectives
  • T6INDIRECT 20643990 ↗Narrative review: the systemic capillary leak syndrome
  • T6INDIRECT 28885612 ↗Understanding CD30 biology and therapeutic targeting: a historical perspective providing insight int
  • T6INDIRECT 22504184 ↗Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia
  • T6 34054126 ↗Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
  • T6 20176269 ↗IgE, mast cells, basophils, and eosinophils
  • T6 37169756 ↗Angiogenic signaling pathways and anti-angiogenic therapy for cancer
  • T6 18982161 ↗The cytokine network in asthma and chronic obstructive pulmonary disease
  • T6 28031180 ↗Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts
ketotifen (mast cell stabiliser)
T2
T2 — RCT in related condition
MCAS
24 sources
  • T6INDIRECT 33283264 ↗Interventions for itch in people with advanced chronic kidney disease
  • T6INDIRECT 33239034 ↗Neurotransmitter and neuropeptide regulation of mast cell function: a systematic review
  • T6INDIRECT 37658939 ↗Vernal Keratoconjunctivitis: A Systematic Review
  • T2 20650926 ↗The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal sympt
  • T6INDIRECT 19491822 ↗The role of mast cell stabilization in treatment of postoperative ileus: a pilot study
  • T6INDIRECT 2972308 ↗The influence of ipratropium bromide and sodium cromoglycate on benzalkonium chloride-induced bronch
  • T6INDIRECT 17765756 ↗Anti-IgE treatment of eosinophil-associated gastrointestinal disorders
  • T2 2654254 ↗A double-blind, placebo-controlled, crossover trial of ketotifen versus hydroxyzine in the treatment
  • T6INDIRECT 2451929 ↗The contribution of histamine release to bronchoconstriction provoked by inhaled benzalkonium chlori
  • T6 29984112 ↗Immune Regulation of Skin Wound Healing: Mechanisms and Novel Therapeutic Targets
  • T6INDIRECT 30813280 ↗Cellular and Molecular Therapeutic Targets in Inflammatory Bowel Disease-Focusing on Intestinal Barr
  • T6INDIRECT 32571129 ↗Diagnosis & management of alpha-gal syndrome: lessons from 2,500 patients
  • T6INDIRECT 26690128 ↗Mast Cell-Mediated Mechanisms of Nociception
  • T6INDIRECT 31256161 ↗Why the 20% + 2 Tryptase Formula Is a Diagnostic Gold Standard for Severe Systemic Mast Cell Activat
  • T6INDIRECT 26755686 ↗Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside
  • T6INDIRECT 33307116 ↗The role of aspirin desensitization followed by oral aspirin therapy in managing patients with aspir
  • T6INDIRECT 27867684 ↗Eosinophilic gastroenteritis: Approach to diagnosis and management
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6 14760748 ↗Key role of mast cells and their major secretory products in inflammatory bowel disease
  • T6 21908429 ↗Mast cell modulation of the vascular and lymphatic endothelium
  • T6 30825305 ↗Immune cells as targets for cardioprotection: new players and novel therapeutic opportunities
  • T6 30744042 ↗Intestinal Mucosal Mast Cells: Key Modulators of Barrier Function and Homeostasis
  • T6 25517090 ↗Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions
  • T6 17005763 ↗Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum
levocetirizine (H1 antihistamine)
T2
T2 — RCT in related condition
MCAS
21 sources
  • T6INDIRECT 33206207 ↗Histamine receptors and COVID-19
  • T6INDIRECT 33030434 ↗Efficacy and Safety of Up-dosing Antihistamines in Chronic Spontaneous Urticaria: A Systematic Revie
  • T2 20226302 ↗The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficu
  • T2 16445787 ↗Levocetirizine in the treatment of chronic idiopathic urticaria: a randomized, double-blind, placebo
  • T6INDIRECT 32429063 ↗Probiotic NVP-1703 Alleviates Allergic Rhinitis by Inducing IL-10 Expression: A Four-week Clinical T
  • T6INDIRECT 24472058 ↗Night-time sedating H1 -antihistamine increases daytime somnolence but not treatment efficacy in chr
  • T6INDIRECT 18480923 ↗Treatment of chronic urticaria with narrowband ultraviolet B phototherapy: a randomized controlled t
  • T2 12968983 ↗Twenty-four-hour activity and consistency of activity of levocetirizine and desloratadine in the ski
  • T6INDIRECT 20406224 ↗No cardiac effects of therapeutic and supratherapeutic doses of rupatadine: results from a 'thorough
  • T6INDIRECT 15298570 ↗Interactions between eotaxin, histamine and mast cells in early microvascular events associated with
  • T6INDIRECT 32571129 ↗Diagnosis & management of alpha-gal syndrome: lessons from 2,500 patients
  • T6INDIRECT 35373533 ↗International consensus statement on allergy and rhinology: Olfaction
  • T6INDIRECT 20426711 ↗Therapy of pruritus
  • T6INDIRECT 32128023 ↗IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position p
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6INDIRECT 22410181 ↗Diagnostic tools in Rhinology EAACI position paper
  • T6INDIRECT 23282382 ↗Diagnosis and treatment of urticaria and angioedema: a worldwide perspective
  • T6INDIRECT 23282578 ↗H1 antihistamines: current status and future directions
  • T6 29949830 ↗Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis
  • T6 36964157 ↗Pathogenesis of allergic diseases and implications for therapeutic interventions
  • T6 33452689 ↗EAACI statement on the diagnosis, management and prevention of severe allergic reactions to COVID-19
loratadine (H1 antihistamine)
T2
T2 — RCT in related condition
MCAS
22 sources
  • T6INDIRECT 33283264 ↗Interventions for itch in people with advanced chronic kidney disease
  • T2 20226302 ↗The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficu
  • T6INDIRECT 15947280 ↗Inflammatory basis of exercise-induced bronchoconstriction
  • T6INDIRECT 28435464 ↗Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of F
  • T6INDIRECT 34750553 ↗Fenebrutinib in H<sub>1</sub> antihistamine-refractory chronic spontaneous urticaria: a randomized p
  • T2 11277962 ↗Once-daily desloratadine improves the signs and symptoms of chronic idiopathic urticaria: a randomiz
  • T2 15347373 ↗Desloratadine in combination with montelukast in the treatment of chronic urticaria: a randomized, d
  • T2 10417497 ↗A double-blind, placebo-controlled investigation of the effects of fexofenadine, loratadine and prom
  • T6INDIRECT 28342911 ↗Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis
  • T6INDIRECT 17765756 ↗Anti-IgE treatment of eosinophil-associated gastrointestinal disorders
  • T6INDIRECT 15577865 ↗Rhinosinusitis: establishing definitions for clinical research and patient care
  • T6INDIRECT 15577816 ↗Rhinosinusitis: Establishing definitions for clinical research and patient care
  • T6INDIRECT 29431216 ↗Mast cell-neural interactions contribute to pain and itch
  • T6INDIRECT 35964548 ↗Optimizing treatment management of trastuzumab deruxtecan in clinical practice of breast cancer
  • T6INDIRECT 20426711 ↗Therapy of pruritus
  • T6INDIRECT 32128023 ↗IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position p
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6INDIRECT 23282382 ↗Diagnosis and treatment of urticaria and angioedema: a worldwide perspective
  • T6 15972446 ↗Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V
  • T6 29949830 ↗Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis
  • T6 36964157 ↗Pathogenesis of allergic diseases and implications for therapeutic interventions
  • T6 21908429 ↗Mast cell modulation of the vascular and lymphatic endothelium
masitinib (KIT inhibitor)
T2
T2 — RCT in related condition
MCAS
23 sources
  • T2 28069279 ↗Masitinib for treatment of severely symptomatic indolent systemic mastocytosis: a randomised, placeb
  • T2 22691628 ↗Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study
  • T2 25858497 ↗A randomized, placebo-controlled phase III trial of masitinib plus gemcitabine in the treatment of a
  • T6INDIRECT 29194765 ↗c-Kit Mutation and Localization Status as Response Predictors in Mast Cell Tumors in Dogs Treated wi
  • T6INDIRECT 24407160 ↗Identification of Ponatinib as a potent inhibitor of growth, migration, and activation of neoplastic
  • T6INDIRECT 35579040 ↗Airway remodelling rather than cellular infiltration characterizes both type2 cytokine biomarker-hig
  • T6 39174535 ↗Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strateg
  • T6 28031180 ↗Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts
  • T6 29618972 ↗An Inflammation-Centric View of Neurological Disease: Beyond the Neuron
  • T6 31256327 ↗Role of Mast Cells in Shaping the Tumor Microenvironment
  • T6INDIRECT 32778962 ↗Repurposing of Kinase Inhibitors for Treatment of COVID-19
  • T6INDIRECT 24262698 ↗Mastocytosis
  • T6INDIRECT 27132234 ↗Pharmacological treatment options for mast cell activation disease
  • T6INDIRECT 28725969 ↗Mastocytosis: from a Molecular Point of View
  • T6INDIRECT 23181448 ↗Advanced systemic mastocytosis: the impact of KIT mutations in diagnosis, treatment, and progression
  • T6INDIRECT 31372066 ↗Novel approaches to treating advanced systemic mastocytosis
  • T6INDIRECT 24044484 ↗Mastocytosis: update on pharmacotherapy and future directions
  • T6INDIRECT 34893494 ↗Learning through a Pandemic: The Current State of Knowledge on COVID-19 and Cancer
  • T6 29925402 ↗Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy
  • T6 33340024 ↗Improving clinical trial outcomes in amyotrophic lateral sclerosis
  • T6 32929378 ↗Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precisi
  • T6 36254250 ↗Small molecule inhibitors targeting the cancers
  • T6 27536065 ↗Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells
midostaurin (KIT inhibitor)
T2
T2 — RCT in related condition
MCAS
21 sources
  • T2 28644114 ↗Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation
  • T2 24085261 ↗Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers
  • T2 24839948 ↗Comparison of two endogenous biomarkers of CYP3A4 activity in a drug-drug interaction study between
  • T2 32437738 ↗Midostaurin improves quality of life and mediator-related symptoms in advanced systemic mastocytosis
  • T6 34054126 ↗Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
  • T6 28031180 ↗Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts
  • T6 26679767 ↗Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive
  • T6 30713991 ↗The growing role of precision and personalized medicine for cancer treatment
  • T6 27355533 ↗Efficacy and Safety of Midostaurin in Advanced Systemic Mastocytosis
  • T6 34873347 ↗Safety and efficacy of avapritinib in advanced systemic mastocytosis: the phase 1 EXPLORER trial
  • T6INDIRECT 25964669 ↗How I treat hypereosinophilic syndromes
  • T6INDIRECT 34774343 ↗A review of FLT3 inhibitors in acute myeloid leukemia
  • T4 29487059 ↗Midostaurin: its odyssey from discovery to approval for treating acute myeloid leukemia and advanced
  • T6INDIRECT 32778962 ↗Repurposing of Kinase Inhibitors for Treatment of COVID-19
  • T6INDIRECT 24262698 ↗Mastocytosis
  • T6INDIRECT 27132234 ↗Pharmacological treatment options for mast cell activation disease
  • T6INDIRECT 28725969 ↗Mastocytosis: from a Molecular Point of View
  • T6 24359404 ↗Targeting the PDGF signaling pathway in tumor treatment
  • T6 37143582 ↗Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, an
  • T6 25650093 ↗KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on
  • T6 27536065 ↗Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells
mycophenolate mofetil
T2
T2 — RCT in related condition
MCAS
23 sources
  • T6 NCT00006251 ↗Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by C
  • T6 NCT00014235 ↗Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transpla
  • T6 NCT00118352 ↗Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophen
  • T6 NCT00112593 ↗Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and M
  • T6INDIRECT 22972085 ↗Systemic interventions for recurrent aphthous stomatitis (mouth ulcers)
  • T6INDIRECT 36578492 ↗Efficacy and safety of rituximab treatment in patients with idiopathic inflammatory myopathies: A sy
  • T6INDIRECT 37189381 ↗Dupilumab in Inflammatory Skin Diseases: A Systematic Review
  • T6INDIRECT 26092582 ↗Immunoglobulin G4-related diseases in the head and neck: a systematic review
  • T6INDIRECT 20431041 ↗Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and l
  • T6INDIRECT 20634300 ↗Addition of azathioprine to corticosteroids does not benefit patients with IgA nephropathy
  • T6INDIRECT 30879003 ↗Effects of an Oral CRTh2 Antagonist (AZD1981) on Eosinophil Activity and Symptoms in Chronic Spontan
  • T2 17040448 ↗Treatment of severe chronic idiopathic urticaria with oral mycophenolate mofetil in patients not res
  • T6 28550082 ↗Primary Membranous Nephropathy
  • T6 28242845 ↗Focal Segmental Glomerulosclerosis
  • T6INDIRECT 30558872 ↗Antibiotic allergy
  • T6INDIRECT 28139263 ↗JAK inhibitors in dermatology: The promise of a new drug class
  • T6INDIRECT 27777266 ↗A Proposal for a Serology-Based Approach to Membranous Nephropathy
  • T6INDIRECT 26907530 ↗Mechanisms of Disease: Pemphigus and Bullous Pemphigoid
  • T6INDIRECT 24366648 ↗Diagnosis and management of Neuro-Behçet's disease: international consensus recommendations
  • T6INDIRECT 26525001 ↗2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines
  • T6 35504917 ↗COVID-19 vaccine development: milestones, lessons and prospects
  • T6 29619379 ↗Eosinophils from Physiology to Disease: A Comprehensive Review
  • T6 25433021 ↗Cardiovascular disease in patients with chronic inflammation: mechanisms underlying premature cardio
omalizumab (anti-IgE)
T2
T2 — RCT in related condition
MCAS
27 sources
  • T2 11483846 ↗Treatment of childhood asthma with anti-immunoglobulin E antibody (omalizumab)
  • T2 26581915 ↗A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy
  • T2 25046337 ↗Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who rema
  • T2 21636116 ↗Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyrope
  • T6INDIRECT 29650949 ↗Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement
  • T6INDIRECT 28514613 ↗KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma
  • T6INDIRECT 25200415 ↗Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-Ig
  • T6INDIRECT 25042748 ↗Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a
  • T2 24176117 ↗A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic pa
  • T2 18774392 ↗Treatment of chronic autoimmune urticaria with omalizumab
  • T6INDIRECT 26907530 ↗Mechanisms of Disease: Pemphigus and Bullous Pemphigoid
  • T6INDIRECT 37630231 ↗Malondialdehyde as a Potential Oxidative Stress Marker for Allergy-Oriented Diseases: An Update
  • T6INDIRECT 32436290 ↗EAACI Allergen Immunotherapy User's Guide
  • T4 27861988 ↗Mechanisms of action that contribute to efficacy of omalizumab in chronic spontaneous urticaria
  • T6INDIRECT 34519063 ↗Advances and highlights in biomarkers of allergic diseases
  • T6INDIRECT 25109885 ↗Advances in clinical management of eosinophilic esophagitis
  • T6INDIRECT 32128023 ↗IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position p
  • T6INDIRECT 26525001 ↗2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines
  • T6 22561833 ↗IgE and mast cells in allergic disease
  • T6 18650915 ↗The development of allergic inflammation
  • T6 20176269 ↗IgE, mast cells, basophils, and eosinophils
  • T6 27795547 ↗Food allergy: immune mechanisms, diagnosis and immunotherapy
  • T6 28780941 ↗The pathophysiology of anaphylaxis
  • T6 25452755 ↗Mast cell mediators: their differential release and the secretory pathways involved
  • T6 19828304 ↗Mast cells in atopic dermatitis
  • T6 23587334 ↗Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of A
  • T6 23268454 ↗World allergy organization guidelines for the assessment and management of anaphylaxis
ranitidine (H2 antihistamine)
T2
T2 — RCT in related condition
MCASPOTS
46 sources
  • T6INDIRECT 31025714 ↗Interventions for hand eczema
  • T6INDIRECT 35268051 ↗Vitamin D Supplementation and Sleep: A Systematic Review and Meta-Analysis of Intervention Studies
  • T6INDIRECT 22419335 ↗Histamine H2-receptor antagonists for urticaria
  • T6INDIRECT 33206207 ↗Histamine receptors and COVID-19
  • T6INDIRECT 33080623 ↗Isatuximab as monotherapy and combined with dexamethasone in patients with relapsed/refractory multi
  • T2 2878811 ↗Treatment of chronic urticaria with terfenadine and ranitidine. A randomized double-blind study in 4
  • T6INDIRECT 24507460 ↗Beneficial role for supplemental vitamin D3 treatment in chronic urticaria: a randomized study
  • T6INDIRECT 8676090 ↗Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia
  • T2 6150641 ↗Comparison of the effectiveness of ranitidine and cimetidine in inhibiting acid secretion in patient
  • T6 30150993 ↗The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hu
  • T6INDIRECT 29926477 ↗Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent
  • T6INDIRECT 29694674 ↗Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent
  • T6INDIRECT 36190739 ↗Pharmacological interventions for prevention of weight gain in people with schizophrenia
  • T6INDIRECT 28893208 ↗Trial design and rationale for APOLLO, a Phase 3, placebo-controlled study of patisiran in patients
  • T6INDIRECT 28655357 ↗Drug-related problems and medication reviews among old people with dementia
  • T6INDIRECT 26461064 ↗Nurse-Led Medicines' Monitoring for Patients with Dementia in Care Homes: A Pragmatic Cohort Stepped
  • T6INDIRECT 23179472 ↗Bioequivalence and tolerability assessment of a novel intravenous ciclosporin lipid emulsion compare
  • T6INDIRECT 10646881 ↗Phase I study of dose-escalated paclitaxel, ifosfamide, and cisplatin (PIC) combination chemotherapy
  • T6 16678566 ↗Childhood functional gastrointestinal disorders: child/adolescent
  • T6 37139824 ↗American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medicatio
  • T6INDIRECT 34684008 ↗Improving Curcumin Bioavailability: Current Strategies and Future Perspectives
  • T6INDIRECT 21668033 ↗Diagnosis and treatment of cutaneous mastocytosis in children: practical recommendations
  • T6INDIRECT 31640115 ↗Adverse Effects of Proton Pump Inhibitors-Evidence and Plausibility
  • T6INDIRECT 35964548 ↗Optimizing treatment management of trastuzumab deruxtecan in clinical practice of breast cancer
  • T6INDIRECT 32128023 ↗IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position p
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6INDIRECT 23452057 ↗Characterization of different courses of atopic dermatitis in adolescent and adult patients
  • T6INDIRECT 15870014 ↗In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation
  • T6 31739596 ↗Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature
  • T6 23476052 ↗Idiosyncratic adverse drug reactions: current concepts
  • T6 27620496 ↗Opportunities for new CT contrast agents to maximize the diagnostic potential of emerging spectral C
  • T6 21134576 ↗Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAI
  • T6 23268454 ↗World allergy organization guidelines for the assessment and management of anaphylaxis
  • T6INDIRECT 18085482 ↗Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide
  • T6INDIRECT 26084539 ↗International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors
  • T6INDIRECT 29796248 ↗Safety of antipsychotics for the treatment of schizophrenia: a focus on the adverse effects of cloza
  • T6INDIRECT 24473486 ↗Medications and impaired driving
  • T6INDIRECT 18959359 ↗Early acute management in adults with spinal cord injury: a clinical practice guideline for health-c
  • T6INDIRECT 29210346 ↗Serious Neurological Adverse Events after Ivermectin-Do They Occur beyond the Indication of Onchocer
  • T6 32872533 ↗Ionic Liquids Toxicity-Benefits and Threats
  • T6 30884251 ↗Recent advances in our understanding of mast cell activation - or should it be mast cell mediator di
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
  • T6 17608249 ↗Risks of combined alcohol/medication use in older adults
  • T6 32785879 ↗A Review of Patisiran (ONPATTRO®) for the Treatment of Polyneuropathy in People with Hereditary Tran
tacrolimus
T2
T2 — RCT in related condition
MCAS
25 sources
  • T6INDIRECT 25919144 ↗Interventions for rosacea
  • T6INDIRECT 31749986 ↗Efficacy and safety of topical and systemic medications: a systematic literature review informing th
  • T6INDIRECT 33283264 ↗Interventions for itch in people with advanced chronic kidney disease
  • T6INDIRECT 31517988 ↗Topical cyclosporine A therapy for dry eye syndrome
  • T6INDIRECT 37487610 ↗The 2022 EULAR/ACR points to consider at the early stages of diagnosis and management of suspected h
  • T2 26132597 ↗Topical tacrolimus for atopic dermatitis
  • T6INDIRECT 37189381 ↗Dupilumab in Inflammatory Skin Diseases: A Systematic Review
  • T6INDIRECT 37486733 ↗The 2022 EULAR/ACR Points to Consider at the Early Stages of Diagnosis and Management of Suspected H
  • T6INDIRECT 30623408 ↗Efficacy and safety of PAC-14028 cream - a novel, topical, nonsteroidal, selective TRPV1 antagonist
  • T6 28293453 ↗An overview and management of osteoporosis
  • T6INDIRECT 19560575 ↗Intestinal barrier function: molecular regulation and disease pathogenesis
  • T6INDIRECT 25686388 ↗The pathophysiology, diagnosis, and treatment of dry eye disease
  • T6INDIRECT 28242845 ↗Focal Segmental Glomerulosclerosis
  • T6INDIRECT 32106302 ↗Overview of Castleman disease
  • T6INDIRECT 27777266 ↗A Proposal for a Serology-Based Approach to Membranous Nephropathy
  • T6INDIRECT 24766381 ↗Osteoporosis prevention, screening, and treatment: a review
  • T6INDIRECT 25279127 ↗Dry eye: an inflammatory ocular disease
  • T6INDIRECT 24813302 ↗Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of a
  • T6 18982161 ↗The cytokine network in asthma and chronic obstructive pulmonary disease
  • T6 28550082 ↗Primary Membranous Nephropathy
  • T6 10456976 ↗Cytokines in asthma
  • T6 35504917 ↗COVID-19 vaccine development: milestones, lessons and prospects
  • T6 36964157 ↗Pathogenesis of allergic diseases and implications for therapeutic interventions
  • T6 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6 25182228 ↗Clinician's Guide to Prevention and Treatment of Osteoporosis
tezepelumab (anti-TSLP)
T2
T2 — RCT in related condition
MCAS
22 sources
  • T6INDIRECT 40696933 ↗Manual acupuncture for the treatment of chronic spontaneous urticaria: a systematic review and meta-
  • T6INDIRECT 41934326 ↗Patterns and Clinical Efficacy of Biologics Switching in Patients With Severe Asthma: A Systematic R
  • T6INDIRECT 40663028 ↗Comparative efficacy and safety of biologics and systemic immunomodulatory treatments for chronic ur
  • T6INDIRECT 40520797 ↗Clinical efficacy and safety of acupuncture in the treatment for chronic spontaneous urticaria: a sy
  • T2 36223848 ↗Effects of combination treatment with tezepelumab and allergen immunotherapy on nasal responses to a
  • T2 39956278 ↗Tezepelumab for the treatment of chronic spontaneous urticaria: Results of the phase 2b INCEPTION st
  • T6 33077936 ↗Kinase inhibition in autoimmunity and inflammation
  • T6 36964157 ↗Pathogenesis of allergic diseases and implications for therapeutic interventions
  • T6 35923421 ↗Type 2 inflammation in asthma and other airway diseases
  • T6 36928371 ↗The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment
  • T6INDIRECT 29259713 ↗The etiopathogenesis of atopic dermatitis: barrier disruption, immunological derangement, and prurit
  • T6INDIRECT 31395149 ↗Pruritus in allergy and immunology
  • T6INDIRECT 35095572 ↗Type 2 Inflammation in Eosinophilic Esophagitis: From Pathophysiology to Therapeutic Targets
  • T6INDIRECT 37215720 ↗Eosinophilic granulomatosis with polyangiitis - Advances in pathogenesis, diagnosis, and treatment
  • T6INDIRECT 30882368 ↗The use of biologics for immune modulation in allergic disease
  • T6INDIRECT 35126131 ↗Biologics in Asthma: A Molecular Perspective to Precision Medicine
  • T6INDIRECT 30021447 ↗Biologics in Chronic Rhinosinusitis: An Update and Thoughts for Future Directions
  • T6 30471983 ↗The Itch-Scratch Cycle: A Neuroimmune Perspective
  • T6 39962262 ↗Type 2 immunity in allergic diseases
  • T6 33807098 ↗Pruritus as a Distinctive Feature of Type 2 Inflammation
  • T6 33233866 ↗Regulation of Skin Barrier Function via Competition between AHR Axis versus IL-13/IL-4‒JAK‒STAT6/STA
  • T6 29988331 ↗Type 2 immunity in asthma
Akt inhibitor MK2206
T4
T4 — Case series
MCAS
14 sources
  • T6 NCT01231919 ↗MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Leukemia
  • T6 31608069 ↗Disruption of Immune Homeostasis in Human Dendritic Cells via Regulation of Autophagy and Apoptosis
  • T6 33694102 ↗Role of TGF-β in pancreatic ductal adenocarcinoma progression and PD-L1 expression
  • T6 36633576 ↗P. gingivalis Infection Upregulates PD-L1 Expression on Dendritic Cells, Suppresses CD8+ T-cell Resp
  • T6 38612585 ↗Oxidative Stress Induced by Cortisol in Human Platelets
  • T6 32291856 ↗Synergistic effect of the inhibitors of RAF/MEK and AXL on KRAS-mutated ovarian cancer cells with hi
  • T6INDIRECT 31592543 ↗17th International Congress of Immunology, 19-23 October 2019, Beijing, China
  • T6INDIRECT 27553392 ↗Oral Free Paper Sessions
  • T4 PMC9049679 ↗Abstracts DEGRO 2022
  • T4 PMC11177578 ↗EHA2024 Hybrid Congress
  • T4 PMC9260650 ↗Posters
  • T6 35945449 ↗Phospholipase D2 controls bone homeostasis by modulating M-CSF-dependent osteoclastic cell migration
  • T6 33000187 ↗The AKT inhibitor MK2206 suppresses airway inflammation and the pro‑remodeling pathway in a TDI‑indu
  • T6 26478515 ↗Sam68 regulates cell proliferation and cell adhesion-mediated drug resistance (CAM-DR) via the AKT p
American ginseng
T4
T4 — Case series
MCAS
15 sources
  • T6 NCT00719563 ↗American Ginseng in Treating Patients With Fatigue Caused by Cancer
  • T6 24311829 ↗The role and place of medicinal plants in the strategies for disease prevention
  • T6 34480749 ↗Cannabinoid Formulations and Delivery Systems: Current and Future Options to Treat Pain
  • T6 27782048 ↗Saponins from Chinese Medicines as Anticancer Agents
  • T6 24288570 ↗Diet and nutrition in cancer survivorship and palliative care
  • T6 23717169 ↗The effect of Korean red ginseng on allergic inflammation in a murine model of allergic rhinitis
  • T6INDIRECT 35329893 ↗Herb-Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements
  • T6INDIRECT 41155644 ↗Immunomodulatory Activities of Emerging Rare Ginsenosides F1, Rg5, Rk1, Rh1, and Rg2: From Molecular
  • T4 PMC5883104 ↗Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 201
  • T4 PMC7159487 ↗Poster Sessions
  • T4 PMC9045590 ↗G. ACHARI PRIZE SESSION: ORAL PRESENTATION
  • T4 PMC7151902 ↗Veterinary Herbal Medicine: A Systems-Based Approach
  • T6 34946029 ↗Nutraceuticals and Herbal Food Supplements for Weight Loss: Is There a Prebiotic Role in the Mechani
  • T6 37416796 ↗Nutraceuticals as Modulators of Immune Function: A Review of Potential Therapeutic Effects
  • T6 40574070 ↗Natural Products for Improving Soft Tissue Healing: Mechanisms, Innovations, and Clinical Potential
Briquilimab
T4
T4 — Case series
MCAS
14 sources
  • T6INDIRECT 40520797 ↗Clinical efficacy and safety of acupuncture in the treatment for chronic spontaneous urticaria: a sy
  • T6 38630620 ↗Mast cells: a novel therapeutic avenue for cardiovascular diseases?
  • T6 39028396 ↗New insights into chronic inducible urticaria
  • T6 40074986 ↗Update on the Treatment of Chronic Spontaneous Urticaria
  • T6 39598410 ↗Therapies for Chronic Spontaneous Urticaria: Present and Future Developments
  • T6 37897679 ↗Inhibition of KIT for chronic urticaria: a status update on drugs in early clinical development
  • T6INDIRECT 40845419 ↗Chronic spontaneous urticaria: update on pathogenesis and therapeutic implications
  • T6INDIRECT 41809769 ↗Treatments and Targets to Achieve Disease Control in Chronic Spontaneous Urticaria: Current and Emer
  • T6INDIRECT 41410910 ↗Advances in Pathophysiology and Therapeutic Paradigm Shifts in Chronic Spontaneous Urticaria: A Narr
  • T4 PMC11177578 ↗EHA2024 Hybrid Congress
  • T6 41009465 ↗Role of Mast Cells in Human Health and Disease: Controversies and Novel Therapies
  • T6 41044830 ↗An Overview of Chronic Spontaneous Urticaria: Diagnosis, Management, and Treatment
  • T6 41654334 ↗Systemic Treatments for Chronic Spontaneous Urticaria: Anti-IgE and Beyond
  • T6 41270830 ↗Emerging IgE and non-IgE targeted therapies for chronic urticaria
Darbepoetin Alfa
T4
T4 — Case series
MCAS
14 sources
  • T6 16931578 ↗JAK2 V617F in myeloid disorders: molecular diagnostic techniques and their clinical utility: a paper
  • T6 26419263 ↗Targeting EPO and EPO receptor pathways in anemia and dysregulated erythropoiesis
  • T6 19802503 ↗Erythropoietin, forkhead proteins, and oxidative injury: biomarkers and biology
  • T6 36350500 ↗Evolving Strategies in the Treatment of Anaemia in Chronic Kidney Disease: The HIF-Prolyl Hydroxylas
  • T6 29455764 ↗Management protocols for chronic heart failure in India
  • T6INDIRECT 22191008 ↗Acquired pincer nail deformity associated with renal failure
  • T6INDIRECT 40597783 ↗A case of chronic myelomonocytic related lysozyme-induced nephropathy
  • T6INDIRECT 35445052 ↗Cardiovascular Protective Effects of Oral Hypoxia Inducible Factor Prolyl Hydroxylase Inhibitor Roxa
  • T6INDIRECT 31248788 ↗Guideline on myeloproliferative neoplasms: Associacão Brasileira de Hematologia, Hemoterapia e Terap
  • T4 PMC7463038 ↗Abstracts TPS
  • T4 PMC13254489 ↗Publication Only
  • T4 PMC9429973 ↗Abstract Book for the 27th Congress of the European Hematology Association
  • T6 26604845 ↗The contributions of the European Medicines Agency and its pediatric committee to the fight against
  • T6 35620165 ↗Darbepoetin alfa injection versus epoetin alfa injection for treating anemia of Chinese hemodialysis
Decitabine/Cedazuridine
T4
T4 — Case series
MCAS
16 sources
  • T6 35008250 ↗FDA-Approved Drugs for Hematological Malignancies-The Last Decade Review
  • T6 33670524 ↗Therapeutic Advances in Oncology
  • T6 38163206 ↗FDA-approved heterocyclic molecules for cancer treatment: Synthesis, dosage, mechanism of action and
  • T6 36140335 ↗The NF-κB Pharmacopeia: Novel Strategies to Subdue an Intractable Target
  • T6 35236051 ↗How I diagnose and treat chronic myelomonocytic leukemia
  • T6INDIRECT 39649724 ↗KIT V560D-Mutated Systemic Mastocytosis Associated With High-Risk Myelodysplastic Syndrome: A Unique
  • T6INDIRECT 40597783 ↗A case of chronic myelomonocytic related lysozyme-induced nephropathy
  • T6INDIRECT 41378161 ↗Atypical chronic myeloid leukemia: From diagnosis to molecular features and therapeutic options
  • T6INDIRECT 37576366 ↗Managing Drug Interactions With Oral Anticancer Treatments
  • T6INDIRECT 41947786 ↗Therapy-related myeloid neoplasms following peptide receptor radionuclide therapy for neuroendocrine
  • T4 PMC12163242 ↗Publication Only
  • T4 PMC12163243 ↗Plenary Abstracts Session & Oral Presentations
  • T4 PMC11177578 ↗EHA2024 Hybrid Congress
  • T6 33792103 ↗Contemporary Risk Stratification and Treatment of Chronic Myelomonocytic Leukemia
  • T6 41514619 ↗Is There a Future for CAR-T Therapy in Acute Myeloid Leukemia?
  • T6 35663104 ↗Chronic Myelomonocytic Leukemia: Hematopathology Perspective
Doxil
T4
T4 — Case series
MCAS
19 sources
  • T6 NCT00237627 ↗Doxorubicin Hydrochloride Liposome and Bortezomib in Treating Patients With Refractory Hematologic C
  • T6 31275462 ↗PEGylated liposomes: immunological responses
  • T6 33857566 ↗Potential mechanisms of anaphylaxis to COVID-19 mRNA vaccines
  • T6 33571463 ↗Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines
  • T6 15785749 ↗NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour a
  • T6 35941223 ↗Cancer nanomedicine
  • T6INDIRECT 34107163 ↗Nanoparticle delivery system, highly active antiretroviral therapy, and testicular morphology: The r
  • T6INDIRECT 39640056 ↗Biopharmaceutical and pharmacokinetic attributes to drive nanoformulations of small molecule tyrosin
  • T6INDIRECT 41155644 ↗Immunomodulatory Activities of Emerging Rare Ginsenosides F1, Rg5, Rk1, Rh1, and Rg2: From Molecular
  • T6INDIRECT 38182056 ↗Development of anti-PEG IgG/IgM/IgE ELISA assays for profiling anti-PEG immunoglobulin response in P
  • T6INDIRECT 30561866 ↗"Abstracts of the 77th Annual Meeting of the Japanese Cancer Association; 2018 Sept 27-29; Osaka, Ja
  • T4 PMC9421640 ↗21st ISoP Annual Meeting “A New Era of Pharmacovigilance: Challenges and Opportunities” 20–23 Septem
  • T4 PMC8901205 ↗Abstract Book: 25th Congress of the European Hematology Association Virtual Edition, 2020
  • T4 PMC7161412 ↗Hematopoietic Tumors
  • T6 26265306 ↗Hypersensitivity to intravenous iron: classification, terminology, mechanisms and management
  • T6 36768330 ↗Nanomaterials and Their Impact on the Immune System
  • T6 26246897 ↗Clinical development methodology for infusion-related reactions with monoclonal antibodies
  • T6 37054953 ↗Engineered nanomaterials that exploit blood-brain barrier dysfunction for delivery to the brain
  • T6 37009262 ↗Nanoparticles advanced from preclinical studies to clinical trials for lung cancer therapy
Flotetuzumab
T4
T4 — Case series
MCAS
15 sources
  • T6 NCT04681105 ↗Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological Malig
  • T6INDIRECT 33129938 ↗Live long and active: Polypeptide-mediated assembly of antibody variable fragments
  • T6 34039409 ↗The landscape of bispecific T cell engager in cancer treatment
  • T6 31547472 ↗CD123 as a Therapeutic Target in the Treatment of Hematological Malignancies
  • T6 30280288 ↗Bispecific Antibodies for the Treatment of Acute Myeloid Leukemia
  • T6 34572809 ↗Multiparametric Flow Cytometry for MRD Monitoring in Hematologic Malignancies: Clinical Applications
  • T6 35368047 ↗Infectious complications of targeted drugs and biotherapies in acute leukemia. Clinical practice gui
  • T6INDIRECT 34071099 ↗BiTEs, DARTS, BiKEs and TriKEs-Are Antibody Based Therapies Changing the Future Treatment of AML?
  • T6INDIRECT 34833353 ↗Precision Medicine in Systemic Mastocytosis
  • T6INDIRECT 32692611 ↗Targeting the alpha subunit of IL-3 receptor (CD123) in patients with acute leukemia
  • T4 PMC12163242 ↗Publication Only
  • T4 PMC11177578 ↗EHA2024 Hybrid Congress
  • T6 33113953 ↗CD123 as a Biomarker in Hematolymphoid Malignancies: Principles of Detection and Targeted Therapies
  • T6 38904305 ↗Recent Advances in Immune-Based Therapies for Acute Myeloid Leukemia
  • T6 34581774 ↗The promise and perils of immunotherapy
Fludarabine Phosphate
T4
T4 — Case series
MCAS
12 sources
  • T6 36145292 ↗Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids
  • T6 33291602 ↗Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes
  • T6 39415291 ↗Natural killer cell-based cancer immunotherapy: from basics to clinical trials
  • T6 40550903 ↗Targeting acute myeloid leukemia through antibody engineering: innovations in immunotherapy and comb
  • T6 40483473 ↗Insights into next-generation immunotherapy designs and tools: molecular mechanisms and therapeutic
  • T4 PMC3563175 ↗XII Congress of the Italian Society of Experimental Hematology
  • T6INDIRECT 1356450 ↗Annual congress of the Austrian Society of Hematology and Oncology and the Hungarian Societies of He
  • T4 PMC13254489 ↗Publication Only
  • T4 PMC7161786 ↗Abstracts of papers presented at the Second Meeting of the European Haematology Association, Paris,
  • T4 PMC7103153 ↗Satellite Symposia and Meet-the-Professor Sessions : Satellite Symposium I
  • T6 39513028 ↗Current Developments in NK Cell Engagers for Cancer Immunotherapy: Focus on CD16A and NKp46
  • T6 39310179 ↗Identification of Potential Tryptase Inhibitors from FDA-Approved Drugs Using Machine Learning, Mole
IL-1 Trap
T4
T4 — Case series
MCAS
13 sources
  • T6 15867089 ↗Blocking IL-1 in systemic inflammation
  • T6 31900383 ↗Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review
  • T6 38177104 ↗The role of inflammasomes in human diseases and their potential as therapeutic targets
  • T6 21143856 ↗The Schnitzler syndrome
  • T6 31850638 ↗Role of inflammasomes in the pathogenesis of periodontal disease and therapeutics
  • T6INDIRECT 40615199 ↗Expanding the Patient Pool for Rilonacept
  • T6INDIRECT 37602078 ↗Adult-Onset Still's Disease (AOSD) Associated With Collagenous Colitis (CC) and Basedow's Disease: A
  • T6INDIRECT 21659854 ↗Biologic modulators in allergic and autoinflammatory diseases
  • T6INDIRECT 24085684 ↗Abstracts of the 2013 Annual Meeting of the American College of Rheumatology. October 25-30, 2013. S
  • T4 PMC11103445 ↗Abstracts of the ECTS 2024 Congress
  • T6 33534121 ↗Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases
  • T6 41085563 ↗The NLRP3 inflammasome: a pivotal orchestrator of multisystem diseases-from molecular mechanisms to
  • T6 35658515 ↗Pericarditis and Autoinflammation: A Clinical and Genetic Analysis of Patients With Idiopathic Recur
LOU064
T4
T4 — Case series
MCAS
18 sources
  • T6INDIRECT 36096203 ↗Remibrutinib, a novel BTK inhibitor, demonstrates promising efficacy and safety in chronic spontaneo
  • T6 36183125 ↗BTK inhibitors in the treatment of hematological malignancies and inflammatory diseases: mechanisms
  • T6 31446134 ↗New treatments for chronic urticaria
  • T6 38101757 ↗Feast for thought: A comprehensive review of food allergy 2021-2023
  • T6 35175630 ↗Bruton's tyrosine kinase inhibition-An emerging therapeutic strategy in immune-mediated dermatologic
  • T6INDIRECT 38492772 ↗Bruton's tyrosine kinase inhibition for the treatment of allergic disorders
  • T6INDIRECT 40532792 ↗Current and future landscape of Bruton tyrosine kinase inhibitors in allergy
  • T6INDIRECT 39598410 ↗Therapies for Chronic Spontaneous Urticaria: Present and Future Developments
  • T6INDIRECT 35956071 ↗Monoclonal Antibodies in Treating Chronic Spontaneous Urticaria: New Drugs for an Old Disease
  • T6INDIRECT 40845419 ↗Chronic spontaneous urticaria: update on pathogenesis and therapeutic implications
  • T6INDIRECT 42194774 ↗A Neuroendocrine-Immune Model of Hidradenitis Suppurativa: Mechanistic Insights into Pain, Pruritus,
  • T6INDIRECT 38621708 ↗British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease
  • T4 PMC10913204 ↗2023 CSACI annual scientific meeting book of abstracts
  • T6 32401033 ↗A Fast and Clean BTK Inhibitor
  • T6 34778053 ↗Clinical Trials of the BTK Inhibitors Ibrutinib and Acalabrutinib in Human Diseases Beyond B Cell Ma
  • T6 31743962 ↗Critical Points on the Use of Biologicals in Allergic Diseases and Asthma
  • T6 33880321 ↗The Use of Bruton's Tyrosine Kinase Inhibitors to Treat Allergic Disorders
  • T6 34141049 ↗The challenges of chronic urticaria part 2: Pharmacological treatment, chronic inducible urticaria,
Mycophenylate mofetil
T4
T4 — Case series
MCAS
10 sources
  • T6 NCT00186628 ↗Phase 2 Trial of Prophylactic Rituximab Therapy for Prevention of CGVHD
  • T6 25452424 ↗Immunology and skin in health and disease
  • T6 15090422 ↗Use of corticosteroid sparing systemic immunosuppression for treatment of corticosteroid dependent o
  • T6INDIRECT 20596252 ↗T-cell infiltration in autosomal dominant neovascular inflammatory vitreoretinopathy
  • T6 21437065 ↗Update on the management of chronic eczema: new approaches and emerging treatment options
  • T6 24085684 ↗Abstracts of the 2013 Annual Meeting of the American College of Rheumatology. October 25-30, 2013. S
  • T6INDIRECT 24737224 ↗Abstracts from the 37th Annual Meeting of the Society of General Internal Medicine, 2014, San Diego,
  • T6INDIRECT 32394034 ↗2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference
  • T6INDIRECT 28188499 ↗2017 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference
  • T4 PMC7168573 ↗The 44th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Pos
Non sedating H1-antihistamine
T4
T4 — Case series
MCAS
17 sources
  • T6INDIRECT 25397904 ↗H1-antihistamines for chronic spontaneous urticaria
  • T6INDIRECT 28818095 ↗Frequency, distribution and immunologic nature of infusion reactions in subjects receiving peglotica
  • T6 30924425 ↗Chronic Urticaria: An Overview of Treatment and Recent Patents
  • T6 24817895 ↗Leukotriene receptor antagonists for chronic urticaria: a systematic review
  • T6 26120520 ↗Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects
  • T6 PMC6494532 ↗Interventions for chronic idiopathic urticaria excluding antihistamines
  • T6 24034140 ↗Revisions to the international guidelines on the diagnosis and therapy of chronic urticaria
  • T6 25705232 ↗Insights and advances in chronic urticaria: a Canadian perspective
  • T6 31906999 ↗Efficacy of switching to bilastine, a histamine H1 receptor antagonist, in patients with chronic spo
  • T6INDIRECT 25694628 ↗The association of cholinergic and cold-induced urticaria: diagnosis and management
  • T6INDIRECT 34513518 ↗A Woman With Solar Urticaria and Heat Urticaria: A Unique Presentation of an Individual With Multipl
  • T6INDIRECT 34457015 ↗Bilastine 10 and 20 mg in paediatric and adult patients: an updated practical approach to treatment
  • T4 PMC7129269 ↗ABSTRACT BOOK
  • T6 35683540 ↗Drugs and Vaccines Hypersensitivity in Children with Mastocytosis
  • T6 28210286 ↗Bilastine in allergic rhinoconjunctivitis and urticaria: a practical approach to treatment decisions
  • T6 28698528 ↗Inflammatory and Noninflammatory Itch: Implications in Pathophysiology-Directed Treatments
  • T6 33643777 ↗Expert consensus on practical aspects in the treatment of chronic urticaria
Psychosocial Assessment And Care
T4
T4 — Case series
MCAS
7 sources
RAD001
T4
T4 — Case series
MCASPOTS
30 sources
  • T6 NCT00449748 ↗Everolimus (RAD001) as Therapy for Patients With Systemic Mastocytosis
  • T6INDIRECT 24407160 ↗Identification of Ponatinib as a potent inhibitor of growth, migration, and activation of neoplastic
  • T6 37169756 ↗Angiogenic signaling pathways and anti-angiogenic therapy for cancer
  • T6 21235428 ↗Mechanisms of drug resistance in kinases
  • T6 26654227 ↗Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell l
  • T6 27549339 ↗Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
  • T6 18559612 ↗Phase II study of dasatinib in Philadelphia chromosome-negative acute and chronic myeloid diseases,
  • T6 20038218 ↗Experience with everolimus (RAD001), an oral mammalian target of rapamycin inhibitor, in patients wi
  • T6 24323045 ↗Autophagy and human diseases
  • T6 31277291 ↗A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifesty
  • T6 20814256 ↗Emerging pharmacotherapies for neurodevelopmental disorders
  • T6 34944054 ↗Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson's Disease
  • T6 22695254 ↗Safety and preliminary efficacy analysis of the mTOR inhibitor ridaforolimus in patients with taxane
  • T6INDIRECT 20405294 ↗Total laparoscopic radical hysterectomy for cervical cancer in prolapsed uterus
  • T6INDIRECT 23258954 ↗Clinical application of development of nonantibiotic macrolides that correct inflammation-driven imm
  • T6INDIRECT 26062813 ↗Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloprol
  • T6INDIRECT 27507155 ↗IL-4 downregulates expression of the target receptor CD30 in neoplastic canine mast cells
  • T6INDIRECT 19259308 ↗Optimizing imatinib mesylate treatment in gastrointestinal stromal tumors
  • T6INDIRECT 21484580 ↗The 21st conference of the asian pacific association for the study of the liver : oral presentations
  • T6INDIRECT 30561866 ↗"Abstracts of the 77th Annual Meeting of the Japanese Cancer Association; 2018 Sept 27-29; Osaka, Ja
  • T4 PMC7163973 ↗Poster Presentations
  • T6 17934482 ↗Aberrant cytokine signaling in leukemia
  • T6 32435640 ↗Targeting the HGF/MET Axis in Cancer Therapy: Challenges in Resistance and Opportunities for Improve
  • T6 21372221 ↗Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a
  • T6INDIRECT 34559267 ↗European Association of Nuclear Medicine October 20-23, 2021 Virtual
  • T6INDIRECT 30480124 ↗Program Abstracts from the 21st International Association of Gerontology and Geriatrics (IAGG) World
  • T6INDIRECT 28894880 ↗EANM'17
  • T4 PMC6216117 ↗Abstracts from the 23rd Annual Scientific Meeting and Education Day of the Society for Neuro-Oncolog
  • T4 PMC4894295 ↗21st Congress of the European Hematology Association Copenhagen, Denmark, June 9–12, 2016
  • T4 PMC2888565 ↗15th Congress of the European Hematology Association, Spain, Barcelona, June 10–13, 2010
Ritlecitinib
T4
T4 — Case series
MCAS
14 sources
  • T6 34824210 ↗The JAK/STAT signaling pathway: from bench to clinic
  • T6 35755063 ↗Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases
  • T6 37188939 ↗Protein kinases: drug targets for immunological disorders
  • T6 39014279 ↗Biologics Versus JAK Inhibitors. Part II: Risk of Infections. A Narrative Review
  • T6 40260013 ↗Alopecia Areata: Pathogenesis, Diagnosis, and Therapies
  • T6INDIRECT 41737950 ↗Alopecia Areata - Effects of Treatment with Upadacitinib - Two Case Reports
  • T6INDIRECT 37510908 ↗Beard Alopecia: An Updated and Comprehensive Review of Etiologies, Presentation and Treatment
  • T6INDIRECT 36860609 ↗JAK Inhibitors: A New Weapon in the Skin Care Providers' Arsenal
  • T4 PMC13299356 ↗Deucravacitinib in dermatology: current indication and existing off-label data
  • T6INDIRECT 42196158 ↗Chemotherapy-Induced Alopecia Beyond Cytotoxicity: Hair Follicle Immune Privilege Collapse and JAK-S
  • T6INDIRECT 41969750 ↗Alopecia Areata and Atopic Dermatitis: Common Mechanisms and Emerging Therapeutics
  • T6 39513029 ↗Th Pathways in Immune-Mediated Skin Disorders: A Guide for Strategic Treatment Decisions
  • T6 37212867 ↗New small molecules in dermatology: for the autoimmunity, inflammation and beyond
  • T6 41654334 ↗Systemic Treatments for Chronic Spontaneous Urticaria: Anti-IgE and Beyond
Rupatadin
T4
T4 — Case series
MCAS
10 sources
  • T6 NCT01481909 ↗Study on Mastocytosis for Rupatadine Treatment
  • T6INDIRECT 33911601 ↗Omalizumab as a Succesfull Therapy in Normocomplementemic Urticarial Vasculitis: A Series of Four Pa
  • T6INDIRECT 34583772 ↗Long term treatment with omalizumab in adolescent with refractory solar urticaria
  • T6 23120659 ↗Rupatadine: pharmacological profile and its use in the treatment of allergic rhinitis
  • T6 34212158 ↗Turkish Guideline for Diagnosis and Treatment of Allergic Rhinitis (ART)
  • T6 PMC7424594 ↗Abstracts of the XXII World Allergy Congress, 4-8 December, 2011 Cancún, México
  • T4 PMC3513125 ↗275 Efficacy of Omalizumab in the Treatment of Urticaria-Vasculitis Associated to Churg-Strauss Synd
  • T6 PMC9441222 ↗Abstracts, 17. Deutscher Allergiekongress, Wiesbaden, 8.-10. September 2022
  • T6 PMC9382619 ↗Abstracts of the 17th German Allergy Congress, Wiesbaden, 08.–10. September 2022
  • T6 PMC9524336 ↗Abstracts der 30. Jahrestagung der Deutschen Gesellschaft für Schlafforschung und Schlafmedizin e. V
Tanespimycin
T4
T4 — Case series
MCAS
14 sources
  • T6 19860730 ↗Update on Hsp90 inhibitors in clinical trial
  • T6 30687710 ↗Epidermolysis Bullosa Acquisita: The 2019 Update
  • T6 14551138 ↗17-Allylamino-17-demethoxygeldanamycin (17-AAG) is effective in down-regulating mutated, constitutiv
  • T6 22714264 ↗The HSP90 inhibitor, AT13387, is effective against imatinib-sensitive and -resistant gastrointestina
  • T6 37100345 ↗The exoprotein Gbp of Fusobacterium nucleatum promotes THP-1 cell lipid deposition by binding to Cyp
  • T6INDIRECT 22577569 ↗Gastrointestinal stromal tumors: a review of case reports, diagnosis, treatment, and future directio
  • T4 PMC8901205 ↗Abstract Book: 25th Congress of the European Hematology Association Virtual Edition, 2020
  • T4 PMC3684198 ↗18th Congress of the European Hematology Association, Stockholm, Sweden, June 13–16, 2013
  • T4 PMC2707164 ↗14th Congress of the European Hematology Association, Berlin, Germany, June 4–7, 2009
  • T6 31357735 ↗Overview of Current Targeted Anti-Cancer Drugs for Therapy in Onco-Hematology
  • T6 40768641 ↗Tissue Fibrosis Decoded via Cellular Senescence: Mechanisms, Treatments, and Emerging Technologies
  • T6 40987035 ↗PDGFRA in paediatric high-grade glioma - target or distraction?
  • T6 36313712 ↗Inflammatory microenvironment in classical Hodgkin's lymphoma with special stress on mast cells
  • T6 34495872 ↗HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells
non sedating H1-antihistamine
T4
T4 — Case series
MCAS
17 sources
  • T6INDIRECT 25397904 ↗H1-antihistamines for chronic spontaneous urticaria
  • T6INDIRECT 28818095 ↗Frequency, distribution and immunologic nature of infusion reactions in subjects receiving peglotica
  • T6 30924425 ↗Chronic Urticaria: An Overview of Treatment and Recent Patents
  • T6 24817895 ↗Leukotriene receptor antagonists for chronic urticaria: a systematic review
  • T6 26120520 ↗Rupatadine: efficacy and safety of a non-sedating antihistamine with PAF-antagonist effects
  • T6 PMC6494532 ↗Interventions for chronic idiopathic urticaria excluding antihistamines
  • T6 24034140 ↗Revisions to the international guidelines on the diagnosis and therapy of chronic urticaria
  • T6 25705232 ↗Insights and advances in chronic urticaria: a Canadian perspective
  • T6 31906999 ↗Efficacy of switching to bilastine, a histamine H1 receptor antagonist, in patients with chronic spo
  • T6INDIRECT 25694628 ↗The association of cholinergic and cold-induced urticaria: diagnosis and management
  • T6INDIRECT 34513518 ↗A Woman With Solar Urticaria and Heat Urticaria: A Unique Presentation of an Individual With Multipl
  • T6INDIRECT 34457015 ↗Bilastine 10 and 20 mg in paediatric and adult patients: an updated practical approach to treatment
  • T4 PMC7129269 ↗ABSTRACT BOOK
  • T6 35683540 ↗Drugs and Vaccines Hypersensitivity in Children with Mastocytosis
  • T6 28210286 ↗Bilastine in allergic rhinoconjunctivitis and urticaria: a practical approach to treatment decisions
  • T6 28698528 ↗Inflammatory and Noninflammatory Itch: Implications in Pathophysiology-Directed Treatments
  • T6 33643777 ↗Expert consensus on practical aspects in the treatment of chronic urticaria
Sunitinib Malate
T5
T5 — Case report
MCAS
17 sources
  • T6 27536065 ↗Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells
  • T6 23639648 ↗Gastrointestinal stromal tumors
  • T6 19011754 ↗Therapeutic protein kinase inhibitors
  • T6 36849435 ↗Molecular and functional imaging in cancer-targeted therapy: current applications and future directi
  • T6 27363818 ↗Regulatory approval of pharmaceuticals without a randomised controlled study: analysis of EMA and FD
  • T6 39666929 ↗Phase II Study of Sunitinib in Tumors With &lt;i&gt;c-KIT&lt;/i&gt; Mutations: Results From the NCI
  • T6INDIRECT 35619994 ↗Presumed bilateral diffuse uveal melanocytic proliferation - A case report and review of literature
  • T5 20737043 ↗Final Report of the First Refractory Germ Cell Tumor Treated with Sunitinib Malate
  • T6INDIRECT 32778962 ↗Repurposing of Kinase Inhibitors for Treatment of COVID-19
  • T6INDIRECT 27843641 ↗ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016
  • T6INDIRECT 36145679 ↗Ocular Drug Delivery: Advancements and Innovations
  • T6INDIRECT 36607590 ↗TKI Treatment Sequencing in Advanced Gastrointestinal Stromal Tumors
  • T6INDIRECT 39640056 ↗Biopharmaceutical and pharmacokinetic attributes to drive nanoformulations of small molecule tyrosin
  • T6INDIRECT 41790711 ↗Unveiling the risk: A comprehensive analysis of drug-induced aphthous ulcers using real-world data f
  • T6 21125679 ↗The GIST paradigm: lessons for other kinase-driven cancers
  • T6 24636470 ↗Food allergy: Insights into etiology, prevention, and treatment provided by murine models
  • T6 33198314 ↗Tyrosine Kinase Receptors in Oncology
10-mg Desloratadine
T6
T6 — Mechanistic / preclinical
MCAS
7 sources
  • T6INDIRECT 25397904 ↗H1-antihistamines for chronic spontaneous urticaria
  • T6INDIRECT 37024900 ↗The efficacy and safety of high-dose nonsedating antihistamines in chronic spontaneous urticaria: a
  • T6 35562767 ↗Insights into urticaria in pediatric and adult populations and its management with fexofenadine hydr
  • T6 24167521 ↗TNF-Alpha Inhibitors for Chronic Urticaria: Experience in 20 Patients
  • T6 25829981 ↗Comparative efficacy of non-sedating antihistamine updosing in patients with chronic urticaria
  • T6INDIRECT 41277234 ↗Gut microbiota dysbiosis at the interface of neuropsychiatric disorders and their dermatological com
  • T6 42305426 ↗Intranasal Corticosteroids Versus Second-Generation Antihistamines for Allergic Rhinitis in Adolesce
20-mg Desloratadine
T6
T6 — Mechanistic / preclinical
MCAS
12 sources
  • T6INDIRECT 25397904 ↗H1-antihistamines for chronic spontaneous urticaria
  • T6INDIRECT 37024900 ↗The efficacy and safety of high-dose nonsedating antihistamines in chronic spontaneous urticaria: a
  • T6INDIRECT 20226302 ↗The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficu
  • T6 31416456 ↗Management of chronic urticaria in children: a clinical guideline
  • T6 25878559 ↗Bilastine: new insight into antihistamine treatment
  • T6 28035215 ↗The role and choice criteria of antihistamines in allergy management - expert opinion
  • T6INDIRECT 25155177 ↗Abstracts from the European Academy of Allergy and Clinical Immunology Congress, 7-11 June, 2014, Co
  • T6 34000363 ↗Ocular redness - II: Progress in development of therapeutics for the management of conjunctival hype
  • T6 23667312 ↗Critical appraisal of bilastine for the treatment of allergic rhinoconjunctivitis and urticaria
  • T6 25829981 ↗Comparative efficacy of non-sedating antihistamine updosing in patients with chronic urticaria
  • T6 27293247 ↗Updosing of Nonsedating Anti-histamines in Recalcitrant Chronic Urticaria
  • T6 30745975 ↗The Efficacy of a Two-Fold Increase of H1-Antihistamine in the Treatment of Chronic Urticaria - the
Abatacept
T6
T6 — Mechanistic / preclinical
MCAS
25 sources
  • T6INDIRECT 31749986 ↗Efficacy and safety of topical and systemic medications: a systematic literature review informing th
  • T6INDIRECT 34504395 ↗The Biological Disease-Modifying Antirheumatic Drugs and the Risk of Cardiovascular Events: A System
  • T6INDIRECT 37189381 ↗Dupilumab in Inflammatory Skin Diseases: A Systematic Review
  • T6INDIRECT 35316551 ↗A systematic review on mucocutaneous presentations after COVID-19 vaccination and expert recommendat
  • T6INDIRECT 35350578 ↗Immunomodulating Therapies in Acute Myocarditis and Recurrent/Acute Pericarditis
  • T6INDIRECT 38139057 ↗The Effects of Periodontal Treatment on Rheumatoid Arthritis and of Anti-Rheumatic Drugs on Periodon
  • T6INDIRECT 22875601 ↗Treatment with the interleukin-17A-blocking antibody secukinumab does not interfere with the efficac
  • T6INDIRECT 24559487 ↗Effect of intermittent aerobic exercise on sleep quality and sleep disturbances in patients with rhe
  • T6INDIRECT 22162990 ↗Psychophysiological responses to stress after stress management training in patients with rheumatoid
  • T6INDIRECT 31484730 ↗Monocyte/Macrophage Abnormalities Specific to Rheumatoid Arthritis Are Linked to miR-155 and Are Dif
  • T6INDIRECT 28242845 ↗Focal Segmental Glomerulosclerosis
  • T6INDIRECT 32571129 ↗Diagnosis & management of alpha-gal syndrome: lessons from 2,500 patients
  • T6INDIRECT 26347200 ↗Relationship between Periodontitis and Rheumatoid Arthritis: Review of the Literature
  • T6INDIRECT 32522746 ↗Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies
  • T6INDIRECT 34739716 ↗COVID-19 Vaccination in Pregnancy, Paediatrics, Immunocompromised Patients, and Persons with History
  • T6INDIRECT 27242652 ↗Idiopathic Inflammatory Myopathies: Clinical Approach and Management
  • T6INDIRECT 32327425 ↗EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events
  • T6INDIRECT 15870014 ↗In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation
  • T6 30774631 ↗The Immunology of Macrophage Activation Syndrome
  • T6 38762484 ↗Regulatory mechanisms of PD-1/PD-L1 in cancers
  • T6 37198232 ↗Targeting strategies for bone diseases: signaling pathways and clinical studies
  • T6 35755063 ↗Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases
  • T6 37849038 ↗Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer
  • T6 25433021 ↗Cardiovascular disease in patients with chronic inflammation: mechanisms underlying premature cardio
  • T6 26509054 ↗EULAR Sjögren's syndrome disease activity index (ESSDAI): a user guide
Acetaminophen
T6
T6 — Mechanistic / preclinical
MCAS
26 sources
  • T6 NCT00186628 ↗Phase 2 Trial of Prophylactic Rituximab Therapy for Prevention of CGVHD
  • T6 NCT04681105 ↗Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological Malig
  • T6INDIRECT 30968949 ↗Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlli
  • T6INDIRECT 28514613 ↗KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma
  • T6INDIRECT 15947280 ↗Inflammatory basis of exercise-induced bronchoconstriction
  • T6INDIRECT 37459086 ↗Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penic
  • T6INDIRECT 26282650 ↗Randomized Phase II Trial Comparing Obinutuzumab (GA101) With Rituximab in Patients With Relapsed CD
  • T6INDIRECT 7798537 ↗Direct evidence for a role of the mast cell in the nasal response to aspirin in aspirin-sensitive as
  • T6INDIRECT 26342029 ↗Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast
  • T6 28293453 ↗An overview and management of osteoporosis
  • T6 25287861 ↗Calcitonin gene-related peptide: physiology and pathophysiology
  • T6 27188216 ↗Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics
  • T6INDIRECT 33821570 ↗Delivery of oligonucleotide-based therapeutics: challenges and opportunities
  • T6INDIRECT 27351598 ↗Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders
  • T6INDIRECT 26690128 ↗Mast Cell-Mediated Mechanisms of Nociception
  • T6INDIRECT 27242652 ↗Idiopathic Inflammatory Myopathies: Clinical Approach and Management
  • T6INDIRECT 26525001 ↗2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines
  • T6INDIRECT 21224201 ↗American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the d
  • T6INDIRECT 23452057 ↗Characterization of different courses of atopic dermatitis in adolescent and adult patients
  • T6INDIRECT 24859366 ↗Activity of SL-401, a targeted therapy directed to interleukin-3 receptor, in blastic plasmacytoid d
  • T6 31275462 ↗PEGylated liposomes: immunological responses
  • T6 29467654 ↗The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?
  • T6 26233910 ↗Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer
  • T6 19815110 ↗Mechanisms of mast cell signaling in anaphylaxis
  • T6 25182228 ↗Clinician's Guide to Prevention and Treatment of Osteoporosis
  • T6 35478046 ↗The clinician's guide to prevention and treatment of osteoporosis
Alemtuzumab
T6
T6 — Mechanistic / preclinical
MCAS
21 sources
  • T6INDIRECT 27091121 ↗Fingolimod for relapsing-remitting multiple sclerosis
  • T6INDIRECT 38822024 ↗Efficacy and safety of stem cell transplantation for multiple sclerosis: a systematic review and met
  • T6INDIRECT 32990324 ↗Anti-cytokine targeted therapies for ANCA-associated vasculitis
  • T6INDIRECT 37487610 ↗The 2022 EULAR/ACR points to consider at the early stages of diagnosis and management of suspected h
  • T6INDIRECT 37486733 ↗The 2022 EULAR/ACR Points to Consider at the Early Stages of Diagnosis and Management of Suspected H
  • T6INDIRECT 35350578 ↗Immunomodulating Therapies in Acute Myocarditis and Recurrent/Acute Pericarditis
  • T6INDIRECT 38473835 ↗The Role of Selected Interleukins in the Development and Progression of Multiple Sclerosis-A Systema
  • T6INDIRECT 26109102 ↗Epigenetic therapy overcomes treatment resistance in T cell prolymphocytic leukemia
  • T6INDIRECT 23935024 ↗Alternative donor hematopoietic stem cell transplantation for mature lymphoid malignancies after red
  • T6 28031180 ↗Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts
  • T6INDIRECT 25964669 ↗How I treat hypereosinophilic syndromes
  • T6INDIRECT 32107531 ↗Pediatric hemophagocytic lymphohistiocytosis
  • T6INDIRECT 29915719 ↗Past, Present, and Future of Rituximab-The World's First Oncology Monoclonal Antibody Therapy
  • T6INDIRECT 31547472 ↗CD123 as a Therapeutic Target in the Treatment of Hematological Malignancies
  • T6INDIRECT 32522746 ↗Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies
  • T6INDIRECT 27242652 ↗Idiopathic Inflammatory Myopathies: Clinical Approach and Management
  • T6INDIRECT 22285672 ↗Pruritus in cutaneous T-cell lymphoma: a review
  • T6 19231593 ↗Biology of the eosinophil
  • T6 20538328 ↗Practical approach to the patient with hypereosinophilia
  • T6 29619379 ↗Eosinophils from Physiology to Disease: A Comprehensive Review
  • T6 26654227 ↗Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell l
Allogeneic Bone Marrow Transplantation
T6
T6 — Mechanistic / preclinical
MCAS
18 sources
  • T6INDIRECT 23660070 ↗Burst-forming unit-erythroid assays to distinguish cellular bone marrow failure disorders
  • T6 27834397 ↗The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia
  • T6 25062998 ↗Mast cell function: a new vision of an old cell
  • T6 18507503 ↗Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a s
  • T6 15870014 ↗In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation
  • T6 18559612 ↗Phase II study of dasatinib in Philadelphia chromosome-negative acute and chronic myeloid diseases,
  • T6INDIRECT 35976468 ↗SOCS1 Haploinsufficiency Presenting as Severe Enthesitis, Bone Marrow Hypocellularity, and Refractor
  • T6INDIRECT 19590986 ↗Evidence for the use of intravenous immunoglobulins--a review of the literature
  • T6INDIRECT 22224765 ↗Monogenic autoimmunity
  • T6INDIRECT 25284845 ↗Biologics in dermatology: an integrated review
  • T6INDIRECT 14692959 ↗Universal leukoreduction and acute transfusion reactions: putting the puzzle together
  • T6INDIRECT 21837236 ↗Eosinophilic colitis: university of Minnesota experience and literature review
  • T6INDIRECT 37122022 ↗French guidelines for the etiological workup of eosinophilia and the management of hypereosinophilic
  • T6 7949167 ↗Origin of human mast cells: development from transplanted hematopoietic stem cells after allogeneic
  • T6 37188939 ↗Protein kinases: drug targets for immunological disorders
  • T6 29232931 ↗Molecular Mechanisms and Management of a Cutaneous Inflammatory Disorder: Psoriasis
  • T6 32107539 ↗Pathobiology and treatment of lymphomatoid granulomatosis, a rare EBV-driven disorder
  • T6 26088795 ↗Osteonecrosis of the femoral head: diagnosis and classification systems
Anti-Thymocyte Globulin
T6
T6 — Mechanistic / preclinical
MCAS
22 sources
  • T6INDIRECT 34402927 ↗Short- and long-term outcomes after heart transplantation in cardiac sarcoidosis and giant-cell myoc
  • T6INDIRECT 32990324 ↗Anti-cytokine targeted therapies for ANCA-associated vasculitis
  • T6INDIRECT 35350578 ↗Immunomodulating Therapies in Acute Myocarditis and Recurrent/Acute Pericarditis
  • T6INDIRECT 41273190 ↗Systematic Review of Immune and Symptomatic Treatments for Stiff-Person Syndrome
  • T6INDIRECT 41622196 ↗Clinical characteristics and treatment outcomes in thymoma- related aplastic anemia: a case report a
  • T6INDIRECT 20978268 ↗First use of thymus transplantation therapy for FOXN1 deficiency (nude/SCID): a report of 2 cases
  • T6INDIRECT 21047561 ↗Reduced-intensity conditioning followed by related allografts in hematologic malignancies: long-term
  • T6INDIRECT 30077015 ↗Reduced-Intensity Conditioning Followed by Related and Unrelated Allografts for Hematologic Malignan
  • T6 35732831 ↗The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid
  • T6 32107531 ↗Pediatric hemophagocytic lymphohistiocytosis
  • T6INDIRECT 33657207 ↗How I manage acquired pure red cell aplasia in adults
  • T6INDIRECT 31475005 ↗Recurrent and <i>de novo</i> Glomerulonephritis After Kidney Transplantation
  • T6INDIRECT 32421085 ↗Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in
  • T6INDIRECT 34031556 ↗Hematopoietic stem cell transplantation for autoimmune diseases in the time of COVID-19: EBMT guidel
  • T6INDIRECT 33880680 ↗Differential Diagnosis and Workup of Monocytosis: A Systematic Approach to a Common Hematologic Find
  • T6INDIRECT 24790407 ↗Ocular manifestations of idiopathic aplastic anemia: retrospective study and literature review
  • T6 33936095 ↗Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity
  • T6 25352848 ↗T cells in vascular inflammatory diseases
  • T6 38361991 ↗Innovative cellular therapies for autoimmune diseases: expert-based position statement and clinical
  • T6 29868474 ↗Therapeutic Antibodies for Myeloid Neoplasms-Current Developments and Future Directions
  • T6 20353479 ↗Recent progress and new perspectives in studying T cell responses to allografts
  • T6 27011916 ↗Immunosuppressive potency of mechanistic target of rapamycin inhibitors in solid-organ transplantati
Anti-thymoglobulin, rabbit
T6
T6 — Mechanistic / preclinical
MCAS
2 sources
  • T6 NCT00186628 ↗Phase 2 Trial of Prophylactic Rituximab Therapy for Prevention of CGVHD
  • T6 26999538 ↗Physicians Poster SessionsPoster Session / Day 1
Assessment Of Therapy Complications
T6
T6 — Mechanistic / preclinical
MCAS
Autologous mesenchymal stem cell
T6
T6 — Mechanistic / preclinical
MCAS
6 sources
  • T6 34200905 ↗Cell-Based Therapies for Traumatic Brain Injury: Therapeutic Treatments and Clinical Trials
  • T6 34468946 ↗Therapeutic Approaches to Systemic Sclerosis: Recent Approvals and Future Candidate Therapies
  • T6 25476233 ↗Bone marrow stromal cells as immunomodulators. A primer for dermatologists
  • T6 29740250 ↗Ilizarov method in combination with autologous mesenchymal stem cells from iliac crest shows improve
  • T6 33957957 ↗Mesenchymal stem and non-stem cell surgery, rescue, and regeneration in glaucomatous optic neuropath
  • T6INDIRECT 42149419 ↗Diseases of the tongue: a review of etiologies and treatments
Busulfan
T6
T6 — Mechanistic / preclinical
RegisteredWithdrawnMCAS
22 sources
  • T6WITHDRAWN NCT01773395 ↗GVAX vs. Placebo for MDS/AML After Allo HSCT
  • T6 NCT01384513 ↗A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Mali
  • T6REGISTERED-ONLY NCT03779854 ↗Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults
  • T6INDIRECT 33823925 ↗Mesenchymal stromal/stem cells and their exosomes for restoration of spermatogenesis in non-obstruct
  • T6INDIRECT 41622196 ↗Clinical characteristics and treatment outcomes in thymoma- related aplastic anemia: a case report a
  • T6INDIRECT 31495201 ↗GENESIS: Phase III trial evaluating BL-8040 + G-CSF to mobilize hematopoietic cells for autologous t
  • T6 23060872 ↗Immune dysregulation, polyendocrinopathy, enteropathy, x-linked syndrome: a paradigm of immunodefici
  • T6 23508552 ↗A proposed role for neutrophil extracellular traps in cancer immunoediting
  • T6 27845343 ↗Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate imm
  • T6 25154823 ↗Hematopoietic stem-cell transplantation for advanced systemic mastocytosis
  • T6 15870014 ↗In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation
  • T6 33513372 ↗MATRix-RICE therapy and autologous haematopoietic stem-cell transplantation in diffuse large B-cell
  • T6INDIRECT 29844705 ↗Severe cutaneous adverse reactions induced by targeted anticancer therapies and immunotherapies
  • T6INDIRECT 31723789 ↗Diagnosis and Treatment of Chronic Myelomonocytic Leukemias in Adults: Recommendations From the Euro
  • T6INDIRECT 33875812 ↗Transplant-associated thrombotic microangiopathy: theoretical considerations and a practical approac
  • T6INDIRECT 30858685 ↗Primary vitreoretinal lymphoma: prevalence, impact, and management challenges
  • T6INDIRECT 28261062 ↗Mitochondrial Neurogastrointestinal Encephalomyopathy Caused by Thymidine Phosphorylase Enzyme Defic
  • T6INDIRECT 20137004 ↗Emesis in dogs: a review
  • T6INDIRECT 29503529 ↗Therapeutic potential of bimatoprost for the treatment of eyebrow hypotrichosis
  • T6 24618482 ↗Etiopathogenesis of cataract: an appraisal
  • T6 22830345 ↗Biology and clinical management of myeloproliferative neoplasms and development of the JAK inhibitor
  • T6 24598853 ↗Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible
CDX-0159
T6
T6 — Mechanistic / preclinical
MCAS
18 sources
  • T6INDIRECT 40415544 ↗Anti-KIT Barzolvolimab for Chronic Spontaneous Urticaria
  • T6 34063789 ↗Mast Cells: A New Frontier for Cancer Immunotherapy
  • T6 35469840 ↗KIT as a master regulator of the mast cell lineage
  • T6 33685605 ↗Biologics for the Use in Chronic Spontaneous Urticaria: When and Which
  • T6 35304158 ↗Single-cell RNA sequencing of mast cells in eosinophilic esophagitis reveals heterogeneity, local pr
  • T6 35184297 ↗Anti-KIT monoclonal antibody CDX-0159 induces profound and durable mast cell suppression in a health
  • T6INDIRECT 37717255 ↗Chronic Prurigo Including Prurigo Nodularis: New Insights and Treatments
  • T6INDIRECT 37190096 ↗Mast Cells as a Target-A Comprehensive Review of Recent Therapeutic Approaches
  • T6INDIRECT 38791201 ↗Prurigo Nodularis: Pathogenesis and the Horizon of Potential Therapeutics
  • T6INDIRECT 39028396 ↗New insights into chronic inducible urticaria
  • T6INDIRECT 33615122 ↗Use of biologics in chronic spontaneous urticaria - beyond omalizumab therapy?
  • T6INDIRECT 39598410 ↗Therapies for Chronic Spontaneous Urticaria: Present and Future Developments
  • T6INDIRECT 36776192 ↗Biologicals in Treatment of Chronic Urticaria: A Narrative Review
  • T6INDIRECT 35956071 ↗Monoclonal Antibodies in Treating Chronic Spontaneous Urticaria: New Drugs for an Old Disease
  • T6 39158477 ↗Therapeutic monoclonal antibodies in allergy: Targeting IgE, cytokine, and alarmin pathways
  • T6 38630620 ↗Mast cells: a novel therapeutic avenue for cardiovascular diseases?
  • T6 36430941 ↗Human Lung Mast Cells: Therapeutic Implications in Asthma
  • T6 38289515 ↗Cellular and Molecular Mechanisms of Mast Cells in Atherosclerotic Plaque Progression and Destabiliz
CMAB007
T6
T6 — Mechanistic / preclinical
MCAS
3 sources
  • T6 40004611 ↗Advances in Biologic Therapies for Allergic Diseases: Current Trends, Emerging Agents, and Future Pe
  • T6 41654334 ↗Systemic Treatments for Chronic Spontaneous Urticaria: Anti-IgE and Beyond
  • T6 41270830 ↗Emerging IgE and non-IgE targeted therapies for chronic urticaria
Dasatinib
T6
T6 — Mechanistic / preclinical
MCAS
23 sources
  • T6 NCT00979160 ↗Evaluation of Response of Dasatinib to Treat Mastocytosis
  • T6 NCT00255346 ↗Dasatinib as Therapy for Myeloproliferative Disorders (MPDs)
  • T6INDIRECT 38474862 ↗Quercetin in the Prevention of Induced Periodontal Disease in Animal Models: A Systematic Review and
  • T6INDIRECT 33952306 ↗Anticancer drugs repurposed for Alzheimer's disease: a systematic review
  • T6INDIRECT 24407160 ↗Identification of Ponatinib as a potent inhibitor of growth, migration, and activation of neoplastic
  • T6INDIRECT 35640224 ↗Efficacy and safety of avapritinib in previously treated patients with advanced systemic mastocytosi
  • T6INDIRECT 31207054 ↗Development and evaluation of a computable phenotype to identify pediatric patients with leukemia an
  • T6 22834835 ↗Functions of S100 proteins
  • T6 34054126 ↗Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
  • T6 28031180 ↗Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts
  • T6 18684881 ↗Mast cells and mastocytosis
  • T6 23656643 ↗Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML
  • T6INDIRECT 25964669 ↗How I treat hypereosinophilic syndromes
  • T6INDIRECT 20643990 ↗Narrative review: the systemic capillary leak syndrome
  • T6INDIRECT 34039409 ↗The landscape of bispecific T cell engager in cancer treatment
  • T6INDIRECT 35343828 ↗Salivary gland function, development, and regeneration
  • T6INDIRECT 32778962 ↗Repurposing of Kinase Inhibitors for Treatment of COVID-19
  • T6INDIRECT 29844705 ↗Severe cutaneous adverse reactions induced by targeted anticancer therapies and immunotherapies
  • T6INDIRECT 32522746 ↗Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies
  • T6 24359404 ↗Targeting the PDGF signaling pathway in tumor treatment
  • T6 22043171 ↗A clinical overview of centrosome amplification in human cancers
  • T6 16721371 ↗AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL
  • T6 24963404 ↗Imatinib: a breakthrough of targeted therapy in cancer
Decitabine
T6
T6 — Mechanistic / preclinical
MCAS
21 sources
  • T6INDIRECT 34176557 ↗Epigenetics of obstructive sleep apnea syndrome: a systematic review
  • T6INDIRECT 35640224 ↗Efficacy and safety of avapritinib in previously treated patients with advanced systemic mastocytosi
  • T6INDIRECT 21047561 ↗Reduced-intensity conditioning followed by related allografts in hematologic malignancies: long-term
  • T6INDIRECT 24498169 ↗Promoter DNA methylation of farnesoid X receptor and pregnane X receptor modulates the intrahepatic
  • T6 34054126 ↗Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
  • T6 27036965 ↗Role of TET enzymes in DNA methylation, development, and cancer
  • T6 31676858 ↗TIM3 comes of age as an inhibitory receptor
  • T6 27834397 ↗The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia
  • T6 38762484 ↗Regulatory mechanisms of PD-1/PD-L1 in cancers
  • T6 24859366 ↗Activity of SL-401, a targeted therapy directed to interleukin-3 receptor, in blastic plasmacytoid d
  • T6INDIRECT 32962122 ↗Atypical Chronic Myeloid Leukemia: Where Are We Now?
  • T6INDIRECT 34774343 ↗A review of FLT3 inhibitors in acute myeloid leukemia
  • T6INDIRECT 31547472 ↗CD123 as a Therapeutic Target in the Treatment of Hematological Malignancies
  • T6INDIRECT 31723789 ↗Diagnosis and Treatment of Chronic Myelomonocytic Leukemias in Adults: Recommendations From the Euro
  • T6INDIRECT 34071099 ↗BiTEs, DARTS, BiKEs and TriKEs-Are Antibody Based Therapies Changing the Future Treatment of AML?
  • T6INDIRECT 34893494 ↗Learning through a Pandemic: The Current State of Knowledge on COVID-19 and Cancer
  • T6INDIRECT 35494081 ↗Atypical Rearrangements in APL-Like Acute Myeloid Leukemias: Molecular Characterization and Prognosi
  • T6INDIRECT 29966370 ↗The Genomics and Molecular Biology of Natural Killer/T-Cell Lymphoma: Opportunities for Translation
  • T6 26679767 ↗Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive
  • T6 25693834 ↗DNMT3A in haematological malignancies
  • T6 24136165 ↗The genetic basis of myelodysplasia and its clinical relevance
Donor Lymphocyte Infusion
T6
T6 — Mechanistic / preclinical
MCAS
14 sources
  • T6 NCT01384513 ↗A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Mali
  • T6 23023713 ↗Pathogenesis of follicular lymphoma
  • T6 34039409 ↗The landscape of bispecific T cell engager in cancer treatment
  • T6 21083034 ↗Relapse after allogeneic stem cell transplantation
  • T6 24859366 ↗Activity of SL-401, a targeted therapy directed to interleukin-3 receptor, in blastic plasmacytoid d
  • T6 15870014 ↗In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation
  • T6INDIRECT 29025582 ↗A novel TRIP11-FLT3 fusion in a patient with a myeloid/lymphoid neoplasm with eosinophilia
  • T6INDIRECT 23483057 ↗A case of systemic mastocytosis associated with acute myeloid leukemia terminating as aleukemic mast
  • T6INDIRECT 33466873 ↗Treatment of Diffuse Alveolar Hemorrhage: Controlling Inflammation and Obtaining Rapid and Effective
  • T6INDIRECT 36599826 ↗Lymphoid clonal hematopoiesis: implications for malignancy, immunity, and treatment
  • T6INDIRECT 14692959 ↗Universal leukoreduction and acute transfusion reactions: putting the puzzle together
  • T6 34572809 ↗Multiparametric Flow Cytometry for MRD Monitoring in Hematologic Malignancies: Clinical Applications
  • T6 22125447 ↗Tirosin kinase inhibitors in chronic graft versus host disease: from bench to bedside
  • T6 31616632 ↗Current Advances in Immunotherapy for Acute Leukemia: An Overview of Antibody, Chimeric Antigen Rece
Donor Lymphocytes
T6
T6 — Mechanistic / preclinical
MCAS
16 sources
  • T6 29619379 ↗Eosinophils from Physiology to Disease: A Comprehensive Review
  • T6 31547472 ↗CD123 as a Therapeutic Target in the Treatment of Hematological Malignancies
  • T6 31244579 ↗Clinical Use of Mesenchymal Stromal Cells in the Treatment of Acute Graft-versus-Host Disease
  • T6INDIRECT 20934998 ↗Extensive pleural and pericardial effusion in chronic myeloid leukemia during treatment with dasatin
  • T6 18721759 ↗Th2 cell therapy of established acute graft-versus-host disease requires IL-4 and IL-10 and is abrog
  • T6INDIRECT 35874756 ↗Roles of Mast Cells in Cutaneous Diseases
  • T6INDIRECT 35629101 ↗Mechanistic Insights in Hemophagocytic Lymphohistiocytosis: Subsequent Acute Hepatic Failure in a Mu
  • T6INDIRECT 18545251 ↗Indications and results of cord blood transplant in children with leukemia
  • T6INDIRECT 33311612 ↗The 46<sup>th</sup> Annual Meeting of the European Society for Blood and Marrow Transplantation: Phy
  • T6INDIRECT 30161072 ↗Recommendations on Selection and Processing of RBC Components for Pediatric Patients From the Pediat
  • T6INDIRECT 29603868 ↗American Society of Pediatric Hematology/Oncology (ASPHO), David L. Lawrence Convention Center, Pitt
  • T6 38223477 ↗CAR-T Cell Therapy in B-Cell Acute Lymphoblastic Leukemia
  • T6 36969182 ↗Impact of oral microbiota on pathophysiology of GVHD
  • T6 20525151 ↗Progress and challenges in the understanding of chronic urticaria
  • T6 34815400 ↗Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human e
  • T6 32907809 ↗IgE-Mediated Immune Response and Antibody-Mediated Rejection
Donor Natural Killer Cell Infusion
T6
T6 — Mechanistic / preclinical
MCAS
EU-approved Xolair
T6
T6 — Mechanistic / preclinical
MCAS
Epoetin Alfa
T6
T6 — Mechanistic / preclinical
MCAS
19 sources
  • T6INDIRECT 17684963 ↗[Erythropoetin and iron preparations in the treatment of anemia in patients with chronic kidney dise
  • T6 16931578 ↗JAK2 V617F in myeloid disorders: molecular diagnostic techniques and their clinical utility: a paper
  • T6 19802503 ↗Erythropoietin, forkhead proteins, and oxidative injury: biomarkers and biology
  • T6 18559612 ↗Phase II study of dasatinib in Philadelphia chromosome-negative acute and chronic myeloid diseases,
  • T6 29217782 ↗Rational management approach to pure red cell aplasia
  • T6 32807237 ↗Repurposed agents in the Alzheimer's disease drug development pipeline
  • T6INDIRECT 36350500 ↗Evolving Strategies in the Treatment of Anaemia in Chronic Kidney Disease: The HIF-Prolyl Hydroxylas
  • T6INDIRECT 30830058 ↗Drug desensitization in allergic children
  • T6INDIRECT 25278804 ↗Peripheral ulcerative keratitis: Our challenging experience
  • T6INDIRECT 35445052 ↗Cardiovascular Protective Effects of Oral Hypoxia Inducible Factor Prolyl Hydroxylase Inhibitor Roxa
  • T6INDIRECT 27114361 ↗Abstracts from the 2016 Society of General Internal Medicine Annual Meeting
  • T6INDIRECT 34808742 ↗Angiotensin-Converting Enzyme Inhibitor-Induced Non-allergic Perioral Angioedema: A Case-Based Scopi
  • T6INDIRECT 31333273 ↗Abstracts Presented at the 120th Annual Meeting of the American Association of Colleges of Pharmacy,
  • T6INDIRECT 33410314 ↗XVI Congress of the Italian Society of Experimental Hematology, Napoli, Italy, October 15-17, 2020
  • T6 27551882 ↗Peginesatide for the treatment of anemia due to chronic kidney disease - an unfulfilled promise
  • T6 27382321 ↗Biosimilars: potential implications for clinicians
  • T6 38731114 ↗A Review of Key Regulators of Steady-State and Ineffective Erythropoiesis
  • T6 28452907 ↗In a Mouse Model of Sepsis, Hepcidin Ablation Ameliorates Anemia More Effectively than Iron and Eryt
  • T6 28370957 ↗Safety of intravenous iron in hemodialysis patients
Fatigue Assessment And Management
T6
T6 — Mechanistic / preclinical
MCAS
Filgrastim
T6
T6 — Mechanistic / preclinical
MCAS
21 sources
  • T6 NCT00186628 ↗Phase 2 Trial of Prophylactic Rituximab Therapy for Prevention of CGVHD
  • T6INDIRECT 17943799 ↗Chemotherapy plus Rituximab versus chemotherapy alone for B-cell non-Hodgkin's lymphoma
  • T6INDIRECT 34388994 ↗What is the impact of granulocyte colony-stimulating factor (G-CSF) in subcutaneous injection or int
  • T6INDIRECT 38682756 ↗Autologous platelet-rich plasma for assisted reproduction
  • T6INDIRECT 41273190 ↗Systematic Review of Immune and Symptomatic Treatments for Stiff-Person Syndrome
  • T6INDIRECT 41408611 ↗Interrater reliability in the assessment of oral mucositis among patients receiving high-dose chemot
  • T6 17655751 ↗Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis
  • T6 27340273 ↗Inflammatory Disequilibrium in Stroke
  • T6 34774343 ↗A review of FLT3 inhibitors in acute myeloid leukemia
  • T6 18378569 ↗Phase II study of dose-adjusted EPOCH and rituximab in untreated diffuse large B-cell lymphoma with
  • T6 20008633 ↗Flavopiridol, fludarabine, and rituximab in mantle cell lymphoma and indolent B-cell lymphoprolifera
  • T6INDIRECT 33611854 ↗Burkitt lymphoma and lactic acidosis: A case report and review of the literature
  • T6INDIRECT 31473638 ↗Macrophage activation syndrome/haemophagocytic lymphohistiocytosis secondary to <i>Burkholderia cepa
  • T6INDIRECT 31461919 ↗Antibiotic Hypersensitivity Mechanisms
  • T6INDIRECT 33443626 ↗Successful treatment of G-CSF-related aortitis with prednisolone during preoperative chemotherapy fo
  • T6INDIRECT 28397154 ↗Abstracts from the 2017 Society of General Internal Medicine Annual Meeting
  • T6 29051803 ↗Midostaurin: a novel therapeutic agent for patients with FLT3-mutated acute myeloid leukemia and sys
  • T6 30135011 ↗Drug Hypersensitivity
  • T6 28993751 ↗Immune Modulation in the Treatment of Amyotrophic Lateral Sclerosis: A Review of Clinical Trials
  • T6 32375354 ↗Aptamers and Antisense Oligonucleotides for Diagnosis and Treatment of Hematological Diseases
  • T6 36061305 ↗Lactic Acid Regulation: A Potential Therapeutic Option in Rheumatoid Arthritis
Foscarnet Sodium
T6
T6 — Mechanistic / preclinical
MCAS
2 sources
  • T6INDIRECT 25563312 ↗Clinical efficacy of oral ganciclovir for prophylaxis and treatment of recurrent herpes simplex kera
  • T6INDIRECT 37954648 ↗Cerebral venous thrombosis caused by spontaneous intracranial hypotension due to spontaneous spinal
Genolar® + Symbicort®
T6
T6 — Mechanistic / preclinical
MCAS
Graft Versus Host Disease Prophylaxis/Therapy
T6
T6 — Mechanistic / preclinical
MCAS
H1 antihistamine, H2 antihistamine, leukotriene receptor antagonist
T6
T6 — Mechanistic / preclinical
MCAS
HL2351
T6
T6 — Mechanistic / preclinical
MCAS
1 source
  • T6 35729334 ↗IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting
HRS-3095 Tablet
T6
T6 — Mechanistic / preclinical
MCAS
Human interleukin-2 injection
T6
T6 — Mechanistic / preclinical
MCAS
IGE025
T6
T6 — Mechanistic / preclinical
MCAS
1 source
  • T6 33628747 ↗Anti-IgE for the Treatment of Chronic Urticaria
Infection Prophylaxis And Management
T6
T6 — Mechanistic / preclinical
MCAS
2 sources
  • T6 41000203 ↗Tocilizumab for Non-Infectious Uveitis: A Systematic Review
  • T6 41694401 ↗Low-dose cyclophosphamide combined with standard immunosuppressive therapy improves early response r
Kineret
T6
T6 — Mechanistic / preclinical
MCAS
18 sources
  • T6INDIRECT 32990324 ↗Anti-cytokine targeted therapies for ANCA-associated vasculitis
  • T6INDIRECT 29141858 ↗Interleukin-1 Blockade in Recently Decompensated Systolic Heart Failure: Results From REDHART (Recen
  • T6 31900383 ↗Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review
  • T6 20583979 ↗Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong d
  • T6 31850638 ↗Role of inflammasomes in the pathogenesis of periodontal disease and therapeutics
  • T6 PMC6464318 ↗Anti‐cytokine targeted therapies for ANCA‐associated vasculitis
  • T6 19234101 ↗IL-1 mediates pulmonary and systemic inflammatory responses to chorioamnionitis induced by lipopolys
  • T6INDIRECT 25784780 ↗Interleukin-1 as a common denominator from autoinflammatory to autoimmune disorders: premises, peril
  • T6INDIRECT 25284976 ↗Pharmacotherapy for uveitis: current management and emerging therapy
  • T6INDIRECT 23970817 ↗Biological treatments: new weapons in the management of monogenic autoinflammatory disorders
  • T6INDIRECT 32421085 ↗Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in
  • T6INDIRECT 36422739 ↗Pathogenesis and current therapies for non-infectious uveitis
  • T6INDIRECT 32823391 ↗Interleukins and cytokine biomarkers in uveitis
  • T6INDIRECT 28203051 ↗A review and update on orphan drugs for the treatment of noninfectious uveitis
  • T6INDIRECT 32508634 ↗New Pharmacological Strategies for the Treatment of Non-Infectious Uveitis. A Minireview
  • T6 27308503 ↗Mechanisms underlying skin disorders induced by EGFR inhibitors
  • T6 32973505 ↗Repurposing Drugs, Ongoing Vaccine, and New Therapeutic Development Initiatives Against COVID-19
  • T6 37123122 ↗<i>Porphyromonas Gingivalis</i> in the Development of Periodontitis: Impact on Dysbiosis and Inflamm
LOU064 as a tablet.
T6
T6 — Mechanistic / preclinical
MCAS
LP-003
T6
T6 — Mechanistic / preclinical
MCAS
24 sources
  • T6INDIRECT 39817495 ↗The Association Between Serum Gamma-Glutamyl Transferase and Gastrointestinal Cancer Risk: A Systema
  • T6INDIRECT 33832066 ↗The necessity or not of the addition of fusion to decompression for lumbar degenerative spondylolist
  • T6INDIRECT 36424485 ↗Effectiveness of using platelet-rich fibrin to increase keratinized tissue around the tooth in the m
  • T6INDIRECT 41364023 ↗High-frequency repetitive transcranial magnetic stimulation for stroke patients lower extremity func
  • T6INDIRECT 34408396 ↗Are Dilated Fundus Examinations Needed for OCT-Guided Retreatment of Exudative Age-Related Macular D
  • T6 32973505 ↗Repurposing Drugs, Ongoing Vaccine, and New Therapeutic Development Initiatives Against COVID-19
  • T6 34693230 ↗Symptom Persistence Despite Improvement in Cardiopulmonary Health - Insights from longitudinal CMR,
  • T6 25190696 ↗Non-Hodgkin's lymphomas, version 4.2014
  • T6 26022641 ↗Association of Geroprotective Effects of Metformin and Risk of Open-Angle Glaucoma in Persons With D
  • T6 27104962 ↗Macular Thickness Measurements with Frequency Domain-OCT for Quantification of Retinal Neural Loss a
  • T6INDIRECT 34297318 ↗Abstracts from the 2021 Annual Meeting of the Society of General Internal Medicine
  • T6INDIRECT 30240102 ↗Abstracts from the 50th Congress of the International Society of Paediatric Oncology (SIOP) Kyoto, J
  • T6INDIRECT 26041557 ↗Abstracts of the XXV Congress of the International Society on Thrombosis and Haemostasis, June 20-25
  • T6INDIRECT 3979758 ↗Abstracts of papers submitted to the American Gastroenterological Association. 86th annual meeting,
  • T6INDIRECT 24085684 ↗Abstracts of the 2013 Annual Meeting of the American College of Rheumatology. October 25-30, 2013. S
  • T6INDIRECT 28397154 ↗Abstracts from the 2017 Society of General Internal Medicine Annual Meeting
  • T6INDIRECT 24737224 ↗Abstracts from the 37th Annual Meeting of the Society of General Internal Medicine, 2014, San Diego,
  • T6INDIRECT 31090026 ↗Abstracts from the 2019 Annual Meeting of the Society of General Internal Medicine
  • T6 40720603 ↗Extracellular Vesicles for Clinical Diagnostics: From Bulk Measurements to Single-Vesicle Analysis
  • T6 40074986 ↗Update on the Treatment of Chronic Spontaneous Urticaria
  • T6 28163052 ↗Airway and serum biochemical correlates of refractory neutrophilic asthma
  • T6 24663285 ↗Impact of cigarette smoke on the human and mouse lungs: a gene-expression comparison study
  • T6 40773543 ↗Intestinal mast cell-derived leukotrienes mediate the anaphylactic response to ingested antigens
  • T6 29290940 ↗Lysophosphatidylcholine induces cytotoxicity/apoptosis and IL-8 production of human endothelial cell
Leucovorin Calcium
T6
T6 — Mechanistic / preclinical
MCAS
7 sources
  • T6 29528507 ↗Potential lymphangiogenesis therapies: Learning from current antiangiogenesis therapies-A review
  • T6 39956859 ↗Molecular principles underlying aggressive cancers
  • T6 38239190 ↗Current trends and future prospects of drug repositioning in gastrointestinal oncology
  • T6 33643693 ↗Infliximab for the treatment of patients with checkpoint inhibitor-associated acute tubular intersti
  • T6 39213447 ↗Nodular regenerative hyperplasia: The role of the CK7 immunohistochemistry pattern of expression in
  • T6INDIRECT 34692291 ↗Methotrexate-Induced Septicemia With Severe Pancytopenia and Diffuse Cutaneous Ulcerative Lesions
  • T6 PMC7119909 ↗Pharmacology and Pharmacotherapy
Management Of Therapy Complications
T6
T6 — Mechanistic / preclinical
MCAS
Massage Therapy
T6
T6 — Mechanistic / preclinical
MCAS
23 sources
  • T6INDIRECT 40052535 ↗Models of care for managing non-specific low back pain
  • T6INDIRECT 26037730 ↗Acupuncture for the sequelae of Bell's palsy: a randomized controlled trial
  • T6INDIRECT 37684652 ↗Evaluation of the efficacy of manual soft tissue therapy and therapeutic exercises in patients with
  • T6INDIRECT 32819949 ↗Comparing two dry needling interventions for plantar heel pain: a randomised controlled trial
  • T6INDIRECT 25537784 ↗Acupuncture at Houxi (SI 3) acupoint for acute neck pain caused by stiff neck: study protocol for a
  • T6INDIRECT 30679283 ↗Is a government-regulated rehabilitation guideline more effective than general practitioner educatio
  • T6INDIRECT 21388554 ↗Acupuncture for sequelae of Bell's palsy: a randomized controlled trial protocol
  • T6INDIRECT 35546396 ↗Assessment of the masseter stiffness in patients during conservative therapy for masticatory muscle
  • T6 33711512 ↗Pain in sickle cell disease: current and potential translational therapies
  • T6 35478046 ↗The clinician's guide to prevention and treatment of osteoporosis
  • T6INDIRECT 20405294 ↗Total laparoscopic radical hysterectomy for cervical cancer in prolapsed uterus
  • T6INDIRECT 28963668 ↗Assessing and treating primary headaches and cranio-facial pain in patients undergoing rehabilitatio
  • T6INDIRECT 19714234 ↗Chiropractic practice in military and veterans health care: The state of the literature
  • T6INDIRECT 30203232 ↗Topical Selenium Sulfide for the Treatment of Hyperkeratosis
  • T6INDIRECT 36008648 ↗World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2022)
  • T6INDIRECT 33429811 ↗Tuina for lumbar disc herniation: A protocol for systematic review and meta analysis
  • T6 38067127 ↗Complementary Approaches to Retinal Health Focusing on Diabetic Retinopathy
  • T6 38878809 ↗Unmet Need: Mechanistic and Translational Studies of Sickle Cell Disease Pain as a Whole-Person Heal
  • T6 31508307 ↗Quantitative ultrasound imaging monitoring progressive disuse osteopenia and mechanical stimulation
  • T6 25414775 ↗The Leaves of Broussonetia kazinoki Siebold Inhibit Atopic Dermatitis-Like Response on Mite Allergen
  • T6 27114361 ↗Abstracts from the 2016 Society of General Internal Medicine Annual Meeting
  • T6 21255460 ↗Effectiveness of trigger point dry needling for plantar heel pain: study protocol for a randomised c
  • T6 25671182 ↗Antimicrobial and Antifungal Activity of Pelargonium roseum Essential Oils
Methotrexate + anti-H1
T6
T6 — Mechanistic / preclinical
MCAS
Nilotinib
T6
T6 — Mechanistic / preclinical
MCAS
23 sources
  • T6 NCT00109707 ↗A Study of Oral AMN107 in Adults With Chronic Myelogenous Leukemia (CML) or Other Hematologic Malign
  • T6INDIRECT 29614103 ↗Characteristics of clinical trials in rare vs. common diseases: A register-based Latvian study
  • T6INDIRECT 33952306 ↗Anticancer drugs repurposed for Alzheimer's disease: a systematic review
  • T6INDIRECT 24407160 ↗Identification of Ponatinib as a potent inhibitor of growth, migration, and activation of neoplastic
  • T6INDIRECT 35640224 ↗Efficacy and safety of avapritinib in previously treated patients with advanced systemic mastocytosi
  • T6 34054126 ↗Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
  • T6 28031180 ↗Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts
  • T6 24359404 ↗Targeting the PDGF signaling pathway in tumor treatment
  • T6 22043171 ↗A clinical overview of centrosome amplification in human cancers
  • T6 30713991 ↗The growing role of precision and personalized medicine for cancer treatment
  • T6 18559612 ↗Phase II study of dasatinib in Philadelphia chromosome-negative acute and chronic myeloid diseases,
  • T6INDIRECT 25964669 ↗How I treat hypereosinophilic syndromes
  • T6INDIRECT 29431216 ↗Mast cell-neural interactions contribute to pain and itch
  • T6INDIRECT 32778962 ↗Repurposing of Kinase Inhibitors for Treatment of COVID-19
  • T6INDIRECT 29844705 ↗Severe cutaneous adverse reactions induced by targeted anticancer therapies and immunotherapies
  • T6INDIRECT 32522746 ↗Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies
  • T6INDIRECT 27132234 ↗Pharmacological treatment options for mast cell activation disease
  • T6INDIRECT 19491913 ↗Tyrosine kinases as targets for the treatment of rheumatoid arthritis
  • T6INDIRECT 28725969 ↗Mastocytosis: from a Molecular Point of View
  • T6 16721371 ↗AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL
  • T6 24963404 ↗Imatinib: a breakthrough of targeted therapy in cancer
  • T6 37143582 ↗Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, an
  • T6 29925402 ↗Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy
Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation
T6
T6 — Mechanistic / preclinical
MCAS
Nucala
T6
T6 — Mechanistic / preclinical
MCAS
19 sources
  • T6INDIRECT 32990324 ↗Anti-cytokine targeted therapies for ANCA-associated vasculitis
  • T6 29682504 ↗Targeting the Interleukin-5 Pathway for Treatment of Eosinophilic Conditions Other than Asthma
  • T6 29035619 ↗Personalized medicine with biologics for severe type 2 asthma: current status and future prospects
  • T6 32004747 ↗Current and Future Treatments of Rhinitis and Sinusitis
  • T6 39158477 ↗Therapeutic monoclonal antibodies in allergy: Targeting IgE, cytokine, and alarmin pathways
  • T6 PMC6464318 ↗Anti‐cytokine targeted therapies for ANCA‐associated vasculitis
  • T6 28121072 ↗Current Status of Companion and Complementary Diagnostics: Strategic Considerations for Development
  • T6INDIRECT 32421085 ↗Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in
  • T6INDIRECT 35987486 ↗Safety of Biologics for Atopic Diseases During Pregnancy
  • T6INDIRECT 37259416 ↗Biologic Therapies for Asthma and Allergic Disease: Past, Present, and Future
  • T6INDIRECT 27803792 ↗Mepolizumab for severe refractory eosinophilic asthma: evidence to date and clinical potential
  • T6INDIRECT 33891135 ↗Lessons learned from targeting eosinophils in human disease
  • T6INDIRECT 32915172 ↗Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic
  • T6 28716883 ↗Role of the β Common (βc) Family of Cytokines in Health and Disease
  • T6 35628333 ↗Therapeutic Strategies of Biologics in Chronic Rhinosinusitis: Current Options and Future Targets
  • T6 26620589 ↗Monoclonal antibodies: the new magic bullets for allergy: IUPHAR Review 17
  • T6 39062104 ↗Insight into IL-5 as a Potential Target for the Treatment of Allergic Diseases
  • T6 35296105 ↗A pragmatic guide to choosing biologic therapies in severe asthma
  • T6 32378146 ↗Resolving Clinical Phenotypes into Endotypes in Allergy: Molecular and Omics Approaches
PA101
T6
T6 — Mechanistic / preclinical
MCAS
7 sources
  • T6 NCT02478957 ↗Treatment of Indolent Systemic Mastocytosis With PA101
  • T6INDIRECT 33085095 ↗Curbing the Cough: Multimodal Treatments for Neurogenic Cough: A Systematic Review and Meta-Analysis
  • T6 36836843 ↗Trials and Treatments: An Update on Pharmacotherapy for Idiopathic Pulmonary Fibrosis
  • T6 27942432 ↗Mast Cell Clonal Disorders: Classification, Diagnosis and Management
  • T6 37006099 ↗Approach to post COVID-19 persistent cough: A narrative review
  • T6 32944204 ↗Improved bioavailability of cromolyn sodium using inhaled PA101 delivered via eFlow® nebulizer
  • T6 40904938 ↗Mast Cell Leukemia: Comprehensive Review of Literature With Current Insights and Updates on Manageme
PS-341
T6
T6 — Mechanistic / preclinical
MCAS
21 sources
  • T6 NCT00237627 ↗Doxorubicin Hydrochloride Liposome and Bortezomib in Treating Patients With Refractory Hematologic C
  • T6INDIRECT 37314034 ↗Pharmacological interventions for pruritus in adult palliative care patients
  • T6INDIRECT 36580956 ↗Risk of perioperative stroke and cerebral autoregulation monitoring: a systematic review
  • T6INDIRECT 37572360 ↗Interventions for bullous pemphigoid
  • T6INDIRECT 36613529 ↗Reported Cases and Diagnostics of Occupational Insect Allergy: A Systematic Review
  • T6INDIRECT 34351016 ↗Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19
  • T6 32632432 ↗Half a century of amyloids: past, present and future
  • T6 10456976 ↗Cytokines in asthma
  • T6 28782570 ↗Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healin
  • T6 24679069 ↗Sublingual immunotherapy: World Allergy Organization position paper 2013 update
  • T6 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6INDIRECT 12194881 ↗Hazardous air pollutants and asthma
  • T6INDIRECT 19590986 ↗Evidence for the use of intravenous immunoglobulins--a review of the literature
  • T6INDIRECT 37295474 ↗Updated guidance regarding the risk of allergic reactions to COVID-19 vaccines and recommended evalu
  • T6INDIRECT 25416152 ↗HMG-CoA reductase inhibitors as adjuvant treatment for hematologic malignancies: what is the current
  • T6INDIRECT 14692959 ↗Universal leukoreduction and acute transfusion reactions: putting the puzzle together
  • T6INDIRECT 21886384 ↗ELECTROPHYSICAL AGENTS - Contraindications And Precautions: An Evidence-Based Approach To Clinical D
  • T6 11842096 ↗Natural and pharmacological regulation of telomerase
  • T6 22154653 ↗Role of reactive oxygen and nitrogen species in the vascular responses to inflammation
  • T6 11405550 ↗Anti-inflammatory cytokines in asthma and allergy: interleukin-10, interleukin-12, interferon-gamma
  • T6 21939239 ↗Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lyso
Pemetrexed
T6
T6 — Mechanistic / preclinical
MCAS
22 sources
  • T6 NCT00424242 ↗Pemetrexed Disodium in the Cerebrospinal Fluid of Patients With Leptomeningeal Metastases
  • T6INDIRECT 34999267 ↗Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, an
  • T6INDIRECT 32546683 ↗A comprehensive map of disease networks and molecular drug discoveries for glaucoma
  • T6INDIRECT 23760662 ↗Increased CD14(+)HLA-DR (-/low) myeloid-derived suppressor cells correlate with extrathoracic metast
  • T6INDIRECT 33331923 ↗Whole-brain radiotherapy with and without concurrent erlotinib in NSCLC with brain metastases: a mul
  • T6INDIRECT 27737534 ↗ERCC1 Expression-Based Randomized Phase II Study of Gemcitabine/Cisplatin Versus Irinotecan/Cisplati
  • T6INDIRECT 24777247 ↗T cells expressing chimeric antigen receptors can cause anaphylaxis in humans
  • T6INDIRECT 33123580 ↗Combined Administration of Bisphosphonates, Chemotherapeutic Agents, and/or Targeted Drugs Increases
  • T6 26391154 ↗Targeted therapy in cancer
  • T6 36254250 ↗Small molecule inhibitors targeting the cancers
  • T6 38462638 ↗Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential
  • T6INDIRECT 30307375 ↗Diagnosis of NUT carcinoma of lung origin by next-generation sequencing: case report and review of t
  • T6INDIRECT 29844705 ↗Severe cutaneous adverse reactions induced by targeted anticancer therapies and immunotherapies
  • T6INDIRECT 31909151 ↗Cutaneous lupus erythematosus: A review of the literature
  • T6INDIRECT 30832285 ↗PD-1 Inhibitors-Related Neurological Toxicities in Patients with Non-Small-Cell Lung Cancer: A Liter
  • T6INDIRECT 34295668 ↗International consensus on severe lung cancer-the first edition
  • T6INDIRECT 29535794 ↗Neoplastic meningitis in solid tumors: from diagnosis to personalized treatments
  • T6INDIRECT 36835299 ↗Allergy in Cancer Care: Antineoplastic Therapy-Induced Hypersensitivity Reactions
  • T6 34834162 ↗Activators and Inhibitors of Protein Kinase C (PKC): Their Applications in Clinical Trials
  • T6 36947256 ↗Receptor tyrosine kinase inhibitors in cancer
  • T6 32775973 ↗When should we order a next generation sequencing test in a patient with cancer?
  • T6 25079860 ↗Acute interstitial nephritis - a reappraisal and update
Peripheral Blood Stem Cell Transplantation
T6
T6 — Mechanistic / preclinical
MCAS
22 sources
  • T6INDIRECT 21047561 ↗Reduced-intensity conditioning followed by related allografts in hematologic malignancies: long-term
  • T6INDIRECT 30635050 ↗Predictors of responders to mononuclear stem cell-based therapeutic angiogenesis for no-option criti
  • T6INDIRECT 30077015 ↗Reduced-Intensity Conditioning Followed by Related and Unrelated Allografts for Hematologic Malignan
  • T6 20643990 ↗Narrative review: the systemic capillary leak syndrome
  • T6 25221694 ↗Xerostomia due to systemic disease: a review of 20 conditions and mechanisms
  • T6 30858685 ↗Primary vitreoretinal lymphoma: prevalence, impact, and management challenges
  • T6 21079133 ↗Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acut
  • T6 19822304 ↗Early and late neurological complications after reduced-intensity conditioning allogeneic stem cell
  • T6 23799412 ↗A dose-escalation study of recombinant human interleukin-18 in combination with rituximab in patient
  • T6 29517616 ↗A Dose-escalation Study of Recombinant Human Interleukin-18 in Combination With Ofatumumab After Aut
  • T6INDIRECT 28761296 ↗Primary Cutaneous Nocardiosis Caused by <i>Nocardia takedensis</i>
  • T6INDIRECT 25143680 ↗Intravascular cytotoxic T-cell lymphoma in a young immunocompetent woman
  • T6INDIRECT 25550705 ↗Wernicke's encephalopathy in a child with high dose thiamine therapy
  • T6INDIRECT 31592543 ↗17th International Congress of Immunology, 19-23 October 2019, Beijing, China
  • T6INDIRECT 30240102 ↗Abstracts from the 50th Congress of the International Society of Paediatric Oncology (SIOP) Kyoto, J
  • T6INDIRECT 18545251 ↗Indications and results of cord blood transplant in children with leukemia
  • T6 36655373 ↗Bone marrow inflammatory memory in cardiometabolic disease and inflammatory comorbidities
  • T6 26604845 ↗The contributions of the European Medicines Agency and its pediatric committee to the fight against
  • T6 31311585 ↗Systemic administration of quality- and quantity-controlled PBMNCs reduces bisphosphonate-related os
  • T6 36831022 ↗Primary Mediastinal Germ Cell Tumors: A Thorough Literature Review
  • T6 34357128 ↗Molecular Pathology and Targeted Therapies for Personalized Management of Central Nervous System Ger
  • T6 38249974 ↗Neutrophilic and eosinophilic dermatoses associated with hematological malignancy
Peripheral blood stem cell transplantation
T6
T6 — Mechanistic / preclinical
MCAS
22 sources
  • T6INDIRECT 21047561 ↗Reduced-intensity conditioning followed by related allografts in hematologic malignancies: long-term
  • T6INDIRECT 30635050 ↗Predictors of responders to mononuclear stem cell-based therapeutic angiogenesis for no-option criti
  • T6INDIRECT 30077015 ↗Reduced-Intensity Conditioning Followed by Related and Unrelated Allografts for Hematologic Malignan
  • T6 20643990 ↗Narrative review: the systemic capillary leak syndrome
  • T6 25221694 ↗Xerostomia due to systemic disease: a review of 20 conditions and mechanisms
  • T6 30858685 ↗Primary vitreoretinal lymphoma: prevalence, impact, and management challenges
  • T6 21079133 ↗Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acut
  • T6 19822304 ↗Early and late neurological complications after reduced-intensity conditioning allogeneic stem cell
  • T6 23799412 ↗A dose-escalation study of recombinant human interleukin-18 in combination with rituximab in patient
  • T6 29517616 ↗A Dose-escalation Study of Recombinant Human Interleukin-18 in Combination With Ofatumumab After Aut
  • T6INDIRECT 28761296 ↗Primary Cutaneous Nocardiosis Caused by <i>Nocardia takedensis</i>
  • T6INDIRECT 25143680 ↗Intravascular cytotoxic T-cell lymphoma in a young immunocompetent woman
  • T6INDIRECT 25550705 ↗Wernicke's encephalopathy in a child with high dose thiamine therapy
  • T6INDIRECT 31592543 ↗17th International Congress of Immunology, 19-23 October 2019, Beijing, China
  • T6INDIRECT 30240102 ↗Abstracts from the 50th Congress of the International Society of Paediatric Oncology (SIOP) Kyoto, J
  • T6INDIRECT 18545251 ↗Indications and results of cord blood transplant in children with leukemia
  • T6 36655373 ↗Bone marrow inflammatory memory in cardiometabolic disease and inflammatory comorbidities
  • T6 26604845 ↗The contributions of the European Medicines Agency and its pediatric committee to the fight against
  • T6 31311585 ↗Systemic administration of quality- and quantity-controlled PBMNCs reduces bisphosphonate-related os
  • T6 36831022 ↗Primary Mediastinal Germ Cell Tumors: A Thorough Literature Review
  • T6 34357128 ↗Molecular Pathology and Targeted Therapies for Personalized Management of Central Nervous System Ger
  • T6 38249974 ↗Neutrophilic and eosinophilic dermatoses associated with hematological malignancy
Probio Histamed®, a multi-species probiotic preparation containing Bifid. breve, Bifid. lactis, Bifid. infantis, Bifid. longum, Lact. gasseri, and Lact. rhamnosus
T6
T6 — Mechanistic / preclinical
MCAS
Rilonacept
T6
T6 — Mechanistic / preclinical
MCAS
20 sources
  • T6INDIRECT 32990324 ↗Anti-cytokine targeted therapies for ANCA-associated vasculitis
  • T6INDIRECT 33129321 ↗Therapeutic options for patients with rare rheumatic diseases: a systematic review and meta-analysis
  • T6INDIRECT 35359659 ↗Targeting Inflammatory Mediators in Epilepsy: A Systematic Review of Its Molecular Basis and Clinica
  • T6INDIRECT 35350578 ↗Immunomodulating Therapies in Acute Myocarditis and Recurrent/Acute Pericarditis
  • T6INDIRECT 33129938 ↗Live long and active: Polypeptide-mediated assembly of antibody variable fragments
  • T6 26121197 ↗Inflammasomes: mechanism of action, role in disease, and therapeutics
  • T6 25625584 ↗NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflamm
  • T6 24275598 ↗Treating inflammation by blocking interleukin-1 in humans
  • T6 30670444 ↗The central role of inflammatory signaling in the pathogenesis of myelodysplastic syndromes
  • T6 31900383 ↗Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review
  • T6INDIRECT 32522746 ↗Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies
  • T6INDIRECT 25905009 ↗Schnitzler's syndrome: lessons from 281 cases
  • T6INDIRECT 25784780 ↗Interleukin-1 as a common denominator from autoinflammatory to autoimmune disorders: premises, peril
  • T6INDIRECT 22120610 ↗Interplay between innate and adaptive immunity in the development of non-infectious uveitis
  • T6INDIRECT 23970817 ↗Biological treatments: new weapons in the management of monogenic autoinflammatory disorders
  • T6INDIRECT 30021447 ↗Biologics in Chronic Rhinosinusitis: An Update and Thoughts for Future Directions
  • T6 38177104 ↗The role of inflammasomes in human diseases and their potential as therapeutic targets
  • T6 26209330 ↗Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies
  • T6 36031601 ↗Emerging strategies in targeting tumor-resident myeloid cells for cancer immunotherapy
  • T6 35729334 ↗IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting
Sarilumab
T6
T6 — Mechanistic / preclinical
MCAS
20 sources
  • T6INDIRECT 34019122 ↗Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomiz
  • T6INDIRECT 32990324 ↗Anti-cytokine targeted therapies for ANCA-associated vasculitis
  • T6INDIRECT 35359659 ↗Targeting Inflammatory Mediators in Epilepsy: A Systematic Review of Its Molecular Basis and Clinica
  • T6INDIRECT 41424786 ↗Effectiveness and safety of tocilizumab in refractory noninfectious uveitis: a systematic review and
  • T6INDIRECT 37612352 ↗A randomized phase 2 study on demeclocycline in patients with mild-to-moderate COVID-19
  • T6 34824210 ↗The JAK/STAT signaling pathway: from bench to clinic
  • T6 37332039 ↗T cells in health and disease
  • T6 32376392 ↗Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventio
  • T6 32467561 ↗Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered
  • T6 34253862 ↗Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms
  • T6INDIRECT 33867315 ↗The immune response to SARS-CoV-2 and COVID-19 immunopathology - Current perspectives
  • T6INDIRECT 32778962 ↗Repurposing of Kinase Inhibitors for Treatment of COVID-19
  • T6INDIRECT 32522746 ↗Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies
  • T6INDIRECT 29521875 ↗Cytokines in uveitis
  • T6INDIRECT 32963819 ↗Ocular Findings in COVID-19 Patients: A Review of Direct Manifestations and Indirect Effects on the
  • T6INDIRECT 33073244 ↗Imperfect storm: is interleukin-33 the Achilles heel of COVID-19?
  • T6INDIRECT 33040064 ↗COVID-19 and Gastrointestinal Disease: Implications for the Gastroenterologist
  • T6INDIRECT 33485845 ↗Systemic diseases and the cornea
  • T6 37198232 ↗Targeting strategies for bone diseases: signaling pathways and clinical studies
  • T6 36031601 ↗Emerging strategies in targeting tumor-resident myeloid cells for cancer immunotherapy
ShotBlocker®
T6
T6 — Mechanistic / preclinical
MCAS
1 source
  • T6 36948491 ↗Biologic Versus Small Molecule Therapy for Treating Moderate to Severe Atopic Dermatitis: Clinical C
Sodium Ferric Gluconate Complex In Sucrose
T6
T6 — Mechanistic / preclinical
MCAS
3 sources
Solumedrol
T6
T6 — Mechanistic / preclinical
MCAS
16 sources
  • T6 NCT00186628 ↗Phase 2 Trial of Prophylactic Rituximab Therapy for Prevention of CGVHD
  • T6INDIRECT 34402927 ↗Short- and long-term outcomes after heart transplantation in cardiac sarcoidosis and giant-cell myoc
  • T6INDIRECT 37598195 ↗Sialendoscopy approach in treating juvenile recurrent parotitis: a systematic review
  • T6 36485140 ↗Approach to the patient with suspected hypereosinophilic syndrome
  • T6 28721077 ↗Food protein-induced enterocolitis syndrome - a review of the literature with focus on clinical mana
  • T6 15870014 ↗In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation
  • T6 38565581 ↗Investigating the metabolite signature of an altered oral microbiota as a discriminant factor for mu
  • T6INDIRECT 32834714 ↗Inflammatory Manifestations of Systemic Diseases in the Central Nervous System
  • T6INDIRECT 14692959 ↗Universal leukoreduction and acute transfusion reactions: putting the puzzle together
  • T6INDIRECT 25621178 ↗Percutaneous Cryoablation of Metastatic Lesions from Colorectal Cancer: Efficacy and Feasibility wit
  • T6INDIRECT 34297318 ↗Abstracts from the 2021 Annual Meeting of the Society of General Internal Medicine
  • T6INDIRECT 28397154 ↗Abstracts from the 2017 Society of General Internal Medicine Annual Meeting
  • T6 3979758 ↗Abstracts of papers submitted to the American Gastroenterological Association. 86th annual meeting,
  • T6 32725471 ↗Abstracts from the 2020 Annual Meeting of the Society of General Internal Medicine
  • T6 32546955 ↗Anterior Segment Optical Coherence Tomography (AS-OCT) Guided Reversal of Edematous Punctal Occlusio
  • T6 34357128 ↗Molecular Pathology and Targeted Therapies for Personalized Management of Central Nervous System Ger
Standard Follow-Up Care
T6
T6 — Mechanistic / preclinical
MCAS
Stem cell transplantation
T6
T6 — Mechanistic / preclinical
MCAS
21 sources
  • T6INDIRECT 28644114 ↗Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation
  • T6INDIRECT 34904799 ↗Polatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma
  • T6INDIRECT 36542826 ↗Lisocabtagene maraleucel as second-line therapy for large B-cell lymphoma: primary analysis of the p
  • T6INDIRECT 31113476 ↗Treatment of knee osteoarthritis with intra-articular injection of autologous adipose-derived mesenc
  • T6INDIRECT 25154820 ↗Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effect
  • T6INDIRECT 34649563 ↗COVID-19 infection in adult patients with hematological malignancies: a European Hematology Associat
  • T6 35732831 ↗The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid
  • T6 32934330 ↗Exploring the NK cell platform for cancer immunotherapy
  • T6 35767897 ↗International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphol
  • T6 32855385 ↗Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clin
  • T6INDIRECT 33219338 ↗Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease
  • T6INDIRECT 23023713 ↗Pathogenesis of follicular lymphoma
  • T6INDIRECT 20643990 ↗Narrative review: the systemic capillary leak syndrome
  • T6INDIRECT 20113479 ↗Rothmund-Thomson syndrome
  • T6INDIRECT 23109216 ↗Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for p
  • T6 20176269 ↗IgE, mast cells, basophils, and eosinophils
  • T6 38311623 ↗Extracellular vesicles as tools and targets in therapy for diseases
  • T6 25861976 ↗Ion channels in innate and adaptive immunity
  • T6 27834397 ↗The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia
  • T6 28484466 ↗The ST2/IL-33 Axis in Immune Cells during Inflammatory Diseases
  • T6 33657296 ↗Diffuse Large B-Cell Lymphoma
TEV-45779
T6
T6 — Mechanistic / preclinical
MCAS
2 sources
  • T6 41654334 ↗Systemic Treatments for Chronic Spontaneous Urticaria: Anti-IgE and Beyond
  • T6 41270830 ↗Emerging IgE and non-IgE targeted therapies for chronic urticaria
TF 002
T6
T6 — Mechanistic / preclinical
Harm signalMCAS
1 source
  • T6HARM NCT00457288 ↗Efficacy and Safety of TF002 in Cutaneous Mastocytosis
Tab Bilastine
T6
T6 — Mechanistic / preclinical
MCAS
1 source
  • T6 39376275 ↗Comparison of the Efficacy and Safety of Bilastine 20 mg versus Fexofenadine 180 mg for Treatment of
Tab Bilastine + Tab Levocetrizine
T6
T6 — Mechanistic / preclinical
MCAS
Thalidomide
T6
T6 — Mechanistic / preclinical
MCAS
23 sources
  • T6INDIRECT 31782132 ↗Pathophysiology and Therapeutic Perspectives of Oxidative Stress and Neurodegenerative Diseases: A N
  • T6INDIRECT 26680308 ↗Revisiting doxycycline in pregnancy and early childhood--time to rebuild its reputation?
  • T6INDIRECT 37189381 ↗Dupilumab in Inflammatory Skin Diseases: A Systematic Review
  • T6INDIRECT 30184451 ↗Rituximab plus Lenalidomide in Advanced Untreated Follicular Lymphoma
  • T6INDIRECT 30943337 ↗Benralizumab for &lt;i&gt;PDGFRA&lt;/i&gt;-Negative Hypereosinophilic Syndrome
  • T6INDIRECT 28069279 ↗Masitinib for treatment of severely symptomatic indolent systemic mastocytosis: a randomised, placeb
  • T6INDIRECT 22733017 ↗Amyloidosis of the gastrointestinal tract: a 13-year, single-center, referral experience
  • T6INDIRECT 38659046 ↗Long-term remission and survival in patients with relapsed or refractory multiple myeloma after trea
  • T6 37169756 ↗Angiogenic signaling pathways and anti-angiogenic therapy for cancer
  • T6 17655751 ↗Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis
  • T6INDIRECT 32106302 ↗Overview of Castleman disease
  • T6INDIRECT 20643990 ↗Narrative review: the systemic capillary leak syndrome
  • T6INDIRECT 35606650 ↗Pyoderma Gangrenosum: An Updated Literature Review on Established and Emerging Pharmacological Treat
  • T6INDIRECT 29222231 ↗AL amyloidosis: from molecular mechanisms to targeted therapies
  • T6INDIRECT 23109216 ↗Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for p
  • T6INDIRECT 25154823 ↗Hematopoietic stem-cell transplantation for advanced systemic mastocytosis
  • T6 27834397 ↗The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia
  • T6 26679767 ↗Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive
  • T6 30042333 ↗Interleukin-1 Beta-A Friend or Foe in Malignancies?
  • T6 22043171 ↗A clinical overview of centrosome amplification in human cancers
  • T6 37143582 ↗Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, an
  • T6 19366917 ↗Update on eosinophilic meningoencephalitis and its clinical relevance
  • T6 14760748 ↗Key role of mast cells and their major secretory products in inflammatory bowel disease
UB-221
T6
T6 — Mechanistic / preclinical
MCAS
17 sources
  • T6 24876674 ↗The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis
  • T6 33077936 ↗Kinase inhibition in autoimmunity and inflammation
  • T6 35504917 ↗COVID-19 vaccine development: milestones, lessons and prospects
  • T6 37143582 ↗Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, an
  • T6 28346442 ↗Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
  • T6INDIRECT 33628747 ↗Anti-IgE for the Treatment of Chronic Urticaria
  • T6INDIRECT 37386330 ↗Current and Emerging Therapies for Chronic Spontaneous Urticaria: A Narrative Review
  • T6INDIRECT 40004611 ↗Advances in Biologic Therapies for Allergic Diseases: Current Trends, Emerging Agents, and Future Pe
  • T6INDIRECT 39598410 ↗Therapies for Chronic Spontaneous Urticaria: Present and Future Developments
  • T6INDIRECT 37193304 ↗Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS-CoV-2
  • T6INDIRECT 31592543 ↗17th International Congress of Immunology, 19-23 October 2019, Beijing, China
  • T6INDIRECT 30240102 ↗Abstracts from the 50th Congress of the International Society of Paediatric Oncology (SIOP) Kyoto, J
  • T6 36814257 ↗Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances (PFAS)
  • T6 38405060 ↗Cholesterol metabolism: physiological regulation and diseases
  • T6 36251242 ↗New Mechanistic Advances in FcεRI-Mast Cell-Mediated Allergic Signaling
  • T6 33923680 ↗Current Methods of Post-Translational Modification Analysis and Their Applications in Blood Cancers
  • T6 35008250 ↗FDA-Approved Drugs for Hematological Malignancies-The Last Decade Review
Valganciclovir
T6
T6 — Mechanistic / preclinical
MCAS
17 sources
  • T6INDIRECT 27428352 ↗Corticosteroids for Bell's palsy (idiopathic facial paralysis)
  • T6INDIRECT 31117264 ↗Herpes Virus, Oral Clinical Signs and QoL: Systematic Review of Recent Data
  • T6INDIRECT 25254615 ↗Interventions for the management of oral ulcers in Behçet's disease
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6 32106302 ↗Overview of Castleman disease
  • T6 35215786 ↗<i>Herpes zoster</i>: A Review of Clinical Manifestations and Management
  • T6 36213536 ↗Carbohydrate-based drugs launched during 2000<i>-</i>2021
  • T6 15870014 ↗In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation
  • T6 36690406 ↗Influence of letermovir treatment on gut inflammation in people living with HIV on antiretroviral th
  • T6INDIRECT 32778962 ↗Repurposing of Kinase Inhibitors for Treatment of COVID-19
  • T6INDIRECT 32522746 ↗Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies
  • T6INDIRECT 30619688 ↗Common viral infections in kidney transplant recipients
  • T6INDIRECT 30859513 ↗A Review of Corneal Endotheliitis and Endotheliopathy: Differential Diagnosis, Evaluation, and Treat
  • T6 31031754 ↗Case Study: Mechanism for Increased Follicular Helper T Cell Development in Activated PI3K Delta Syn
  • T6 27597852 ↗Challenges in the Role of Gammaglobulin Replacement Therapy and Vaccination Strategies for Hematolog
  • T6 36831439 ↗Oral Human Papillomavirus Benign Lesions and HPV-Related Cancer in Healthy Children: A Systematic Re
  • T6 34840688 ↗Intravitreal Methotrexate
Velcade
T6
T6 — Mechanistic / preclinical
MCAS
21 sources
  • T6 NCT00237627 ↗Doxorubicin Hydrochloride Liposome and Bortezomib in Treating Patients With Refractory Hematologic C
  • T6 34054126 ↗Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
  • T6 29699936 ↗IL-6 family cytokines: Key inflammatory mediators as biomarkers and potential therapeutic targets
  • T6 26654227 ↗Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell l
  • T6 19490893 ↗A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
  • T6 20404331 ↗Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits
  • T6 21447728 ↗Phase I trial of bortezomib (PS-341; NSC 681239) and alvocidib (flavopiridol; NSC 649890) in patient
  • T6 28103725 ↗A phase 1 study of bortezomib and romidepsin in patients with chronic lymphocytic leukemia/small lym
  • T6 20540156 ↗Phase I/II study of single-agent bortezomib for the treatment of patients with myelofibrosis. Clinic
  • T6INDIRECT 31040892 ↗Gastrointestinal bleeding as initial presentation of extramedullary plasma cell neoplasms: A case re
  • T6INDIRECT 37724175 ↗Daratumumab in the treatment of C3 glomerulopathy with monoclonal gammopathy: a case report and lite
  • T6INDIRECT 33911709 ↗Necrobiotic Xanthogranuloma Coexists with Diffuse Normolipidemic Plane Xanthoma and Multiple Myeloma
  • T6INDIRECT 31183267 ↗Thrombocytosis as an Initial Presentation of Plasma Cell Neoplasm: A Case Report
  • T6INDIRECT 34456724 ↗The Evolution of AIFA Registries to Support Managed Entry Agreements for Orphan Medicinal Products i
  • T6INDIRECT 18545251 ↗Indications and results of cord blood transplant in children with leukemia
  • T6INDIRECT 33311612 ↗The 46<sup>th</sup> Annual Meeting of the European Society for Blood and Marrow Transplantation: Phy
  • T6INDIRECT 32745248 ↗Abstracts from the European Academy of Allergy and Clinical Immunology Congress, 26-30 May 2018, Mun
  • T6 19616124 ↗Nanodelivery in airway diseases: challenges and therapeutic applications
  • T6 28862319 ↗Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research-practice gaps,
  • T6 33923680 ↗Current Methods of Post-Translational Modification Analysis and Their Applications in Blood Cancers
  • T6 23209294 ↗Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) is essential for
XOLAIR® Injection
T6
T6 — Mechanistic / preclinical
MCAS
1 source
  • T6INDIRECT 28330497 ↗Atopic Dermatitis Anti-IgE Paediatric Trial (ADAPT): the role of anti-IgE in severe paediatric eczem
Xolair Prefilled Syringe
T6
T6 — Mechanistic / preclinical
MCAS
Xolair®
T6
T6 — Mechanistic / preclinical
MCAS
19 sources
  • T6INDIRECT 25200415 ↗Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-Ig
  • T6INDIRECT 28435464 ↗Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of F
  • T6INDIRECT 28330497 ↗Atopic Dermatitis Anti-IgE Paediatric Trial (ADAPT): the role of anti-IgE in severe paediatric eczem
  • T6INDIRECT 24176117 ↗A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic pa
  • T6INDIRECT 17765756 ↗Anti-IgE treatment of eosinophil-associated gastrointestinal disorders
  • T6INDIRECT 29737044 ↗A clinical follow-up of omalizumab in routine treatment of allergic asthma monitored by CD-sens
  • T6 23452057 ↗Characterization of different courses of atopic dermatitis in adolescent and adult patients
  • T6 24642143 ↗Accelerated dissociation of IgE-FcεRI complexes by disruptive inhibitors actively desensitizes aller
  • T6INDIRECT 23341807 ↗Treatment of severe cold contact urticaria with omalizumab: case reports
  • T6INDIRECT 25754717 ↗Biologic therapies targeting eosinophils: current status and future prospects
  • T6INDIRECT 28725969 ↗Mastocytosis: from a Molecular Point of View
  • T6INDIRECT 32421085 ↗Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in
  • T6INDIRECT 33628747 ↗Anti-IgE for the Treatment of Chronic Urticaria
  • T6INDIRECT 37259416 ↗Biologic Therapies for Asthma and Allergic Disease: Past, Present, and Future
  • T6INDIRECT 32915172 ↗Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic
  • T6 29035619 ↗Personalized medicine with biologics for severe type 2 asthma: current status and future prospects
  • T6 34212542 ↗COVID-19 Vaccine-associated Anaphylaxis and Allergic Reactions: Consensus Statements of the KAAACI U
  • T6 32086776 ↗The Role of Mast Cells in IgE-Independent Lung Diseases
  • T6 29163536 ↗Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: The Role of Desen
Xolair® + Symbicort®
T6
T6 — Mechanistic / preclinical
MCAS
cyclosporine
T6
T6 — Mechanistic / preclinical
MCASPOTS
51 sources
  • T6 NCT00006251 ↗Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by C
  • T6 NCT00014235 ↗Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transpla
  • T6 NCT00118352 ↗Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophen
  • T6 NCT00112593 ↗Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and M
  • T6INDIRECT 21497847 ↗AUA guideline for the diagnosis and treatment of interstitial cystitis/bladder pain syndrome
  • T6INDIRECT 37056675 ↗The crucial role and mechanism of insulin resistance in metabolic disease
  • T6INDIRECT 30968949 ↗Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlli
  • T6INDIRECT 26110030 ↗Clinical and diagnostic utility of saliva as a non-invasive diagnostic fluid: 
a systematic review
  • T6INDIRECT 10951147 ↗Randomized double-blind study of cyclosporin in chronic 'idiopathic' urticaria
  • T6INDIRECT 25046337 ↗Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who rema
  • T6INDIRECT 20431041 ↗Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and l
  • T6INDIRECT 29652551 ↗n-3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease
  • T6INDIRECT 30943337 ↗Benralizumab for &lt;i&gt;PDGFRA&lt;/i&gt;-Negative Hypereosinophilic Syndrome
  • T6 22878108 ↗Cell biology of ischemia/reperfusion injury
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 24554461 ↗Echinacea for preventing and treating the common cold
  • T6INDIRECT 25919144 ↗Interventions for rosacea
  • T6INDIRECT 29271481 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 35603936 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 31917873 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 22251436 ↗Maraviroc, a chemokine receptor-5 antagonist, fails to demonstrate efficacy in the treatment of pati
  • T6 28293453 ↗An overview and management of osteoporosis
  • T6 33243615 ↗Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on
  • T6 37436070 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 17655751 ↗Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis
  • T6INDIRECT 25686388 ↗The pathophysiology, diagnosis, and treatment of dry eye disease
  • T6INDIRECT 24275598 ↗Treating inflammation by blocking interleukin-1 in humans
  • T6INDIRECT 28242845 ↗Focal Segmental Glomerulosclerosis
  • T6INDIRECT 30558872 ↗Antibiotic allergy
  • T6INDIRECT 32106302 ↗Overview of Castleman disease
  • T6 26228647 ↗Colchicine--Update on mechanisms of action and therapeutic uses
  • T6 25861976 ↗Ion channels in innate and adaptive immunity
  • T6 28736339 ↗TFOS DEWS II pain and sensation report
  • T6 32376392 ↗Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventio
  • T6 30774631 ↗The Immunology of Macrophage Activation Syndrome
  • T6INDIRECT 31485575 ↗Clinical Manifestations, Diagnosis, and Treatment of Sarcoidosis
  • T6INDIRECT 29399043 ↗Treatment strategies for autoimmune encephalitis
  • T6INDIRECT 23184849 ↗Grapefruit-medication interactions: forbidden fruit or avoidable consequences?
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 23147521 ↗Clinical guideline: management of gastroparesis
  • T6INDIRECT 31210940 ↗European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gl
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6 29565029 ↗Hypertension
  • T6 34988090 ↗Treatment of Inflammatory Bowel Disease: A Comprehensive Review
  • T6 19165601 ↗Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps
  • T6 23241069 ↗A review of the efficacy and safety of oral antidiabetic drugs
  • T6 33909761 ↗Brazilian Guidelines of Hypertension - 2020
  • T6 25182228 ↗Clinician's Guide to Prevention and Treatment of Osteoporosis
  • T6 35478046 ↗The clinician's guide to prevention and treatment of osteoporosis
  • T6 30354828 ↗Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the Ameri
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
diphenhydramine (H1 antihistamine)
T6
T6 — Mechanistic / preclinical
MCASPOTS
43 sources
  • T6INDIRECT 25046337 ↗Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who rema
  • T6INDIRECT 29650949 ↗Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement
  • T6INDIRECT 20226302 ↗The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficu
  • T6INDIRECT 25200415 ↗Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-Ig
  • T6INDIRECT 12867500 ↗Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin
  • T6INDIRECT 10377184 ↗Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-indu
  • T6INDIRECT 24176117 ↗A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic pa
  • T6INDIRECT 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
  • T6INDIRECT 18774392 ↗Treatment of chronic autoimmune urticaria with omalizumab
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 23633371 ↗Interventions for treating pain and disability in adults with complex regional pain syndrome
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 18787227 ↗Antipsychotic therapy during early and late pregnancy. A systematic review
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  • T6INDIRECT 24813302 ↗Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of a
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  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
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  • T6INDIRECT 37139824 ↗American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medicatio
  • T6INDIRECT 23147521 ↗Clinical guideline: management of gastroparesis
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epinephrine (adrenaline)
T6
T6 — Mechanistic / preclinical
MCAS
24 sources
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  • T6INDIRECT 26110030 ↗Clinical and diagnostic utility of saliva as a non-invasive diagnostic fluid: 
a systematic review
  • T6INDIRECT 26581915 ↗A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy
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  • T6INDIRECT 24176117 ↗A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic pa
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  • T6INDIRECT 32128023 ↗IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position p
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ibuprofen (NSAID)
T6
T6 — Mechanistic / preclinical
MCASPOTS
51 sources
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  • T6INDIRECT 24595586 ↗Non-surgical interventions for the management of chronic pelvic pain
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  • T6INDIRECT 31132795 ↗Phase 3 randomized, placebo-controlled, double-blind study of lasmiditan for acute treatment of migr
  • T6INDIRECT 31207169 ↗The Efficacy, Tolerability, and Joint Safety of Fasinumab in Osteoarthritis Pain: A Phase IIb/III Do
  • T6INDIRECT 15345500 ↗A randomised, placebo controlled, comparative trial of the gastrointestinal safety and efficacy of A
  • T6INDIRECT 28655357 ↗Drug-related problems and medication reviews among old people with dementia
  • T6INDIRECT 9727818 ↗Contrasting actions of pressor agents in severe autonomic failure
  • T6INDIRECT 33723532 ↗Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrom
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  • T6INDIRECT 26525001 ↗2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines
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  • T6INDIRECT 23452057 ↗Characterization of different courses of atopic dermatitis in adolescent and adult patients
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  • T6 26834959 ↗Predicting risk of adverse drug reactions in older adults
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prednisolone
T6
T6 — Mechanistic / preclinical
MCAS
23 sources
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  • T6INDIRECT 23109216 ↗Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for p
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