⚠ Provisional — human review required. Tiers are computationally assigned. Per OSMF Grading Methodology §5, every Tier 1/2 entry must be verified against the source paper before publication.
📊 OSMF Grading Methodology v1.0

Therapeutic Agent
Evidence Map

Candidate agents for Long COVID, PACVS, ME/CFS, POTS, and MCAS — computationally graded by evidence tier, with linked trial and paper references for every entry.

1,355Unique agents
202Tier 1 (LC RCT)
310Tier 2 (Related RCT)
11,557Source entries
Evidence tiers: T1 — RCT in LC/PASC/PACVS T2 — RCT in related condition T3 — Observational in LC T4 — Case series T5 — Case report T6 — Mechanistic / preclinical
🦠

Long COVID / PASC

Evidence-graded therapeutic candidates from RCTs, observational studies, and mechanistic literature.

205 agents 201 Tier-1 2 Tier-2
Explore Long COVID / PASC agents →
💉

PACVS

Evidence-graded therapeutic candidates from RCTs, observational studies, and mechanistic literature.

2 agents 1 Tier-1 0 Tier-2
Explore PACVS agents →
⚡

ME/CFS

Evidence-graded therapeutic candidates from RCTs, observational studies, and mechanistic literature.

117 agents 12 Tier-1 105 Tier-2
Explore ME/CFS agents →
💓

POTS / Dysautonomia

Evidence-graded therapeutic candidates from RCTs, observational studies, and mechanistic literature.

379 agents 6 Tier-1 157 Tier-2
Explore POTS / Dysautonomia agents →
🧬

MCAS

Evidence-graded therapeutic candidates from RCTs, observational studies, and mechanistic literature.

145 agents 0 Tier-1 55 Tier-2
Explore MCAS agents →