⚠ Provisional — human review required. Tiers are computationally assigned. Per OSMF Grading Methodology §5, every Tier 1/2 entry must be verified against the source paper before publication.
⚡ ME/CFS

Therapeutic Agents
ME/CFS

Evidence-graded candidate agents from the OSMF discovery pipeline. Click any source count to see linked trial and paper references.

117Agents
12Tier 1 (LC RCT)
105Tier 2 (Related RCT)
1739Source entries
Evidence tiers: T1 — RCT in LC/PASC/PACVS T2 — RCT in related condition T3 — Observational in LC T4 — Case series T5 — Case report T6 — Mechanistic / preclinical
117 agents
Exercise
T1
T1 — RCT in LC/PASC/PACVS
RegisteredWithdrawnLong COVIDME/CFS
46 sources
  • T1 NCT04718506 ↗Rehabilitation for Post-COVID-19 Syndrome Through a Supervised Exercise Intervention
  • T1REGISTERED-ONLY NCT05566483 ↗Physiology of Long COVID-19 and the Impact of Cardiopulmonary Rehabilitation on Quality-of-Life and
  • T1 NCT04841759 ↗The Effects of a Multi-factorial Rehabilitation Program for Healthcare Workers Suffering From Post-C
  • T2 NCT04378634 ↗Epigenetics of Post-exertional Malaise in Patients With ME/CFS
  • T6WITHDRAWN NCT06065033 ↗Exercise Interventions in Post-acute Sequelae of Covid-19
  • T6INDIRECT 34373540 ↗More than 50 long-term effects of COVID-19: a systematic review and meta-analysis
  • T6INDIRECT 33760236 ↗Rapid, point-of-care antigen and molecular-based tests for diagnosis of SARS-CoV-2 infection
  • T6INDIRECT 35739136 ↗Long-COVID in children and adolescents: a systematic review and meta-analyses
  • T1 36731907 ↗Exercise as medicine for depressive symptoms? A systematic review and meta-analysis with meta-regres
  • T6INDIRECT 34643720 ↗Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection: A Systematic Review
  • T6INDIRECT 34192010 ↗Changes in physical activity and sedentary behaviours from before to during the COVID-19 pandemic lo
  • T6INDIRECT 34580069 ↗Characterising long COVID: a living systematic review
  • T6INDIRECT 32503818 ↗Medical and Surgical Education Challenges and Innovations in the COVID-19 Era: A Systematic Review
  • T6INDIRECT 34339806 ↗Psychiatric and neuropsychiatric sequelae of COVID-19 - A systematic review
  • T6INDIRECT 34268556 ↗Post-acute and long-COVID-19 symptoms in patients with mild diseases: a systematic review
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6 33753937 ↗Post-acute COVID-19 syndrome
  • T6INDIRECT 32437679 ↗Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a syst
  • T6INDIRECT 28089638 ↗The effects of acute psychological stress on circulating and stimulated inflammatory markers: A syst
  • T6INDIRECT 22018588 ↗Validity of the International Physical Activity Questionnaire Short Form (IPAQ-SF): a systematic rev
  • T6INDIRECT 18287602 ↗Surgical versus nonsurgical therapy for lumbar spinal stenosis
  • T6INDIRECT 17119140 ↗Surgical vs nonoperative treatment for lumbar disk herniation: the Spine Patient Outcomes Research T
  • T2 21334061 ↗Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and spe
  • T6INDIRECT 17119141 ↗Surgical vs nonoperative treatment for lumbar disk herniation: the Spine Patient Outcomes Research T
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6 18923511 ↗The molecular neurobiology of depression
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 34024217 ↗Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 34687662 ↗The 2021 report of the Lancet Countdown on health and climate change: code red for a healthy future
  • T6 33497610 ↗Adaptive immunity to SARS-CoV-2 and COVID-19
  • T6 38433280 ↗NF-κB in biology and targeted therapy: new insights and translational implications
  • T6 36050306 ↗Lactate metabolism in human health and disease
  • T6 35304603 ↗Exerkines in health, resilience and disease
  • T6 34248921 ↗Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Con
  • T6 34308300 ↗Characterizing long COVID in an international cohort: 7 months of symptoms and their impact
  • T6INDIRECT 29016840 ↗2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atr
  • T6INDIRECT 19375665 ↗Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6INDIRECT 25266247 ↗Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task fo
  • T6 23798298 ↗Lack of exercise is a major cause of chronic diseases
  • T6 17493201 ↗Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept
  • T6 20201874 ↗Central role of the brain in stress and adaptation: links to socioeconomic status, health, and disea
  • T6 29884281 ↗Interoception and Mental Health: A Roadmap
  • T6 30496104 ↗Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseas
  • T6 23459093 ↗The Efficacy of Cognitive Behavioral Therapy: A Review of Meta-analyses
Follow Up Phone Calls
T1
T1 — RCT in LC/PASC/PACVS
RegisteredLong COVIDME/CFS
43 sources
  • T1REGISTERED-ONLY NCT06095297 ↗Long COVID Brain Fog: Cognitive Rehabilitation Trial
  • T2REGISTERED-ONLY NCT07523113 ↗ME/CFS Brain Fog: Cognitive Rehabilitation Trial
  • T6INDIRECT 37299488 ↗Effectiveness of Lifestyle Nutrition and Physical Activity Interventions for Childhood Obesity and A
  • T6INDIRECT 38847297 ↗Integrated care models for youth mental health: A systematic review and meta-analysis
  • T6INDIRECT 35902951 ↗Impact of the COVID-19 pandemic on suicidal attempts and death rates: a systematic review
  • T6INDIRECT 34857029 ↗Clinical and cost-effectiveness of a New psychosocial intervention to support Independence in Dement
  • T6INDIRECT 36056378 ↗Research interrupted: applying the CONSERVE 2021 Statement to a randomized trial of rehabilitation d
  • T6INDIRECT 37739466 ↗Dietary supplements to reduce symptom severity and duration in people with SARS-CoV-2: a double-blin
  • T1 38312212 ↗Pulmonary Function and Survival 1 Year After Dupilumab Treatment of Acute Moderate to Severe Coronav
  • T6 34162913 ↗Acute and persistent symptoms in non-hospitalized PCR-confirmed COVID-19 patients
  • T6 34874962 ↗Prevalence and predictors of Post-Acute COVID-19 Syndrome (PACS) after hospital discharge: A cohort
  • T6 36512382 ↗'I don't know what to do or where to go'. Experiences of accessing healthcare support from the persp
  • T6 34861604 ↗Long term predictors of breathlessness, exercise intolerance, chronic fatigue and well-being in hosp
  • T6 38580370 ↗Personalised Exercise-Rehabilitation FOR people with Multiple long-term conditions (PERFORM): protoc
  • T6INDIRECT 29376559 ↗Physical activity for women with breast cancer after adjuvant therapy
  • T6INDIRECT 27883365 ↗Educational interventions for the management of cancer-related fatigue in adults
  • T6INDIRECT 34532852 ↗Cannabinoids for the treatment of dementia
  • T6INDIRECT 28854852 ↗Effects of Self-Management Interventions in Patients With Irritable Bowel Syndrome: Systematic Revie
  • T6INDIRECT 28931531 ↗Clinical and cost-effectiveness of the Lightning Process in addition to specialist medical care for
  • T6INDIRECT 26179651 ↗Assessing Cognitive behavioural Therapy in Irritable Bowel (ACTIB): protocol for a randomised contro
  • T6INDIRECT 24304689 ↗The feasibility and acceptability of conducting a trial of specialist medical care and the Lightning
  • T6INDIRECT 35671133 ↗Reframe the pain: Divided attention and positive memory reframing to reduce needle pain and distress
  • T6INDIRECT 24315246 ↗Early experience with a brief, multimodal, multidisciplinary treatment program for fibromyalgia
  • T6 35940683 ↗Optimal Emergency Department Care Practices for Persons Living With Dementia: A Scoping Review
  • T6INDIRECT 33653852 ↗Treatment of unexplained coma and hypokinetic-rigid syndrome in a patient with COVID-19
  • T6INDIRECT 33313986 ↗ESICM LIVES 2020
  • T6INDIRECT 35859555 ↗Immediate and short-term prevalence of depression in covid-19 patients and its correlation with cont
  • T6 35747260 ↗Cost and Satisfaction Implications of Using Telehealth for Plagiocephaly
  • T6 38350825 ↗Fourth Controlled Human Infection Model (CHIM) meeting - CHIMs in endemic countries, May 22-23, 2023
  • T6 40542608 ↗Special Issue: Abstracts of the 11<sup>th</sup> Congress of the European Academy of Neur
  • T6 41386990 ↗Canadian Spine Society: 25th Annual Scientific Conference, February 25 to 28, 2025, Fairmont Le Mano
  • T6 35122083 ↗Editorial: Post Acute Care for Frail Older Persons: Time for a Standardized Model of Care
  • T6 PMC13111897 ↗2026 International Congress Abstract Supplement
  • T6 34551007 ↗SARS-CoV-2 pneumonia follow-up and long COVID in primary care: A retrospective observational study i
  • T6INDIRECT 29196279 ↗Using mHealth Technology in a Self-Management Intervention to Promote Physical Activity Among Adults
  • T6INDIRECT 25869016 ↗Abstracts from the 38th annual meeting of the society of general internal medicine
  • T6INDIRECT 32725471 ↗Abstracts from the 2020 Annual Meeting of the Society of General Internal Medicine
  • T6INDIRECT 36365042 ↗The Troublesome Ticks Research Protocol: Developing a Comprehensive, Multidiscipline Research Plan f
  • T6INDIRECT 30480124 ↗Program Abstracts from the 21st International Association of Gerontology and Geriatrics (IAGG) World
  • T6 28156288 ↗Proceedings of the 15th International Congress on Circumpolar Health
  • T6 24085684 ↗Abstracts of the 2013 Annual Meeting of the American College of Rheumatology. October 25-30, 2013. S
  • T6 36832443 ↗Developmental Pathway Choices of Young People Presenting to a Gender Service with Gender Distress: A
  • T6 36471349 ↗Personalised rehabilitation to improve return to work in patients with persistent spinal pain syndro
Inspiratory muscle training
T1
T1 — RCT in LC/PASC/PACVS
Long COVIDME/CFS
41 sources
  • T1 NCT04718506 ↗Rehabilitation for Post-COVID-19 Syndrome Through a Supervised Exercise Intervention
  • T2 NCT05196529 ↗Inspiratory Muscle Training in ME/CFS and COVID-19 Survivors
  • T6 NCT05024474 ↗Effects of Inspiratory Muscle Training After Covid-19 (ReCOV)
  • T6INDIRECT 37725376 ↗Rehabilitation Interventions for Physical Capacity and Quality of Life in Adults With Post-COVID-19
  • T6INDIRECT 34523128 ↗Continuing education meetings and workshops: effects on professional practice and healthcare outcome
  • T6INDIRECT 35265644 ↗Effect of Pulmonary Rehabilitation for Patients With Post-COVID-19: A Systematic Review and Meta-Ana
  • T1 36606682 ↗Inspiratory muscle training, with or without concomitant pulmonary rehabilitation, for chronic obstr
  • T6INDIRECT 39603702 ↗Interventions for the management of long covid (post-covid condition): living systematic review
  • T1 35236727 ↗Inspiratory muscle training enhances recovery post-COVID-19: a randomised controlled trial
  • T6INDIRECT 36111386 ↗Rehabilitation for post-COVID-19 condition through a supervised exercise intervention: A randomized
  • T6INDIRECT 36476156 ↗Effects of a concurrent training, respiratory muscle exercise, and self-management recommendations o
  • T6INDIRECT 36191860 ↗Home-based respiratory muscle training on quality of life and exercise tolerance in long-term post-C
  • T6INDIRECT 35409815 ↗Cardiopulmonary Rehabilitation in Long-COVID-19 Patients with Persistent Breathlessness and Fatigue:
  • T6INDIRECT 35203084 ↗Outpatient Pulmonary Rehabilitation in Patients with Long COVID Improves Exercise Capacity, Function
  • T6 36412084 ↗Long COVID: mechanisms, risk factors and recovery
  • T6INDIRECT 26358158 ↗Exercise therapy for fatigue in multiple sclerosis
  • T6INDIRECT 37651553 ↗Interventions for fatigue in people with kidney failure requiring dialysis
  • T6INDIRECT 35768406 ↗Interventions for mental health, cognition, and psychological wellbeing in long COVID: a systematic
  • T6INDIRECT 38214047 ↗Rehabilitation and COVID-19: systematic review by Cochrane Rehabilitation
  • T6INDIRECT 37344767 ↗Clinical effectiveness of rehabilitation in ambulatory care for patients with persisting symptoms af
  • T6INDIRECT 25753362 ↗Protocol for the PREHAB study-Pre-operative Rehabilitation for reduction of Hospitalization After co
  • T6 31092666 ↗PREhabilitation for improving QUality of recovery after ELective cardiac surgery (PREQUEL) study: pr
  • T6INDIRECT 36130789 ↗Effectiveness of home-based pulmonary rehabilitation: systematic review and meta-analysis
  • T6INDIRECT 37193738 ↗Effectiveness of a telerehabilitation intervention using ReCOVery APP of long COVID patients: a rand
  • T6INDIRECT 36560801 ↗Efficacy of Therapeutic Exercise in Reversing Decreased Strength, Impaired Respiratory Function, Dec
  • T6INDIRECT 36198415 ↗The effects of COVID-19 on respiratory muscle performance: making the case for respiratory muscle te
  • T6INDIRECT 33364571 ↗Pulmonary Rehabilitation in COVID-19 patients: A scoping review of current practice and its applicat
  • T6 37907497 ↗The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of lon
  • T6 35416359 ↗Muscle dysfunction in the long coronavirus disease 2019 syndrome: Pathogenesis and clinical approach
  • T6 34066560 ↗Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges
  • T6 35615417 ↗ERS International Congress 2021: highlights from the Respiratory Clinical Care and Physiology Assemb
  • T6 40724982 ↗Pulmonary Embolism in Acute Ischaemic Stroke: Evolving Evidence, Diagnostic Challenges, and a Novel
  • T6 37099534 ↗Battling the unknown: Using composite vignettes to portray lived experiences of COVID-19 and long-CO
  • T6 37216955 ↗Respiratory sequelae of COVID-19: pulmonary and extrapulmonary origins, and approaches to clinical c
  • T6INDIRECT 39010975 ↗Evidence for exercise-based interventions across 45 different long-term conditions: an overview of s
  • T6INDIRECT 34160029 ↗Apparent Discordance Between the Epidemiology of COVID-19 and Recommended Outcomes and Treatments: A
  • T6INDIRECT 39663173 ↗Defining and measuring long COVID fatigue: a scoping review
  • T6INDIRECT 39337079 ↗A Pilot Study on the Effects of Exercise Training on Cardiorespiratory Performance, Quality of Life,
  • T6INDIRECT 34633571 ↗ESICM LIVES 2021: Part 2
  • T6 38999923 ↗The Effect of Physical Activity/Exercise on miRNA Expression and Function in Non-Communicable Diseas
  • T6 8322233 ↗Skeletal muscle metabolism during exercise and recovery in patients with respiratory failure
Processing Speed Training
T1
T1 — RCT in LC/PASC/PACVS
RegisteredLong COVIDME/CFS
7 sources
  • T1REGISTERED-ONLY NCT06095297 ↗Long COVID Brain Fog: Cognitive Rehabilitation Trial
  • T2REGISTERED-ONLY NCT07523113 ↗ME/CFS Brain Fog: Cognitive Rehabilitation Trial
  • T6 PMC11688754 ↗Full GSA 2024 Abstract Book PDF
  • T6 24960594 ↗NIH Toolbox Cognitive Battery (NIHTB-CB): the NIHTB Pattern Comparison Processing Speed Test
  • T6 25859431 ↗Psychological intervention for improving cognitive function in cancer survivors: a literature review
  • T6 36175973 ↗Effectiveness of the Unified Barlow Protocol (UP) and neuropsychological treatment in cancer survivo
  • T6 PMC6840740 ↗Program Abstracts from the GSA 2019 Annual Scientific Meeting “Strength in Age—Harnessing the Power
Psychotherapy
T1
T1 — RCT in LC/PASC/PACVS
RegisteredWithdrawnLong COVIDME/CFS
56 sources
  • T1REGISTERED-ONLY NCT06042751 ↗Psychosomatic, Physical Activity or Both for Post-covid19 Syndrom
  • T2WITHDRAWN NCT05967052 ↗Investigation of Treating Chronic Fatigue Syndrome After COVID With Pharmacotherapy (Pregabalin) or
  • T6INDIRECT 36731907 ↗Exercise as medicine for depressive symptoms? A systematic review and meta-analysis with meta-regres
  • T6INDIRECT 33781283 ↗Mental burden and its risk and protective factors during the early phase of the SARS-CoV-2 pandemic:
  • T6INDIRECT 33426733 ↗Cerebral venous thrombosis and severe acute respiratory syndrome coronavirus-2 infection: A systemat
  • T6INDIRECT 34592585 ↗Telehealth utilization during the Covid-19 pandemic: A systematic review
  • T6INDIRECT 34523128 ↗Continuing education meetings and workshops: effects on professional practice and healthcare outcome
  • T6INDIRECT 34600257 ↗The early impact of COVID-19 on the incidence, prevalence, and severity of alcohol use and other dru
  • T6INDIRECT 36032234 ↗Post-COVID-19 fatigue: A systematic review
  • T6INDIRECT 34844624 ↗The impact of the novel coronavirus disease (COVID-19) pandemic on drug overdose-related deaths in t
  • T6INDIRECT 35322449 ↗A mixed-studies systematic review of the experiences of body image, disordered eating, and eating di
  • T6INDIRECT 36129719 ↗Effectiveness of Standard Sequential Bilateral Repetitive Transcranial Magnetic Stimulation vs Bilat
  • T6 32682460 ↗How mental health care should change as a consequence of the COVID-19 pandemic
  • T6 36192553 ↗How COVID-19 shaped mental health: from infection to pandemic effects
  • T6INDIRECT 20350028 ↗The effect of mindfulness-based therapy on anxiety and depression: A meta-analytic review
  • T6INDIRECT 22895961 ↗Exercise interventions on health-related quality of life for cancer survivors
  • T6INDIRECT 26730878 ↗Exercise-based cardiac rehabilitation for coronary heart disease
  • T6INDIRECT 22895974 ↗Exercise interventions on health-related quality of life for people with cancer during active treatm
  • T6INDIRECT 24805797 ↗Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis
  • T6INDIRECT 18165893 ↗Internet-administered cognitive behavior therapy for health problems: a systematic review
  • T6INDIRECT 24881045 ↗Bias due to lack of patient blinding in clinical trials. A systematic review of trials randomizing p
  • T6INDIRECT 11265953 ↗Cognitive behaviour therapy for chronic fatigue syndrome: a multicentre randomised controlled trial
  • T6INDIRECT 28943228 ↗Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiet
  • T6INDIRECT 8555852 ↗Cognitive behaviour therapy for the chronic fatigue syndrome: a randomized controlled trial
  • T6 18923511 ↗The molecular neurobiology of depression
  • T6 23798298 ↗Lack of exercise is a major cause of chronic diseases
  • T6INDIRECT 32685700 ↗Germany's digital health reforms in the COVID-19 era: lessons and opportunities for other countries
  • T6INDIRECT 35373533 ↗International consensus statement on allergy and rhinology: Olfaction
  • T6INDIRECT 34682909 ↗Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview
  • T6INDIRECT 34027514 ↗Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort st
  • T6INDIRECT 34051516 ↗Physical and mental health complications post-COVID-19: Scoping review
  • T6 37907497 ↗The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of lon
  • T6 33441072 ↗PTSD in the COVID-19 Era
  • T6 34155207 ↗SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
  • T6 37713568 ↗Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epide
  • T6 36202135 ↗Clinical guidelines for the use of lifestyle-based mental health care in major depressive disorder:
  • T6 33049215 ↗COVID-19 and Cancer: Current Challenges and Perspectives
  • T6 34505369 ↗The growing field of digital psychiatry: current evidence and the future of apps, social media, chat
  • T6 33444560 ↗Effects of the COVID-19 pandemic on primary care-recorded mental illness and self-harm episodes in t
  • T6 41092926 ↗Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life e
  • T6INDIRECT 23076904 ↗Printed educational materials: effects on professional practice and healthcare outcomes
  • T6INDIRECT 30284240 ↗Psychological interventions for needle-related procedural pain and distress in children and adolesce
  • T6INDIRECT 24366490 ↗Cultural concepts of distress and psychiatric disorders: literature review and research recommendati
  • T6INDIRECT 20471738 ↗Sleep disturbance as transdiagnostic: consideration of neurobiological mechanisms
  • T6INDIRECT 15774430 ↗Depression in multiple sclerosis: a review
  • T6INDIRECT 12830308 ↗Patients presenting with somatic complaints: epidemiology, psychiatric comorbidity and management
  • T6INDIRECT 24518354 ↗Social media: a review and tutorial of applications in medicine and health care
  • T6INDIRECT 25365763 ↗Interoceptive dysfunction: toward an integrated framework for understanding somatic and affective di
  • T6 17716101 ↗Stress and health: psychological, behavioral, and biological determinants
  • T6 29884281 ↗Interoception and Mental Health: A Roadmap
  • T6 36116464 ↗Amyotrophic lateral sclerosis
  • T6 29876878 ↗Role of the Prefrontal Cortex in Pain Processing
  • T6 31379879 ↗The Role of Inflammation in Depression and Fatigue
  • T6 23459093 ↗The Efficacy of Cognitive Behavioral Therapy: A Review of Meta-analyses
  • T6 27159638 ↗Irritable bowel syndrome
  • T6 17488783 ↗Guidelines on the irritable bowel syndrome: mechanisms and practical management
Reaction Time Training
T1
T1 — RCT in LC/PASC/PACVS
RegisteredLong COVIDME/CFS
5 sources
  • T1REGISTERED-ONLY NCT06095297 ↗Long COVID Brain Fog: Cognitive Rehabilitation Trial
  • T2REGISTERED-ONLY NCT07523113 ↗ME/CFS Brain Fog: Cognitive Rehabilitation Trial
  • T6INDIRECT 40952658 ↗Effects of exergaming with a resistance component versus traditional resistance training on sarcopen
  • T6 37190625 ↗The Use of Neurofeedback in Sports Training: Systematic Review
  • T6 39727822 ↗Physical Exercise Intervention Characteristics and Outcomes in Frail and Pre-Frail Older Adults
Transfer Package
T1
T1 — RCT in LC/PASC/PACVS
RegisteredLong COVIDME/CFS
7 sources
  • T1REGISTERED-ONLY NCT06095297 ↗Long COVID Brain Fog: Cognitive Rehabilitation Trial
  • T2REGISTERED-ONLY NCT07523113 ↗ME/CFS Brain Fog: Cognitive Rehabilitation Trial
  • T6INDIRECT 40310209 ↗Long COVID brain fog treatment: An early-phase randomized controlled trial of constraint-induced cog
  • T6 PPR342074 ↗Fiscal Policy Responses to COVID-19 in Danida Priority Countries in Sub-Saharan Africa
  • T6 37373305 ↗Bioengineered Enzymes and Precision Fermentation in the Food Industry
  • T6 40726475 ↗11th European Stroke Organisation Conference Abstracts - 21-23 May 2025, Helsinki, Finland
  • T6 PMC7103908 ↗Symposia
Treatment as Usual
T1
T1 — RCT in LC/PASC/PACVS
RegisteredLong COVIDME/CFS
44 sources
  • T1REGISTERED-ONLY NCT06928480 ↗Effectiveness and Acceptability of the Unified Protocol for the Transdiagnostic Treatment of Emotion
  • T2 NCT04593225 ↗Effectiveness of VIRTUAL SFCAMINA STUDY
  • T6INDIRECT 34964542 ↗Remote provision of breastfeeding support and education: Systematic review and meta-analysis
  • T6INDIRECT 36634261 ↗The Usability, Feasibility, Acceptability, and Efficacy of Digital Mental Health Services in the COV
  • T6INDIRECT 34523128 ↗Continuing education meetings and workshops: effects on professional practice and healthcare outcome
  • T6INDIRECT 35414491 ↗Telerehabilitation improves physical function and reduces dyspnoea in people with COVID-19 and post-
  • T6INDIRECT 34693988 ↗Telehealth interventions: remote monitoring and consultations for people with chronic obstructive pu
  • T6INDIRECT 33326409 ↗Implementation of Telehealth Services to Assess, Monitor, and Treat Neurodevelopmental Disorders: Sy
  • T1 36695483 ↗Remdesivir for the treatment of COVID-19
  • T6INDIRECT 35768406 ↗Interventions for mental health, cognition, and psychological wellbeing in long COVID: a systematic
  • T6INDIRECT 34913421 ↗Early Intervention in Psychosis services: A systematic review and narrative synthesis of the barrier
  • T6INDIRECT 37193738 ↗Effectiveness of a telerehabilitation intervention using ReCOVery APP of long COVID patients: a rand
  • T6 35039676 ↗Immune targets for therapeutic development in depression: towards precision medicine
  • T6HARM 35727534 ↗Post-COVID-19 Depressive Symptoms: Epidemiology, Pathophysiology, and Pharmacological Treatment
  • T6INDIRECT 20350028 ↗The effect of mindfulness-based therapy on anxiety and depression: A meta-analytic review
  • T6INDIRECT 26730878 ↗Exercise-based cardiac rehabilitation for coronary heart disease
  • T6INDIRECT 28045199 ↗Yoga for improving health-related quality of life, mental health and cancer-related symptoms in wome
  • T6INDIRECT 30284240 ↗Psychological interventions for needle-related procedural pain and distress in children and adolesce
  • T6INDIRECT 18646067 ↗Cognitive behaviour therapy for chronic fatigue syndrome in adults
  • T6INDIRECT 26358158 ↗Exercise therapy for fatigue in multiple sclerosis
  • T6INDIRECT 31369582 ↗Helping patients help themselves: A systematic review of self-management support strategies in prima
  • T6INDIRECT 20091628 ↗Shared decision making interventions for people with mental health conditions
  • T2 17119141 ↗Surgical vs nonoperative treatment for lumbar disk herniation: the Spine Patient Outcomes Research T
  • T6INDIRECT 35654766 ↗Clinical, gut microbial and neural effects of a probiotic add-on therapy in depressed patients: a ra
  • T6 20471738 ↗Sleep disturbance as transdiagnostic: consideration of neurobiological mechanisms
  • T6 23459093 ↗The Efficacy of Cognitive Behavioral Therapy: A Review of Meta-analyses
  • T6INDIRECT 39482575 ↗Hallmarks of primary headache: part 1 - migraine
  • T6INDIRECT 35571085 ↗Oxidative Stress and Hyper-Inflammation as Major Drivers of Severe COVID-19 and Long COVID: Implicat
  • T6INDIRECT 34118499 ↗Addressing Pediatric Mental Health Using Telehealth During Coronavirus Disease-2019 and Beyond: A Na
  • T6 39363044 ↗Vagus nerve stimulation (VNS): recent advances and future directions
  • T6 38891970 ↗Human Gut Microbiota for Diagnosis and Treatment of Depression
  • T6 37795783 ↗Psychosocial interventions for survivors of rape and sexual assault experienced during adulthood
  • T6 37713568 ↗Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epide
  • T2 23990997 ↗Mindfulness-based therapies in the treatment of somatization disorders: a systematic review and meta
  • T6INDIRECT 34770209 ↗Sleep Disorders in Cancer-A Systematic Review
  • T6INDIRECT 25365763 ↗Interoceptive dysfunction: toward an integrated framework for understanding somatic and affective di
  • T4 28052319 ↗Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Ro
  • T6 23235630 ↗Interventions to facilitate return to work in adults with adjustment disorders
  • T6 32691879 ↗Psychological interventions to foster resilience in healthcare students
  • T6 35561510 ↗How do psychologically based interventions for chronic musculoskeletal pain work? A systematic revie
  • T6 34352116 ↗Primary-level worker interventions for the care of people living with mental disorders and distress
  • T6 32296353 ↗Depression, Mindfulness, and Psilocybin: Possible Complementary Effects of Mindfulness Meditation an
  • T6 37049975 ↗The Role of Probiotics and Their Metabolites in the Treatment of Depression
  • T6 35115105 ↗Interventions for Frailty Among Older Adults With Cardiovascular Disease: JACC State-of-the-Art Revi
acupuncture
T1
T1 — RCT in LC/PASC/PACVS
RegisteredLong COVIDME/CFS
54 sources
  • T1 NCT05890508 ↗Electro-acupuncture for Long Covid Neuropsychiatric Symptoms
  • T1 NCT05212688 ↗Randomised Study to Investigate the Effectiveness of Acupuncture for the Relief of Long COVID-19 Rel
  • T1REGISTERED-ONLY NCT07357688 ↗The Effect of Acupuncture Therapy on Cognitive Function in Post-COVID-19 Myalgic Encephalomyelitis/C
  • T2 NCT01534130 ↗Acupuncture for the Sleep Disorder of Chronic Fatigue Syndrome
  • T2 NCT01907711 ↗Clinical Trial to Evaluate the Effectiveness of Acupuncture as a Treatment in Patients Diagnosed Wit
  • T2 NCT02924831 ↗High-tech Acupuncture for Treatment of Chronic Fatigue Syndrome
  • T6INDIRECT 35182760 ↗ESCMID rapid guidelines for assessment and management of long COVID
  • T6INDIRECT 35265644 ↗Effect of Pulmonary Rehabilitation for Patients With Post-COVID-19: A Systematic Review and Meta-Ana
  • T6INDIRECT 39603702 ↗Interventions for the management of long covid (post-covid condition): living systematic review
  • T6INDIRECT 35893864 ↗The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musc
  • T6INDIRECT 34752489 ↗A mixed-methods systematic review of post-viral fatigue interventions: Are there lessons for long Co
  • T6INDIRECT 36642173 ↗A systematic review of trials currently investigating therapeutic modalities for post-acute COVID-19
  • T6INDIRECT 34425929 ↗Impact of olfactory dysfunction on quality of life in coronavirus disease 2019 patients: a systemati
  • T6INDIRECT 29544455 ↗Identification, description and appraisal of generic PROMs for primary care: a systematic review
  • T6INDIRECT 35489367 ↗An online breathing and wellbeing programme (ENO Breathe) for people with persistent symptoms follow
  • T6INDIRECT 35416437 ↗Qingjin Yiqi granules for post-COVID-19 condition: A randomized clinical trial
  • T6 35176758 ↗Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus
  • T6 37402746 ↗TRP (transient receptor potential) ion channel family: structures, biological functions and therapeu
  • T6INDIRECT 22197740 ↗Neuroimaging of the periaqueductal gray: state of the field
  • T6INDIRECT 30284240 ↗Psychological interventions for needle-related procedural pain and distress in children and adolesce
  • T6INDIRECT 18646067 ↗Cognitive behaviour therapy for chronic fatigue syndrome in adults
  • T6INDIRECT 21833945 ↗Bulking agents, antispasmodics and antidepressants for the treatment of irritable bowel syndrome
  • T6INDIRECT 29652088 ↗Non-invasive brain stimulation techniques for chronic pain
  • T6INDIRECT 29370149 ↗A Systematic Review and Meta-Analysis of Mindfulness-Based (Baduanjin) Exercise for Alleviating Musc
  • T6INDIRECT 24881045 ↗Bias due to lack of patient blinding in clinical trials. A systematic review of trials randomizing p
  • T6INDIRECT 34770209 ↗Sleep Disorders in Cancer-A Systematic Review
  • T6INDIRECT 29710099 ↗Effect of Pain Neuroscience Education Combined With Cognition-Targeted Motor Control Training on Chr
  • T6INDIRECT 19597976 ↗"Maybe I made up the whole thing": placebos and patients' experiences in a randomized controlled tri
  • T6 29462012 ↗Neuroinflammation and Central Sensitization in Chronic and Widespread Pain
  • T6 29876878 ↗Role of the Prefrontal Cortex in Pain Processing
  • T6INDIRECT 36174032 ↗Post-acute sequelae of COVID-19 symptom phenotypes and therapeutic strategies: A prospective, observ
  • T6INDIRECT 34682909 ↗Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview
  • T6INDIRECT 36969241 ↗Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOV
  • T6INDIRECT 37298527 ↗Neurodegenerative and Neurodevelopmental Diseases and the Gut-Brain Axis: The Potential of Therapeut
  • T6INDIRECT 35449490 ↗Association of mast-cell-related conditions with hypermobile syndromes: a review of the literature
  • T6INDIRECT 34607799 ↗Recommendations for the recognition, diagnosis, and management of long COVID: a Delphi study
  • T6 38152837 ↗Engineered Exosome for Drug Delivery: Recent Development and Clinical Applications
  • T6 37907497 ↗The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of lon
  • T6 36174571 ↗Bioelectronic medicine: Preclinical insights and clinical advances
  • T6 33441072 ↗PTSD in the COVID-19 Era
  • T6 37372912 ↗What Do We Know about Nociplastic Pain?
  • T6 35198136 ↗Neurological manifestations of long-COVID syndrome: a narrative review
  • T6 37840685 ↗Current challenges and potential solutions to the use of digital health technologies in evidence gen
  • T6 33909761 ↗Brazilian Guidelines of Hypertension - 2020
  • T6 41092926 ↗Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life e
  • T6INDIRECT 12830308 ↗Patients presenting with somatic complaints: epidemiology, psychiatric comorbidity and management
  • T6INDIRECT 26267006 ↗Physical exercise as non-pharmacological treatment of chronic pain: Why and when
  • T6INDIRECT 26330672 ↗Chronic Pain: Where the Body Meets the Brain
  • T6 23235630 ↗Interventions to facilitate return to work in adults with adjustment disorders
  • T6 24239063 ↗The neuroimmune basis of fatigue
  • T6 29357856 ↗Clinical relevance of contextual factors as triggers of placebo and nocebo effects in musculoskeleta
  • T6 29487504 ↗Potential Mechanisms Underlying Centralized Pain and Emerging Therapeutic Interventions
  • T6 25573802 ↗Chemobrain: a critical review and causal hypothesis of link between cytokines and epigenetic reprogr
  • T6 24944467 ↗Irritable bowel syndrome: pathogenesis, diagnosis, treatment, and evidence-based medicine
hyperbaric oxygen therapy (HBOT)
T1
T1 — RCT in LC/PASC/PACVS
RegisteredLong COVIDME/CFS
33 sources
  • T1REGISTERED-ONLY NCT06452095 ↗Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial - Effect of Hyperbar
  • T2REGISTERED-ONLY NCT07621068 ↗Hyperbaric Oxygen Therapy for Chronic Fatigue Syndrome (CFS)
  • T6INDIRECT 36032234 ↗Post-COVID-19 fatigue: A systematic review
  • T6INDIRECT 36349400 ↗Clinical trials on the pharmacological treatment of long COVID: A systematic review
  • T6INDIRECT 35768406 ↗Interventions for mental health, cognition, and psychological wellbeing in long COVID: a systematic
  • T6INDIRECT 34752489 ↗A mixed-methods systematic review of post-viral fatigue interventions: Are there lessons for long Co
  • T6INDIRECT 37344767 ↗Clinical effectiveness of rehabilitation in ambulatory care for patients with persisting symptoms af
  • T6INDIRECT 38673384 ↗Pathophysiological Mechanisms in Long COVID: A Mixed Method Systematic Review
  • T1 35821512 ↗Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: ra
  • T1 36208548 ↗Effects of hyperbaric oxygen therapy on functional and structural connectivity in post-COVID-19 cond
  • T1 36670365 ↗Hyperbaric oxygen therapy for long COVID (HOT-LoCO), an interim safety report from a randomised cont
  • T1 38360929 ↗Long term outcomes of hyperbaric oxygen therapy in post covid condition: longitudinal follow-up of a
  • T6 34163217 ↗The Conundrum of 'Long-COVID-19': A Narrative Review
  • T6 38374451 ↗Diabetes and infection: review of the epidemiology, mechanisms and principles of treatment
  • T2 36690401 ↗Efficacy and safety of hyperbaric oxygen therapy for fibromyalgia: a systematic review and meta-anal
  • T2 26010952 ↗Hyperbaric oxygen therapy can diminish fibromyalgia syndrome--prospective clinical trial
  • T6 24752591 ↗The glutathione system: a new drug target in neuroimmune disorders
  • T6 39548502 ↗Nanotechnology in healthcare, and its safety and environmental risks
  • T6 37907497 ↗The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of lon
  • T6INDIRECT 34215639 ↗Avascular necrosis as a part of 'long COVID-19'
  • T6INDIRECT 35373533 ↗International consensus statement on allergy and rhinology: Olfaction
  • T6INDIRECT 36299969 ↗Sudden Sensorineural Hearing Loss: A Review
  • T6 38534355 ↗Recent Research Trends in Neuroinflammatory and Neurodegenerative Disorders
  • T6 36043493 ↗The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid
  • T6 38998660 ↗<i>Aloe vera</i>-An Extensive Review Focused on Recent Studies
  • T6 34395187 ↗COVID-19 associated mucormycosis: Staging and management recommendations (Report of a multi-discipli
  • T6 37759498 ↗A Molecular Troika of Angiogenesis, Coagulopathy and Endothelial Dysfunction in the Pathology of Ava
  • T6 36283919 ↗Long COVID: An inevitable sequela of SARS-CoV-2 infection
  • T6INDIRECT 30210433 ↗Delayed Post-hypoxic Leukoencephalopathy (DPHL)-An Uncommon Variant of Hypoxic Brain Damage in Adult
  • T6INDIRECT 32161563 ↗Identification and Management of Paroxysmal Sympathetic Hyperactivity After Traumatic Brain Injury
  • T6INDIRECT 36246401 ↗Oxidative Stress in Fibromyalgia: From Pathology to Treatment
  • T6INDIRECT 24115194 ↗Cutaneous manifestations of ESRD
  • T6 33114203 ↗Fibromyalgia: Recent Advances in Diagnosis, Classification, Pharmacotherapy and Alternative Remedies
melatonin
T1
T1 — RCT in LC/PASC/PACVS
RegisteredLong COVIDME/CFSPOTS
81 sources
  • T1 NCT06404112 ↗RECOVER-SLEEP: Platform Protocol, Appendix_B (CPSD)
  • T1 NCT06404086 ↗RECOVER-SLEEP: Platform Protocol
  • T2 NCT05454683 ↗Melatonin and Zinc Administration on Cardinal Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue
  • T2 NCT03000777 ↗Oral Melatonin Plus Zinc Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T6INDIRECT 36235869 ↗Vitamin C Supplementation for the Treatment of COVID-19: A Systematic Review and Meta-Analysis
  • T6INDIRECT 38732592 ↗The Efficacy of Multivitamin, Vitamin A, Vitamin B, Vitamin C, and Vitamin D Supplements in the Prev
  • T6INDIRECT 38105461 ↗Outpatient randomized controlled trials to reduce COVID-19 hospitalization: Systematic review and me
  • T6INDIRECT 33205450 ↗Case report and systematic review suggest that children may experience similar long-term effects to
  • T6INDIRECT 33584506 ↗COVID-19 Pathophysiology Predicts That Ischemic Stroke Occurrence Is an Expectation, Not an Exceptio
  • T6INDIRECT 35893864 ↗The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musc
  • T6INDIRECT 37397709 ↗A systematic review of self-medication practice during the COVID-19 pandemic: implications for pharm
  • T6INDIRECT 36334288 ↗Recognizing the psychological impact of a glioma diagnosis on mental and behavioral health: a system
  • T6INDIRECT 34837648 ↗Comparing efficacy and safety of different doses of dexamethasone in the treatment of COVID-19: a th
  • T6INDIRECT 38908733 ↗Fecal Microbiota Transplantation for Sleep Disturbance in Post-acute COVID-19 Syndrome
  • T6 39174535 ↗Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strateg
  • T6 37117704 ↗Wearable chemical sensors for biomarker discovery in the omics era
  • T6INDIRECT 27664125 ↗Adult ADHD and Comorbid Somatic Disease: A Systematic Literature Review
  • T6INDIRECT 34902819 ↗Sleep, cerebrospinal fluid, and the glymphatic system: A systematic review
  • T6INDIRECT 34770209 ↗Sleep Disorders in Cancer-A Systematic Review
  • T6INDIRECT 17021301 ↗Interventions for the treatment, management and rehabilitation of patients with chronic fatigue synd
  • T6INDIRECT 19856109 ↗Biofield therapies: helpful or full of hype? A best evidence synthesis
  • T6INDIRECT 31478755 ↗Probiotics for Gastrointestinal Symptoms and Quality of Life in Autism: A Placebo-Controlled Pilot T
  • T6INDIRECT 22728166 ↗Antioxidant supplementation reduces endometriosis-related pelvic pain in humans
  • T6INDIRECT 25002497 ↗Effect of sleep deprivation on the human metabolome
  • T6INDIRECT 17081700 ↗Stress sensitivity in metastatic breast cancer: analysis of hypothalamic-pituitary-adrenal axis func
  • T6 30920354 ↗The Sleep-Immune Crosstalk in Health and Disease
  • T6 24370461 ↗The role of microbiome in central nervous system disorders
  • T6 29936690 ↗The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer's Disease-a Critica
  • T6INDIRECT 22328094 ↗REM sleep behavior disorder and REM sleep without atonia as an early manifestation of degenerative n
  • T6INDIRECT 33224097 ↗Cyclic Vomiting Syndrome in Children
  • T6INDIRECT 33173517 ↗Perioperative Sleep Disturbances and Postoperative Delirium in Adult Patients: A Systematic Review a
  • T6INDIRECT 36268467 ↗Clinical Features in Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency: A Systematic Review
  • T6INDIRECT 34472659 ↗Movement disorders in patients with Rett syndrome: A systematic review of evidence and associated cl
  • T2 21729284 ↗The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a ra
  • T2 24495468 ↗Melatonin reduces tachycardia in postural tachycardia syndrome: a randomized, crossover trial
  • T6INDIRECT 32986682 ↗The D1/D5 Dopamine Partial Agonist PF-06412562 in Advanced-Stage Parkinson's Disease: A Feasibility
  • T6INDIRECT 36751940 ↗Baseline characteristics of the North American prodromal Synucleinopathy cohort
  • T6 23672628 ↗Understanding the somatic consequences of depression: biological mechanisms and the role of depressi
  • T6 33856918 ↗COVID-19 and Cardiovascular Disease: From Bench to Bedside
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
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  • T6INDIRECT 23233021 ↗A randomised controlled trial of bumetanide in the treatment of autism in children
  • T6INDIRECT 22549286 ↗Orexin receptor antagonism, a new sleep-enabling paradigm: a proof-of-concept clinical trial
  • T2 22348451 ↗Melatonin pharmacokinetics following two different oral surge-sustained release doses in older adult
  • T6 29075003 ↗Trends in GPCR drug discovery: new agents, targets and indications
  • T6 25731881 ↗Assessment and management of behavioral and psychological symptoms of dementia
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6INDIRECT 35727534 ↗Post-COVID-19 Depressive Symptoms: Epidemiology, Pathophysiology, and Pharmacological Treatment
  • T6INDIRECT 33519510 ↗SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress
  • T6INDIRECT 36464706 ↗Small molecules in the treatment of COVID-19
  • T6INDIRECT 36713204 ↗The role of oxidative stress in the pathogenesis of infections with coronaviruses
  • T6INDIRECT 32637987 ↗The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings
  • T6INDIRECT 35589549 ↗Identifying who has long COVID in the USA: a machine learning approach using N3C data
  • T6 36253560 ↗Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential t
  • T6 36899952 ↗Pathogenesis Underlying Neurological Manifestations of Long COVID Syndrome and Potential Therapeutic
  • T6 34997196 ↗Mechanisms of action of fluvoxamine for COVID-19: a historical review
  • T6 35029046 ↗"LONG COVID"-A hypothesis for understanding the biological basis and pharmacological treatment strat
  • T6 34400495 ↗Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome
  • T6 37080828 ↗Long COVID: pathophysiological factors and abnormalities of coagulation
  • T6INDIRECT 20471738 ↗Sleep disturbance as transdiagnostic: consideration of neurobiological mechanisms
  • T6INDIRECT 23939821 ↗Key role of CRF in the skin stress response system
  • T6INDIRECT 37760929 ↗Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Op
  • T6INDIRECT 31885788 ↗Oxidative Stress Indexes for Diagnosis of Health or Disease in Humans
  • T6INDIRECT 23227356 ↗Ehlers-danlos syndrome, hypermobility type: an underdiagnosed hereditary connective tissue disorder
  • T6 27749086 ↗The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids
  • T6 38185705 ↗Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
  • T6 33918736 ↗Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update
  • T6 30525268 ↗Role of pyroptosis in cardiovascular disease
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 19484833 ↗Evidence-based recommendations for the assessment and management of sleep disorders in older persons
  • T6INDIRECT 31519472 ↗New evidence on the management of Lewy body dementia
  • T6INDIRECT 34741573 ↗Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considera
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  • T6 31710717 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 26595642 ↗Lewy body dementias
  • T6 21034217 ↗Orexin receptors: pharmacology and therapeutic opportunities
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
naltrexone (LDN)
T1
T1 — RCT in LC/PASC/PACVS
RegisteredWithdrawnLong COVIDME/CFSPOTS
65 sources
  • T1REGISTERED-ONLY NCT06366724 ↗LIFT: Life Improvement Trial
  • T2REGISTERED-ONLY NCT07285473 ↗Low-Dose Naltrexone For ME/CFS: Dose-Finding
  • T2WITHDRAWN NCT02965768 ↗Immune Effects of Low-dose Naltrexone in ME/CFS
  • T2REGISTERED-ONLY NCT05363514 ↗Low Dose Naltrexone Use in Patients With POTS
  • T6INDIRECT 39483457 ↗Meta-analysis of natural killer cell cytotoxicity in myalgic encephalomyelitis/chronic fatigue syndr
  • T6INDIRECT 36349400 ↗Clinical trials on the pharmacological treatment of long COVID: A systematic review
  • T6INDIRECT 34658014 ↗Colchicine for the treatment of COVID-19
  • T6INDIRECT 36409650 ↗A systematic review of the biological mediators of fat taste and smell
  • T6INDIRECT 39940333 ↗Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (
  • T6INDIRECT 38554565 ↗Examining inequities in access to opioid agonist treatment (OAT) take-home doses (THD): A Canadian O
  • T6INDIRECT 38360929 ↗Long term outcomes of hyperbaric oxygen therapy in post covid condition: longitudinal follow-up of a
  • T6INDIRECT 36196533 ↗Enhancing Use of Medications for Opioid Use Disorder Through External Coaching
  • T6INDIRECT 38012333 ↗A practice quit model to test early efficacy of medications for alcohol use disorder in a randomized
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T2HARM 30642329 ↗Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a system
  • T6INDIRECT 36690401 ↗Efficacy and safety of hyperbaric oxygen therapy for fibromyalgia: a systematic review and meta-anal
  • T6INDIRECT 27894343 ↗Post-marketing withdrawal of anti-obesity medicinal products because of adverse drug reactions: a sy
  • T6INDIRECT 34352116 ↗Primary-level worker interventions for the care of people living with mental disorders and distress
  • T6INDIRECT 34601272 ↗Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine
  • T6INDIRECT 25879513 ↗Excessive Sugar Consumption May Be a Difficult Habit to Break: A View From the Brain and Body
  • T6INDIRECT 34014691 ↗Applying methods for personalized medicine to the treatment of alcohol use disorder
  • T2 19453963 ↗Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study
  • T6INDIRECT 15834216 ↗Dissection of hypothalamic-pituitary-adrenal axis pathology in 1-month-abstinent alcohol-dependent m
  • T2 31736966 ↗Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natur
  • T6 2683611 ↗Biology of natural killer cells
  • T6INDIRECT 33687070 ↗Smoking cessation for improving mental health
  • T6INDIRECT 37189381 ↗Dupilumab in Inflammatory Skin Diseases: A Systematic Review
  • T6INDIRECT 31702122 ↗Autonomic dysfunction and sudden death in patients with Rett syndrome: a systematic review
  • T6INDIRECT 39882369 ↗Oral medications for the treatment of postural orthostatic tachycardia syndrome; a systematic review
  • T6INDIRECT 39042627 ↗Six-year follow-up of participants in two clinical trials of rituximab or cyclophosphamide in Myalgi
  • T6 34942142 ↗The neuropsychiatry of Parkinson's disease: advances and challenges
  • T6 34067776 ↗Post-COVID-19 Syndrome and the Potential Benefits of Exercise
  • T6 35172971 ↗Risks of mental health outcomes in people with covid-19: cohort study
  • T6INDIRECT 28922704 ↗Direct-acting antivirals for chronic hepatitis C
  • T6INDIRECT 23450540 ↗Methadone at tapered doses for the management of opioid withdrawal
  • T6INDIRECT 20680369 ↗A systematic review on the effectiveness of pharmacological interventions for chronic non-specific l
  • T6INDIRECT 35234292 ↗Pharmacotherapy for post traumatic stress disorder (PTSD)
  • T6INDIRECT 18161012 ↗Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse
  • T6INDIRECT 25827659 ↗A pilot trial of prazosin, an alpha-1 adrenergic antagonist, for comorbid alcohol dependence and pos
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 36100326 ↗Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue s
  • T6INDIRECT 36464706 ↗Small molecules in the treatment of COVID-19
  • T6INDIRECT 36969241 ↗Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOV
  • T6 36899952 ↗Pathogenesis Underlying Neurological Manifestations of Long COVID Syndrome and Potential Therapeutic
  • T6 37907497 ↗The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of lon
  • T6 33240091 ↗Challenges for Drug Repurposing in the COVID-19 Pandemic Era
  • T5 31911410 ↗Low-dose naltrexone as a treatment for chronic fatigue syndrome
  • T6INDIRECT 37445634 ↗Laboratory Findings and Biomarkers in Long COVID: What Do We Know So Far? Insights into Epidemiology
  • T6INDIRECT 36169154 ↗Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of aut
  • T6 29462012 ↗Neuroinflammation and Central Sensitization in Chronic and Widespread Pain
  • T6 29867317 ↗Current Enlightenment About Etiology and Pharmacological Treatment of Autism Spectrum Disorder
  • T6 37069462 ↗Microglia polarization in nociplastic pain: mechanisms and perspectives
  • T6 30146050 ↗Pain Modulation: From Conditioned Pain Modulation to Placebo and Nocebo Effects in Experimental and
  • T6 33062901 ↗Exercise-induced hypoalgesia after acute and regular exercise: experimental and clinical manifestati
  • T6 30223011 ↗Brain glial activation in fibromyalgia - A multi-site positron emission tomography investigation
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 24433463 ↗Review of pharmacological therapies in fibromyalgia syndrome
  • T6 19345246 ↗Opioid receptors in the gastrointestinal tract
  • T6 31387301 ↗Mechanisms of Botulinum Toxin Type A Action on Pain
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 30291106 ↗Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes As
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
"Yiqi Fuyuan Paste Formula" test group
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT07320937 ↗Effects of Yiqi Fuyuan Paste Formula in Chronic Fatigue Syndrome: A Randomized Double-Blind Controll
3-day course
T2
T2 — RCT in related condition
RegisteredME/CFS
15 sources
  • T2REGISTERED-ONLY NCT05236465 ↗A 3-day Course for CFS/ME
  • T6INDIRECT 23235630 ↗Interventions to facilitate return to work in adults with adjustment disorders
  • T6INDIRECT 37658939 ↗Vernal Keratoconjunctivitis: A Systematic Review
  • T6 24092857 ↗Recent advances in understanding enteric pathogenic Escherichia coli
  • T6 16847088 ↗Prevention and self-treatment of traveler's diarrhea
  • T6 34378955 ↗Giardia duodenalis: Biology and Pathogenesis
  • T6 21515735 ↗Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3a
  • T6INDIRECT 41169897 ↗Case Report: Nystagmus as a core presenting sign in pediatric anti-Ma2 antibody-associated cerebella
  • T6INDIRECT 41745378 ↗Management of Dry Eye Disease Pre- and Post-Cataract Surgery: A Personalized Approach
  • T6INDIRECT 33313986 ↗ESICM LIVES 2020
  • T6INDIRECT 34633571 ↗ESICM LIVES 2021: Part 2
  • T4 PMC12452013 ↗Abstracts from the 8th International Conference on Prevention & Infection Control (ICPIC 2025)
  • T4 PMC11231130 ↗Abstracts from the 2024 Annual Meeting of the Society of General Internal Medicine
  • T6 38771027 ↗COVID-19 therapeutics
  • T6 36080323 ↗Organic Acids Secreted by <i>Lactobacillus</i> spp. Isolated from Urine and Their Antimicrobial Acti
APA program
T2
T2 — RCT in related condition
RegisteredME/CFS
2 sources
  • T2REGISTERED-ONLY NCT06170645 ↗Transcutaneous Vagus Nerve Stimulation as a Complementary Therapy to Exercise in Chronic Fatigue
  • T6 32218879 ↗Abstracts of the 14th International Congress of the European Geriatric Medicine Society: 10-12 Octob
ASARM
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT02082730 ↗The Feasibility, Acceptability and Clinical Utility of a New Remote-mobile Technology Intervention (
Acceptance Commitment Therapy for chronic fatigue
T2
T2 — RCT in related condition
RegisteredME/CFS
1 source
  • T2REGISTERED-ONLY NCT05168124 ↗Effectiveness of Acceptance Commitment Therapy or Micro Breaks in Patients with Chronic Fatigue Synd
Acceptance and Commitment Therapy
T2
T2 — RCT in related condition
ME/CFS
21 sources
  • T2 NCT03562325 ↗ACT for ME/CFS - an Open Case Trial
  • T6INDIRECT 20350028 ↗The effect of mindfulness-based therapy on anxiety and depression: A meta-analytic review
  • T6INDIRECT 18646067 ↗Cognitive behaviour therapy for chronic fatigue syndrome in adults
  • T6INDIRECT 25362239 ↗Non-pharmacological interventions for somatoform disorders and medically unexplained physical sympto
  • T6INDIRECT 35727200 ↗A meta-analysis of the associations of elements of the fear-avoidance model of chronic pain with neg
  • T6INDIRECT 32691879 ↗Psychological interventions to foster resilience in healthcare students
  • T6INDIRECT 29768436 ↗The effectiveness of various computer-based interventions for patients with chronic pain or function
  • T6INDIRECT 35561510 ↗How do psychologically based interventions for chronic musculoskeletal pain work? A systematic revie
  • T6INDIRECT 34352116 ↗Primary-level worker interventions for the care of people living with mental disorders and distress
  • T6INDIRECT 32706713 ↗Implementing Web-Based Therapy in Routine Mental Health Care: Systematic Review of Health Profession
  • T6INDIRECT 35768406 ↗Interventions for mental health, cognition, and psychological wellbeing in long COVID: a systematic
  • T6 29876878 ↗Role of the Prefrontal Cortex in Pain Processing
  • T6 30858740 ↗Psychological impact of fibromyalgia: current perspectives
  • T6INDIRECT 34757810 ↗Brain circuits for pain and its treatment
  • T6INDIRECT 36918177 ↗Diagnosis and management of endometriosis
  • T6INDIRECT 26924998 ↗Psychological Treatments and Psychotherapies in the Neurorehabilitation of Pain: Evidences and Recom
  • T6INDIRECT 34744825 ↗Study Protocol for "Psilocybin as a Treatment for Anorexia Nervosa: A Pilot Study"
  • T6INDIRECT 23504301 ↗Energy Conservation/Envelope Theory Interventions to Help Patients with Myalgic Encephalomyelitis/Ch
  • T6 34941859 ↗Pet Ownership and Quality of Life: A Systematic Review of the Literature
  • T6 36983246 ↗The Biology of Stress Intolerance in Patients with Chronic Pain-State of the Art and Future Directio
  • T6 37795766 ↗A meta-ethnography of how children and young people with chronic non-cancer pain and their families
Active
T2
T2 — RCT in related condition
ME/CFS
27 sources
  • T2 NCT04301609 ↗Clinical Trial to Assess the Improvement of Fatigue, Sleep Problems, Anxiety / Depression, Neurovege
  • T6INDIRECT 34373540 ↗More than 50 long-term effects of COVID-19: a systematic review and meta-analysis
  • T6INDIRECT 20350028 ↗The effect of mindfulness-based therapy on anxiety and depression: A meta-analytic review
  • T6INDIRECT 28676896 ↗The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis
  • T6INDIRECT 22895961 ↗Exercise interventions on health-related quality of life for cancer survivors
  • T6INDIRECT 22018588 ↗Validity of the International Physical Activity Questionnaire Short Form (IPAQ-SF): a systematic rev
  • T6INDIRECT 18287602 ↗Surgical versus nonsurgical therapy for lumbar spinal stenosis
  • T6INDIRECT 17119140 ↗Surgical vs nonoperative treatment for lumbar disk herniation: the Spine Patient Outcomes Research T
  • T6INDIRECT 17538085 ↗Surgical versus nonsurgical treatment for lumbar degenerative spondylolisthesis
  • T6INDIRECT 21334061 ↗Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and spe
  • T6INDIRECT 17119141 ↗Surgical vs nonoperative treatment for lumbar disk herniation: the Spine Patient Outcomes Research T
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6 19502515 ↗Endocrine-disrupting chemicals: an Endocrine Society scientific statement
  • T6INDIRECT 32582143 ↗The Genus <i>Alistipes</i>: Gut Bacteria With Emerging Implications to Inflammation, Cancer, and Men
  • T6INDIRECT 29016840 ↗2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atr
  • T6INDIRECT 27856520 ↗From Q Fever to Coxiella burnetii Infection: a Paradigm Change
  • T6INDIRECT 15297906 ↗The World Mental Health (WMH) Survey Initiative Version of the World Health Organization (WHO) Compo
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6INDIRECT 25266247 ↗Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task fo
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6 18923511 ↗The molecular neurobiology of depression
  • T6 2683611 ↗Biology of natural killer cells
  • T6 23798298 ↗Lack of exercise is a major cause of chronic diseases
  • T6 10515901 ↗Q fever
  • T6 26987915 ↗Cardiac Fibrosis: The Fibroblast Awakens
  • T6 26077718 ↗A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
  • T6 34308300 ↗Characterizing long COVID in an international cohort: 7 months of symptoms and their impact
Acupressure
T2
T2 — RCT in related condition
ME/CFS
27 sources
  • T2 NCT04435002 ↗The Effect of Acupressure on Fatigue in Individuals With Chronic Fatigue Syndrome
  • T6INDIRECT 34489268 ↗Acupuncture-related adverse events: systematic review and meta-analyses of prospective clinical stud
  • T6INDIRECT 34501749 ↗Effect of Distraction Intervention for Needle-Related Pain and Distress in Children: A Systematic Re
  • T6INDIRECT 16824230 ↗How might acupuncture work? A systematic review of physiologic rationales from clinical trials
  • T2 21982157 ↗The evidence for Shiatsu: a systematic review of Shiatsu and acupressure
  • T6INDIRECT 34490854 ↗Pragmatic trials of pain therapies: a systematic review of methods
  • T6INDIRECT 38214047 ↗Rehabilitation and COVID-19: systematic review by Cochrane Rehabilitation
  • T6INDIRECT 36416820 ↗Use of Acupuncture for Adult Health Conditions, 2013 to 2021: A Systematic Review
  • T6INDIRECT 23067573 ↗The effectiveness of acupuncture research across components of the trauma spectrum response (tsr): a
  • T6INDIRECT 34910080 ↗Outcomes of a Delirium Prevention Program in Older Persons After Elective Surgery: A Stepped-Wedge C
  • T6 18572290 ↗Fatigue in patients receiving maintenance dialysis: a review of definitions, measures, and contribut
  • T6 29222399 ↗Pediatric Disorders of Orthostatic Intolerance
  • T6 25309504 ↗Management of fatigue in persons with multiple sclerosis
  • T6INDIRECT 37651553 ↗Interventions for fatigue in people with kidney failure requiring dialysis
  • T6INDIRECT 18686748 ↗Treatment of fragile X-associated tremor ataxia syndrome (FXTAS) and related neurological problems
  • T6INDIRECT 22340435 ↗Societal and individual burden of illness among fibromyalgia patients in France: association between
  • T6INDIRECT 34160029 ↗Apparent Discordance Between the Epidemiology of COVID-19 and Recommended Outcomes and Treatments: A
  • T6INDIRECT 39610577 ↗Effectiveness of Digital Health Interventions (DHI) in Chronic Pain Management: A Scoping Review of
  • T6 35636805 ↗Approach to Diagnosis and Management of Chronic Pelvic Pain in Women: Incorporating Chronic Overlapp
  • T6 37746720 ↗Moxibustion for the Treatment of Cancer and its Complications: Efficacies and Mechanisms
  • T6 37363407 ↗Acupoint stimulation for long COVID: A promising intervention:
  • T6 36558965 ↗Vulvodynia: Pain Management Strategies
  • T6 40498265 ↗Chronic Fatigue in Cancer Survivorship: Psychiatry Versus Oncology or Psychiatry with Oncology?
  • T6 40843597 ↗European S2k Guideline on Chronic Pruritus
  • T6 28156288 ↗Proceedings of the 15th International Congress on Circumpolar Health
  • T6 29682691 ↗Abstracts of the MASCC/ISOO Annual Meeting 2018
  • T6 34069603 ↗European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus
Ampligen
T2
T2 — RCT in related condition
Harm signalME/CFS
18 sources
  • T2HARM NCT00215800 ↗The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome
  • T6INDIRECT 22431963 ↗A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in
  • T6INDIRECT 33119613 ↗Effect of disease duration in a randomized Phase III trial of rintatolimod, an immune modulator for
  • T6INDIRECT 24486326 ↗Discordant biological and toxicological species responses to TLR3 activation
  • T6 24316048 ↗Toll-like receptors in antiviral innate immunity
  • T6 29730580 ↗Toll-like receptors in immunity and inflammatory diseases: Past, present, and future
  • T6 20713100 ↗TLR-based immune adjuvants
  • T6 18202435 ↗Sensing of viral infection and activation of innate immunity by toll-like receptor 3
  • T6 33499143 ↗TLR Agonists as Vaccine Adjuvants Targeting Cancer and Infectious Diseases
  • T6INDIRECT 15082846 ↗Midodrine treatment for chronic fatigue syndrome
  • T6INDIRECT 21643519 ↗The pharmacokinetics of Toll-like receptor agonists and the impact on the immune system
  • T6INDIRECT 28052319 ↗Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Ro
  • T6INDIRECT 39714175 ↗Henipaviruses: epidemiology, ecology, disease, and the development of vaccines and therapeutics
  • T6INDIRECT 38256459 ↗Advancing Research and Treatment: An Overview of Clinical Trials in Myalgic Encephalomyelitis/Chroni
  • T6INDIRECT 42325370 ↗Viral persistence in long COVID: Research advances and treatment strategies
  • T6INDIRECT 37396922 ↗Fighting Post-COVID and ME/CFS - development of curative therapies
  • T6 9623881 ↗The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation
  • T6 27350884 ↗Toll-like receptors: the swiss army knife of immunity and vaccine development
Applied Relaxation
T2
T2 — RCT in related condition
RegisteredME/CFS
15 sources
  • T2REGISTERED-ONLY NCT06235177 ↗Psychoneuromentalism Disorder: A Medical Condition That Affects People With Psychological Impairment
  • T6INDIRECT 35561510 ↗How do psychologically based interventions for chronic musculoskeletal pain work? A systematic revie
  • T6INDIRECT 32880104 ↗Psychological interventions for antisocial personality disorder
  • T6INDIRECT 18165893 ↗Internet-administered cognitive behavior therapy for health problems: a systematic review
  • T6INDIRECT 29370787 ↗The association between electrodermal activity (EDA), depression and suicidal behaviour: A systemati
  • T6INDIRECT 34066174 ↗A Review of Prolonged Post-COVID-19 Symptoms and Their Implications on Dental Management
  • T6INDIRECT 36071425 ↗A systematic review of economic analyses of psychological interventions and therapies in health-rela
  • T6HARM 26740928 ↗Treating comorbid anxiety and depression: Psychosocial and pharmacological approaches
  • T6 23459093 ↗The Efficacy of Cognitive Behavioral Therapy: A Review of Meta-analyses
  • T6 18470741 ↗The panic attack-posttraumatic stress disorder model: applicability to orthostatic panic among Cambo
  • T6INDIRECT 9224087 ↗Cognitive behaviour therapy--clinical applications
  • T6INDIRECT 30671234 ↗Chronic pain: a consequence of dysregulated protective action
  • T6 39487925 ↗The Importance of Including Psychophysiological Methods in Psychotherapy
  • T6 36458830 ↗Exhaustion disorder: scoping review of research on a recently introduced stress-related diagnosis
  • T6 36687807 ↗A randomized controlled trial protocol for persistent physical symptoms associated with indoor envir
Bright light therapy
T2
T2 — RCT in related condition
ME/CFS
21 sources
  • T2 NCT06635928 ↗Bright Light Therapy in ME/CFS Patients
  • T6INDIRECT 27664125 ↗Adult ADHD and Comorbid Somatic Disease: A Systematic Literature Review
  • T6INDIRECT 34534071 ↗Change in circadian preference predicts sustained treatment outcomes in patients with unipolar depre
  • T6INDIRECT 34225698 ↗Home-based light therapy for fatigue following acquired brain injury: a pilot randomized controlled
  • T6INDIRECT 35978435 ↗SHIFTPLAN: a randomized controlled trial investigating the effects of a multimodal shift-work interv
  • T2 40120538 ↗Assessing fatigue in myalgic encephalomyelitis/chronic fatigue syndrome patients before and after tr
  • T6 30602059 ↗The role of neuro-immune interactions in cancer-related fatigue: Biobehavioral risk factors and mech
  • T6 28974591 ↗Sleep in adolescents and young adults
  • T6 29755330 ↗The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-En
  • T6HARM PMC6831364 ↗Interventions (other than psychosocial, psychological and pharmacological) for treating postpartum d
  • T6 20722821 ↗Bedside-to-Bench conference: research agenda for idiopathic fatigue and aging
  • T6INDIRECT 16076658 ↗Working under daylight intensity lamp: an occupational risk for developing circadian rhythm sleep di
  • T6INDIRECT 32849926 ↗Insomnia and obstructive sleep apnea as potential triggers of dementia: is personalized prediction a
  • T6INDIRECT 30363949 ↗Cognitive Behavioral Therapy in Movement Disorders: A Review
  • T6INDIRECT 24773429 ↗Basic sleep and circadian science as building blocks for behavioral interventions: a translational a
  • T6INDIRECT 23700366 ↗Mood disorders and complementary and alternative medicine: a literature review
  • T6 37049975 ↗The Role of Probiotics and Their Metabolites in the Treatment of Depression
  • T6 35465246 ↗Circadian rhythm disruption in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for
  • T6 28216789 ↗Clinical Practice Guidelines for Sleep Disorders
  • T6 40843597 ↗European S2k Guideline on Chronic Pruritus
  • T6 30363584 ↗The Pathophysiology of Fatigue in Parkinson's Disease and its Pragmatic Management
Bupivacaine Injection
T2
T2 — RCT in related condition
ME/CFS
6 sources
  • T2 NCT05664711 ↗Effect of Stellate Ganglion Block on ME/CFS
  • T6 24260531 ↗Peripheral afferent mechanisms underlying acupuncture inhibition of cocaine behavioral effects in ra
  • T6 36267612 ↗Comparison between 10 and 12 mg doses of intrathecal hyperbaric (0.5%) bupivacaine on sensory block
  • T6 PMC7163517 ↗Poster Sessions
  • T6 PMC10795779 ↗Book of Posters
  • T6 PMC4070603 ↗UEG Week 2013 Poster Presentations
CT38
T2
T2 — RCT in related condition
ME/CFS
7 sources
  • T2 NCT03613129 ↗Clinical Trial to Investigate CT38 in the Treatment of Myalgic Encephalomyelitis / Chronic Fatigue S
  • T6 38256459 ↗Advancing Research and Treatment: An Overview of Clinical Trials in Myalgic Encephalomyelitis/Chroni
  • T6 34539356 ↗Acute Corticotropin-Releasing Factor Receptor Type 2 Agonism Results in Sustained Symptom Improvemen
  • T6 21378412 ↗FAM190A rearrangements provide a multitude of individualized tumor signatures and neo-antigens in ca
  • T6 42063971 ↗A unifying theory of brain signaling and its possible role in acquired chronic disease
  • T6 39611435 ↗Association of bi-parametric MRI measures with continence after robot-assisted radical prostatectomy
  • T4 PMC7111423 ↗Poster Sessions
Case formulation with web-program
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT04532827 ↗Web-based Rehabilitation for Persistent Physical Symptoms.
CoQ10 (ubiquinone)
T2
T2 — RCT in related condition
ME/CFS
28 sources
  • T2 NCT05128292 ↗Effect of CoQ10 Plus Selenium Supplementation on Clinical Outcomes and Biochemical Markers in ME/CFS
  • T6INDIRECT 32727475 ↗A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue synd
  • T6INDIRECT 31906979 ↗Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyel
  • T6INDIRECT 28111818 ↗Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgi
  • T6INDIRECT 36091835 ↗Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Ana
  • T6INDIRECT 25386668 ↗Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chron
  • T6INDIRECT 26212172 ↗Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate
  • T6INDIRECT 34444817 ↗Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Qu
  • T6INDIRECT 26482687 ↗Improved Health-Related Quality of Life, and More Days out of Hospital with Supplementation with Sel
  • T6INDIRECT 25746727 ↗Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients
  • T6INDIRECT 23116302 ↗Noninvasive optical characterization of muscle blood flow, oxygenation, and metabolism in women with
  • T6 33918736 ↗Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update
  • T6 26078821 ↗Markers of Oxidative Stress and Neuroprogression in Depression Disorder
  • T6INDIRECT 37760929 ↗Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Op
  • T6INDIRECT 31327219 ↗Parkinson's Disease: The Emerging Role of Gut Dysbiosis, Antibiotics, Probiotics, and Fecal Microbio
  • T6INDIRECT 28052319 ↗Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Ro
  • T6INDIRECT 37888449 ↗Astaxanthin: Past, Present, and Future
  • T6INDIRECT 33646563 ↗Current and Emerging Clinical Treatment in Mitochondrial Disease
  • T6INDIRECT 34067632 ↗Coenzyme Q<sub>10</sub>: Clinical Applications beyond Cardiovascular Diseases
  • T6INDIRECT 36246401 ↗Oxidative Stress in Fibromyalgia: From Pathology to Treatment
  • T6INDIRECT 36293457 ↗Mitochondrial Dysfunction and Neurodegenerative Disorders: Role of Nutritional Supplementation
  • T6 29459830 ↗Coenzyme Q<sub>10</sub> Supplementation in Aging and Disease
  • T6 29755330 ↗The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-En
  • T6 36918543 ↗Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications
  • T6 24876913 ↗Oxidative stress and mitochondrial dysfunction across broad-ranging pathologies: toward mitochondria
  • T6 34400495 ↗Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome
  • T6 35874958 ↗Long COVID and its Management
  • T6 34181102 ↗The Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 infection
Cognitive-behavioral self-management
T2
T2 — RCT in related condition
ME/CFS
4 sources
  • T2 NCT00997451 ↗Fatigue Self-Management in Primary Care
  • T6INDIRECT 39607990 ↗Systematic review and meta-analysis of the effect of psychological interventions on anxiety in child
  • T6INDIRECT 23922399 ↗Chronic fatigue self-management in primary care: a randomized trial
  • T6 30931176 ↗Cost-Utility of Home-Based Fatigue Self-Management versus Usual Care for the Treatment of Chronic Fa
Comparison of adaptive pacing therapy
T2
T2 — RCT in related condition
ME/CFS
11 sources
  • T2 21334061 ↗Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and spe
  • T6INDIRECT 28444695 ↗Exercise therapy for chronic fatigue syndrome
  • T6INDIRECT 27995604 ↗Exercise therapy for chronic fatigue syndrome
  • T6INDIRECT 39697147 ↗Exercise therapy for chronic fatigue syndrome
  • T6INDIRECT 34752489 ↗A mixed-methods systematic review of post-viral fatigue interventions: Are there lessons for long Co
  • T6INDIRECT 29562932 ↗Rethinking the treatment of chronic fatigue syndrome-a reanalysis and evaluation of findings from a
  • T6 31577366 ↗Exercise therapy for chronic fatigue syndrome
  • T6INDIRECT 30871632 ↗The PACE trial of treatments for chronic fatigue syndrome: a response to WILSHIRE et al
  • T4 PPR649417 ↗Disregarding Uncertainty, Marginalizing Patients
  • T4 PMC6915863 ↗Proceedings of the International Scientific Conference AIFI 2017. Therapeutic Exercise: Foundations,
  • T6 PMC10659638 ↗Frontiers in chronic fatigue syndrome research: An analysis of the top 100 most influential articles
Compound Ciwujia Granules, Guipi Granules
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT06245642 ↗Compound Ciwujia Granules Treat Chronic Fatigue Syndrome
Comprehensive Theocentric Psychological Assessment
T2
T2 — RCT in related condition
RegisteredME/CFS
1 source
  • T2REGISTERED-ONLY NCT06235177 ↗Psychoneuromentalism Disorder: A Medical Condition That Affects People With Psychological Impairment
Conventional Physiotherapy
T2
T2 — RCT in related condition
RegisteredME/CFS
17 sources
  • T2REGISTERED-ONLY NCT07242573 ↗Effect of Physical Exercise and Neuromodulation on Pain, Sleep and Fatigue in Patients With Fibromya
  • T6INDIRECT 36360901 ↗Manual Therapy Effect in Placebo-Controlled Trials: A Systematic Review and Meta-Analysis
  • T6INDIRECT 40643771 ↗Psychometric properties of patient-reported outcome measures in chronic pain conditions with central
  • T6INDIRECT 40788745 ↗Guided motor imagery and deep breathing exercises on radiation therapy-induced fatigue in head and n
  • T6 40072495 ↗Sarcopenia and frailty in critical illness
  • T6 24679336 ↗Clinical effectiveness of manual therapy for the management of musculoskeletal and non-musculoskelet
  • T6 32331323 ↗Pain Neuroscience Education and Physical Therapeutic Exercise for Patients with Chronic Spinal Pain
  • T6 38029040 ↗Effect of Pain Neuroscience Education with Conventional Physiotherapy via Telerehabilitation on Pain
  • T6INDIRECT 39335441 ↗Pain Neuroscience Education and Neuroimaging-A Narrative Review
  • T6INDIRECT 40726475 ↗11th European Stroke Organisation Conference Abstracts - 21-23 May 2025, Helsinki, Finland
  • T6INDIRECT 40958115 ↗Proceedings of the 32nd European Paediatric Rheumatology Congress
  • T6INDIRECT 35252582 ↗Main Abstracts
  • T6INDIRECT 36454442 ↗Abstracts of the 52nd Annual Conference of the Italian Society of Neurology
  • T6INDIRECT 40986224 ↗World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2025)
  • T6INDIRECT 17242961 ↗European Academy of Paediatrics, Barcelona, Spain, October 7-10, 2006. Abstracts
  • T6 PMC12978741 ↗Abstracts - IANCON 2025
  • T6 PMC7103906 ↗Posters
Conventional exercise
T2
T2 — RCT in related condition
RegisteredME/CFS
21 sources
  • T2REGISTERED-ONLY NCT06978582 ↗Effectiveness and Safety of a Tele-Rehabilitation Program on Fatigue and Related Variables in Chroni
  • T6INDIRECT 38281020 ↗Effects of traditional Chinese exercise therapy on pain scores, sleep quality, and anxiety-depressio
  • T6INDIRECT 40421669 ↗Yoga for fatigue in people with cancer
  • T6INDIRECT 36398843 ↗Yoga for chronic non-specific low back pain
  • T6INDIRECT 32696918 ↗Benefits of Qigong as an integrative and complementary practice for health: a systematic review
  • T6INDIRECT 41356241 ↗Effectiveness and safety of exercise therapy in patients with myalgic encephalomyelitis/chronic fati
  • T6INDIRECT 25124456 ↗Randomized controlled trial of Qigong/Tai Chi Easy on cancer-related fatigue in breast cancer surviv
  • T6 34567220 ↗Mind-Body Health Benefits of Traditional Chinese <i>Qigong</i> on Women: A Systematic Review of Rand
  • T6 31975898 ↗Qigong and Tai-Chi for Mood Regulation
  • T6 38658496 ↗Practical Recommendations for Exercise Training in Patients with Long COVID with or without Post-exe
  • T6 31533854 ↗The effect of Baduanjin exercise on health-related physical fitness of college students: study proto
  • T6INDIRECT 40726475 ↗11th European Stroke Organisation Conference Abstracts - 21-23 May 2025, Helsinki, Finland
  • T6INDIRECT 36570860 ↗Full GSA 2022 Abstract Book PDF
  • T6INDIRECT 27650181 ↗EANM'16
  • T4 PMC10020848 ↗Abstracts
  • T4 PMC11688754 ↗Full GSA 2024 Abstract Book PDF
  • T4 PMC6915863 ↗Proceedings of the International Scientific Conference AIFI 2017. Therapeutic Exercise: Foundations,
  • T6 28930252 ↗Qigong and Fibromyalgia circa 2017
  • T6 25477991 ↗Qigong and fibromyalgia: randomized controlled trials and beyond
  • T6 28930273 ↗Qigong Exercises for the Management of Type 2 Diabetes Mellitus
  • T6 37628475 ↗Exercise Training in Non-Hospitalized Patients with Post-COVID-19 Syndrome-A Narrative Review
Creatine
T2
T2 — RCT in related condition
RegisteredME/CFS
23 sources
  • T2REGISTERED-ONLY NCT02374112 ↗Creatine Supplementation in Chronic Fatigue Syndrome
  • T6INDIRECT 22895961 ↗Exercise interventions on health-related quality of life for cancer survivors
  • T6INDIRECT 26730878 ↗Exercise-based cardiac rehabilitation for coronary heart disease
  • T6INDIRECT 21396670 ↗Ginsenosides from American ginseng: chemical and pharmacological diversity
  • T6INDIRECT 29671914 ↗The neurological complications of chikungunya virus: A systematic review
  • T2 33572884 ↗Creatine in Health and Disease
  • T6INDIRECT 27223465 ↗Fatigue following Acute Q-Fever: A Systematic Literature Review
  • T6INDIRECT 32873297 ↗Neuroimaging characteristics of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a syste
  • T6INDIRECT 30678686 ↗A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochon
  • T6 23798298 ↗Lack of exercise is a major cause of chronic diseases
  • T6 10515901 ↗Q fever
  • T6 9560217 ↗Bax directly induces release of cytochrome c from isolated mitochondria
  • T6 25266247 ↗Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task fo
  • T6INDIRECT 29016840 ↗2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atr
  • T6INDIRECT 32289472 ↗Evidence based management guideline for the COVID-19 pandemic - Review article
  • T6INDIRECT 33903743 ↗Systemic and organ-specific immune-related manifestations of COVID-19
  • T6INDIRECT 34997689 ↗Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19
  • T6INDIRECT 32593341 ↗Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance
  • T6INDIRECT 33028215 ↗A scoping review of the Clinical Frailty Scale
  • T6 36116464 ↗Amyotrophic lateral sclerosis
  • T6 26404370 ↗Magnesium in Prevention and Therapy
  • T6 22522929 ↗In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes
  • T6 8666911 ↗Mitochondrial control of nuclear apoptosis
Cyclophosphamide
T2
T2 — RCT in related condition
RegisteredME/CFSMCASPOTS
70 sources
  • T2 NCT02444091 ↗Cyclophosphamide in Myalgic Encephalopathy/ Chronic Fatigue Syndrome (ME/CFS)
  • T6 NCT01384513 ↗A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Mali
  • T6REGISTERED-ONLY NCT03779854 ↗Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults
  • T6INDIRECT 21491378 ↗Interventions for preventing oral mucositis for patients with cancer receiving treatment
  • T6INDIRECT 20687070 ↗Interventions for treating oral mucositis for patients with cancer receiving treatment
  • T6INDIRECT 36103991 ↗Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 d
  • T6INDIRECT 36228963 ↗Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline patho
  • T6INDIRECT 23599118 ↗Topical interleukin 1 receptor antagonist for treatment of dry eye disease: a randomized clinical tr
  • T6INDIRECT 15471655 ↗Course of fatigue in women receiving chemotherapy and/or radiotherapy for early stage breast cancer
  • T6INDIRECT 26844275 ↗Radiation-induced CD8 T-lymphocyte Apoptosis as a Predictor of Breast Fibrosis After Radiotherapy: R
  • T6 2683611 ↗Biology of natural killer cells
  • T6 10515901 ↗Q fever
  • T6 32762681 ↗Natural killer cells in cancer biology and therapy
  • T6 19375665 ↗Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity
  • T6 9560217 ↗Bax directly induces release of cytochrome c from isolated mitochondria
  • T6INDIRECT 20548096 ↗Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-
  • T6INDIRECT 34904799 ↗Polatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma
  • T2 30901302 ↗Randomized Phase III Trial of Ibrutinib and Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristin
  • T6INDIRECT 36542826 ↗Lisocabtagene maraleucel as second-line therapy for large B-cell lymphoma: primary analysis of the p
  • T6INDIRECT 30184451 ↗Rituximab plus Lenalidomide in Advanced Untreated Follicular Lymphoma
  • T6INDIRECT 25046337 ↗Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who rema
  • T6INDIRECT 30811293 ↗First-Line Treatment of Patients With Indolent Non-Hodgkin Lymphoma or Mantle-Cell Lymphoma With Ben
  • T6INDIRECT 20431041 ↗Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and l
  • T6INDIRECT 25154820 ↗Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effect
  • T6INDIRECT 25842160 ↗Circulating tumour DNA and CT monitoring in patients with untreated diffuse large B-cell lymphoma: a
  • T6INDIRECT 34542573 ↗Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephaliti
  • T6INDIRECT 26561338 ↗Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy
  • T6INDIRECT 29217664 ↗Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Re
  • T6INDIRECT 29271481 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 30361325 ↗DUET: A Phase 2 Study Evaluating the Efficacy and Safety of Sparsentan in Patients with FSGS
  • T6INDIRECT 32244252 ↗Daratumumab plus CyBorD for patients with newly diagnosed AL amyloidosis: safety run-in results of A
  • T6INDIRECT 1739631 ↗Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)
  • T6INDIRECT 8774401 ↗Intravenous immunoglobulin treatment in paraneoplastic neurological syndromes with antineuronal auto
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 17655751 ↗Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis
  • T6INDIRECT 24247168 ↗Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer
  • T6INDIRECT 29523094 ↗Pediatric multiple sclerosis: a review
  • T6INDIRECT 29186062 ↗Viral Oncology: Molecular Biology and Pathogenesis
  • T6INDIRECT 23452057 ↗Characterization of different courses of atopic dermatitis in adolescent and adult patients
  • T6 34630027 ↗Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy
  • T6 22544865 ↗Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action,
  • T6 25315420 ↗Autoimmune encephalopathies
  • T6 29344421 ↗Anti-Aging Implications of <i>Astragalus Membranaceus</i> (Huangqi): A Well-Known Chinese Tonic
  • T6INDIRECT 28242845 ↗Focal Segmental Glomerulosclerosis
  • T6INDIRECT 33649022 ↗Autoimmune encephalitis: proposed best practice recommendations for diagnosis and acute management
  • T6INDIRECT 32106302 ↗Overview of Castleman disease
  • T6INDIRECT 28213891 ↗Opioids and the immune system - friend or foe
  • T6INDIRECT 35215786 ↗<i>Herpes zoster</i>: A Review of Clinical Manifestations and Management
  • T6INDIRECT 29915719 ↗Past, Present, and Future of Rituximab-The World's First Oncology Monoclonal Antibody Therapy
  • T6INDIRECT 27777266 ↗A Proposal for a Serology-Based Approach to Membranous Nephropathy
  • T6 32433595 ↗Interaction between microbiota and immunity in health and disease
  • T6 32934330 ↗Exploring the NK cell platform for cancer immunotherapy
  • T6 37169756 ↗Angiogenic signaling pathways and anti-angiogenic therapy for cancer
  • T6 19597008 ↗Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis
  • T6 26228647 ↗Colchicine--Update on mechanisms of action and therapeutic uses
  • T6 32376392 ↗Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventio
  • T6 28550082 ↗Primary Membranous Nephropathy
  • T6 33657296 ↗Diffuse Large B-Cell Lymphoma
  • T6INDIRECT 30049614 ↗Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex ence
  • T6INDIRECT 24462240 ↗Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a c
  • T6INDIRECT 24703753 ↗A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder assoc
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 24423978 ↗Adrenocortical carcinoma
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 32792490 ↗Podocytopathies
  • T6 34988090 ↗Treatment of Inflammatory Bowel Disease: A Comprehensive Review
  • T6 24323045 ↗Autophagy and human diseases
Dietary Supplements
T2
T2 — RCT in related condition
RegisteredME/CFS
26 sources
  • T2REGISTERED-ONLY NCT06235177 ↗Psychoneuromentalism Disorder: A Medical Condition That Affects People With Psychological Impairment
  • T6INDIRECT 24805797 ↗Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis
  • T6INDIRECT 21931319 ↗Omega-3 fatty acids for the treatment of depression: systematic review and meta-analysis
  • T6INDIRECT 24423304 ↗Efficacy of vitamin D supplementation in depression in adults: a systematic review
  • T6INDIRECT 11560542 ↗Interventions for the treatment and management of chronic fatigue syndrome: a systematic review
  • T6INDIRECT 33572884 ↗Creatine in Health and Disease
  • T6INDIRECT 25733639 ↗Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profil
  • T6INDIRECT 12763985 ↗Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo c
  • T6INDIRECT 35654766 ↗Clinical, gut microbial and neural effects of a probiotic add-on therapy in depressed patients: a ra
  • T6INDIRECT 26275453 ↗Effect of fortified complementary food supplementation on child growth in rural Bangladesh: a cluste
  • T6INDIRECT 34135619 ↗Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infe
  • T6 27159638 ↗Irritable bowel syndrome
  • T6 28482838 ↗Beneficial effects on host energy metabolism of short-chain fatty acids and vitamins produced by com
  • T6INDIRECT 25379990 ↗Pharmacological interventions for somatoform disorders in adults
  • T6INDIRECT 24412527 ↗From stool transplants to next-generation microbiota therapeutics
  • T6INDIRECT 36364899 ↗A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges
  • T6INDIRECT 28052319 ↗Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Ro
  • T6INDIRECT 35267907 ↗Effects of Creatine Supplementation on Brain Function and Health
  • T6INDIRECT 25266247 ↗Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task fo
  • T6INDIRECT 31210940 ↗European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gl
  • T6 26404370 ↗Magnesium in Prevention and Therapy
  • T6 29976412 ↗Benefaction of probiotics for human health: A review
  • T6 28983090 ↗Muscle fatigue: general understanding and treatment
  • T6 29173175 ↗Imaging the Role of Inflammation in Mood and Anxiety-related Disorders
  • T6 24239063 ↗The neuroimmune basis of fatigue
  • T6 33808247 ↗Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficienc
Droxidopa
T2
T2 — RCT in related condition
WithdrawnME/CFSPOTS
57 sources
  • T2WITHDRAWN NCT00977171 ↗Study To Assess The Clinical Benefit Of Droxidopa In Subjects With Chronic Fatigue Syndrome
  • T2WITHDRAWN NCT03070730 ↗Hemodynamic Response of Neuropathic And Non-Neuropathic POTS Patients To Adrenoreceptor Agonist And
  • T6INDIRECT 41225175 ↗Systematic literature review: treatment of postural orthostatic tachycardia syndrome (POTS)
  • T6 29222399 ↗Pediatric Disorders of Orthostatic Intolerance
  • T6 23569093 ↗Common syndromes of orthostatic intolerance
  • T6 34821709 ↗Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?
  • T6 24819031 ↗Adolescent fatigue, POTS, and recovery: a guide for clinicians
  • T6INDIRECT 33723532 ↗Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrom
  • T6INDIRECT 28885363 ↗Prevalence, risk factors, and prognosis of orthostatic hypotension in diabetic patients: A systemati
  • T6INDIRECT 34000076 ↗Fludrocortisone for orthostatic hypotension
  • T2 24944260 ↗Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial
  • T6INDIRECT 10599797 ↗The treatment of neurogenic orthostatic hypotension with 3,4-DL-threo-dihydroxyphenylserine: a rando
  • T2 28494751 ↗Integrated analysis of droxidopa trials for neurogenic orthostatic hypotension
  • T6INDIRECT 23616163 ↗Low-dose propranolol and exercise capacity in postural tachycardia syndrome: a randomized study
  • T6INDIRECT 27372462 ↗Clinical benefit of midodrine hydrochloride in symptomatic orthostatic hypotension: a phase 4, doubl
  • T6INDIRECT 32986682 ↗The D1/D5 Dopamine Partial Agonist PF-06412562 in Advanced-Stage Parkinson's Disease: A Feasibility
  • T6INDIRECT 34657222 ↗Safety and efficacy of ampreloxetine in symptomatic neurogenic orthostatic hypotension: a phase 2 tr
  • T6INDIRECT 28967294 ↗An Autonomic Neuroprosthesis: Noninvasive Electrical Spinal Cord Stimulation Restores Autonomic Card
  • T6 27999003 ↗Diabetic Neuropathy: A Position Statement by the American Diabetes Association
  • T6 31519472 ↗New evidence on the management of Lewy body dementia
  • T6INDIRECT 34752479 ↗Drug-induced orthostatic hypotension: A systematic review and meta-analysis of randomised controlled
  • T2 25350981 ↗Randomized withdrawal study of patients with symptomatic neurogenic orthostatic hypotension responsi
  • T2 25487613 ↗Droxidopa for the short-term treatment of symptomatic neurogenic orthostatic hypotension in Parkinso
  • T6INDIRECT 25185131 ↗Efficacy of atomoxetine versus midodrine for the treatment of orthostatic hypotension in autonomic f
  • T2 24326693 ↗Droxidopa in patients with neurogenic orthostatic hypotension associated with Parkinson's disease (N
  • T6INDIRECT 12885750 ↗Norepinephrine precursor therapy in neurogenic orthostatic hypotension
  • T6INDIRECT 2890806 ↗Endogenous restoration of noradrenaline by precursor therapy in dopamine-beta-hydroxylase deficiency
  • T2 11710796 ↗L-threo-dihydroxyphenylserine (L-threo-DOPS; droxidopa) in the management of neurogenic orthostatic
  • T6INDIRECT 29326369 ↗Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using na
  • T6INDIRECT 34403043 ↗Autonomic dysfunction in SARS-COV-2 infection acute and long-term implications COVID-19 editor's pag
  • T6INDIRECT 38390594 ↗Dysautonomia following Lyme disease: a key component of post-treatment Lyme disease syndrome?
  • T6INDIRECT 37204997 ↗Postural Orthostatic Tachycardia Syndrome in COVID-19: A Contemporary Review of Mechanisms, Clinical
  • T6INDIRECT 41089328 ↗Immunotherapies for postural orthostatic tachycardia syndrome, other common autonomic disorders, and
  • T6INDIRECT 37654428 ↗Postural orthostatic tachycardia syndrome and other related dysautonomic disorders after SARS-CoV-2
  • T6 33786405 ↗Recent advances in carbon nanomaterials for biomedical applications: A review
  • T6 33886735 ↗Dysautonomia: A Forgotten Condition - Part 1
  • T6 37764145 ↗Comparison of the Efficacy of Longer versus Shorter Pulsed High Dose Dapsone Combination Therapy in
  • T6 32949293 ↗Program and Abstracts of the 31st International Symposium on the Autonomic Nervous System
  • T6 PMC11231130 ↗Abstracts from the 2024 Annual Meeting of the Society of General Internal Medicine
  • T6 35212554 ↗Orthostatic Hypotension: Management of a Complex, But Common, Medical Problem
  • T6 32222376 ↗Postural Orthostatic Tachycardia Syndrome (POTS): A critical assessment
  • T6 35720084 ↗Dysautonomia in COVID-19 Patients: A Narrative Review on Clinical Course, Diagnostic and Therapeutic
  • T6INDIRECT 32402162 ↗Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease
  • T6INDIRECT 29508455 ↗Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
  • T6INDIRECT 35841911 ↗Diagnosis and treatment of orthostatic hypotension
  • T6INDIRECT 24433463 ↗Review of pharmacological therapies in fibromyalgia syndrome
  • T6INDIRECT 33649021 ↗Autoimmune encephalitis: proposed recommendations for symptomatic and long-term management
  • T6 29075003 ↗Trends in GPCR drug discovery: new agents, targets and indications
  • T6 39353925 ↗Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy
  • T6 36810524 ↗Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions
  • T6 30793549 ↗Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: W
  • T6 26729077 ↗The Prodrug Approach: A Successful Tool for Improving Drug Solubility
  • T6 33924103 ↗Treatment Options for Motor and Non-Motor Symptoms of Parkinson's Disease
  • T6 33427939 ↗The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 23425518 ↗Guideline of transthyretin-related hereditary amyloidosis for clinicians
  • T6 28050656 ↗The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic o
Duloxetine
T2
T2 — RCT in related condition
ME/CFS
27 sources
  • T2 NCT00375973 ↗Double Blind Trial of Duloxetine in Chronic Fatigue Syndrome
  • T6 NCT00552682 ↗Pilot, Opened, Randomized Clinical Trial to Assess the Efficacy of Duloxetine in the Treatment of Fi
  • T6INDIRECT 20238354 ↗Antidepressants for depression in physically ill people
  • T6INDIRECT 26133313 ↗Interventions for post-stroke fatigue
  • T6INDIRECT 25379990 ↗Pharmacological interventions for somatoform disorders in adults
  • T2 23076926 ↗Duloxetine versus other anti-depressive agents for depression
  • T6INDIRECT 24920437 ↗Central changes associated with chronic pelvic pain and endometriosis
  • T6INDIRECT 35654766 ↗Clinical, gut microbial and neural effects of a probiotic add-on therapy in depressed patients: a ra
  • T6INDIRECT 19411061 ↗Adrenergic dysregulation and pain with and without acute beta-blockade in women with fibromyalgia an
  • T6INDIRECT 27207917 ↗Absolute Measurements of Macrophage Migration Inhibitory Factor and Interleukin-1-β mRNA Levels Accu
  • T2 25575488 ↗A randomized, double-blind, duloxetine-referenced study comparing efficacy and tolerability of 2 fix
  • T6INDIRECT 19453963 ↗Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study
  • T6 29876878 ↗Role of the Prefrontal Cortex in Pain Processing
  • T6HARM 26267006 ↗Physical exercise as non-pharmacological treatment of chronic pain: Why and when
  • T6INDIRECT 28052319 ↗Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Ro
  • T6INDIRECT 32193596 ↗Management of functional neurological disorder
  • T6INDIRECT 24348701 ↗Treatment of fibromyalgia syndrome: recommendations of recent evidence-based interdisciplinary guide
  • T6INDIRECT 32161761 ↗Post-treatment Lyme Disease as a Model for Persistent Symptoms in Lyme Disease
  • T6INDIRECT 24833921 ↗Etiology, diagnosis, and clinical management of vulvodynia
  • T6INDIRECT 23227356 ↗Ehlers-danlos syndrome, hypermobility type: an underdiagnosed hereditary connective tissue disorder
  • T6 30975301 ↗Screening and Management of Depression in Patients With Cardiovascular Disease: JACC State-of-the-Ar
  • T6 27586831 ↗Toward a Mechanism-Based Approach to Pain Diagnosis
  • T6 29615850 ↗Interplay Between the Gut-Brain Axis, Obesity and Cognitive Function
  • T6 29523389 ↗Postural tachycardia syndrome - Diagnosis, physiology, and prognosis
  • T6 31731606 ↗An Association of Serotonin with Pain Disorders and Its Modulation by Estrogens
  • T6 22094191 ↗Central pain mechanisms in chronic pain states--maybe it is all in their head
  • T6 30223011 ↗Brain glial activation in fibromyalgia - A multi-site positron emission tomography investigation
Etanercept
T2
T2 — RCT in related condition
WithdrawnME/CFS
23 sources
  • T2WITHDRAWN NCT01730495 ↗Tumor Necrosis Factor-alpha Inhibition Using Etanercept in Chronic Fatigue Syndrome
  • T6INDIRECT 22421340 ↗The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomi
  • T6INDIRECT 30605549 ↗Systematic Review and Meta-analysis: Optimal Salvage Therapy in Acute Severe Ulcerative Colitis
  • T6INDIRECT 31749986 ↗Efficacy and safety of topical and systemic medications: a systematic literature review informing th
  • T6INDIRECT 25603545 ↗Rituximab for rheumatoid arthritis
  • T6INDIRECT 20614448 ↗Drug therapy for the management of cancer-related fatigue
  • T6INDIRECT 27555379 ↗Genetic Contributions of Inflammation to Depression
  • T6INDIRECT 27207917 ↗Absolute Measurements of Macrophage Migration Inhibitory Factor and Interleukin-1-β mRNA Levels Accu
  • T6INDIRECT 31745072 ↗High-dose eicosapentaenoic acid (EPA) improves attention and vigilance in children and adolescents w
  • T6 23644052 ↗Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
  • T6 37332039 ↗T cells in health and disease
  • T6 19375665 ↗Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity
  • T6 29802206 ↗Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation
  • T6INDIRECT 17655751 ↗Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis
  • T6INDIRECT 28555037 ↗Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Disease
  • T6INDIRECT 29260466 ↗Targeting Neuroinflammation to Treat Alzheimer's Disease
  • T6INDIRECT 36851614 ↗Persistent SARS-CoV-2 Infection, EBV, HHV-6 and Other Factors May Contribute to Inflammation and Aut
  • T6INDIRECT 23531234 ↗Experimental designs for small randomised clinical trials: an algorithm for choice
  • T6 37076602 ↗Therapeutic strategies for COVID-19: progress and lessons learned
  • T6 22747645 ↗Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways
  • T6 29173175 ↗Imaging the Role of Inflammation in Mood and Anxiety-related Disorders
  • T6 19116888 ↗Stress, depression and cardiovascular dysregulation: a review of neurobiological mechanisms and the
  • T6 22776268 ↗Inflammation and cancer-related fatigue: mechanisms, contributing factors, and treatment implication
Exercise test on ergocycle
T2
T2 — RCT in related condition
RegisteredME/CFS
1 source
  • T2REGISTERED-ONLY NCT07491315 ↗Is Post-exertional Symptom Exacerbation Specific to Patients With Myalgic Encephalomyelitis / Chroni
Experimental: Nutrilite® High dose
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT02807649 ↗Effect of Ginko and Cistanche Against Fatigue Symptoms
Experimental: Nutrilite® Low dose
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT02807649 ↗Effect of Ginko and Cistanche Against Fatigue Symptoms
FitNet treatment
T2
T2 — RCT in related condition
ME/CFS
5 sources
  • T2 NCT00893438 ↗Efficacy of Web-based Cognitive Behavioural Treatment for Adolescents With Chronic Fatigue Syndrome
  • T2 21333021 ↗Fatigue In Teenagers on the interNET--the FITNET Trial. A randomized clinical trial of web-based cog
  • T6INDIRECT 34397389 ↗Effectiveness of Internet-Based Cognitive Behavior Therapy (Fatigue in Teenagers on the Internet) fo
  • T6 28800089 ↗FITNET's Internet-Based Cognitive Behavioural Therapy Is Ineffective and May Impede Natural Recovery
  • T6 23669515 ↗Internet-based therapy for adolescents with chronic fatigue syndrome: long-term follow-up
Floradapt Intensive GI
T2
T2 — RCT in related condition
RegisteredME/CFS
1 source
  • T2REGISTERED-ONLY NCT06211062 ↗The Use of Directed Probiotics in ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
GCJBP Laennec Inj.
T2
T2 — RCT in related condition
Harm signalME/CFS
1 source
  • T2HARM NCT01742013 ↗Investigator Initiated Clinical Study to Explore the Efficacy and Safety of Human Placenta Hydrolysa
Graded dobutamine infusions
T2
T2 — RCT in related condition
ME/CFS
1 source
Graded phenylephrine injections
T2
T2 — RCT in related condition
ME/CFS
1 source
Gradual movement therapy in the ward
T2
T2 — RCT in related condition
WithdrawnME/CFS
1 source
  • T2WITHDRAWN NCT05967052 ↗Investigation of Treating Chronic Fatigue Syndrome After COVID With Pharmacotherapy (Pregabalin) or
Guanidinoacetic acid
T2
T2 — RCT in related condition
ME/CFS
18 sources
  • T2 NCT02213679 ↗Guanidinoacetic Acid Loading for Chronic Fatigue Syndrome
  • T6INDIRECT 28111818 ↗Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgi
  • T6INDIRECT 33596913 ↗A systematic review of nutraceutical interventions for mitochondrial dysfunctions in myalgic encepha
  • T6INDIRECT 39940333 ↗Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (
  • T2 26840330 ↗Supplementation with Guanidinoacetic Acid in Women with Chronic Fatigue Syndrome
  • T6 35267907 ↗Effects of Creatine Supplementation on Brain Function and Health
  • T6 35276888 ↗Role of Creatine Supplementation in Conditions Involving Mitochondrial Dysfunction: A Narrative Revi
  • T6 30235878 ↗Guanidinoacetic Acid Regulates Myogenic Differentiation and Muscle Growth Through miR-133a-3p and mi
  • T4 35010949 ↗Safety of Dietary Guanidinoacetic Acid: A Villain of a Good Guy?
  • T6INDIRECT 38256459 ↗Advancing Research and Treatment: An Overview of Clinical Trials in Myalgic Encephalomyelitis/Chroni
  • T6INDIRECT 40481620 ↗Creatine and post-viral fatigue syndrome: an update
  • T6INDIRECT 30889846 ↗Impact of Polypharmacy on Candidate Biomarker miRNomes for the Diagnosis of Fibromyalgia and Myalgic
  • T6 34680179 ↗Hyperhomocysteinemia: Metabolic Role and Animal Studies with a Focus on Cognitive Performance and De
  • T6 40076522 ↗Cognitive Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Aetiology and Potential
  • T6 42247154 ↗Metabolic reprogramming in fibrosis-related diseases: underlying mechanisms and therapeutics
  • T6 40755709 ↗Nutraceutical Supplementation Effects on Subjective Fatigue Symptoms in Myalgic Encephalomyelitis/Ch
  • T6 40823492 ↗Identification of novel &lt;i&gt;N&lt;/i&gt;-benzyloxy-amino acid hydroxamates as inhibitors of the
  • T6 33557013 ↗Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue Syndrome
GutMagnific™ H.
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT04741841 ↗Effect of Probiotics in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
GutMagnific™ L.
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT04741841 ↗Effect of Probiotics in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Health Psychological Group Rehabilitation for Patients With Chronic Fatigue Syndrome
T2
T2 — RCT in related condition
RegisteredME/CFS
1 source
  • T2REGISTERED-ONLY NCT04151693 ↗Health Psychological Group Rehabilitation for Patients With Chronic Fatigue Syndrome (ME/CFS)
Health promoting dialogue
T2
T2 — RCT in related condition
WithdrawnME/CFS
2 sources
  • T2WITHDRAWN NCT04177459 ↗Rehabilitation of Adolescents Living With Chronic Fatigue
  • T6 37790179 ↗Proceedings of the Sixth Conference of the Society for Implementation Research Collaboration (SIRC)
Heart Rhythm Biofeedback
T2
T2 — RCT in related condition
ME/CFS
2 sources
  • T2 NCT05397626 ↗Biofeedback and Hydrogen Water as Treatments for Chronic Fatigue Syndrome
  • T6 41930109 ↗Molecular hydrogen as a treatment for ME/CFS: a mini-review of clinical evidence and mechanistic rat
In-session Brain Health Training
T2
T2 — RCT in related condition
RegisteredME/CFS
1 source
  • T2REGISTERED-ONLY NCT07523113 ↗ME/CFS Brain Fog: Cognitive Rehabilitation Trial
In-session Instrumental Activities of Living Training
T2
T2 — RCT in related condition
RegisteredME/CFS
1 source
  • T2REGISTERED-ONLY NCT07523113 ↗ME/CFS Brain Fog: Cognitive Rehabilitation Trial
Inactive Kinetic Oscillation Stimulation
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT03502044 ↗New MRT Imaging Biomarkers and Treatment With Kinetic Oscillatory Stimulation (KOS) in Nasal Cavity
Independent walking training
T2
T2 — RCT in related condition
WithdrawnME/CFS
1 source
  • T2WITHDRAWN NCT05967052 ↗Investigation of Treating Chronic Fatigue Syndrome After COVID With Pharmacotherapy (Pregabalin) or
Interdisciplinary complex intervention
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT05130099 ↗A Complex Intervention for Chronically Fatigued Lymphoma Survivors
Intermittent hypoxia-hyperoxia treatment
T2
T2 — RCT in related condition
RegisteredME/CFS
1 source
  • T2REGISTERED-ONLY NCT07317401 ↗Investigating the Effects of Intermittent Hypoxia-Hyperoxia Treatment (IHHT) in People With Myalgic
Intervention Group
T2
T2 — RCT in related condition
ME/CFS
26 sources
  • T2 NCT07363655 ↗Effects of a Rehabilitation Programme Focused on Energy Management in People With Myalgic Encephalom
  • T2 22895961 ↗Exercise interventions on health-related quality of life for cancer survivors
  • T6INDIRECT 26730878 ↗Exercise-based cardiac rehabilitation for coronary heart disease
  • T2 22895974 ↗Exercise interventions on health-related quality of life for people with cancer during active treatm
  • T6INDIRECT 23076904 ↗Printed educational materials: effects on professional practice and healthcare outcomes
  • T6INDIRECT 28045199 ↗Yoga for improving health-related quality of life, mental health and cancer-related symptoms in wome
  • T2 29324562 ↗Effectiveness of interventions to prevent pre-frailty and frailty progression in older adults: a sys
  • T6INDIRECT 31369582 ↗Helping patients help themselves: A systematic review of self-management support strategies in prima
  • T6INDIRECT 24881045 ↗Bias due to lack of patient blinding in clinical trials. A systematic review of trials randomizing p
  • T6INDIRECT 29740819 ↗Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursor
  • T6INDIRECT 27338436 ↗Compassion Fatigue among Healthcare, Emergency and Community Service Workers: A Systematic Review
  • T6 23798298 ↗Lack of exercise is a major cause of chronic diseases
  • T6 29016840 ↗2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atr
  • T2 30284240 ↗Psychological interventions for needle-related procedural pain and distress in children and adolesce
  • T6INDIRECT 18646067 ↗Cognitive behaviour therapy for chronic fatigue syndrome in adults
  • T6INDIRECT 29652088 ↗Non-invasive brain stimulation techniques for chronic pain
  • T2 20091628 ↗Shared decision making interventions for people with mental health conditions
  • T6 23235630 ↗Interventions to facilitate return to work in adults with adjustment disorders
  • T6 34991982 ↗An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment
  • T6 36230169 ↗Postbiotics: Current Trends in Food and Pharmaceutical Industry
  • T6 34944546 ↗Prebiotics, Probiotics, Synbiotics, Paraprobiotics and Postbiotic Compounds in IBD
  • T6 34375047 ↗Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Trea
  • T6 19338686 ↗A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of c
  • T6 24944467 ↗Irritable bowel syndrome: pathogenesis, diagnosis, treatment, and evidence-based medicine
  • T6 35115105 ↗Interventions for Frailty Among Older Adults With Cardiovascular Disease: JACC State-of-the-Art Revi
  • T6 32033578 ↗Surgery for spontaneous intracerebral hemorrhage
IodoCarb
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT01793415 ↗Treatment of Chronic Fatigue Syndrome (CFS) With Iodinated Activated Charcoal (IodoCarb®)
Journaling
T2
T2 — RCT in related condition
ME/CFS
21 sources
  • T2 NCT00468013 ↗A Computer-Based Intervention for Medically Unexplained Physical Symptoms
  • T6INDIRECT 29376559 ↗Physical activity for women with breast cancer after adjuvant therapy
  • T6INDIRECT 32691879 ↗Psychological interventions to foster resilience in healthcare students
  • T6INDIRECT 31480748 ↗A Systematic Review and Meta-Analysis of Nature-Based Mindfulness: Effects of Moving Mindfulness Tra
  • T6INDIRECT 39354706 ↗Impact of psilocybin on cognitive function: A systematic review
  • T6INDIRECT 27612943 ↗The Mental Health in Diabetes Service (MINDS) to enhance psychosocial health: study protocol for a r
  • T6INDIRECT 27612562 ↗The Stroke and Carer Optimal Health Program (SCOHP) to enhance psychosocial health: study protocol f
  • T6 25926809 ↗The role of language in emotion: predictions from psychological constructionism
  • T6 19843967 ↗African American Women's beliefs, coping behaviors, and barriers to seeking mental health services
  • T6 26876889 ↗Translational bioinformatics in the era of real-time biomedical, health care and wellness data strea
  • T6INDIRECT 38887496 ↗Complete remission of depression and anxiety using a ketogenic diet: case series
  • T6INDIRECT 31750018 ↗The Physical and the Emotional: Case Report, Mixed-Methods Development, and Discussion
  • T6INDIRECT 41246705 ↗Self-Directed Recovery of Gu Syndrome: Reversal of Multisystem Dysfunction via Microbiome Restoratio
  • T6INDIRECT 35197250 ↗The response is like a big ship': community feedback as a case study of evidence uptake and use in t
  • T6INDIRECT 30480150 ↗Program Abstracts from the GSA 2018 Annual Scientific Meeting "The Purposes of Longer Lives"
  • T6INDIRECT 34926835 ↗Program Abstracts from The GSA 2021 Annual Scientific Meeting, "Disruption to Transformation: Aging
  • T6 38711299 ↗The Stress Phenotyping Framework: A multidisciplinary biobehavioral approach for assessing and thera
  • T6 PMC13111897 ↗2026 International Congress Abstract Supplement
  • T6 PMC12755232 ↗Full GSA 2025 Abstract Book PDF
  • T6 37185640 ↗Lived experience of patients with Long COVID: a qualitative study in the UK
  • T6 34065069 ↗Elements of Suffering in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Experience of Loss,
Kinetic Oscillation Stimulation
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT03502044 ↗New MRT Imaging Biomarkers and Treatment With Kinetic Oscillatory Stimulation (KOS) in Nasal Cavity
Liquid Herbal TInctures
T2
T2 — RCT in related condition
RegisteredME/CFS
1 source
  • T2REGISTERED-ONLY NCT06235177 ↗Psychoneuromentalism Disorder: A Medical Condition That Affects People With Psychological Impairment
Maximal effort test
T2
T2 — RCT in related condition
WithdrawnME/CFS
4 sources
  • T2WITHDRAWN NCT03849326 ↗Chronic Fatigue Etiology in Intensive Care Unit Survivors: the Role of Neuromuscular Function
  • T6INDIRECT 36805865 ↗Reduced athletic performance post-COVID-19 is associated with reduced anaerobic threshold
  • T6 35781843 ↗Urinary extracellular vesicle as a potential biomarker of exercise-induced fatigue in young adult ma
  • T6 28674599 ↗The Effect of Betaine on Nitrate and Cardiovascular Response to Exercise
Medical Food - Anhydrous Enol-Oxaloacetate
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT05273372 ↗RESTORE ME -- RCT of Oxaloacetate on Improving Fatigue in ME/CFS
Mental Imagery
T2
T2 — RCT in related condition
RegisteredME/CFS
21 sources
  • T2REGISTERED-ONLY NCT06235177 ↗Psychoneuromentalism Disorder: A Medical Condition That Affects People With Psychological Impairment
  • T6INDIRECT 19160308 ↗Psychosocial interventions for reducing fatigue during cancer treatment in adults
  • T2 34352116 ↗Primary-level worker interventions for the care of people living with mental disorders and distress
  • T6INDIRECT 35449074 ↗Impact of contextual factors on patient outcomes following conservative low back pain treatment: sys
  • T6INDIRECT 36545350 ↗EEG-based Brain-Computer Interfaces for people with Disorders of Consciousness: Features and applica
  • T6INDIRECT 27341675 ↗Guided Imagery And Progressive Muscle Relaxation as a Cluster of Symptoms Management Intervention in
  • T2 23305089 ↗Two types of mental fatigue affect spontaneous oscillatory brain activities in different ways
  • T2 31694691 ↗Alterations of mental defeat and cognitive flexibility during cognitive behavioral therapy in patien
  • T6 20363063 ↗Upward spirals of positive emotions counter downward spirals of negativity: insights from the broade
  • T6 20129310 ↗Top-down and bottom-up mechanisms in mind-body medicine: development of an integrative framework for
  • T6 27013686 ↗Theta-Alpha Oscillations Bind the Hippocampus, Prefrontal Cortex, and Striatum during Recollection:
  • T6 21029785 ↗Gray matter volume changes following reading intervention in dyslexic children
  • T6INDIRECT 41688232 ↗Clinical utility and prospective of TMS-EEG: Updated review from an international expert group
  • T6INDIRECT 21400108 ↗Activity-dependent acetylation of alpha tubulin in the hippocampus
  • T6INDIRECT 23263794 ↗Influences of "spasmolytic powder" on pgp expression of Coriaria Lactone-kindling drug-resistant epi
  • T6INDIRECT 34912263 ↗Split-Second Unlearning: Developing a Theory of Psychophysiological Dis-ease
  • T6INDIRECT 30480124 ↗Program Abstracts from the 21st International Association of Gerontology and Geriatrics (IAGG) World
  • T6INDIRECT 40726475 ↗11th European Stroke Organisation Conference Abstracts - 21-23 May 2025, Helsinki, Finland
  • T6 35624910 ↗Cerebellum-Cortical Interaction in Spatial Navigation and Its Alteration in Dementias
  • T6 33613671 ↗The Current Evidence Levels for Biofeedback and Neurofeedback Interventions in Treating Depression:
  • T6 24639579 ↗Multisensory constraints on awareness
Mental Stress Test
T2
T2 — RCT in related condition
ME/CFS
9 sources
  • T2 NCT04378634 ↗Epigenetics of Post-exertional Malaise in Patients With ME/CFS
  • T6INDIRECT 27557747 ↗Adrenal fatigue does not exist: a systematic review
  • T6 31133864 ↗Is the Brain a Key Player in Glucose Regulation and Development of Type 2 Diabetes?
  • T6 29977237 ↗Phenotype, Function, and Mobilization of 6-Sulfo LacNAc-Expressing Monocytes in Atopic Dermatitis
  • T6 34483954 ↗Fatigue Is Associated With Diminished Cardiovascular Response to Anticipatory Stress in Patients Wit
  • T6 34797307 ↗Glucose tolerance in fibromyalgia
  • T4 PMC3476934 ↗22nd European Students' Conference. Promising medical scientists willing to look beyond
  • T4 PMC7122588 ↗Abkürzungen
  • T6 39768508 ↗Effects of Oral Ingestion of L-Ornithine on Mental Stress and Fatigue Based on the Trier Social Stre
Methyl-P plus Nutrient Formula
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT01966276 ↗The Synergy Trial: Methylphenidate Plus a CFS-Specific Nutrient Formula as a Treatment for Chronic F
Micro breaks in everyday life for chronic fatigue
T2
T2 — RCT in related condition
RegisteredME/CFS
1 source
  • T2REGISTERED-ONLY NCT05168124 ↗Effectiveness of Acceptance Commitment Therapy or Micro Breaks in Patients with Chronic Fatigue Synd
Mindful and conscious movement-based exercise
T2
T2 — RCT in related condition
RegisteredME/CFS
1 source
  • T2REGISTERED-ONLY NCT06978582 ↗Effectiveness and Safety of a Tele-Rehabilitation Program on Fatigue and Related Variables in Chroni
Movement to rhythm
T2
T2 — RCT in related condition
ME/CFS
3 sources
  • T2 NCT01873482 ↗Traditional African Healing Ceremony in a U.S. Population
  • T6 31709972 ↗Sleep-Related Disorders in Neurology and Psychiatry
  • T6 40735382 ↗Polyvagal Theory: Current Status, Clinical Applications, and Future Directions
NAC /day
T2
T2 — RCT in related condition
RegisteredME/CFS
1 source
  • T2REGISTERED-ONLY NCT04542161 ↗Assessment of N-Acetylcysteine as Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
NESA X-Signal
T2
T2 — RCT in related condition
RegisteredME/CFS
1 source
  • T2REGISTERED-ONLY NCT07242573 ↗Effect of Physical Exercise and Neuromodulation on Pain, Sleep and Fatigue in Patients With Fibromya
Nasal CPAP treatment during sleep
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT00252629 ↗Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment
Neuromuscular evaluation
T2
T2 — RCT in related condition
WithdrawnME/CFS
4 sources
  • T2WITHDRAWN NCT03849326 ↗Chronic Fatigue Etiology in Intensive Care Unit Survivors: the Role of Neuromuscular Function
  • T6 23549648 ↗Neuromuscular and systemic presentations in adults: diagnoses beyond MERRF and MELAS
  • T6 16687265 ↗Neurological disorders in Gulf War veterans
  • T6 36454442 ↗Abstracts of the 52nd Annual Conference of the Italian Society of Neurology
Pain Relaxation Techniques
T2
T2 — RCT in related condition
RegisteredME/CFS
1 source
  • T2REGISTERED-ONLY NCT06235177 ↗Psychoneuromentalism Disorder: A Medical Condition That Affects People With Psychological Impairment
Patient education program
T2
T2 — RCT in related condition
ME/CFS
23 sources
  • T2 NCT01765725 ↗Coping With Chronic Fatigue Syndrome: Development of a Community-based Patient Education Program
  • T2 18023128 ↗Meta-analysis of patient education interventions to increase physical activity among chronically ill
  • T6INDIRECT 27883365 ↗Educational interventions for the management of cancer-related fatigue in adults
  • T6INDIRECT 41225175 ↗Systematic literature review: treatment of postural orthostatic tachycardia syndrome (POTS)
  • T6INDIRECT 41634440 ↗Effect of Bioptron light therapy on dryness of eyes in postmenopausal women: a randomized controlled
  • T6 27088131 ↗Factor Analysis of the DePaul Symptom Questionnaire: Identifying Core Domains
  • T6 31318234 ↗The development of a short form of the DePaul Symptom Questionnaire
  • T6 35236205 ↗Evaluating case diagnostic criteria for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS):
  • T4 31118841 ↗Managing fatigue in patients with primary Sjögren's syndrome: challenges and solutions
  • T6INDIRECT 26345409 ↗Chronic Fatigue Syndrome versus Systemic Exertion Intolerance Disease
  • T6INDIRECT 37653505 ↗Psychological interventions for individuals with Ehlers-Danlos syndrome and hypermobility spectrum d
  • T6INDIRECT 40726475 ↗11th European Stroke Organisation Conference Abstracts - 21-23 May 2025, Helsinki, Finland
  • T6INDIRECT 24085684 ↗Abstracts of the 2013 Annual Meeting of the American College of Rheumatology. October 25-30, 2013. S
  • T6INDIRECT 40986224 ↗World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2025)
  • T4 PMC12496561 ↗UEG Week 2025 Poster Presentations
  • T4 PMC11470995 ↗UEG Week 2024 Poster Presentations
  • T6 PMC5042925 ↗ESICM LIVES 2016: part three : Milan, Italy. 1–5 October 2016
  • T6 PMC4070603 ↗UEG Week 2013 Poster Presentations
  • T6 11357836 ↗Society of General Internal Medicine 24th annual meeting. San Diego, California, May 2-5, 2001. Abst
  • T6 34354626 ↗Understanding Experiences of Fibromyalgia Patients Involved in the Fimouv Study During COVID-19 Lock
  • T6 27088059 ↗Case definitions integrating empiric and consensus perspectives
  • T6 29457646 ↗A reexamination of the cognitive behavioral model of chronic fatigue syndrome
  • T6 35005437 ↗Creation of a Multispecialty Clinic for Patients with Central Sensitization-Based Chronic Pain Condi
Patient-Partner Videotelephone-delivered Cognitive Behavioral Stress Management intervention
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT01650636 ↗Patient-Partner Stress Management Effects on Chronic Fatigue Syndrome Symptoms and Neuroimmune Proce
Patient-Partner Videotelephone-delivered Health Information
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT01650636 ↗Patient-Partner Stress Management Effects on Chronic Fatigue Syndrome Symptoms and Neuroimmune Proce
Photobiomodulation therapy
T2
T2 — RCT in related condition
ME/CFS
21 sources
  • T2 NCT06145867 ↗A Feasibility Study: Assessing Photobiomodulation in Myalgic Encephalomyelitis
  • T6INDIRECT 37651553 ↗Interventions for fatigue in people with kidney failure requiring dialysis
  • T2 42334638 ↗Effect of photobiomodulation on pain and quality of life in fibromyalgia syndrome: a systematic revi
  • T2 37847246 ↗Photobiomodulation therapy combined with static magnetic field is better than placebo in patients wi
  • T6INDIRECT 41634440 ↗Effect of Bioptron light therapy on dryness of eyes in postmenopausal women: a randomized controlled
  • T2 41047274 ↗Effects of photobiomodulation therapy combined with static magnetic field on pain and function in pa
  • T6HARM 33114203 ↗Fibromyalgia: Recent Advances in Diagnosis, Classification, Pharmacotherapy and Alternative Remedies
  • T6 36925674 ↗Recent progress in the manipulation of biochemical and biophysical cues for engineering functional t
  • T6 36139746 ↗Can Photobiomodulation Therapy (PBMT) Minimize Exercise-Induced Oxidative Stress? A Systematic Revie
  • T6 31839802 ↗Unique heterologous fibrin biopolymer with hemostatic, adhesive, sealant, scaffold and drug delivery
  • T6 35541894 ↗Photobiomodulation Drives MiR-136-5p Expression to Promote Injury Repair after Myocardial Infarction
  • T4 33269093 ↗A Potential Role for Photobiomodulation Therapy in Disease Treatment and Prevention in the Era of CO
  • T4 33099039 ↗Association of antimicrobial photodynamic therapy and photobiomodulation for herpes simplex labialis
  • T6INDIRECT 29682691 ↗Abstracts of the MASCC/ISOO Annual Meeting 2018
  • T6INDIRECT 33656611 ↗World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2020): Po
  • T4 PPR1117356 ↗Photobiomodulation therapy for children’s eye and vision conditions
  • T6 34947870 ↗Photobiomodulation and Sports: Results of a Narrative Review
  • T6 38875041 ↗Approaches for Increasing Cerebral Efflux of Amyloid-β in Experimental Systems
  • T6 41012726 ↗Comprehensive Prevention and Control of Mastitis in Dairy Cows: From Etiology to Prevention
  • T6 40424201 ↗The silent saboteur: oxidative stress and the path to cognitive dysfunction
  • T6 37897034 ↗A Review Article on Exercise Intolerance in Long COVID: Unmasking the Causes and Optimizing Treatmen
Physical Training Program
T2
T2 — RCT in related condition
RegisteredME/CFS
10 sources
  • T2REGISTERED-ONLY NCT07242573 ↗Effect of Physical Exercise and Neuromodulation on Pain, Sleep and Fatigue in Patients With Fibromya
  • T6INDIRECT 22895961 ↗Exercise interventions on health-related quality of life for cancer survivors
  • T6INDIRECT 26730878 ↗Exercise-based cardiac rehabilitation for coronary heart disease
  • T6INDIRECT 37344767 ↗Clinical effectiveness of rehabilitation in ambulatory care for patients with persisting symptoms af
  • T6 33917586 ↗Relationship between Cardiopulmonary, Mitochondrial and Autonomic Nervous System Function Improvemen
  • T6 27058145 ↗Post-exercise depression following submaximal and maximal isometric voluntary contraction
  • T4 37759324 ↗Functional performance recovery after individualized nutrition therapy combined with a patient-tailo
  • T4 PPR647630 ↗Faster functional performance recovery after individualized nutrition therapy combined with a patien
  • T4 PMC7103906 ↗Posters
  • T6 41078375 ↗Advancing the allostatic load model in military training research: from theory to application
Pregabalin
T2
T2 — RCT in related condition
WithdrawnME/CFS
26 sources
  • T2WITHDRAWN NCT05967052 ↗Investigation of Treating Chronic Fatigue Syndrome After COVID With Pharmacotherapy (Pregabalin) or
  • T6INDIRECT 29652088 ↗Non-invasive brain stimulation techniques for chronic pain
  • T6INDIRECT 35182760 ↗ESCMID rapid guidelines for assessment and management of long COVID
  • T6INDIRECT 25379990 ↗Pharmacological interventions for somatoform disorders in adults
  • T6INDIRECT 29547226 ↗Non-invasive brain stimulation techniques for chronic pain
  • T6INDIRECT 29757454 ↗Non-pharmacological interventions for treating chronic prostatitis/chronic pelvic pain syndrome
  • T6INDIRECT 38839884 ↗Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, diseas
  • T6INDIRECT 31554544 ↗Functional Somatic Symptoms
  • T6INDIRECT 19411061 ↗Adrenergic dysregulation and pain with and without acute beta-blockade in women with fibromyalgia an
  • T6INDIRECT 19453963 ↗Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study
  • T6 29876878 ↗Role of the Prefrontal Cortex in Pain Processing
  • T6 33918736 ↗Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update
  • T6HARM 26267006 ↗Physical exercise as non-pharmacological treatment of chronic pain: Why and when
  • T6INDIRECT 30560936 ↗Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network
  • T6INDIRECT 28052319 ↗Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Ro
  • T6INDIRECT 32193596 ↗Management of functional neurological disorder
  • T6INDIRECT 25358508 ↗Medical management of brain tumors and the sequelae of treatment
  • T6INDIRECT 26456676 ↗Functional Connectivity is Associated With Altered Brain Chemistry in Women With Endometriosis-Assoc
  • T6 33857435 ↗Confronting COVID-19-associated cough and the post-COVID syndrome: role of viral neurotropism, neuro
  • T6 27586831 ↗Toward a Mechanism-Based Approach to Pain Diagnosis
  • T6 30844399 ↗Composite Pain Biomarker Signatures for Objective Assessment and Effective Treatment
  • T6 17626613 ↗Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia
  • T6 27472486 ↗Irritable bowel syndrome, the microbiota and the gut-brain axis
  • T6 34853604 ↗Temporomandibular disorders: a review of current concepts in aetiology, diagnosis and management
  • T6 22094191 ↗Central pain mechanisms in chronic pain states--maybe it is all in their head
  • T6 23213512 ↗Fibromyalgia syndrome: etiology, pathogenesis, diagnosis, and treatment
Preprocessed thawed autologous FMT
T2
T2 — RCT in related condition
ME/CFS
1 source
Preprocessed thawed donor FMT
T2
T2 — RCT in related condition
ME/CFS
1 source
Psychosocial challenge involving socioevaluative public speaking
T2
T2 — RCT in related condition
ME/CFS
1 source
Psycoeducation/counseling
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT00860236 ↗Giardia Induced Fatigue and Functional Gastrointestinal Diseases
Questionnaires
T2
T2 — RCT in related condition
WithdrawnME/CFS
23 sources
  • T2WITHDRAWN NCT03849326 ↗Chronic Fatigue Etiology in Intensive Care Unit Survivors: the Role of Neuromuscular Function
  • T6INDIRECT 32437679 ↗Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a syst
  • T6INDIRECT 34973396 ↗Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis
  • T6INDIRECT 25011450 ↗Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on in
  • T6INDIRECT 22895961 ↗Exercise interventions on health-related quality of life for cancer survivors
  • T6INDIRECT 26730878 ↗Exercise-based cardiac rehabilitation for coronary heart disease
  • T6INDIRECT 24336429 ↗Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis
  • T6INDIRECT 22895974 ↗Exercise interventions on health-related quality of life for people with cancer during active treatm
  • T6INDIRECT 22018588 ↗Validity of the International Physical Activity Questionnaire Short Form (IPAQ-SF): a systematic rev
  • T6INDIRECT 34037731 ↗Assessment of the Frequency and Variety of Persistent Symptoms Among Patients With COVID-19: A Syste
  • T6INDIRECT 21334061 ↗Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and spe
  • T6 18923511 ↗The molecular neurobiology of depression
  • T6 7636775 ↗The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatig
  • T6INDIRECT 29016840 ↗2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atr
  • T6INDIRECT 27856520 ↗From Q Fever to Coxiella burnetii Infection: a Paradigm Change
  • T6INDIRECT 15577865 ↗Rhinosinusitis: establishing definitions for clinical research and patient care
  • T6INDIRECT 25266247 ↗Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task fo
  • T6INDIRECT 31210940 ↗European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gl
  • T6 23798298 ↗Lack of exercise is a major cause of chronic diseases
  • T6 30920354 ↗The Sleep-Immune Crosstalk in Health and Disease
  • T6 27159638 ↗Irritable bowel syndrome
  • T6 33568819 ↗Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
  • T6 36178003 ↗World guidelines for falls prevention and management for older adults: a global initiative
ReConnect
T2
T2 — RCT in related condition
ME/CFS
23 sources
  • T2 NCT02063126 ↗Clinical Trial to Measure the Maximun HR After ReConnect ® Supplementation vs. Placebo in CFS.
  • T6INDIRECT 35739494 ↗Community gardens and their effects on diet, health, psychosocial and community outcomes: a systemat
  • T6INDIRECT 36091835 ↗Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Ana
  • T6INDIRECT 38331778 ↗Strategies to improve care for older adults who present to the emergency department: a systematic re
  • T6INDIRECT 39899533 ↗A systematic review of military-to-civilian transition, The role of gender
  • T6INDIRECT 24938492 ↗Aligning everyday life priorities with people's self-management support networks: an exploration of
  • T6INDIRECT 19678772 ↗An HMO-based prospective pilot study of energy medicine for chronic headaches: whole-person outcomes
  • T6 28052319 ↗Treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis: all roads lead to Ro
  • T6 34114614 ↗Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the he
  • T6 34366998 ↗From Therapeutic Factors to Mechanisms of Change in the Creative Arts Therapies: A Scoping Review
  • T6 37795509 ↗Naturalistic psilocybin use is associated with persisting improvements in mental health and wellbein
  • T6INDIRECT 36580406 ↗The long tail of COVID and the tale of long COVID: Diagnostic construction and the management of ign
  • T6INDIRECT 32725471 ↗Abstracts from the 2020 Annual Meeting of the Society of General Internal Medicine
  • T6INDIRECT 37362965 ↗Toward food waste reduction at universities
  • T6INDIRECT 39654264 ↗Worsening suicidal ideation and prolonged adverse event following psilocybin administration in a cli
  • T6INDIRECT 32745277 ↗Abstracts of the Heart Failure 2019 and the World Congress on Acute Heart Failure, 25-28 May 2019, M
  • T6INDIRECT 30480124 ↗Program Abstracts from the 21st International Association of Gerontology and Geriatrics (IAGG) World
  • T6INDIRECT 29682691 ↗Abstracts of the MASCC/ISOO Annual Meeting 2018
  • T6 27957200 ↗Better Lesion Creation And Assessment During Catheter Ablation
  • T6 39766218 ↗Transcutaneous Non-Invasive Vagus Nerve Stimulation: Changing the Paradigm for Stroke and Atrial Fib
  • T6 33562500 ↗Nuclear Receptor Nur77 Controls Cardiac Fibrosis through Distinct Actions on Fibroblasts and Cardiom
  • T6 32618207 ↗Impact of a Multimodal and Combination Therapy on Self-Regulation and Internal Coherence in German B
  • T6 33429922 ↗Intrinsic Self-Healing Epoxies in Polymer Matrix Composites (PMCs) for Aerospace Applications
Recovery Factors
T2
T2 — RCT in related condition
ME/CFS
12 sources
  • T2 NCT04381780 ↗Treatment of Fibromyalgia With Recovery Factors
  • T2 NCT04381793 ↗Treatment of CFS & Fibromyalgia With Recovery Factors
  • T6 37655303 ↗Long COVID as a functional somatic symptom disorder caused by abnormally precise prior expectations
  • T6 40528196 ↗Muscle weakness after critical illness: unravelling biological mechanisms and clinical hurdles
  • T6 27983583 ↗Treated Seawater as a Magnesium Source for Phosphorous Recovery from Wastewater-A Feasibility and Co
  • T6 29766354 ↗Image-based SPECT calibration based on the evaluation of the Fraction of Activity in the Field of Vi
  • T6 35682257 ↗Effect of Indoor Forest Bathing on Reducing Feelings of Fatigue Using Cerebral Activity as an Indica
  • T6 41053260 ↗Experimental and numerical simulation studies of the zwitterionic polymers for enhanced oil recovery
  • T6 38586411 ↗Maximizing oil recovery: Innovative chemical EOR solutions for residual oil mobilization in Kazakhst
  • T6 40978377 ↗Hydrothermal Synthesis of γ‑Al&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;3&lt;/sub&gt; Nanofluids for Enhan
  • T6 41682067 ↗A Hybrid Ionic Liquid-HPAM Flooding for Enhanced Oil Recovery: An Integrated Experimental and Numeri
  • T6 PMC11207498 ↗Combining Thermal Effect and Mobility Control Mechanism to Reduce Water Cut in a Sandstone Reservoir
Resilience Building Exercises
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT00468013 ↗A Computer-Based Intervention for Medically Unexplained Physical Symptoms
Ribose
T2
T2 — RCT in related condition
ME/CFS
26 sources
  • T2 NCT01108549 ↗Treatment of Chronic Fatigue Syndrome and Fibromyalgia With D-ribose- a Multicenter Study
  • T6INDIRECT 36408147 ↗Trabectedin and lurbinectedin: Mechanisms of action, clinical impact, and future perspectives in ute
  • T6INDIRECT 28616881 ↗Role of dietary modification in alleviating chronic fatigue syndrome symptoms: a systematic review
  • T6INDIRECT 37175544 ↗Compartmental Cerebrospinal Fluid Events Occurring after Subarachnoid Hemorrhage: An "Heparin Orient
  • T6INDIRECT 40260854 ↗Anti-fibrosis effect of astragaloside IV in animal models of cardiovascular diseases and its mechani
  • T6INDIRECT 36228963 ↗Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline patho
  • T6INDIRECT 29495607 ↗Effects of Dietary Supplementation of Astaxanthin and Sesamin on Daily Fatigue: A Randomized, Double
  • T6INDIRECT 35206569 ↗Differential Metabolites and Metabolic Pathways Involved in Aerobic Exercise Improvement of Chronic
  • T6INDIRECT 28275109 ↗Intermittent and graded exercise effects on NK cell degranulation markers LAMP-1/LAMP-2 and CD8<sup>
  • T2 17109576 ↗The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study
  • T6INDIRECT 28330481 ↗Diverse characteristics of the urinary excretion of amino acids in humans and the use of amino acid
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6 32029455 ↗PARP and PARG inhibitors in cancer treatment
  • T6INDIRECT 33821570 ↗Delivery of oligonucleotide-based therapeutics: challenges and opportunities
  • T6INDIRECT 33371494 ↗Chromosome Instability in Fanconi Anemia: From Breaks to Phenotypic Consequences
  • T6INDIRECT 34067632 ↗Coenzyme Q<sub>10</sub>: Clinical Applications beyond Cardiovascular Diseases
  • T6INDIRECT 32953841 ↗Autoimmunity as the comet tail of COVID-19 pandemic
  • T6INDIRECT 27126805 ↗DNA Damage in Major Psychiatric Diseases
  • T6INDIRECT 31168764 ↗Inosine Pranobex: A Key Player in the Game Against a Wide Range of Viral Infections and Non-Infectio
  • T6 26404370 ↗Magnesium in Prevention and Therapy
  • T6 24606147 ↗Human RecQ helicases in DNA repair, recombination, and replication
  • T6 22544865 ↗Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action,
  • T6 28525309 ↗From Chaos to Harmony: Responses and Signaling upon Microbial Pattern Recognition
  • T6 8666911 ↗Mitochondrial control of nuclear apoptosis
  • T6 8879205 ↗Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
  • T6 10891486 ↗BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transit
Seasonal influenza vaccination
T2
T2 — RCT in related condition
ME/CFS
18 sources
  • T2 NCT01651754 ↗Humoral and Cellular Immune Responses After Influenza Vaccination in Patients With Postcancer Fatigu
  • T6INDIRECT 34671861 ↗Moving the Needle on Atherosclerotic Cardiovascular Disease and Heart Failure with Influenza Vaccina
  • T6INDIRECT 34777351 ↗Safety of Influenza A H1N1pdm09 Vaccines: An Overview of Systematic Reviews
  • T6INDIRECT 40334011 ↗Use of virtual reality in the reduction of pain after the administration of vaccines among children
  • T6 35642867 ↗Perceived threat of COVID-19, attitudes towards vaccination, and vaccine hesitancy: A prospective lo
  • T6 23244635 ↗Humoral and cellular immune responses after influenza vaccination in patients with chronic fatigue s
  • T6 31592543 ↗17th International Congress of Immunology, 19-23 October 2019, Beijing, China
  • T6 24085684 ↗Abstracts of the 2013 Annual Meeting of the American College of Rheumatology. October 25-30, 2013. S
  • T6INDIRECT 36570860 ↗Full GSA 2022 Abstract Book PDF
  • T6INDIRECT 33420677 ↗Critical Care Canada Forum 2020 Abstracts
  • T6INDIRECT 31559498 ↗ESICM LIVES 2019 : Berlin, Germany. 28 September - 2 October 2019
  • T4 PMC12452013 ↗Abstracts from the 8th International Conference on Prevention & Infection Control (ICPIC 2025)
  • T6 PMC7162281 ↗Posters
  • T6 PMC7128307 ↗Abstracts accepted for publication only
  • T6 PMC7111423 ↗Poster Sessions
  • T6 25996472 ↗Humoral and cellular immune responses after influenza vaccination in patients with postcancer fatigu
  • T6 40640868 ↗Decreased risk of chronic fatigue syndrome following influenza vaccine: a 20-year population-based r
  • T6 PMC7863043 ↗Determinants of persistent post-COVID-19 symptoms: value of a novel COVID-19 symptom score
Sodium Oxybate
T2
T2 — RCT in related condition
ME/CFS
21 sources
  • T2 NCT02055898 ↗SWS And Daytime Functioning in Chronic FatiguE Syndrome (SAFFE)
  • T2 36967111 ↗Subacute changes in brain functional network connectivity after nocturnal sodium oxybate intake are
  • T6 24348701 ↗Treatment of fibromyalgia syndrome: recommendations of recent evidence-based interdisciplinary guide
  • T6 24289848 ↗Beyond pain in fibromyalgia: insights into the symptom of fatigue
  • T6HARM 19225604 ↗Fibromyalgia: presentation and management with a focus on pharmacological treatment
  • T6 22811766 ↗Fibromyalgia syndrome: an overview of pathophysiology, diagnosis and management
  • T6 22802155 ↗Peripheral and central mechanisms of fatigue in inflammatory and noninflammatory rheumatic diseases
  • T6INDIRECT 18266111 ↗Baclofen and gamma-hydroxybutyrate withdrawal
  • T6INDIRECT 39727797 ↗Relationship Between Sleep Disturbances and Chronic Pain: A Narrative Review
  • T6INDIRECT 35445831 ↗Narcolepsy: a model interaction between immune system, nervous system, and sleep-wake regulation
  • T6INDIRECT 38217475 ↗Brain fog in central disorders of hypersomnolence: a review
  • T6INDIRECT 39484177 ↗Exploring the Literature on Narcolepsy: Insights into the Sleep Disorder That Strikes during the Day
  • T6INDIRECT 41076550 ↗Orexin Deficiency in Narcolepsy: Molecular Mechanisms, Clinical Phenotypes, and Emerging Therapeutic
  • T6INDIRECT 28216789 ↗Clinical Practice Guidelines for Sleep Disorders
  • T6 23563879 ↗Diagnostic and management approach to common sleep disorders during pregnancy
  • T6 41424515 ↗From macro to micro: slow-wave sleep and its pivotal health implications
  • T6 40726475 ↗11th European Stroke Organisation Conference Abstracts - 21-23 May 2025, Helsinki, Finland
  • T6 36454442 ↗Abstracts of the 52nd Annual Conference of the Italian Society of Neurology
  • T6 33231810 ↗Abstracts of the 51st Annual Conference of the Italian Society of Neurology : November 28- 30, 2020
  • T6 37223370 ↗Fibromyalgia - etiology, diagnosis and treatment including perioperative management in patients with
  • T6 22110942 ↗A comprehensive evaluation of standardized assessment tools in the diagnosis of fibromyalgia and in
Sodium oxybate
T2
T2 — RCT in related condition
WithdrawnME/CFS
21 sources
  • T2WITHDRAWN NCT01584934 ↗Sodium Oxybate in Patients With Chronic Fatigue Syndrome.
  • T2 36967111 ↗Subacute changes in brain functional network connectivity after nocturnal sodium oxybate intake are
  • T6 24348701 ↗Treatment of fibromyalgia syndrome: recommendations of recent evidence-based interdisciplinary guide
  • T6 24289848 ↗Beyond pain in fibromyalgia: insights into the symptom of fatigue
  • T6HARM 19225604 ↗Fibromyalgia: presentation and management with a focus on pharmacological treatment
  • T6 22811766 ↗Fibromyalgia syndrome: an overview of pathophysiology, diagnosis and management
  • T6 22802155 ↗Peripheral and central mechanisms of fatigue in inflammatory and noninflammatory rheumatic diseases
  • T6INDIRECT 18266111 ↗Baclofen and gamma-hydroxybutyrate withdrawal
  • T6INDIRECT 39727797 ↗Relationship Between Sleep Disturbances and Chronic Pain: A Narrative Review
  • T6INDIRECT 35445831 ↗Narcolepsy: a model interaction between immune system, nervous system, and sleep-wake regulation
  • T6INDIRECT 38217475 ↗Brain fog in central disorders of hypersomnolence: a review
  • T6INDIRECT 39484177 ↗Exploring the Literature on Narcolepsy: Insights into the Sleep Disorder That Strikes during the Day
  • T6INDIRECT 41076550 ↗Orexin Deficiency in Narcolepsy: Molecular Mechanisms, Clinical Phenotypes, and Emerging Therapeutic
  • T6INDIRECT 28216789 ↗Clinical Practice Guidelines for Sleep Disorders
  • T6 23563879 ↗Diagnostic and management approach to common sleep disorders during pregnancy
  • T6 41424515 ↗From macro to micro: slow-wave sleep and its pivotal health implications
  • T6 40726475 ↗11th European Stroke Organisation Conference Abstracts - 21-23 May 2025, Helsinki, Finland
  • T6 36454442 ↗Abstracts of the 52nd Annual Conference of the Italian Society of Neurology
  • T6 33231810 ↗Abstracts of the 51st Annual Conference of the Italian Society of Neurology : November 28- 30, 2020
  • T6 37223370 ↗Fibromyalgia - etiology, diagnosis and treatment including perioperative management in patients with
  • T6 22110942 ↗A comprehensive evaluation of standardized assessment tools in the diagnosis of fibromyalgia and in
Symptom monitoring
T2
T2 — RCT in related condition
ME/CFS
21 sources
  • T2 NCT00997451 ↗Fatigue Self-Management in Primary Care
  • T6INDIRECT 18023128 ↗Meta-analysis of patient education interventions to increase physical activity among chronically ill
  • T6INDIRECT 28230899 ↗Shared care across the interface between primary and specialty care in management of long term condi
  • T2 26123045 ↗Psychological interventions for symptomatic management of non-specific chest pain in patients with n
  • T6INDIRECT 31369582 ↗Helping patients help themselves: A systematic review of self-management support strategies in prima
  • T6INDIRECT 27128779 ↗The Empirical Foundations of Telemedicine Interventions in Primary Care
  • T6INDIRECT 34352116 ↗Primary-level worker interventions for the care of people living with mental disorders and distress
  • T2 12424170 ↗Systematic review of mental health interventions for patients with common somatic symptoms: can rese
  • T2 32483832 ↗Telephone interventions for symptom management in adults with cancer
  • T6INDIRECT 39593045 ↗The use of patient-reported outcome measures to improve patient-related outcomes - a systematic revi
  • T6INDIRECT 34329719 ↗Fatigue in Persons With Heart Failure: A Systematic Literature Review and Meta-Synthesis Using the B
  • T6 27586833 ↗Overlapping Chronic Pain Conditions: Implications for Diagnosis and Classification
  • T6 36100326 ↗Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue s
  • T6INDIRECT 37651553 ↗Interventions for fatigue in people with kidney failure requiring dialysis
  • T6INDIRECT 41688232 ↗Clinical utility and prospective of TMS-EEG: Updated review from an international expert group
  • T6INDIRECT 37340400 ↗Interventions to support mental health in people with long COVID: a scoping review
  • T6INDIRECT 25869016 ↗Abstracts from the 38th annual meeting of the society of general internal medicine
  • T6 29409505 ↗Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue
  • T6 25458588 ↗Cancer-related and treatment-related fatigue
  • T6 29440464 ↗Outcome measures in coeliac disease trials: the Tampere recommendations
  • T6 29102451 ↗Autonomic Dysfunction in Cardiology: Pathophysiology, Investigation, and Management
TAU + multicomponent treatment VIRTUAL SFCAMINA
T2
T2 — RCT in related condition
ME/CFS
1 source
Telerehabilitation
T2
T2 — RCT in related condition
WithdrawnME/CFS
25 sources
  • T2WITHDRAWN NCT05967052 ↗Investigation of Treating Chronic Fatigue Syndrome After COVID With Pharmacotherapy (Pregabalin) or
  • T6INDIRECT 29376559 ↗Physical activity for women with breast cancer after adjuvant therapy
  • T6INDIRECT 37185637 ↗Fatigue outcomes following COVID-19: a systematic review and meta-analysis
  • T6INDIRECT 39603702 ↗Interventions for the management of long covid (post-covid condition): living systematic review
  • T6INDIRECT 36834176 ↗Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review
  • T6INDIRECT 38214047 ↗Rehabilitation and COVID-19: systematic review by Cochrane Rehabilitation
  • T6INDIRECT 32092069 ↗Feasibility of remotely supervised transcranial direct current stimulation and cognitive remediation
  • T6INDIRECT 37344767 ↗Clinical effectiveness of rehabilitation in ambulatory care for patients with persisting symptoms af
  • T6INDIRECT 35206179 ↗Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patie
  • T6INDIRECT 34639600 ↗Efficacy of the FIBROWALK Multicomponent Program Moved to a Virtual Setting for Patients with Fibrom
  • T6HARM 37775758 ↗Multimodal non-invasive non-pharmacological therapies for chronic pain: mechanisms and progress
  • T6 34051516 ↗Physical and mental health complications post-COVID-19: Scoping review
  • T6 32635468 ↗Frailty and COVID-19: A Systematic Scoping Review
  • T6INDIRECT 36246401 ↗Oxidative Stress in Fibromyalgia: From Pathology to Treatment
  • T6INDIRECT 33920796 ↗Frailty in Acute and Chronic Coronary Syndrome Patients Entering Cardiac Rehabilitation
  • T6INDIRECT 36169154 ↗Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of aut
  • T6 36530872 ↗Cardiopulmonary disease as sequelae of long-term COVID-19: Current perspectives and challenges
  • T6 41282339 ↗Frailty and cardiovascular disease: a bidirectional relationship with clinical implications
  • T6 32745277 ↗Abstracts of the Heart Failure 2019 and the World Congress on Acute Heart Failure, 25-28 May 2019, M
  • T6 30480124 ↗Program Abstracts from the 21st International Association of Gerontology and Geriatrics (IAGG) World
  • T6 40726475 ↗11th European Stroke Organisation Conference Abstracts - 21-23 May 2025, Helsinki, Finland
  • T6 36454442 ↗Abstracts of the 52nd Annual Conference of the Italian Society of Neurology
  • T6 38217059 ↗Post-intensive care syndrome follow-up system after hospital discharge: a narrative review
  • T6 38500880 ↗The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches
  • T6 35282780 ↗Registered clinical trials investigating treatment of long COVID: a scoping review and recommendatio
Two-day cardiopulmonary exercise test
T2
T2 — RCT in related condition
ME/CFS
11 sources
  • T2 NCT04026425 ↗Analysis of Post-exertional Malaise Using a Two-day CPET in People With ME/CFS
  • T6 33327624 ↗The Prospects of the Two-Day Cardiopulmonary Exercise Test (CPET) in ME/CFS Patients: A Meta-Analysi
  • T6INDIRECT 27721367 ↗A Pair of Identical Twins Discordant for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Differ i
  • T6 38965566 ↗Cardiopulmonary and metabolic responses during a 2-day CPET in myalgic encephalomyelitis/chronic fat
  • T6 32629923 ↗Two-Day Cardiopulmonary Exercise Testing in Females with a Severe Grade of Myalgic Encephalomyelitis
  • T6 36835097 ↗Urine Metabolomics Exposes Anomalous Recovery after Maximal Exertion in Female ME/CFS Patients
  • T6INDIRECT 36611357 ↗Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-COVID Syndrome: A Common Neuroimmune Gro
  • T4 PPR547740 ↗Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-COVID Syndrome: A Common Neuroimmune Gro
  • T6 41341517 ↗Assessment of symptoms in myalgic encephalomyelitis/chronic fatigue syndrome: a comparative study of
  • T6 27226928 ↗The biological challenge of myalgic encephalomyelitis/chronic fatigue syndrome: a solvable problem
  • T6 PPR356950 ↗Chronic fatigue and post-exertional malaise in people living with long COVID
Waiting list
T2
T2 — RCT in related condition
RegisteredME/CFS
30 sources
  • T2REGISTERED-ONLY NCT05236465 ↗A 3-day Course for CFS/ME
  • T6INDIRECT 22895961 ↗Exercise interventions on health-related quality of life for cancer survivors
  • T6INDIRECT 22895974 ↗Exercise interventions on health-related quality of life for people with cancer during active treatm
  • T6INDIRECT 18646067 ↗Cognitive behaviour therapy for chronic fatigue syndrome in adults
  • T6INDIRECT 29376559 ↗Physical activity for women with breast cancer after adjuvant therapy
  • T6INDIRECT 26358158 ↗Exercise therapy for fatigue in multiple sclerosis
  • T6INDIRECT 18165893 ↗Internet-administered cognitive behavior therapy for health problems: a systematic review
  • T6INDIRECT 33044541 ↗A systematic review of physical activity and quality of life and well-being
  • T6INDIRECT 21549010 ↗A systematic review of different models of home and community care services for older persons
  • T6INDIRECT 8555852 ↗Cognitive behaviour therapy for the chronic fatigue syndrome: a randomized controlled trial
  • T6INDIRECT 15585538 ↗Cognitive behaviour therapy for adolescents with chronic fatigue syndrome: randomised controlled tri
  • T6 17488783 ↗Guidelines on the irritable bowel syndrome: mechanisms and practical management
  • T6 23459093 ↗The Efficacy of Cognitive Behavioral Therapy: A Review of Meta-analyses
  • T6INDIRECT 23990997 ↗Mindfulness-based therapies in the treatment of somatization disorders: a systematic review and meta
  • T6INDIRECT 34770209 ↗Sleep Disorders in Cancer-A Systematic Review
  • T6INDIRECT 34352116 ↗Primary-level worker interventions for the care of people living with mental disorders and distress
  • T6INDIRECT 25358508 ↗Medical management of brain tumors and the sequelae of treatment
  • T6INDIRECT 33151337 ↗COVID-19-related mortality in kidney transplant and dialysis patients: results of the ERACODA collab
  • T6INDIRECT 29073924 ↗Home-based preoperative rehabilitation (prehab) to improve physical function and reduce hospital len
  • T6INDIRECT 24679336 ↗Clinical effectiveness of manual therapy for the management of musculoskeletal and non-musculoskelet
  • T6 23235630 ↗Interventions to facilitate return to work in adults with adjustment disorders
  • T6 32691879 ↗Psychological interventions to foster resilience in healthcare students
  • T6 35561510 ↗How do psychologically based interventions for chronic musculoskeletal pain work? A systematic revie
  • T6 22491774 ↗Infection barriers to successful xenotransplantation focusing on porcine endogenous retroviruses
  • T6 37268741 ↗Irritable bowel syndrome and mental health comorbidity - approach to multidisciplinary management
  • T6 31936597 ↗Assessment of Malnutrition, Sarcopenia and Frailty in Patients with Cirrhosis: Which Tools Should We
  • T6 33553361 ↗A narrative review of central nervous system involvement in acute leukemias
  • T6 14694702 ↗Beyond somatisation: a review of the understanding and treatment of medically unexplained physical s
  • T6 29445285 ↗The effect of exercise on cancer-related fatigue in cancer survivors: a systematic review and meta-a
  • T6 30497279 ↗'People like me don't get support': Autistic adults' experiences of support and treatment for mental
Yan Nian Jiu Zhuan Fa
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT03496961 ↗Yan Nian Jiu Zhuan Fa Improve Chronic Fatigue Syndromes
actigraphy
T2
T2 — RCT in related condition
WithdrawnME/CFS
26 sources
  • T2WITHDRAWN NCT03849326 ↗Chronic Fatigue Etiology in Intensive Care Unit Survivors: the Role of Neuromuscular Function
  • T6INDIRECT 19160308 ↗Psychosocial interventions for reducing fatigue during cancer treatment in adults
  • T6INDIRECT 28444695 ↗Exercise therapy for chronic fatigue syndrome
  • T6INDIRECT 34902819 ↗Sleep, cerebrospinal fluid, and the glymphatic system: A systematic review
  • T6INDIRECT 34770209 ↗Sleep Disorders in Cancer-A Systematic Review
  • T6INDIRECT 33590975 ↗How gait influences frailty models and health-related outcomes in clinical-based and population-base
  • T6INDIRECT 18768089 ↗Biology and therapy of fibromyalgia. Evidence-based biomarkers for fibromyalgia syndrome
  • T6INDIRECT 25515106 ↗Treating Acute Insomnia: A Randomized Controlled Trial of a "Single-Shot" of Cognitive Behavioral Th
  • T6INDIRECT 19884558 ↗One-year outcomes of a behavioral therapy intervention trial on sleep quality and cancer-related fat
  • T6INDIRECT 23618477 ↗Carnosine treatment for gulf war illness: a randomized controlled trial
  • T6INDIRECT 20423926 ↗Treatment of obesity with extension of sleep duration: a randomized, prospective, controlled trial
  • T6 30920354 ↗The Sleep-Immune Crosstalk in Health and Disease
  • T6 21967449 ↗(Mis)perception of sleep in insomnia: a puzzle and a resolution
  • T6INDIRECT 26198889 ↗Postural Tachycardia Syndrome: Beyond Orthostatic Intolerance
  • T6INDIRECT 29628432 ↗Cognitive and psychological issues in postural tachycardia syndrome
  • T6INDIRECT 31760611 ↗Fatigue in Inflammatory Bowel Diseases: Etiologies and Management
  • T6INDIRECT 17397525 ↗Protocol for the PACE trial: a randomised controlled trial of adaptive pacing, cognitive behaviour t
  • T6 35215405 ↗Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Perf
  • T6 32512782 ↗Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older Peo
  • T6 30568608 ↗The Role of Microbiome in Insomnia, Circadian Disturbance and Depression
  • T6 30602059 ↗The role of neuro-immune interactions in cancer-related fatigue: Biobehavioral risk factors and mech
  • T6 29755330 ↗The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-En
  • T6 37494945 ↗The 2023 wearable photoplethysmography roadmap
  • T6 14702202 ↗Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and reco
  • T6 20815187 ↗Fatigue in multiple sclerosis: mechanisms, evaluation, and treatment
  • T6 27070134 ↗Scaling Up Scientific Discovery in Sleep Medicine: The National Sleep Research Resource
anakinra
T2
T2 — RCT in related condition
ME/CFS
25 sources
  • T2 NCT02108210 ↗Cytokine Inhibition in Chronic Fatigue Syndrome Patients
  • T6INDIRECT 31749986 ↗Efficacy and safety of topical and systemic medications: a systematic literature review informing th
  • T6INDIRECT 25603545 ↗Rituximab for rheumatoid arthritis
  • T6INDIRECT 31906979 ↗Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyel
  • T6INDIRECT 33743344 ↗Status epilepticus and COVID-19: A systematic review
  • T6INDIRECT 35359659 ↗Targeting Inflammatory Mediators in Epilepsy: A Systematic Review of Its Molecular Basis and Clinica
  • T6INDIRECT 22151924 ↗Abatacept with methotrexate versus other biologic agents in treatment of patients with active rheuma
  • T6INDIRECT 23599118 ↗Topical interleukin 1 receptor antagonist for treatment of dry eye disease: a randomized clinical tr
  • T6INDIRECT 27086024 ↗A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone i
  • T6INDIRECT 28265678 ↗Cytokine Inhibition in Patients With Chronic Fatigue Syndrome: A Randomized Trial
  • T6INDIRECT 29572107 ↗Reduced Efficacy of Low-dose Topical Steroids in Dry Eye Disease Associated With Graft-versus-Host D
  • T6 29462012 ↗Neuroinflammation and Central Sensitization in Chronic and Widespread Pain
  • T6 30920354 ↗The Sleep-Immune Crosstalk in Health and Disease
  • T6INDIRECT 29260466 ↗Targeting Neuroinflammation to Treat Alzheimer's Disease
  • T6INDIRECT 33584343 ↗Pathogenesis of Multiple Organ Injury in COVID-19 and Potential Therapeutic Strategies
  • T6INDIRECT 33586189 ↗COVID-19: immunopathology, pathophysiological mechanisms, and treatment options
  • T6INDIRECT 32953841 ↗Autoimmunity as the comet tail of COVID-19 pandemic
  • T6INDIRECT 25406359 ↗Indications for IVIG in rheumatic diseases
  • T6INDIRECT 38078329 ↗Neuroinflammation and status epilepticus: a narrative review unraveling a complex interplay
  • T6 32762681 ↗Natural killer cells in cancer biology and therapy
  • T6 33743212 ↗COVID-19 and the human innate immune system
  • T6 37076602 ↗Therapeutic strategies for COVID-19: progress and lessons learned
  • T6 34991982 ↗An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment
  • T6 38816371 ↗Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets
  • T6 35176758 ↗Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus
clonidine
T2
T2 — RCT in related condition
RegisteredME/CFSPOTS
61 sources
  • T2 NCT01507701 ↗Pilot Study for the NorCAPITAL Trial
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T6INDIRECT 23076904 ↗Printed educational materials: effects on professional practice and healthcare outcomes
  • T6INDIRECT 25379990 ↗Pharmacological interventions for somatoform disorders in adults
  • T6INDIRECT 17021301 ↗Interventions for the treatment, management and rehabilitation of patients with chronic fatigue synd
  • T6INDIRECT 31906979 ↗Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyel
  • T6INDIRECT 31478755 ↗Probiotics for Gastrointestinal Symptoms and Quality of Life in Autism: A Placebo-Controlled Pilot T
  • T6INDIRECT 22824921 ↗The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spin
  • T2 24493300 ↗Disease mechanisms and clonidine treatment in adolescent chronic fatigue syndrome: a combined cross-
  • T2 37296432 ↗Effect of propranolol and clonidine after severe traumatic brain injury: a pilot randomized clinical
  • T2 27457818 ↗Genetic variation in catechol-O-methyltransferase modifies effects of clonidine treatment in chronic
  • T2 25887557 ↗The protocol of the Oslo Study of Clonidine in Elderly Patients with Delirium; LUCID: a randomised p
  • T6 35176758 ↗Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus
  • T6 19207771 ↗Postural tachycardia syndrome (POTS)
  • T6INDIRECT 19406310 ↗A systematic review of the management of orthostatic hypotension after spinal cord injury
  • T6INDIRECT 28852322 ↗Acute colonic pseudo-obstruction: A systematic review of aetiology and mechanisms
  • T6INDIRECT 37189381 ↗Dupilumab in Inflammatory Skin Diseases: A Systematic Review
  • T6INDIRECT 23266540 ↗Angiotensin II, independent of plasma renin activity, contributes to the hypertension of autonomic f
  • T6INDIRECT 14695722 ↗Nefopam, a nonsedative benzoxazocine analgesic, selectively reduces the shivering threshold in unane
  • T6INDIRECT 24002370 ↗Effects of norepinephrine reuptake inhibition on postural tachycardia syndrome
  • T6INDIRECT 9819368 ↗Yohimbine in neurally mediated syncope. Pathophysiological implications
  • T6INDIRECT 21876972 ↗Dexmedetomidine for the prevention of shivering during spinal anesthesia
  • T6INDIRECT 33926653 ↗Effect of High Dietary Sodium Intake in Patients With Postural Tachycardia Syndrome
  • T6INDIRECT 9244228 ↗Effects of volume loading and pressor agents in idiopathic orthostatic tachycardia
  • T6 33243837 ↗Autonomic dysfunction in 'long COVID': rationale, physiology and management strategies
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T2 19602964 ↗Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysi
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 26355598 ↗Local Anesthetic Peripheral Nerve Block Adjuvants for Prolongation of Analgesia: A Systematic Qualit
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 24902920 ↗The design and rationale of a multicenter clinical trial comparing two strategies for control of sys
  • T6INDIRECT 16864724 ↗Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis in
  • T6INDIRECT 29133606 ↗Effects of Bariatric Surgery in Obese Patients With Hypertension: The GATEWAY Randomized Trial (Gast
  • T6INDIRECT 18161012 ↗Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse
  • T6INDIRECT 33723532 ↗Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrom
  • T6INDIRECT 26198889 ↗Postural Tachycardia Syndrome: Beyond Orthostatic Intolerance
  • T6INDIRECT 34821709 ↗Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6INDIRECT 32787804 ↗Females with ADHD: An expert consensus statement taking a lifespan approach providing guidance for t
  • T6 21575632 ↗Stress and visceral pain: from animal models to clinical therapies
  • T6 29867317 ↗Current Enlightenment About Etiology and Pharmacological Treatment of Autism Spectrum Disorder
  • T6 33936095 ↗Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity
  • T6 34414219 ↗Antidepressant Drugs Effects on Blood Pressure
  • T6 19789072 ↗Targeting voltage-gated calcium channels for neuropathic pain management
  • T6 38123150 ↗The Concise Guide to PHARMACOLOGY 2023/24: Ion channels
  • T6 22593735 ↗Synaptic regulation of the hypothalamic-pituitary-adrenal axis and its modulation by glucocorticoids
  • T6 29222399 ↗Pediatric Disorders of Orthostatic Intolerance
  • T6 15298528 ↗The burden of illness of irritable bowel syndrome: current challenges and hope for the future
  • T6INDIRECT 22187469 ↗Standards of medical care in diabetes--2012
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
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  • T6INDIRECT 21193625 ↗Standards of medical care in diabetes--2011
  • T6INDIRECT 19118286 ↗Standards of medical care in diabetes--2009
  • T6 33769101 ↗Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
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cognitive behavioural therapy (CBT)
T2
T2 — RCT in related condition
ME/CFS
31 sources
  • T2 NCT00860236 ↗Giardia Induced Fatigue and Functional Gastrointestinal Diseases
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  • T6INDIRECT 29376559 ↗Physical activity for women with breast cancer after adjuvant therapy
  • T6INDIRECT 26358158 ↗Exercise therapy for fatigue in multiple sclerosis
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  • T2 8555852 ↗Cognitive behaviour therapy for the chronic fatigue syndrome: a randomized controlled trial
  • T2 21540202 ↗Self-management of fatigue in rheumatoid arthritis: a randomised controlled trial of group cognitive
  • T2 22385683 ↗Effectiveness of internet-based cognitive behavioural treatment for adolescents with chronic fatigue
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6 34024217 ↗Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments
  • T6INDIRECT 15774430 ↗Depression in multiple sclerosis: a review
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  • T6INDIRECT 36918177 ↗Diagnosis and management of endometriosis
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  • T6 26133313 ↗Interventions for post-stroke fatigue
  • T6 32691879 ↗Psychological interventions to foster resilience in healthcare students
  • T6 34352116 ↗Primary-level worker interventions for the care of people living with mental disorders and distress
  • T6 37268741 ↗Irritable bowel syndrome and mental health comorbidity - approach to multidisciplinary management
  • T6 30560936 ↗Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network
  • T6 16550262 ↗Fatigue in liver disease: pathophysiology and clinical management
  • T6 20550693 ↗Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) mo
  • T6 27159638 ↗Irritable bowel syndrome
  • T6 17488783 ↗Guidelines on the irritable bowel syndrome: mechanisms and practical management
  • T6 35176758 ↗Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus
  • T6 17822818 ↗The cognitive behavioural model of medically unexplained symptoms: a theoretical and empirical revie
  • T6 36178003 ↗World guidelines for falls prevention and management for older adults: a global initiative
  • T6 33166287 ↗Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial i
graded exercise therapy (GET)
T2
T2 — RCT in related condition
ME/CFS
25 sources
  • T2 21334061 ↗Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and spe
  • T6INDIRECT 32093722 ↗Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic encephalom
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  • T6INDIRECT 26359750 ↗Rehabilitative therapies for chronic fatigue syndrome: a secondary mediation analysis of the PACE tr
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
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  • T6INDIRECT 34682909 ↗Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview
  • T6 26133313 ↗Interventions for post-stroke fatigue
  • T6 34991982 ↗An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment
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  • T6 37080828 ↗Long COVID: pathophysiological factors and abnormalities of coagulation
integrative rehabilitation program
T2
T2 — RCT in related condition
ME/CFS
2 sources
  • T2 NCT01806246 ↗A Rehabilitation Program for Adolescents With Chronic Fatigue Syndrome
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isomaltose and magnesium stearate
T2
T2 — RCT in related condition
ME/CFS
2 sources
  • T2 NCT05454683 ↗Melatonin and Zinc Administration on Cardinal Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue
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moxibustion
T2
T2 — RCT in related condition
ME/CFS
25 sources
  • T2 NCT02924831 ↗High-tech Acupuncture for Treatment of Chronic Fatigue Syndrome
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  • T6 37402746 ↗TRP (transient receptor potential) ion channel family: structures, biological functions and therapeu
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  • T6INDIRECT 29020263 ↗2017 HIVMA of IDSA Clinical Practice Guideline for the Management of Chronic Pain in Patients Living
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multicomponent treatment
T2
T2 — RCT in related condition
RegisteredME/CFS
18 sources
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  • T4 PMC9735049 ↗Abstracts of the 18th Congress of the European Geriatric Medicine Society : Live from London and Onl
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  • T6 19835639 ↗Developments in the scientific and clinical understanding of fibromyalgia
  • T6 34476403 ↗Safety and Feasibility of an Interdisciplinary Treatment Approach to Optimize Recovery From Critical
phosphoserine plus vitamin C
T2
T2 — RCT in related condition
ME/CFS
1 source
  • T2 NCT03186027 ↗Coenzyme Q10 Plus NADH Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
probiotics
T2
T2 — RCT in related condition
RegisteredLong COVIDME/CFS
49 sources
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rituximab
T2
T2 — RCT in related condition
RegisteredWithdrawnME/CFS
28 sources
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  • T6 39326415 ↗Mechanisms of long COVID and the path toward therapeutics
standard treatment / treatment as usual
T2
T2 — RCT in related condition
WithdrawnME/CFS
1 source
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transcutaneous VNS
T2
T2 — RCT in related condition
RegisteredME/CFS
7 sources
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valganciclovir
T2
T2 — RCT in related condition
ME/CFS
21 sources
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  • T2 23959519 ↗Randomized clinical trial to evaluate the efficacy and safety of valganciclovir in a subset of patie
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6 30285773 ↗Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
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  • T6INDIRECT 36969241 ↗Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOV
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  • T6 29601503 ↗The Immunomodulatory Capacity of an Epstein-Barr Virus Abortive Lytic Cycle: Potential Contribution