⚠ Provisional — human review required. Tiers are computationally assigned. Per OSMF Grading Methodology §5, every Tier 1/2 entry must be verified against the source paper before publication.
💓 POTS / Dysautonomia

Therapeutic Agents
POTS / Dysautonomia

Evidence-graded candidate agents from the OSMF discovery pipeline. Click any source count to see linked trial and paper references.

379Agents
6Tier 1 (LC RCT)
157Tier 2 (Related RCT)
5404Source entries
Evidence tiers: T1 — RCT in LC/PASC/PACVS T2 — RCT in related condition T3 — Observational in LC T4 — Case series T5 — Case report T6 — Mechanistic / preclinical
379 agents
Celecoxib
T1
T1 — RCT in LC/PASC/PACVS
RegisteredLong COVIDPOTS
44 sources
  • T1REGISTERED-ONLY NCT07597902 ↗SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction
  • T6INDIRECT 36219278 ↗Circulating Tumor DNA, Imaging, and Carcinoembryonic Antigen: Comparison of Surveillance Strategies
  • T6INDIRECT 34659109 ↗COVID-19-Associated Subacute Thyroiditis: Evidence-Based Data From a Systematic Review
  • T6INDIRECT 35893864 ↗The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musc
  • T6INDIRECT 37091856 ↗Subacute thyroiditis following COVID-19: A systematic review
  • T6INDIRECT 35395090 ↗The development of inflammatory arthritis following SARS-CoV-2 infection: a systematic review of the
  • T6INDIRECT 40597703 ↗Subacute thyroiditis as a post-COVID-19 complication: a systematic review
  • T1 37660680 ↗Efficacy and safety of celecoxib monotherapy for treatment of moderate depressive symptoms following
  • T6INDIRECT 41562079 ↗Patient-reported improvements from use of IMC-2 alone and IMC-2 and Paxlovid<sup>®</sup>
  • T6 35039676 ↗Immune targets for therapeutic development in depression: towards precision medicine
  • T6 23988267 ↗Molecular mechanisms underlying chronic inflammation-associated cancers
  • T6 33733315 ↗COVID-19 and the clinical course of rheumatic manifestations
  • T6 32840756 ↗Pain Management During the COVID-19 Pandemic
  • T6INDIRECT 29926477 ↗Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent
  • T6INDIRECT 29694674 ↗Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent
  • T6INDIRECT 24683057 ↗Pharmacological interventions for prevention or treatment of postoperative pain in people undergoing
  • T6INDIRECT 33179245 ↗Alpha-blockers after shock wave lithotripsy for renal or ureteral stones in adults
  • T6INDIRECT 36269595 ↗Antidepressants for hip and knee osteoarthritis
  • T6INDIRECT 31207169 ↗The Efficacy, Tolerability, and Joint Safety of Fasinumab in Osteoarthritis Pain: A Phase IIb/III Do
  • T6INDIRECT 31680610 ↗Outpatient total hip or knee arthroplasty in ambulatory surgery center versus arthroplasty ward: a r
  • T6INDIRECT 24954491 ↗Role of preoperative pain, muscle function, and activity level in discharge readiness after fast-tra
  • T6 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 33409010 ↗Reactive Arthritis After COVID-19 Infection
  • T6INDIRECT 36969241 ↗Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOV
  • T6INDIRECT 33421734 ↗The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacol
  • T6INDIRECT 34015983 ↗SARS-COV-2-related immune-inflammatory thyroid disorders: facts and perspectives
  • T6INDIRECT 36736220 ↗Lung fibrosis: Post-COVID-19 complications and evidences
  • T6 38868666 ↗Alzheimer's disease and its treatment-yesterday, today, and tomorrow
  • T6 39861782 ↗Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques
  • T6 37759498 ↗A Molecular Troika of Angiogenesis, Coagulopathy and Endothelial Dysfunction in the Pathology of Ava
  • T6 37251376 ↗The chemokine landscape: one system multiple shades
  • T6INDIRECT 26084539 ↗International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors
  • T6INDIRECT 20357277 ↗Pain management in the cirrhotic patient: the clinical challenge
  • T6INDIRECT 27973405 ↗Chronic Pain in Children and Adolescents: Diagnosis and Treatment of Primary Pain Disorders in Head,
  • T6INDIRECT 37139824 ↗American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medicatio
  • T6INDIRECT 21445724 ↗European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological
  • T6INDIRECT 23227356 ↗Ehlers-danlos syndrome, hypermobility type: an underdiagnosed hereditary connective tissue disorder
  • T6 20696139 ↗Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic dise
  • T6 23588782 ↗Applications of CYP450 testing in the clinical setting
  • T6 29315692 ↗Comprehensive review of cardiovascular toxicity of drugs and related agents
  • T6 30712918 ↗Type 2 diabetes mellitus and osteoarthritis
  • T6 30578418 ↗Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
  • T6 30354828 ↗Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the Ameri
  • T6 22066560 ↗Why still in hospital after fast-track hip and knee arthroplasty?
Modafinil
T1
T1 — RCT in LC/PASC/PACVS
RegisteredLong COVIDPOTS
57 sources
  • T1 NCT06404086 ↗RECOVER-SLEEP: Platform Protocol
  • T1 NCT06404099 ↗RECOVER-SLEEP: Platform Protocol, Appendix_A (Hypersomnia)
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T2REGISTERED-ONLY NCT01988883 ↗Modafinil and Cognitive Function in POTS
  • T6INDIRECT 39882369 ↗Oral medications for the treatment of postural orthostatic tachycardia syndrome; a systematic review
  • T6INDIRECT 38228914 ↗Connectivity-guided intermittent theta burst versus repetitive transcranial magnetic stimulation for
  • T6INDIRECT 39207396 ↗Undervaluing nondrug rewards or overvaluing cocaine? Cocaine demand relates to cocaine use severity
  • T6 34991982 ↗An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment
  • T6 34390682 ↗Post-COVID-19 Tachycardia Syndrome: A Distinct Phenotype of Post-Acute COVID-19 Syndrome
  • T6INDIRECT 33723532 ↗Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrom
  • T6 33755344 ↗Persistent neurologic symptoms and cognitive dysfunction in non-hospitalized Covid-19 "long haulers"
  • T6 34346558 ↗Multidisciplinary collaborative consensus guidance statement on the assessment and treatment of fati
  • T6 35577469 ↗Telehealth cancer-related fatigue clinic model for cancer survivors: a pilot randomised controlled t
  • T6 38384879 ↗Self-managing symptoms of Long COVID: an education and strategies research protocol
  • T6HARM 35277411 ↗Pharmacological and non-pharmacological interventions for adults with ADHD: protocol for a systemati
  • T6INDIRECT 27153153 ↗Pharmacological treatment for Kleine-Levin syndrome
  • T6INDIRECT 35651342 ↗Sleep Disturbances in Pediatric Craniopharyngioma: A Systematic Review
  • T6INDIRECT 40653179 ↗The evidence for treatments for postural orthostatic tachycardia syndrome: a systematic review of ra
  • T6INDIRECT 41225175 ↗Systematic literature review: treatment of postural orthostatic tachycardia syndrome (POTS)
  • T2 25222185 ↗Hemodynamic profiles and tolerability of modafinil in the treatment of postural tachycardia syndrome
  • T6INDIRECT 37447210 ↗Combination of Chemically Characterized Pomegranate Extract and Hydrophilic Vitamins against Prolong
  • T6 22519513 ↗The solute carrier 6 family of transporters
  • T6INDIRECT 23753844 ↗Postural tachycardia syndrome (POTS)
  • T6 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6 34144933 ↗Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 26447539 ↗Interventions for fatigue in Parkinson's disease
  • T6INDIRECT 36190739 ↗Pharmacological interventions for prevention of weight gain in people with schizophrenia
  • T6INDIRECT 27863901 ↗A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease f
  • T6INDIRECT 32402075 ↗Pharmacological Augmentation in Unipolar Depression: A Guide to the Guidelines
  • T6INDIRECT 36138129 ↗The impact of pharmacological and non-pharmacological interventions on physical health outcomes in p
  • T6INDIRECT 36971690 ↗Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
  • T6INDIRECT 20679638 ↗Atomoxetine for depression and other neuropsychiatric symptoms in Parkinson disease
  • T6INDIRECT 17134849 ↗Safety, tolerability and efficacy of levodopa-carbidopa treatment for cocaine dependence: two double
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6INDIRECT 35853576 ↗Postural orthostatic tachycardia syndrome as a sequela of COVID-19
  • T6INDIRECT 33421734 ↗The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacol
  • T6INDIRECT 36946625 ↗An update on the use of sphingosine 1-phosphate receptor modulators for the treatment of relapsing m
  • T6INDIRECT 36002784 ↗Treatment of Cushing's syndrome with osilodrostat: practical applications of recent studies with cas
  • T6INDIRECT 33681293 ↗Neurological Consequences of SARS-CoV-2 Infection and Concurrence of Treatment-Induced Neuropsychiat
  • T6INDIRECT 36169154 ↗Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of aut
  • T6 39125722 ↗Comprehensive Review of COVID-19: Epidemiology, Pathogenesis, Advancement in Diagnostic and Detectio
  • T6 34646278 ↗Multiple Sclerosis and SARS-CoV-2: Has the Interplay Started?
  • T6 35454890 ↗A New Approach to Understanding Cancer-Related Fatigue: Leveraging the 3P Model to Facilitate Risk P
  • T6 35883527 ↗Pathological Features and Neuroinflammatory Mechanisms of SARS-CoV-2 in the Brain and Potential Ther
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 26084539 ↗International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors
  • T6INDIRECT 19484833 ↗Evidence-based recommendations for the assessment and management of sleep disorders in older persons
  • T6INDIRECT 25200111 ↗Drooling in Parkinson's disease: a review
  • T6INDIRECT 29101940 ↗REM Sleep Behavior Disorder: Diagnosis, Clinical Implications, and Future Directions
  • T6 26595642 ↗Lewy body dementias
  • T6 28837986 ↗Sleep Disturbance, Cognitive Decline, and Dementia: A Review
  • T6 24699931 ↗Non-motor Parkinson's: integral to motor Parkinson's, yet often neglected
  • T6 33924103 ↗Treatment Options for Motor and Non-Motor Symptoms of Parkinson's Disease
  • T6 19603170 ↗Primary biliary cirrhosis
  • T6 23065655 ↗A practical guide to the therapy of narcolepsy and hypersomnia syndromes
  • T6 20815187 ↗Fatigue in multiple sclerosis: mechanisms, evaluation, and treatment
ivabradine
T1
T1 — RCT in LC/PASC/PACVS
RegisteredLong COVIDPOTS
48 sources
  • T1 NCT06305806 ↗RECOVER-AUTONOMIC: Platform Protocol, Appendix B (Ivabradine)
  • T1 NCT06305780 ↗RECOVER-AUTONOMIC Platform Protocol
  • T2REGISTERED-ONLY NCT04186286 ↗Crossover Study of Propranolol vs Ivabradine in POTS
  • T2 NCT05481177 ↗Ivabradine for Long-Term Effects of COVID-19 With POTS Cohort
  • T2 NCT03182725 ↗Effect of Ivabradine on Patients With Postural Orthostatic Tachycardia Syndrome
  • T6 NCT01761825 ↗The Effect of Ivabradine on Patients With Postural Tachycardia Syndrome
  • T6INDIRECT 36349400 ↗Clinical trials on the pharmacological treatment of long COVID: A systematic review
  • T6INDIRECT 38673384 ↗Pathophysiological Mechanisms in Long COVID: A Mixed Method Systematic Review
  • T6INDIRECT 36237182 ↗Graves' disease following vaccination against SARS-CoV-2: A systematic review of the reported cases
  • T6INDIRECT 37094584 ↗Postural Orthostatic Tachycardia Syndrome After COVID-19: A Systematic Review of Therapeutic Interve
  • T6INDIRECT 39882369 ↗Oral medications for the treatment of postural orthostatic tachycardia syndrome; a systematic review
  • T6INDIRECT 39538129 ↗Postural orthostatic tachycardia syndrome after COVID-19 vaccination: A systematic review
  • T6INDIRECT 36549786 ↗Effect of a home-based inspiratory muscle training programme on functional capacity in postdischarge
  • T6INDIRECT 39859026 ↗The Role of Omega-3 Polyunsaturated Fatty Acids in Patients with Metabolic Syndrome and Endothelial
  • T6INDIRECT 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
  • T6 32201335 ↗Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID
  • T6 34024217 ↗Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments
  • T6 35176758 ↗Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus
  • T6INDIRECT 29759520 ↗Ablation of Inappropriate Sinus Tachycardia: A Systematic Review of the Literature
  • T2 29330767 ↗Ivabradine for the Treatment of Postural Orthostatic Tachycardia Syndrome: A Systematic Review
  • T6INDIRECT 36723919 ↗Effect of Personalized Accelerated Pacing on Quality of Life, Physical Activity, and Atrial Fibrilla
  • T2 33602468 ↗Randomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syn
  • T6INDIRECT 37999672 ↗Noninvasive Vagus Nerve Stimulation in Postural Tachycardia Syndrome: A Randomized Clinical Trial
  • T6INDIRECT 37598401 ↗Semi-supervised exercise training program more effective for individuals with postural orthostatic t
  • T6INDIRECT 29217664 ↗Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Re
  • T6INDIRECT 31841279 ↗Central blood pressure for the management of hypertension: Is it a practical clinical tool in curren
  • T6INDIRECT 33723532 ↗Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrom
  • T6INDIRECT 33262898 ↗New-onset Postural Orthostatic Tachycardia Syndrome Following Coronavirus Disease 2019 Infection
  • T6INDIRECT 34821709 ↗Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?
  • T6INDIRECT 35853576 ↗Postural orthostatic tachycardia syndrome as a sequela of COVID-19
  • T6INDIRECT 36969241 ↗Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOV
  • T6 39326415 ↗Mechanisms of long COVID and the path toward therapeutics
  • T6 37907497 ↗The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of lon
  • T6 39125722 ↗Comprehensive Review of COVID-19: Epidemiology, Pathogenesis, Advancement in Diagnostic and Detectio
  • T6 34403043 ↗Autonomic dysfunction in SARS-COV-2 infection acute and long-term implications COVID-19 editor's pag
  • T6 34909198 ↗How COVID-19 can cause autonomic dysfunctions and postural orthostatic syndrome? A Review of mechani
  • T6 36113768 ↗Three-dimensional functional anatomy of the human sinoatrial node for epicardial and endocardial map
  • T6 39536116 ↗Translating insights into therapies for Long Covid
  • T6 34390682 ↗Post-COVID-19 Tachycardia Syndrome: A Distinct Phenotype of Post-Acute COVID-19 Syndrome
  • T6 35307156 ↗2022 ACC Expert Consensus Decision Pathway on Cardiovascular Sequelae of COVID-19 in Adults: Myocard
  • T6INDIRECT 32117030 ↗Posterior Reversible Encephalopathy Syndrome: Clinical Features and Outcome
  • T6INDIRECT 26198889 ↗Postural Tachycardia Syndrome: Beyond Orthostatic Intolerance
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6 29359025 ↗Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment
  • T6 34134525 ↗Recognition, Prevention, and Management of Arrhythmias and Autonomic Disorders in Cardio-Oncology: A
  • T6 33999297 ↗The autonomic nervous system in septic shock and its role as a future therapeutic target: a narrativ
  • T6 28428055 ↗Sex differences in cardiovascular disease - Impact on care and outcomes
  • T6 29222399 ↗Pediatric Disorders of Orthostatic Intolerance
melatonin
T1
T1 — RCT in LC/PASC/PACVS
RegisteredLong COVIDME/CFSPOTS
81 sources
  • T1 NCT06404112 ↗RECOVER-SLEEP: Platform Protocol, Appendix_B (CPSD)
  • T1 NCT06404086 ↗RECOVER-SLEEP: Platform Protocol
  • T2 NCT05454683 ↗Melatonin and Zinc Administration on Cardinal Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue
  • T2 NCT03000777 ↗Oral Melatonin Plus Zinc Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T6INDIRECT 36235869 ↗Vitamin C Supplementation for the Treatment of COVID-19: A Systematic Review and Meta-Analysis
  • T6INDIRECT 38732592 ↗The Efficacy of Multivitamin, Vitamin A, Vitamin B, Vitamin C, and Vitamin D Supplements in the Prev
  • T6INDIRECT 38105461 ↗Outpatient randomized controlled trials to reduce COVID-19 hospitalization: Systematic review and me
  • T6INDIRECT 33205450 ↗Case report and systematic review suggest that children may experience similar long-term effects to
  • T6INDIRECT 33584506 ↗COVID-19 Pathophysiology Predicts That Ischemic Stroke Occurrence Is an Expectation, Not an Exceptio
  • T6INDIRECT 35893864 ↗The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musc
  • T6INDIRECT 37397709 ↗A systematic review of self-medication practice during the COVID-19 pandemic: implications for pharm
  • T6INDIRECT 36334288 ↗Recognizing the psychological impact of a glioma diagnosis on mental and behavioral health: a system
  • T6INDIRECT 34837648 ↗Comparing efficacy and safety of different doses of dexamethasone in the treatment of COVID-19: a th
  • T6INDIRECT 38908733 ↗Fecal Microbiota Transplantation for Sleep Disturbance in Post-acute COVID-19 Syndrome
  • T6 39174535 ↗Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strateg
  • T6 37117704 ↗Wearable chemical sensors for biomarker discovery in the omics era
  • T6INDIRECT 27664125 ↗Adult ADHD and Comorbid Somatic Disease: A Systematic Literature Review
  • T6INDIRECT 34902819 ↗Sleep, cerebrospinal fluid, and the glymphatic system: A systematic review
  • T6INDIRECT 34770209 ↗Sleep Disorders in Cancer-A Systematic Review
  • T6INDIRECT 17021301 ↗Interventions for the treatment, management and rehabilitation of patients with chronic fatigue synd
  • T6INDIRECT 19856109 ↗Biofield therapies: helpful or full of hype? A best evidence synthesis
  • T6INDIRECT 31478755 ↗Probiotics for Gastrointestinal Symptoms and Quality of Life in Autism: A Placebo-Controlled Pilot T
  • T6INDIRECT 22728166 ↗Antioxidant supplementation reduces endometriosis-related pelvic pain in humans
  • T6INDIRECT 25002497 ↗Effect of sleep deprivation on the human metabolome
  • T6INDIRECT 17081700 ↗Stress sensitivity in metastatic breast cancer: analysis of hypothalamic-pituitary-adrenal axis func
  • T6 30920354 ↗The Sleep-Immune Crosstalk in Health and Disease
  • T6 24370461 ↗The role of microbiome in central nervous system disorders
  • T6 29936690 ↗The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer's Disease-a Critica
  • T6INDIRECT 22328094 ↗REM sleep behavior disorder and REM sleep without atonia as an early manifestation of degenerative n
  • T6INDIRECT 33224097 ↗Cyclic Vomiting Syndrome in Children
  • T6INDIRECT 33173517 ↗Perioperative Sleep Disturbances and Postoperative Delirium in Adult Patients: A Systematic Review a
  • T6INDIRECT 36268467 ↗Clinical Features in Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency: A Systematic Review
  • T6INDIRECT 34472659 ↗Movement disorders in patients with Rett syndrome: A systematic review of evidence and associated cl
  • T2 21729284 ↗The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a ra
  • T2 24495468 ↗Melatonin reduces tachycardia in postural tachycardia syndrome: a randomized, crossover trial
  • T6INDIRECT 32986682 ↗The D1/D5 Dopamine Partial Agonist PF-06412562 in Advanced-Stage Parkinson's Disease: A Feasibility
  • T6INDIRECT 36751940 ↗Baseline characteristics of the North American prodromal Synucleinopathy cohort
  • T6 23672628 ↗Understanding the somatic consequences of depression: biological mechanisms and the role of depressi
  • T6 33856918 ↗COVID-19 and Cardiovascular Disease: From Bench to Bedside
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 27863901 ↗A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease f
  • T6INDIRECT 32244523 ↗Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioact
  • T6INDIRECT 23233021 ↗A randomised controlled trial of bumetanide in the treatment of autism in children
  • T6INDIRECT 22549286 ↗Orexin receptor antagonism, a new sleep-enabling paradigm: a proof-of-concept clinical trial
  • T2 22348451 ↗Melatonin pharmacokinetics following two different oral surge-sustained release doses in older adult
  • T6 29075003 ↗Trends in GPCR drug discovery: new agents, targets and indications
  • T6 25731881 ↗Assessment and management of behavioral and psychological symptoms of dementia
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6INDIRECT 35727534 ↗Post-COVID-19 Depressive Symptoms: Epidemiology, Pathophysiology, and Pharmacological Treatment
  • T6INDIRECT 33519510 ↗SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress
  • T6INDIRECT 36464706 ↗Small molecules in the treatment of COVID-19
  • T6INDIRECT 36713204 ↗The role of oxidative stress in the pathogenesis of infections with coronaviruses
  • T6INDIRECT 32637987 ↗The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings
  • T6INDIRECT 35589549 ↗Identifying who has long COVID in the USA: a machine learning approach using N3C data
  • T6 36253560 ↗Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential t
  • T6 36899952 ↗Pathogenesis Underlying Neurological Manifestations of Long COVID Syndrome and Potential Therapeutic
  • T6 34997196 ↗Mechanisms of action of fluvoxamine for COVID-19: a historical review
  • T6 35029046 ↗"LONG COVID"-A hypothesis for understanding the biological basis and pharmacological treatment strat
  • T6 34400495 ↗Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome
  • T6 37080828 ↗Long COVID: pathophysiological factors and abnormalities of coagulation
  • T6INDIRECT 20471738 ↗Sleep disturbance as transdiagnostic: consideration of neurobiological mechanisms
  • T6INDIRECT 23939821 ↗Key role of CRF in the skin stress response system
  • T6INDIRECT 37760929 ↗Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Op
  • T6INDIRECT 31885788 ↗Oxidative Stress Indexes for Diagnosis of Health or Disease in Humans
  • T6INDIRECT 23227356 ↗Ehlers-danlos syndrome, hypermobility type: an underdiagnosed hereditary connective tissue disorder
  • T6 27749086 ↗The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids
  • T6 38185705 ↗Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
  • T6 33918736 ↗Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update
  • T6 30525268 ↗Role of pyroptosis in cardiovascular disease
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 19484833 ↗Evidence-based recommendations for the assessment and management of sleep disorders in older persons
  • T6INDIRECT 31519472 ↗New evidence on the management of Lewy body dementia
  • T6INDIRECT 34741573 ↗Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considera
  • T6INDIRECT 28781611 ↗Best practice in the management of behavioural and psychological symptoms of dementia
  • T6 31710717 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 26595642 ↗Lewy body dementias
  • T6 21034217 ↗Orexin receptors: pharmacology and therapeutic opportunities
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
naltrexone (LDN)
T1
T1 — RCT in LC/PASC/PACVS
RegisteredWithdrawnLong COVIDME/CFSPOTS
65 sources
  • T1REGISTERED-ONLY NCT06366724 ↗LIFT: Life Improvement Trial
  • T2REGISTERED-ONLY NCT07285473 ↗Low-Dose Naltrexone For ME/CFS: Dose-Finding
  • T2WITHDRAWN NCT02965768 ↗Immune Effects of Low-dose Naltrexone in ME/CFS
  • T2REGISTERED-ONLY NCT05363514 ↗Low Dose Naltrexone Use in Patients With POTS
  • T6INDIRECT 39483457 ↗Meta-analysis of natural killer cell cytotoxicity in myalgic encephalomyelitis/chronic fatigue syndr
  • T6INDIRECT 36349400 ↗Clinical trials on the pharmacological treatment of long COVID: A systematic review
  • T6INDIRECT 34658014 ↗Colchicine for the treatment of COVID-19
  • T6INDIRECT 36409650 ↗A systematic review of the biological mediators of fat taste and smell
  • T6INDIRECT 39940333 ↗Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (
  • T6INDIRECT 38554565 ↗Examining inequities in access to opioid agonist treatment (OAT) take-home doses (THD): A Canadian O
  • T6INDIRECT 38360929 ↗Long term outcomes of hyperbaric oxygen therapy in post covid condition: longitudinal follow-up of a
  • T6INDIRECT 36196533 ↗Enhancing Use of Medications for Opioid Use Disorder Through External Coaching
  • T6INDIRECT 38012333 ↗A practice quit model to test early efficacy of medications for alcohol use disorder in a randomized
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T2HARM 30642329 ↗Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a system
  • T6INDIRECT 36690401 ↗Efficacy and safety of hyperbaric oxygen therapy for fibromyalgia: a systematic review and meta-anal
  • T6INDIRECT 27894343 ↗Post-marketing withdrawal of anti-obesity medicinal products because of adverse drug reactions: a sy
  • T6INDIRECT 34352116 ↗Primary-level worker interventions for the care of people living with mental disorders and distress
  • T6INDIRECT 34601272 ↗Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine
  • T6INDIRECT 25879513 ↗Excessive Sugar Consumption May Be a Difficult Habit to Break: A View From the Brain and Body
  • T6INDIRECT 34014691 ↗Applying methods for personalized medicine to the treatment of alcohol use disorder
  • T2 19453963 ↗Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study
  • T6INDIRECT 15834216 ↗Dissection of hypothalamic-pituitary-adrenal axis pathology in 1-month-abstinent alcohol-dependent m
  • T2 31736966 ↗Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natur
  • T6 2683611 ↗Biology of natural killer cells
  • T6INDIRECT 33687070 ↗Smoking cessation for improving mental health
  • T6INDIRECT 37189381 ↗Dupilumab in Inflammatory Skin Diseases: A Systematic Review
  • T6INDIRECT 31702122 ↗Autonomic dysfunction and sudden death in patients with Rett syndrome: a systematic review
  • T6INDIRECT 39882369 ↗Oral medications for the treatment of postural orthostatic tachycardia syndrome; a systematic review
  • T6INDIRECT 39042627 ↗Six-year follow-up of participants in two clinical trials of rituximab or cyclophosphamide in Myalgi
  • T6 34942142 ↗The neuropsychiatry of Parkinson's disease: advances and challenges
  • T6 34067776 ↗Post-COVID-19 Syndrome and the Potential Benefits of Exercise
  • T6 35172971 ↗Risks of mental health outcomes in people with covid-19: cohort study
  • T6INDIRECT 28922704 ↗Direct-acting antivirals for chronic hepatitis C
  • T6INDIRECT 23450540 ↗Methadone at tapered doses for the management of opioid withdrawal
  • T6INDIRECT 20680369 ↗A systematic review on the effectiveness of pharmacological interventions for chronic non-specific l
  • T6INDIRECT 35234292 ↗Pharmacotherapy for post traumatic stress disorder (PTSD)
  • T6INDIRECT 18161012 ↗Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse
  • T6INDIRECT 25827659 ↗A pilot trial of prazosin, an alpha-1 adrenergic antagonist, for comorbid alcohol dependence and pos
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 36100326 ↗Analysis of post COVID-19 condition and its overlap with myalgic encephalomyelitis/chronic fatigue s
  • T6INDIRECT 36464706 ↗Small molecules in the treatment of COVID-19
  • T6INDIRECT 36969241 ↗Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOV
  • T6 36899952 ↗Pathogenesis Underlying Neurological Manifestations of Long COVID Syndrome and Potential Therapeutic
  • T6 37907497 ↗The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of lon
  • T6 33240091 ↗Challenges for Drug Repurposing in the COVID-19 Pandemic Era
  • T5 31911410 ↗Low-dose naltrexone as a treatment for chronic fatigue syndrome
  • T6INDIRECT 37445634 ↗Laboratory Findings and Biomarkers in Long COVID: What Do We Know So Far? Insights into Epidemiology
  • T6INDIRECT 36169154 ↗Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of aut
  • T6 29462012 ↗Neuroinflammation and Central Sensitization in Chronic and Widespread Pain
  • T6 29867317 ↗Current Enlightenment About Etiology and Pharmacological Treatment of Autism Spectrum Disorder
  • T6 37069462 ↗Microglia polarization in nociplastic pain: mechanisms and perspectives
  • T6 30146050 ↗Pain Modulation: From Conditioned Pain Modulation to Placebo and Nocebo Effects in Experimental and
  • T6 33062901 ↗Exercise-induced hypoalgesia after acute and regular exercise: experimental and clinical manifestati
  • T6 30223011 ↗Brain glial activation in fibromyalgia - A multi-site positron emission tomography investigation
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 24433463 ↗Review of pharmacological therapies in fibromyalgia syndrome
  • T6 19345246 ↗Opioid receptors in the gastrointestinal tract
  • T6 31387301 ↗Mechanisms of Botulinum Toxin Type A Action on Pain
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 30291106 ↗Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes As
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
pyridostigmine
T1
T1 — RCT in LC/PASC/PACVS
Harm signalRegisteredLong COVIDPOTS
57 sources
  • T1REGISTERED-ONLY NCT06366724 ↗LIFT: Life Improvement Trial
  • T2REGISTERED-ONLY NCT03124355 ↗Vagal Stimulation in POTS
  • T2 NCT03261570 ↗Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTS
  • T2HARM NCT03674541 ↗The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chroni
  • T6REGISTERED-ONLY NCT00409435 ↗A Study of Pyridostigmine in Postural Tachycardia Syndrome
  • T6INDIRECT 39882369 ↗Oral medications for the treatment of postural orthostatic tachycardia syndrome; a systematic review
  • T6INDIRECT 39538129 ↗Postural orthostatic tachycardia syndrome after COVID-19 vaccination: A systematic review
  • T6INDIRECT 40426137 ↗Inspiratory muscle training and aerobic exercise for respiratory muscle strength in myasthenia gravi
  • T6INDIRECT 33460984 ↗Impact of COVID-19 pandemic and lockdown in a cohort of myasthenia gravis patients in India
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6 34024217 ↗Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments
  • T6 33595463 ↗COVID-19 and Eye: A Review of Ophthalmic Manifestations of COVID-19
  • T6 34991982 ↗An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment
  • T6INDIRECT 33723532 ↗Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrom
  • T6INDIRECT 15911704 ↗Acetylcholinesterase inhibition improves tachycardia in postural tachycardia syndrome
  • T6INDIRECT 22677718 ↗A randomised controlled study of the effect of cholinesterase inhibition on colon function in patien
  • T6INDIRECT 23978222 ↗A double-blind placebo-controlled cross-over study of the vascular effects of midodrine in neuropath
  • T2 18240245 ↗A six-month randomized controlled trial of exercise and pyridostigmine in the treatment of fibromyal
  • T2 29500811 ↗Efficacy of Propranolol, Bisoprolol, and Pyridostigmine for Postural Tachycardia Syndrome: a Randomi
  • T6INDIRECT 19506222 ↗Efficacy of immunotherapy in seropositive and seronegative putative autoimmune autonomic ganglionopa
  • T6INDIRECT 26387781 ↗Effect of neostigmine on gastroduodenal motility in patients with suspected gastrointestinal motilit
  • T6INDIRECT 17016160 ↗Acetylcholinesterase inhibition in patients with orthostatic intolerance
  • T6INDIRECT 23116538 ↗Treatment of multiple system atrophy using intravenous immunoglobulin
  • T6HARM 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 34752479 ↗Drug-induced orthostatic hypotension: A systematic review and meta-analysis of randomised controlled
  • T6INDIRECT 22591985 ↗Efficacy of treatments for orthostatic hypotension: a systematic review
  • T6INDIRECT 31214762 ↗Aspects of vincristine-induced neuropathy in hematologic malignancies: a systematic review
  • T2 16476804 ↗Pyridostigmine treatment trial in neurogenic orthostatic hypotension
  • T2 20837887 ↗Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotensio
  • T6INDIRECT 12933939 ↗Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic hypoten
  • T6INDIRECT 33262898 ↗New-onset Postural Orthostatic Tachycardia Syndrome Following Coronavirus Disease 2019 Infection
  • T6INDIRECT 33047223 ↗New onset of ocular myasthenia gravis in a patient with COVID-19: a novel case report and literature
  • T6INDIRECT 34821709 ↗Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?
  • T6INDIRECT 34216297 ↗COVID-19 and Myositis: What We Know So Far
  • T6 33240091 ↗Challenges for Drug Repurposing in the COVID-19 Pandemic Era
  • T6 36174571 ↗Bioelectronic medicine: Preclinical insights and clinical advances
  • T6 38534355 ↗Recent Research Trends in Neuroinflammatory and Neurodegenerative Disorders
  • T6 38887284 ↗Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: the biology of a neglected disease
  • T6 37028776 ↗Neuroimmune nexus in the pathophysiology and therapy of inflammatory disorders: Role of α7 nicotinic
  • T6 39444797 ↗Understanding autoimmune response after SARS-CoV-2 infection and the pathogenesis/mechanisms of long
  • T6 34390682 ↗Post-COVID-19 Tachycardia Syndrome: A Distinct Phenotype of Post-Acute COVID-19 Syndrome
  • T6INDIRECT 29508455 ↗Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
  • T6INDIRECT 23186897 ↗Transverse myelitis
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6 26493934 ↗Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effe
  • T6 28303218 ↗The modification of natural products for medical use
  • T6 29717928 ↗Impact of the Autonomic Nervous System on the Skeleton
  • T6 30793549 ↗Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: W
  • T6 33924103 ↗Treatment Options for Motor and Non-Motor Symptoms of Parkinson's Disease
  • T6 29359025 ↗Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment
  • T6 21962754 ↗Multiple system atrophy: a clinical and neuropathological perspective
  • T6 34134525 ↗Recognition, Prevention, and Management of Arrhythmias and Autonomic Disorders in Cardio-Oncology: A
  • T6 20103559 ↗Cardiac autonomic neuropathy in diabetes: a clinical perspective
  • T6 28050656 ↗The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic o
  • T6 23122672 ↗Postural tachycardia syndrome: a heterogeneous and multifactorial disorder
  • T6 19207771 ↗Postural tachycardia syndrome (POTS)
Abdominal Compression Garments
T2
T2 — RCT in related condition
RegisteredPOTS
3 sources
  • T2REGISTERED-ONLY NCT04881318 ↗Compression Garments in the Community With POTS
  • T2 41338488 ↗Abdominal-only Compression Garments Reduce Orthostatic Tachycardia and Improve Symptoms in Patients
  • T6 39685762 ↗Current Landscape of Compression Products for Treatment of Postural Orthostatic Tachycardia Syndrome
Abdominal binder
T2
T2 — RCT in related condition
RegisteredPOTS
30 sources
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T6INDIRECT 19406310 ↗A systematic review of the management of orthostatic hypotension after spinal cord injury
  • T6INDIRECT 37930742 ↗Thermal stability and storage of human insulin
  • T6INDIRECT 20552588 ↗Clinostatic hypertension and orthostatic hypotension
  • T6INDIRECT 24944260 ↗Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial
  • T6INDIRECT 23616163 ↗Low-dose propranolol and exercise capacity in postural tachycardia syndrome: a randomized study
  • T2 25448247 ↗Effects of patient-controlled abdominal compression on standing systolic blood pressure in adults wi
  • T6INDIRECT 34657222 ↗Safety and efficacy of ampreloxetine in symptomatic neurogenic orthostatic hypotension: a phase 2 tr
  • T6INDIRECT 32673517 ↗Splanchnic Venous Compression Enhances the Effects of ß-Blockade in the Treatment of Postural Tachyc
  • T6INDIRECT 39294522 ↗Atomoxetine on neurogenic orthostatic hypotension: a randomized, double-blind, placebo-controlled cr
  • T2 41483109 ↗A Portable, Active Abdominal Compression Binder for Orthostatic Intolerance: Design and Evaluation i
  • T6 23122672 ↗Postural tachycardia syndrome: a heterogeneous and multifactorial disorder
  • T6 19207771 ↗Postural tachycardia syndrome (POTS)
  • T6INDIRECT 27271310 ↗Efficacy of Servo-Controlled Splanchnic Venous Compression in the Treatment of Orthostatic Hypotensi
  • T6INDIRECT 37045845 ↗A case study of percutaneous epidural stimulation to enable motor control in two men after spinal co
  • T6INDIRECT 29508455 ↗Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
  • T6INDIRECT 30001836 ↗Exercise and non-pharmacological treatment of POTS
  • T6INDIRECT 34295184 ↗The American Society of Pain and Neuroscience (ASPN) Best Practices and Guidelines for the Intervent
  • T6INDIRECT 29058089 ↗Evidence-based treatment of neurogenic orthostatic hypotension and related symptoms
  • T6INDIRECT 21664375 ↗Pharmacotherapy of autonomic failure
  • T6INDIRECT 34144933 ↗Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019
  • T6INDIRECT 28713844 ↗Epidemiology, Diagnosis, and Management of Neurogenic Orthostatic Hypotension
  • T6 26595642 ↗Lewy body dementias
  • T6 27495201 ↗Diagnostic Approach to Atypical Parkinsonian Syndromes
  • T6 23472781 ↗Medical therapy and physical maneuvers in the treatment of the vasovagal syncope and orthostatic hyp
  • T6 24265239 ↗Concepts of scientific integrative medicine applied to the physiology and pathophysiology of catecho
  • T6 32767032 ↗Current Management and Emerging Therapies in Multiple System Atrophy
  • T6 38390594 ↗Dysautonomia following Lyme disease: a key component of post-treatment Lyme disease syndrome?
  • T6 28050656 ↗The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic o
  • T6 18420158 ↗Management of neurogenic orthostatic hypotension: an update
Abdominal compression
T2
T2 — RCT in related condition
POTS
27 sources
  • T6INDIRECT 32773495 ↗Effectiveness of non-pharmacological interventions to treat orthostatic hypotension in elderly peopl
  • T6INDIRECT 24659590 ↗Compression therapy in patients with orthostatic hypotension: a systematic review
  • T2 17010806 ↗Lower limb and abdominal compression bandages prevent progressive orthostatic hypotension in elderly
  • T6INDIRECT 9430805 ↗Efficacy of compression of different capacitance beds in the amelioration of orthostatic hypotension
  • T6INDIRECT 27271310 ↗Efficacy of Servo-Controlled Splanchnic Venous Compression in the Treatment of Orthostatic Hypotensi
  • T6INDIRECT 33478652 ↗Compression Garment Reduces Orthostatic Tachycardia and Symptoms in Patients With Postural Orthostat
  • T2 25448247 ↗Effects of patient-controlled abdominal compression on standing systolic blood pressure in adults wi
  • T2 15241645 ↗Use of lower abdominal compression to combat orthostatic hypotension in patients with autonomic dysf
  • T6INDIRECT 16096819 ↗Effect of physical countermaneuvers on orthostatic hypotension in familial dysautonomia
  • T6 10432334 ↗Pathophysiological basis of orthostatic hypotension in autonomic failure
  • T6INDIRECT 36981522 ↗A Case Study of Successful Application of the Principles of ME/CFS Care to an Individual with Long C
  • T6INDIRECT 26198889 ↗Postural Tachycardia Syndrome: Beyond Orthostatic Intolerance
  • T6INDIRECT 30001836 ↗Exercise and non-pharmacological treatment of POTS
  • T6INDIRECT 29058089 ↗Evidence-based treatment of neurogenic orthostatic hypotension and related symptoms
  • T6INDIRECT 25323828 ↗Current treatments in familial dysautonomia
  • T6INDIRECT 36074973 ↗Sinus Tachycardia: a Multidisciplinary Expert Focused Review
  • T6INDIRECT 34321060 ↗Improving lung compliance by external compression of the chest wall
  • T6 39827884 ↗Radiotherapy toxicities: mechanisms, management, and future directions
  • T6 39130717 ↗Clinical Applications of Pressure-Volume Assessment in Congenital Heart Disease
  • T6 25824068 ↗Drug therapies in older adults (part 2)
  • T6 40843281 ↗Orthostatic hypotension in Parkinson's disease: therapeutic considerations
  • T6 37303338 ↗Ampreloxetine Versus Droxidopa in Neurogenic Orthostatic Hypotension: A Comparative Review
  • T6 35591450 ↗Assessment of Abdominal Constrictor's Forces for Informing Computational Models of Orthostatic Hypot
  • T6 20439562 ↗Preventing and treating orthostatic hypotension: As easy as A, B, C
  • T6 26174784 ↗Orthostatic Hypotension: Mechanisms, Causes, Management
  • T6 35212554 ↗Orthostatic Hypotension: Management of a Complex, But Common, Medical Problem
  • T6 25538626 ↗Syncope: epidemiology, etiology, and prognosis
Acetazolamide
T2
T2 — RCT in related condition
RegisteredPOTS
31 sources
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T6INDIRECT 37147116 ↗Multidisciplinary consensus guideline for the diagnosis and management of spontaneous intracranial h
  • T6INDIRECT 33224097 ↗Cyclic Vomiting Syndrome in Children
  • T6INDIRECT 34671311 ↗Visual Snow Syndrome as a Network Disorder: A Systematic Review
  • T6INDIRECT 30053970 ↗Respiratory care in familial dysautonomia: Systematic review and expert consensus recommendations
  • T6INDIRECT 31832265 ↗Slow Orthostatic Tremor: Review of the Current Evidence
  • T6INDIRECT 40299270 ↗Spinocerebellar ataxia 27B (SCA27B)-a systematic review and a case report of a Polish family
  • T6INDIRECT 39756820 ↗Right ventricular strain impairment due to hypoxia in patients with COPD: a post hoc analysis of two
  • T6 32792490 ↗Podocytopathies
  • T6 37230968 ↗Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
  • T6 30177711 ↗Carboxysome encapsulation of the CO<sub>2</sub>-fixing enzyme Rubisco in tobacco chloroplasts
  • T6 31695035 ↗A combination of chitooligosaccharide and lipochitooligosaccharide recognition promotes arbuscular m
  • T6 26846157 ↗The NIH Undiagnosed Diseases Program and Network: Applications to modern medicine
  • T6INDIRECT 31794067 ↗Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in pe
  • T6INDIRECT 36827524 ↗Systemic pharmacological interventions for Ménière's disease
  • T6INDIRECT 35897016 ↗Neurological vertigo in the emergency room in pediatric and adult age: systematic literature review
  • T6INDIRECT 29440005 ↗Interaction Between the Sodium-Glucose-Linked Transporter 2 Inhibitor Dapagliflozin and the Loop Diu
  • T6INDIRECT 31841279 ↗Central blood pressure for the management of hypertension: Is it a practical clinical tool in curren
  • T6INDIRECT 10219753 ↗Neurotrophic factors in peripheral neuropathies: therapeutic implications
  • T6INDIRECT 30961531 ↗Primary headaches during lifespan
  • T6INDIRECT 24381726 ↗Glaucoma management: relative value and place in therapy of available drug treatments
  • T6INDIRECT 26132530 ↗Primary and secondary ataxias
  • T6INDIRECT 28031858 ↗Medical treatment of dystonia
  • T6INDIRECT 32443735 ↗Clinical and Genetic Overview of Paroxysmal Movement Disorders and Episodic Ataxias
  • T6INDIRECT 36787124 ↗Cardiorenal Syndrome in the Hospital
  • T6INDIRECT 19730409 ↗Guidelines for the Prevention and Treatment of Opportunistic Infections among HIV-exposed and HIV-in
  • T6 20978471 ↗The relationship between blood pressure and cognitive function
  • T6 31141884 ↗Natural Antioxidant Anthocyanins-A Hidden Therapeutic Candidate in Metabolic Disorders with Major Fo
  • T6 36152050 ↗The inherited cerebellar ataxias: an update
  • T6 27403447 ↗Cerebral blood flow and autoregulation: current measurement techniques and prospects for noninvasive
  • T6 28050656 ↗The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic o
Acoustic vagal nerve stimulation treatment
T2
T2 — RCT in related condition
RegisteredPOTS
1 source
  • T2REGISTERED-ONLY NCT05212129 ↗Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome
Aerobic Training
T2
T2 — RCT in related condition
POTS
32 sources
  • T2 NCT05404672 ↗Breathing Exercises With And Without Aerobic Training In Patients With Postural Orthostatic Tachycar
  • T6INDIRECT 37725376 ↗Rehabilitation Interventions for Physical Capacity and Quality of Life in Adults With Post-COVID-19
  • T6INDIRECT 31651868 ↗Evidence of altered cardiac autonomic regulation in myalgic encephalomyelitis/chronic fatigue syndro
  • T6INDIRECT 34579012 ↗Positive Effects of Exercise Intervention without Weight Loss and Dietary Changes in NAFLD-Related C
  • T6INDIRECT 36032234 ↗Post-COVID-19 fatigue: A systematic review
  • T6INDIRECT 31076938 ↗Physical activity and dietary interventions in diabetic neuropathy: a systematic review
  • T6INDIRECT 35893864 ↗The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musc
  • T6INDIRECT 23531226 ↗Exercise training in childhood-onset systemic lupus erythematosus: a controlled randomized trial
  • T6INDIRECT 33652910 ↗The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metaboli
  • T6INDIRECT 32198423 ↗Effects of exergames on heart rate variability of women with fibromyalgia: A randomized controlled t
  • T6INDIRECT 37717560 ↗Impact of 14 Days of Bed Rest in Older Adults and an Exercise Countermeasure on Body Composition, Mu
  • T6 34942142 ↗The neuropsychiatry of Parkinson's disease: advances and challenges
  • T6 30018614 ↗Immune System Dysregulation During Spaceflight: Potential Countermeasures for Deep Space Exploration
  • T6INDIRECT 30191554 ↗Interventions for preventing falls in older people in care facilities and hospitals
  • T6INDIRECT 24018704 ↗Physiotherapy versus placebo or no intervention in Parkinson's disease
  • T6INDIRECT 24748784 ↗Physical activity and cognitive function in individuals over 60 years of age: a systematic review
  • T6INDIRECT 36602886 ↗Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis
  • T6INDIRECT 25229735 ↗A randomized trial of functional electrical stimulation for walking in incomplete spinal cord injury
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 35679471 ↗Human temperature regulation under heat stress in health, disease, and injury
  • T6INDIRECT 24567799 ↗Cardiac autonomic neuropathy in patients with diabetes mellitus
  • T6INDIRECT 26715466 ↗The Therapeutic Potential of Exercise to Improve Mood, Cognition, and Sleep in Parkinson's Disease
  • T6INDIRECT 25274845 ↗Cerebrovascular regulation, exercise, and mild traumatic brain injury
  • T6 29785098 ↗Sarcopenia: assessment of disease burden and strategies to improve outcomes
  • T6 27366343 ↗Pathophysiology of Motor Dysfunction in Parkinson's Disease as the Rationale for Drug Treatment and
  • T6 30793549 ↗Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: W
  • T6 25514304 ↗The diagnosis and management of mild cognitive impairment: a clinical review
  • T6 21115758 ↗Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Asso
  • T6 34409961 ↗International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines
  • T6 33909761 ↗Brazilian Guidelines of Hypertension - 2020
Albumin
T2
T2 — RCT in related condition
POTS
33 sources
  • T2 NCT03919773 ↗IVIG (Gamunex-C) Treatment Study for POTS Subjects
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 23013600 ↗Associations of kidney disease measures with mortality and end-stage renal disease in individuals wi
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30019766 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30521670 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 32840686 ↗Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cas
  • T6INDIRECT 25233067 ↗Systematic review of potential health risks posed by pharmaceutical, occupational and consumer expos
  • T6INDIRECT 34017846 ↗Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic
  • T6INDIRECT 32855289 ↗Guillain-Barré syndrome in SARS-CoV-2 infection: an instant systematic review of the first six month
  • T6INDIRECT 28893208 ↗Trial design and rationale for APOLLO, a Phase 3, placebo-controlled study of patisiran in patients
  • T6 6326753 ↗Oxygen toxicity, oxygen radicals, transition metals and disease
  • T6 28585944 ↗Cellular uptake of nanoparticles: journey inside the cell
  • T6INDIRECT 26551272 ↗A Randomized Trial of Intensive versus Standard Blood-Pressure Control
  • T6INDIRECT 20228401 ↗Effects of intensive blood-pressure control in type 2 diabetes mellitus
  • T6INDIRECT 27195814 ↗Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75
  • T6INDIRECT 32409561 ↗Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, ra
  • T6INDIRECT 20566676 ↗Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and e
  • T6INDIRECT 24067431 ↗Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflo
  • T6INDIRECT 24902920 ↗The design and rationale of a multicenter clinical trial comparing two strategies for control of sys
  • T6INDIRECT 23464594 ↗Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease
  • T6INDIRECT 28642330 ↗Effects of Intensive BP Control in CKD
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 22187469 ↗Standards of medical care in diabetes--2012
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 23264422 ↗Standards of medical care in diabetes--2013
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 21193625 ↗Standards of medical care in diabetes--2011
  • T6INDIRECT 19118286 ↗Standards of medical care in diabetes--2009
  • T6 36148880 ↗Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes As
  • T6 21092187 ↗Fabry disease
  • T6 30291106 ↗Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes As
Albumin 5%, USP
T2
T2 — RCT in related condition
WithdrawnPOTS
1 source
  • T2WITHDRAWN NCT03365414 ↗A Study to Systematically Assess the Efficacy and Safety of Intravenous Albumin Infusions in Severe
Aliskiren
T2
T2 — RCT in related condition
POTS
28 sources
  • T6INDIRECT 24869750 ↗Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension
  • T6INDIRECT 32519776 ↗Withdrawal of antihypertensive drugs in older people
  • T6INDIRECT 30480768 ↗First-line drugs inhibiting the renin angiotensin system versus other first-line antihypertensive dr
  • T6INDIRECT 31167038 ↗Pharmacotherapy for hypertension in adults 60 years or older
  • T2 21236483 ↗Aliskiren and the calcium channel blocker amlodipine combination as an initial treatment strategy fo
  • T6INDIRECT 27113485 ↗Phosphodiesterase Type 5 Inhibition Reduces Albuminuria in Subjects with Overt Diabetic Nephropathy
  • T2 23999456 ↗Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized
  • T2 19527323 ↗Combination therapy with various combinations of aliskiren, valsartan, and hydrochlorothiazide in hy
  • T2 17118124 ↗Aliskiren, a novel orally effective renin inhibitor, exhibits similar pharmacokinetics and pharmacod
  • T6 23552514 ↗Chinese herbal formulas for treating hypertension in traditional Chinese medicine: perspective of mo
  • T6INDIRECT 32103487 ↗Pharmacological interventions for heart failure in people with chronic kidney disease
  • T6INDIRECT 25565857 ↗Safety and effectiveness of a fixed-dose combination of olmesartan, amlodipine, and hydrochlorothiaz
  • T6INDIRECT 24093037 ↗Reducing pill burden and helping with medication awareness to improve adherence
  • T6INDIRECT 32925078 ↗COVID-19: Review of a 21st Century Pandemic from Etiology to Neuro-psychiatric Implications
  • T6INDIRECT 32880078 ↗Therapeutics for COVID-19: from computation to practices-where we are, where we are heading to
  • T6INDIRECT 33086572 ↗Age-Related Diseases and Driving Safety
  • T6INDIRECT 34094953 ↗The Use of Antihypertensive Drugs as Coadjuvant Therapy in Cancer
  • T6 34948113 ↗Genophenotypic Factors and Pharmacogenomics in Adverse Drug Reactions
  • T6 33708784 ↗Therapeutic Insights in Chronic Kidney Disease Progression
  • T6 26569322 ↗Renin-Angiotensin-Aldosterone System Blockade in Diabetic Nephropathy. Present Evidences
  • T6 37022667 ↗Sparsentan: First Approval
  • T6 34327491 ↗Ten things to know about ten cardiovascular disease risk factors
  • T6 28056987 ↗Blood pressure control in type 2 diabetic patients
  • T6 30425103 ↗Clinical Pharmacology of Antihypertensive Therapy for the Treatment of Hypertension in CKD
  • T6 35517870 ↗Ten things to know about ten cardiovascular disease risk factors - 2022
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
  • T6 33909761 ↗Brazilian Guidelines of Hypertension - 2020
  • T6 31388453 ↗2018 Korean Society of Hypertension Guidelines for the management of hypertension: part II-diagnosis
Alumnium Pot
T2
T2 — RCT in related condition
WithdrawnPOTS
1 source
  • T2WITHDRAWN NCT02341300 ↗Use of Cast Iron Pots to Improve Maternal Anemia
Ampreloxetine
T2
T2 — RCT in related condition
POTS
20 sources
  • T2 34657222 ↗Safety and efficacy of ampreloxetine in symptomatic neurogenic orthostatic hypotension: a phase 2 tr
  • T6INDIRECT 39294522 ↗Atomoxetine on neurogenic orthostatic hypotension: a randomized, double-blind, placebo-controlled cr
  • T6INDIRECT 41134458 ↗Establishing minimally clinically important differences for the orthostatic hypotension questionnair
  • T6 32741777 ↗Parkinson's Disease Drug Therapies in the Clinical Trial Pipeline: 2020
  • T6 31733702 ↗Orthostatic Hypotension in Parkinson Disease
  • T6 36467081 ↗Treatment of ADHD: Drugs, psychological therapies, devices, complementary and alternative methods as
  • T6INDIRECT 31996627 ↗Management of Orthostatic Hypotension
  • T6 34403043 ↗Autonomic dysfunction in SARS-COV-2 infection acute and long-term implications COVID-19 editor's pag
  • T6 PMC10056828 ↗Interventions for orthostatic hypotension in Parkinson's disease: a systematic review and network me
  • T6INDIRECT 32767032 ↗Current Management and Emerging Therapies in Multiple System Atrophy
  • T6INDIRECT 32316335 ↗Current Symptomatic and Disease-Modifying Treatments in Multiple System Atrophy
  • T6INDIRECT 36376534 ↗Updates on the Diagnosis and Treatment of Peripheral Autonomic Neuropathies
  • T6INDIRECT 32906173 ↗Clinical Trials for Neurogenic Orthostatic Hypotension: A Comprehensive Review of Endpoints, Pitfall
  • T6INDIRECT 38766862 ↗Norepinephrine Reuptake Inhibition, an Emergent Treatment for Neurogenic Orthostatic Hypotension
  • T6INDIRECT 39027973 ↗Treating Lows: Management of Orthostatic Hypotension
  • T4 37303338 ↗Ampreloxetine Versus Droxidopa in Neurogenic Orthostatic Hypotension: A Comparative Review
  • T6 39120318 ↗The Potential of Metabolomics to Find Proper Biomarkers for Addressing the Neuroprotective Efficacy
  • T6 34564798 ↗32nd International Symposium on the Autonomic Nervous System
  • T6 35293295 ↗Advances in the Pharmacological and Non-pharmacological Management of Non-motor Symptoms in Parkinso
  • T6 35614479 ↗The role of basket trials in drug development for neurodegenerative disorders
Angiotensin II
T2
T2 — RCT in related condition
POTS
29 sources
  • T2 NCT00962949 ↗The Renin-Aldosterone Axis in Postural Tachycardia Syndrome
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30019766 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 34509649 ↗Post-COVID syndrome. A case series and comprehensive review
  • T6INDIRECT 30521670 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 39774607 ↗Mucosal immune response in biology, disease prevention and treatment
  • T2 23266540 ↗Angiotensin II, independent of plasma renin activity, contributes to the hypertension of autonomic f
  • T6INDIRECT 26607249 ↗Effects of sodium nitrite supplementation on vascular function and related small metabolite signatur
  • T6INDIRECT 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6 34248921 ↗Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Con
  • T6 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6INDIRECT 28816346 ↗Homocysteine-lowering interventions for preventing cardiovascular events
  • T6INDIRECT 34352984 ↗2021 Clinical Practice Guidelines for Diabetes Mellitus of the Korean Diabetes Association
  • T6INDIRECT 27195814 ↗Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75
  • T6INDIRECT 29499873 ↗Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihype
  • T6INDIRECT 1540729 ↗Renal protective effect of enalapril in diabetic nephropathy
  • T6INDIRECT 21993710 ↗Effects of olmesartan on renal and cardiovascular outcomes in type 2 diabetes with overt nephropathy
  • T6INDIRECT 17923654 ↗Effect of perindopril on physical function in elderly people with functional impairment: a randomize
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6 29075003 ↗Trends in GPCR drug discovery: new agents, targets and indications
  • T6 29565029 ↗Hypertension
  • T6 33769101 ↗Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
  • T6 31710717 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors
Aquatic Occupational Therapy
T2
T2 — RCT in related condition
POTS
1 source
Assessment of splanchnic capacitance
T2
T2 — RCT in related condition
POTS
1 source
Atenolol
T2
T2 — RCT in related condition
WithdrawnPOTS
32 sources
  • T2WITHDRAWN NCT03070730 ↗Hemodynamic Response of Neuropathic And Non-Neuropathic POTS Patients To Adrenoreceptor Agonist And
  • T6INDIRECT 34307254 ↗Hypertension in Children and Adolescents: A Position Statement From a Panel of Multidisciplinary Exp
  • T6INDIRECT 31788462 ↗Efficacy of β-Blockers on Postural Tachycardia Syndrome in Children and Adolescents: A Systematic Re
  • T6INDIRECT 39882369 ↗Oral medications for the treatment of postural orthostatic tachycardia syndrome; a systematic review
  • T6INDIRECT 25267802 ↗Nebivolol, but not metoprolol, lowers blood pressure in nitric oxide-sensitive human hypertension
  • T6INDIRECT 8098220 ↗Beta adrenoreceptor subtype cross regulation in the human heart
  • T6INDIRECT 34414903 ↗Comparative effectiveness of metoprolol, ivabradine, and its combination in the management of inappr
  • T6INDIRECT 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
  • T6INDIRECT 7437237 ↗Evaluation of indoramin added to oxprenolol and bendrofluazide as a third agent in severe hypertensi
  • T6 19207771 ↗Postural tachycardia syndrome (POTS)
  • T6HARM 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6 33909761 ↗Brazilian Guidelines of Hypertension - 2020
  • T6INDIRECT 19821318 ↗Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitiv
  • T6INDIRECT 24158454 ↗Blood pressure control and primary prevention of stroke: summary of the recent clinical trial data a
  • T6INDIRECT 24869750 ↗Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension
  • T6INDIRECT 24902920 ↗The design and rationale of a multicenter clinical trial comparing two strategies for control of sys
  • T6INDIRECT 34739197 ↗Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease
  • T6INDIRECT 11435337 ↗Permanent cardiac pacing versus medical treatment for the prevention of recurrent vasovagal syncope:
  • T2 11216978 ↗Lack of efficacy of atenolol for the prevention of neurally mediated syncope in a highly symptomatic
  • T2 7484777 ↗Randomized double-blind, placebo-controlled trial of oral atenolol in patients with unexplained sync
  • T6 33769101 ↗Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 30184160 ↗Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints
  • T6INDIRECT 31954495 ↗Diagnosis and management of toxicities of immune checkpoint inhibitors in hepatocellular carcinoma
  • T6INDIRECT 24636754 ↗Pheochromocytoma and paraganglioma: diagnosis, genetics, management, and treatment
  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
Atomoxetine
T2
T2 — RCT in related condition
RegisteredPOTS
34 sources
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T6INDIRECT 32151742 ↗Pharmacological norepinephrine transporter inhibition for the prevention of vasovagal syncope in you
  • T6INDIRECT 34000076 ↗Fludrocortisone for orthostatic hypotension
  • T6INDIRECT 39882369 ↗Oral medications for the treatment of postural orthostatic tachycardia syndrome; a systematic review
  • T6INDIRECT 31853557 ↗Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide
  • T2 34919634 ↗A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment
  • T6INDIRECT 24002370 ↗Effects of norepinephrine reuptake inhibition on postural tachycardia syndrome
  • T2 31856425 ↗Efficacy of atomoxetine versus midodrine for neurogenic orthostatic hypotension
  • T2 22803597 ↗Effects of atomoxetine on the QT interval in healthy CYP2D6 poor metabolizers
  • T2 39294522 ↗Atomoxetine on neurogenic orthostatic hypotension: a randomized, double-blind, placebo-controlled cr
  • T6INDIRECT 21484416 ↗Still Struggling: characteristics of youth with OCD who are partial responders to medication treatme
  • T6 37230968 ↗Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
  • T6 31333129 ↗Prader-Willi Syndrome - Clinical Genetics, Diagnosis and Treatment Approaches: An Update
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 22071859 ↗Antidepressants for pain management in rheumatoid arthritis
  • T6INDIRECT 27863901 ↗A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease f
  • T2 20679638 ↗Atomoxetine for depression and other neuropsychiatric symptoms in Parkinson disease
  • T2 25185131 ↗Efficacy of atomoxetine versus midodrine for the treatment of orthostatic hypotension in autonomic f
  • T6INDIRECT 22311903 ↗Synergistic effect of norepinephrine transporter blockade and α-2 antagonism on blood pressure in au
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 31519472 ↗New evidence on the management of Lewy body dementia
  • T6INDIRECT 29508455 ↗Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
  • T6INDIRECT 35841911 ↗Diagnosis and treatment of orthostatic hypotension
  • T6INDIRECT 31031694 ↗Autonomic Dysfunction in α-Synucleinopathies
  • T6INDIRECT 21445724 ↗European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological
  • T6 28837986 ↗Sleep Disturbance, Cognitive Decline, and Dementia: A Review
  • T6 29315692 ↗Comprehensive review of cardiovascular toxicity of drugs and related agents
  • T6 21956442 ↗Parkinson's disease therapeutics: new developments and challenges since the introduction of levodopa
  • T6 16554257 ↗Contemporary assessment and pharmacotherapy of Tourette syndrome
  • T6 29523389 ↗Postural tachycardia syndrome - Diagnosis, physiology, and prognosis
  • T6 23753844 ↗Postural tachycardia syndrome (POTS)
  • T6 22519513 ↗The solute carrier 6 family of transporters
Atomoxetine & Propranolol
T2
T2 — RCT in related condition
RegisteredPOTS
1 source
Autonomic Function Testing
T2
T2 — RCT in related condition
RegisteredPOTS
31 sources
  • T2 NCT00580619 ↗Autonomic Nervous System and Chronic Fatigue Syndrome
  • T6REGISTERED-ONLY NCT01783288 ↗Aldosterone & Sodium Regulation in Postural Tachycardia Syndrome - Screening
  • T6INDIRECT 32801135 ↗Epidermal Neurite Density in Skin Biopsies From Patients With Juvenile Fibromyalgia
  • T2 31447757 ↗Autonomic Dysfunction in Preeclampsia: A Systematic Review
  • T2 23266540 ↗Angiotensin II, independent of plasma renin activity, contributes to the hypertension of autonomic f
  • T6INDIRECT 23616163 ↗Low-dose propranolol and exercise capacity in postural tachycardia syndrome: a randomized study
  • T6INDIRECT 31802596 ↗Open-label pilot study: Non-invasive vagal nerve stimulation improves symptoms and gastric emptying
  • T6INDIRECT 8988490 ↗Postural tachycardia syndrome: time frequency mapping
  • T5 33860871 ↗Autonomic dysfunction following COVID-19 infection: an early experience
  • T6 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6 34144933 ↗Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019
  • T6 21279414 ↗Low frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic
  • T6 28655059 ↗Association of Autonomic Dysfunction With Disease Progression and Survival in Parkinson Disease
  • T6 31152011 ↗Intrathecal administration of autologous mesenchymal stem cells in multiple system atrophy
  • T2 22311903 ↗Synergistic effect of norepinephrine transporter blockade and α-2 antagonism on blood pressure in au
  • T2 26644241 ↗Mineralocorticoid Receptor Activation Contributes to the Supine Hypertension of Autonomic Failure
  • T2 9727818 ↗Contrasting actions of pressor agents in severe autonomic failure
  • T2 15548493 ↗The effects of water ingestion on orthostatic hypotension in two groups of chronic autonomic failure
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 28093795 ↗Natural history of pure autonomic failure: A United States prospective cohort
  • T4 24567799 ↗Cardiac autonomic neuropathy in patients with diabetes mellitus
  • T6INDIRECT 35841911 ↗Diagnosis and treatment of orthostatic hypotension
  • T6INDIRECT 36071155 ↗Long Covid: where we stand and challenges ahead
  • T6INDIRECT 35853576 ↗Postural orthostatic tachycardia syndrome as a sequela of COVID-19
  • T6INDIRECT 33316414 ↗The possible association between COVID-19 and postural tachycardia syndrome
  • T6 28984582 ↗Multiple System Atrophy: An Oligodendroglioneural Synucleinopathy1
  • T6 29523389 ↗Postural tachycardia syndrome - Diagnosis, physiology, and prognosis
  • T6 29111419 ↗Diagnosis of multiple system atrophy
  • T6 18194747 ↗The spectrum of diabetic neuropathies
  • T6 37494945 ↗The 2023 wearable photoplethysmography roadmap
  • T6 26306801 ↗Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA dupl
Baseline Stand
T2
T2 — RCT in related condition
RegisteredPOTS
5 sources
  • T2REGISTERED-ONLY NCT05633693 ↗Postural Sway and Counterpressure Maneuvers for Pediatric Syncope
  • T6 29988521 ↗Comparison of Autonomic Control of Blood Pressure During Standing and Artificial Gravity Induced via
  • T6 36873416 ↗Exaggerated postural sway improves orthostatic cardiovascular and cerebrovascular control
  • T6 37227184 ↗Anticipatory central command on standing decreases cerebral blood velocity causing hypocapnia in hyp
  • T6 36205820 ↗33RD International Symposium on the Autonomic Nervous System
Best clinical practice
T2
T2 — RCT in related condition
RegisteredPOTS
20 sources
  • T2REGISTERED-ONLY NCT06936319 ↗Counterpressure Maneuvers in Postural Orthostatic Tachycardia Syndrome
  • T6INDIRECT 25233067 ↗Systematic review of potential health risks posed by pharmaceutical, occupational and consumer expos
  • T6 28821991 ↗Transcranial Doppler in autonomic testing: standards and clinical applications
  • T6 35676796 ↗Prognostic value of 24-hour ambulatory blood pressure patterns in diabetes: A 21-year longitudinal s
  • T6 40697073 ↗Alternative Treatments to Selected Medications in the 2023 American Geriatrics Society Beers Criteri
  • T6 37072581 ↗Assessment of the psychometric properties of the Italian version of the New Freezing of Gait Questio
  • T6INDIRECT 36971690 ↗Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
  • T2 40526204 ↗Joint Clinical Practice Guideline on Benzodiazepine Tapering: Considerations When Risks Outweigh Ben
  • T2 37658155 ↗Practical use of apomorphine infusion in Parkinson's disease: lessons from the TOLEDO study and clin
  • T6 19436724 ↗Incidence and prediction of falls in dementia: a prospective study in older people
  • T6 35963508 ↗American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Me
  • T6 36787983 ↗Glomerular Hyperfiltration Predicts Kidney Function Decline and Mortality in Type 1 and Type 2 Diabe
  • T6INDIRECT 21536160 ↗New wine in old bottle: late-life psychosis
  • T6INDIRECT 31526331 ↗American Academy of Spinal Cord Injury Professionals ASCIP 2019 Educational Conference & Expo Septem
  • T6INDIRECT 34585268 ↗The false myth of "iodine allergy" also in nuclear medicine
  • T6INDIRECT 32218879 ↗Abstracts of the 14th International Congress of the European Geriatric Medicine Society: 10-12 Octob
  • T4 PMC4212304 ↗UEG Week 2014 Oral Presentations
  • T6 41969957 ↗Therapeutic Spectrum of Intermittent Apomorphine in Parkinson's Disease: Neuropsychiatric, Behaviora
  • T6 39847311 ↗Pathophysiology, symptoms, outcomes, and evaluation of hyponatremia: comprehension and best clinical
  • T6 34595836 ↗Prognostic score based on physical frailty in patients with heart failure: a multicenter prospective
Best clinical practice plus CPM-biofeedback training
T2
T2 — RCT in related condition
RegisteredPOTS
1 source
  • T2REGISTERED-ONLY NCT06936319 ↗Counterpressure Maneuvers in Postural Orthostatic Tachycardia Syndrome
Bisoprolol
T2
T2 — RCT in related condition
POTS
36 sources
  • T2 NCT02171988 ↗Effect of Medical Treatment and Prognosis of Postural Orthostatic Tachycardia Syndrome (POTS)
  • T6INDIRECT 27388039 ↗Pharmacological interventions for treating heart failure in patients with Chagas cardiomyopathy
  • T6INDIRECT 36525900 ↗Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review
  • T6INDIRECT 39882369 ↗Oral medications for the treatment of postural orthostatic tachycardia syndrome; a systematic review
  • T6INDIRECT 41225175 ↗Systematic literature review: treatment of postural orthostatic tachycardia syndrome (POTS)
  • T6INDIRECT 24650926 ↗A randomized pilot study of aortic waveform guided therapy in chronic heart failure
  • T2 29500811 ↗Efficacy of Propranolol, Bisoprolol, and Pyridostigmine for Postural Tachycardia Syndrome: a Randomi
  • T6INDIRECT 8098220 ↗Beta adrenoreceptor subtype cross regulation in the human heart
  • T6INDIRECT 39987007 ↗Exercise rehabilitation for people with postural tachycardia syndrome at two secondary care centres
  • T2 11198485 ↗Clinical improvement in patients with orthostatic intolerance after treatment with bisoprolol and fl
  • T6 28428055 ↗Sex differences in cardiovascular disease - Impact on care and outcomes
  • T6 33909761 ↗Brazilian Guidelines of Hypertension - 2020
  • T6 35307156 ↗2022 ACC Expert Consensus Decision Pathway on Cardiovascular Sequelae of COVID-19 in Adults: Myocard
  • T6INDIRECT 24869750 ↗Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension
  • T6INDIRECT 32519776 ↗Withdrawal of antihypertensive drugs in older people
  • T6INDIRECT 29059199 ↗Effectiveness of beta-blockers depending on the genotype of congenital long-QT syndrome: A meta-anal
  • T6INDIRECT 23796325 ↗Systematic review of genuine versus spurious side-effects of beta-blockers in heart failure using pl
  • T6INDIRECT 31167038 ↗Pharmacotherapy for hypertension in adults 60 years or older
  • T6INDIRECT 23730991 ↗Effects of intensive antihypertensive treatment on Chinese hypertensive patients older than 70 years
  • T6INDIRECT 28655357 ↗Drug-related problems and medication reviews among old people with dementia
  • T6INDIRECT 17786067 ↗A randomized, double-blind, placebo-controlled parallel-group study to assess the efficacy and safet
  • T6INDIRECT 24567799 ↗Cardiac autonomic neuropathy in patients with diabetes mellitus
  • T6INDIRECT 38441582 ↗Cardiac Amyloidosis Due to Transthyretin Protein: A Review
  • T6INDIRECT 35830976 ↗Incidence, risk factors, natural history, and hypothesised mechanisms of myocarditis and pericarditi
  • T6INDIRECT 28261151 ↗The Treatment of Sleep Disorders in Parkinson's Disease: From Research to Clinical Practice
  • T6INDIRECT 35853576 ↗Postural orthostatic tachycardia syndrome as a sequela of COVID-19
  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 31710717 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors
  • T6 11129673 ↗Chagas' heart disease
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
  • T6 28050656 ↗The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic o
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
Bisoprolol+pyridostgmine
T2
T2 — RCT in related condition
POTS
1 source
  • T2 NCT02171988 ↗Effect of Medical Treatment and Prognosis of Postural Orthostatic Tachycardia Syndrome (POTS)
Blood Pressure Self-Monitoring
T2
T2 — RCT in related condition
POTS
15 sources
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 33769555 ↗Mobile phone-based interventions for improving adherence to medication prescribed for the primary pr
  • T2 29499873 ↗Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihype
  • T2 28193176 ↗Telemonitoring and/or self-monitoring of blood pressure in hypertension (TASMINH4): protocol for a r
  • T6 22187469 ↗Standards of medical care in diabetes--2012
  • T6 23264422 ↗Standards of medical care in diabetes--2013
  • T6 20042772 ↗Standards of medical care in diabetes--2010
  • T6 21193625 ↗Standards of medical care in diabetes--2011
  • T6 19118286 ↗Standards of medical care in diabetes--2009
  • T6 30249203 ↗Rationale and design of a pragmatic clinical trial to assess the impact of self-monitoring blood pre
  • T4 30023362 ↗Blood pressure targets for hypertension in patients with type 2 diabetes
  • T6 36507632 ↗10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2023
  • T6 38078592 ↗10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2024
  • T6 39651970 ↗10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2025
  • T6 34327491 ↗Ten things to know about ten cardiovascular disease risk factors
Blood Sample Collection
T2
T2 — RCT in related condition
RegisteredPOTS
27 sources
  • T2REGISTERED-ONLY NCT07405515 ↗Pathophysiology of Dysautonomia and Postural Tachycardia Syndrome (POTS) in Post-viral Syndromes and
  • T6INDIRECT 25689743 ↗Effects of two dietary fibers as part of ready-to-eat cereal (RTEC) breakfasts on perceived appetite
  • T6INDIRECT 23271912 ↗Microencapsulated conjugated linoleic acid associated with hypocaloric diet reduces body fat in sede
  • T6INDIRECT 33176826 ↗Assessing the impact of a mushroom-derived food ingredient on vitamin D levels in healthy volunteers
  • T6INDIRECT 29370744 ↗Protocol for a cluster randomised controlled trial on information technology-enabled nutrition inter
  • T6INDIRECT 39064619 ↗Effect of Low-Dose Mulberry Fruit Extract on Postprandial Glucose and Insulin Responses: A Randomize
  • T6 33188616 ↗Hereditary transthyretin amyloidosis overview
  • T6 34425843 ↗Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accomp
  • T6 35933347 ↗Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individua
  • T6 10737392 ↗The United Kingdom Childhood Cancer Study: objectives, materials and methods. UK Childhood Cancer St
  • T6 34996973 ↗Inappropriate sinus tachycardia in post-COVID-19 syndrome
  • T6INDIRECT 35594017 ↗HLX11, a Proposed Pertuzumab Biosimilar: Pharmacokinetics, Immunogenicity, and Safety Profiles Compa
  • T6INDIRECT 36558506 ↗Comparative Pharmacokinetic of Curcuminoids Formulations with an Omega-3 Fatty Acids Monoglyceride C
  • T6INDIRECT 22848387 ↗Low serum urate levels are associated to female gender in multiple sclerosis patients
  • T6INDIRECT 24134216 ↗Pharmacokinetics and pharmacodynamics of liposomal mifamurtide in adult volunteers with mild or mode
  • T6INDIRECT 37377258 ↗SBC Guideline on the Diagnosis and Treatment of Patients with Cardiomyopathy of Chagas Disease - 202
  • T6INDIRECT 26911448 ↗COPPADIS-2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015), a global--clinical evalu
  • T6INDIRECT 32750291 ↗Serum Activity Against G Protein-Coupled Receptors and Severity of Orthostatic Symptoms in Postural
  • T6INDIRECT 35251166 ↗Changes in Physiological Levels of Cortisol and Adrenocorticotropic Hormone upon Hospitalization Can
  • T6INDIRECT 31401614 ↗Sensitivity of point-of-care testing C reactive protein and procalcitonin to diagnose urinary tract
  • T6INDIRECT 35978253 ↗The effect of the BNT162b2 vaccine on antinuclear antibody and antiphospholipid antibody levels
  • T6 30362018 ↗The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description
  • T6 34376193 ↗High-fat diet-induced diabetes leads to vascular alterations, pericyte reduction, and perivascular d
  • T6 35482424 ↗EBV/HHV-6A dUTPases contribute to myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology
  • T6 32414139 ↗Zinc Concentration Dynamics Indicate Neurological Impairment Odds after Traumatic Spinal Cord Injury
  • T6 26561290 ↗Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders
  • T6 34829952 ↗Tryptophan Metabolites, Cytokines, and Fatty Acid Binding Protein 2 in Myalgic Encephalomyelitis/Chr
Bosentan
T2
T2 — RCT in related condition
POTS
21 sources
  • T6INDIRECT 30701543 ↗Phosphodiesterase 5 inhibitors for pulmonary hypertension
  • T6INDIRECT 15846646 ↗Prostacyclin for pulmonary hypertension in adults
  • T6INDIRECT 31096477 ↗What is the position of pulmonary arterial hypertension-specific drug therapy in patients with Eisen
  • T6INDIRECT 16060962 ↗Pilot study of losartan for pulmonary hypertension in chronic obstructive pulmonary disease
  • T6INDIRECT 34262260 ↗A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosp
  • T2 40034063 ↗Early Administration of Bosentan in High-Risk COVID-19 Outpatients at Risk of Sarcopenia: A Randomiz
  • T6INDIRECT 42023995 ↗Effect of Once-Daily Macitentan 75 mg on the Pharmacokinetics of Sildenafil, Riociguat, or Rosuvasta
  • T6INDIRECT 28881378 ↗Effects of Rifampin on the Pharmacokinetics of a Single Dose of Istradefylline in Healthy Subjects
  • T6 30218025 ↗Mechanisms, biomarkers and targets for adult-onset Still's disease
  • T6 26711459 ↗Cerebrovascular disease in ageing and Alzheimer's disease
  • T6INDIRECT 10219752 ↗Diabetic neuropathies: features and mechanisms
  • T6INDIRECT 40159403 ↗Practical compendium of antiarrhythmic drugs: a clinical consensus statement of the European Heart R
  • T6INDIRECT 33230704 ↗Cardiovascular disease and its management in children and adults undergoing hematopoietic stem cell
  • T6INDIRECT 35772032 ↗State-of-the-Art Treatments for Sarcoidosis
  • T6INDIRECT 26836930 ↗Persistent Challenges in Pediatric Pulmonary Hypertension
  • T6INDIRECT 26401246 ↗Statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute
  • T6 34948113 ↗Genophenotypic Factors and Pharmacogenomics in Adverse Drug Reactions
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
  • T6 11094506 ↗Understanding gastrointestinal perfusion in critical care: so near, and yet so far
Breathing Device
T2
T2 — RCT in related condition
RegisteredPOTS
6 sources
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T6INDIRECT 25792354 ↗Inspiratory resistance improves postural tachycardia: a randomized study
  • T6 26198889 ↗Postural Tachycardia Syndrome: Beyond Orthostatic Intolerance
  • T6 32848835 ↗Venous and Arterial Responses to Partial Gravity
  • T6 34062971 ↗Effects of Respiratory Muscle Training on Baroreflex Sensitivity, Respiratory Function, and Serum Ox
  • T6 33755181 ↗Loss of putative GABAergic neurons in the ventrolateral medulla in multiple system atrophy
CCK agonist
T2
T2 — RCT in related condition
RegisteredPOTS
1 source
  • T2REGISTERED-ONLY NCT07019519 ↗POTS-FLOW: Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patien
Captopril
T2
T2 — RCT in related condition
POTS
30 sources
  • T6INDIRECT 19821318 ↗Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitiv
  • T6INDIRECT 20537128 ↗Post-injection delirium/sedation syndrome in patients with schizophrenia treated with olanzapine lon
  • T6INDIRECT 24869750 ↗Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension
  • T6INDIRECT 32909814 ↗Effects of Intensive Blood Pressure Treatment on Orthostatic Hypotension : A Systematic Review and I
  • T6INDIRECT 32519776 ↗Withdrawal of antihypertensive drugs in older people
  • T6INDIRECT 1540729 ↗Renal protective effect of enalapril in diabetic nephropathy
  • T6INDIRECT 2337713 ↗Contrasting effects of enalapril and metoprolol on proteinuria in diabetic nephropathy
  • T6INDIRECT 23266540 ↗Angiotensin II, independent of plasma renin activity, contributes to the hypertension of autonomic f
  • T2 6986949 ↗Effects of an angiotensin-converting enzyme inhibitor (captopril) on blood pressure in anephric subj
  • T6INDIRECT 16060962 ↗Pilot study of losartan for pulmonary hypertension in chronic obstructive pulmonary disease
  • T6INDIRECT 29508455 ↗Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
  • T6INDIRECT 24090418 ↗Life-threatening outcomes associated with autonomic dysreflexia: a clinical review
  • T6INDIRECT 28862947 ↗Role of Volume Redistribution in the Congestion of Heart Failure
  • T6INDIRECT 23594434 ↗A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival
  • T6INDIRECT 36787743 ↗Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic
  • T6INDIRECT 18514747 ↗Salt craving: the psychobiology of pathogenic sodium intake
  • T6INDIRECT 9467687 ↗Depression in Parkinson's disease. Pharmacological characteristics and treatment
  • T6 29565029 ↗Hypertension
  • T6 33769101 ↗Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
  • T6 32213941 ↗Chemical Constituents and Pharmacological Activities of Garlic (<i>Allium sativum</i> L.): A Review
  • T6 38078592 ↗10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2024
  • T6 25114297 ↗Type 1 diabetes mellitus and cardiovascular disease: a scientific statement from the American Heart
  • T6 34589395 ↗Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic n
  • T6 20978471 ↗The relationship between blood pressure and cognitive function
  • T6 33909761 ↗Brazilian Guidelines of Hypertension - 2020
  • T6 25621208 ↗Chronic complications of spinal cord injury
  • T6 17308214 ↗Blood pressure and ageing
  • T6 30354828 ↗Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the Ameri
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
  • T6 16365341 ↗JBS 2: Joint British Societies' guidelines on prevention of cardiovascular disease in clinical pract
Carbidopa
T2
T2 — RCT in related condition
POTS
34 sources
  • T2 NCT00685919 ↗Peripheral Dopamine in Postural Tachycardia Syndrome
  • T6INDIRECT 30979821 ↗Presynaptic Striatal Dopaminergic Function in Atypical Parkinsonism: A Metaanalysis of Imaging Studi
  • T6INDIRECT 33674954 ↗Overall Efficacy and Safety of Safinamide in Parkinson's Disease: A Systematic Review and a Meta-ana
  • T6INDIRECT 34472659 ↗Movement disorders in patients with Rett syndrome: A systematic review of evidence and associated cl
  • T6INDIRECT 38054428 ↗A systematic practice review: Providing palliative care for people with Parkinson's disease and thei
  • T6INDIRECT 24944260 ↗Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial
  • T6INDIRECT 28494751 ↗Integrated analysis of droxidopa trials for neurogenic orthostatic hypotension
  • T2 23553478 ↗Hyperdopaminergic crises in familial dysautonomia: a randomized trial of carbidopa
  • T6INDIRECT 32986682 ↗The D1/D5 Dopamine Partial Agonist PF-06412562 in Advanced-Stage Parkinson's Disease: A Feasibility
  • T2 32654554 ↗Carbidopa for Afferent Baroreflex Failure in Familial Dysautonomia: A Double-Blind Randomized Crosso
  • T6INDIRECT 38701159 ↗Effects of Blood Flow Restriction Resistance Training on Autonomic and Endothelial Function in Perso
  • T6 28716886 ↗Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases
  • T6HARM 28273839 ↗Parkinson's Disease: From Pathogenesis to Pharmacogenomics
  • T6INDIRECT 27863901 ↗A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease f
  • T2 24361112 ↗Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Par
  • T6INDIRECT 15548480 ↗Mucuna pruriens in Parkinson's disease: a double blind clinical and pharmacological study
  • T6INDIRECT 9343116 ↗Catechol-O-methyltransferase inhibition with tolcapone reduces the "wearing off" phenomenon and levo
  • T6INDIRECT 8558148 ↗Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients wit
  • T6INDIRECT 8527287 ↗Pharmacokinetic-pharmacodynamic interaction between the COMT inhibitor tolcapone and single-dose lev
  • T6INDIRECT 12388617 ↗Dopamine modulates the response of the human amygdala: a study in Parkinson's disease
  • T6INDIRECT 12885750 ↗Norepinephrine precursor therapy in neurogenic orthostatic hypotension
  • T6INDIRECT 32402162 ↗Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease
  • T6INDIRECT 26350119 ↗Autosomal dominant Parkinson's disease caused by SNCA duplications
  • T6INDIRECT 2545827 ↗Diffuse Lewy body disease: clinical features in 15 cases
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 23225012 ↗Parkinson's disease
  • T6INDIRECT 19484833 ↗Evidence-based recommendations for the assessment and management of sleep disorders in older persons
  • T6INDIRECT 28100251 ↗Consensus guideline for the diagnosis and treatment of aromatic l-amino acid decarboxylase (AADC) de
  • T6INDIRECT 19933976 ↗Medical records documentation of constipation preceding Parkinson disease: A case-control study
  • T6 28887905 ↗Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Sh
  • T6 29090092 ↗Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential trea
  • T6 26324905 ↗Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism
  • T6 31196984 ↗Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
Cardioneuroablation
T2
T2 — RCT in related condition
POTS
29 sources
  • T2 35716859 ↗Cardioneuroablation for vasovagal syncope: A systematic review and meta-analysis
  • T2 39067734 ↗Cardioneuroablation in patients with vasovagal syncope: An updated systematic review and meta-analys
  • T6INDIRECT 38890128 ↗Therapeutic options for neurocardiogenic syncope: a meta-analysis of randomised trials with and with
  • T2 36114133 ↗Cardioneuroablation for Reflex Syncope: Efficacy and Effects on Autonomic Cardiac Regulation-A Prosp
  • T2 40117421 ↗The Efficacy of Left Atrial vs Biatrial Cardioneuroablation in Patients With Vasovagal Syncope: A Ra
  • T6INDIRECT 41914517 ↗Catheter Ablation for Frequent Premature Ventricular Contractions or Paroxysmal Supraventricular Tac
  • T6INDIRECT 33999698 ↗Durable Physiological Changes and Decreased Syncope Burden 12 Months After Unifocal Right-Sided Abla
  • T3 30054828 ↗Electroanatomic-mapping-guided cardioneuroablation versus combined approach for vasovagal syncope: a
  • T6 21712276 ↗Catheter ablation of severe neurally meditated reflex (neurocardiogenic or vasovagal) syncope: cardi
  • T6 31330187 ↗Right anterior ganglionated plexus: The primary target of cardioneuroablation?
  • T5 28491512 ↗Functional permanent 2:1 atrioventricular block treated with cardioneuroablation: Case report
  • T5 35860784 ↗Recurrent vasovagal syncope following successful cardioneuroablation
  • T4 39082698 ↗Cardioneuroablation for the treatment of reflex syncope and functional bradyarrhythmias: A Scientifi
  • T6INDIRECT 40056025 ↗Clinical neurocardiology: defining the value of neuroscience-based cardiovascular therapeutics - 202
  • T4 30906551 ↗Potential usage of cardioneuroablation in vagally mediated functional atrioventricular block
  • T6INDIRECT 37124975 ↗Arrhythmic syncope: From diagnosis to management
  • T6INDIRECT 36845167 ↗Ganglionic Plexus Ablation: A Step-by-step Guide for Electrophysiologists and Review of Modalities f
  • T4 37361615 ↗Cardioneuroablation: Where are we at?
  • T6 37367403 ↗Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation
  • T6 36836740 ↗Intrinsic Cardiac Neuromodulation in the Management of Atrial Fibrillation- A Potential Missing Link
  • T6 39000068 ↗The Brain-Heart Network of Syncope
  • T6 37562487 ↗Ischemia-induced ventricular proarrhythmia and cardiovascular autonomic dysreflexia after cardioneur
  • T6 35924289 ↗Procedural Characteristics, Safety, and Follow-up of Modified Right-Sided Approach for Cardioneuroab
  • T6 33886735 ↗Dysautonomia: A Forgotten Condition - Part 1
  • T6 36699671 ↗An assessment of heart rate and blood pressure asymmetry in the diagnosis of vasovagal syncope in fe
  • T6 32036025 ↗Pacing in vasovagal syncope: Physiology, pacemaker sensors, and recent clinical trials-Precise patie
  • T6 37021351 ↗Clinical controversy: methodology and indications of cardioneuroablation for reflex syncope
  • T6 32034611 ↗Medium-term results of cardioneuroablation for clinical bradyarrhythmias and vasovagal syncope: effe
  • T6 37622579 ↗Twenty-five years of research on syncope
Cast Iron Pot
T2
T2 — RCT in related condition
WithdrawnPOTS
6 sources
  • T2WITHDRAWN NCT02341300 ↗Use of Cast Iron Pots to Improve Maternal Anemia
  • T6 34684539 ↗Plant-Based Dietary Practices and Socioeconomic Factors That Influence Anemia in India
  • T6 34007348 ↗Managing Genetic Hemochromatosis: An Overview of Dietary Measures, Which May Reduce Intestinal Iron
  • T6 6066580 ↗On a turf (peat) fire cancer: malignant change superimposed on erythema ab igne
  • T6 33171944 ↗Micronutrient Status and Dietary Diversity of Women of Reproductive Age in Rural Pakistan
  • T6 26509730 ↗Traditional Glue, Adhesive and Poison Used for Composite Weapons by Ju/'hoan San in Nyae Nyae, Namib
Conventional Treatment
T2
T2 — RCT in related condition
POTS
32 sources
  • T2 NCT05404672 ↗Breathing Exercises With And Without Aerobic Training In Patients With Postural Orthostatic Tachycar
  • T6INDIRECT 24895945 ↗Thermal insulation for preventing inadvertent perioperative hypothermia
  • T6INDIRECT 34207492 ↗Impact of Portion Control Tools on Portion Size Awareness, Choice and Intake: Systematic Review and
  • T6INDIRECT 38900335 ↗Botulinum Toxin-A for the Treatment of Myogenous Temporomandibular Disorders: An Umbrella Review of
  • T6INDIRECT 39348282 ↗Efficacy of Probiotics Compared With Pharmacological Treatments for Maintenance Therapy for Function
  • T6INDIRECT 21745374 ↗Comparison of intravenous immunoglobulin and plasma exchange in treatment of mechanically ventilated
  • T6INDIRECT 23978222 ↗A double-blind placebo-controlled cross-over study of the vascular effects of midodrine in neuropath
  • T6INDIRECT 35388029 ↗Effect of psychotherapy on recurrence of events and quality of life in patients with vasovagal synco
  • T6INDIRECT 6801211 ↗Effects of aldose reductase inhibitor treatment in diabetic polyneuropathy - a clinical and neurophy
  • T6 18085482 ↗Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide
  • T6 21221114 ↗ATP7A-related copper transport diseases-emerging concepts and future trends
  • T6 29622808 ↗Expert consensus document: Advances in the diagnosis and classification of gastric and intestinal mo
  • T6 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6INDIRECT 33091160 ↗Electromechanical-assisted training for walking after stroke
  • T6INDIRECT 23633371 ↗Interventions for treating pain and disability in adults with complex regional pain syndrome
  • T6INDIRECT 15846598 ↗Electroconvulsive therapy for schizophrenia
  • T6INDIRECT 34018146 ↗The Long-Term Impact of Levodopa/Carbidopa Intestinal Gel on 'Off'-time in Patients with Advanced Pa
  • T6INDIRECT 9562345 ↗The effect of intensive diabetes therapy on measures of autonomic nervous system function in the Dia
  • T6INDIRECT 17045903 ↗Effectiveness of physical counterpressure maneuvers in preventing vasovagal syncope: the Physical Co
  • T6INDIRECT 34455813 ↗SPARTE Study: Normalization of Arterial Stiffness and Cardiovascular Events in Patients With Hyperte
  • T6INDIRECT 19470886 ↗Effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 di
  • T6INDIRECT 24567799 ↗Cardiac autonomic neuropathy in patients with diabetes mellitus
  • T6INDIRECT 23008748 ↗The therapeutic potential of cannabis and cannabinoids
  • T6INDIRECT 29387043 ↗Strategies to Combat Antibiotic Resistance in the Wastewater Treatment Plants
  • T6INDIRECT 35483386 ↗CDKL5 deficiency disorder: clinical features, diagnosis, and management
  • T6 21092187 ↗Fabry disease
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 25114297 ↗Type 1 diabetes mellitus and cardiovascular disease: a scientific statement from the American Heart
  • T6 30786722 ↗Cardio-Oncology: Vascular and Metabolic Perspectives: A Scientific Statement From the American Heart
  • T6 33909761 ↗Brazilian Guidelines of Hypertension - 2020
  • T6 30291106 ↗Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes As
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
Cosyntropin administration
T2
T2 — RCT in related condition
POTS
11 sources
  • T2 NCT01764711 ↗Adrenocorticotropic Hormone Stimulation in Postural Orthostatic Tachycardia Syndrome (POTS)
  • T6 27739587 ↗2016 Annual Meetings
  • T6 27114361 ↗Abstracts from the 2016 Society of General Internal Medicine Annual Meeting
  • T6 31090026 ↗Abstracts from the 2019 Annual Meeting of the Society of General Internal Medicine
  • T6 PMC7138092 ↗Research Abstract Program of the 2010 ACVIM Forum
  • T6 PMC11231130 ↗Abstracts from the 2024 Annual Meeting of the Society of General Internal Medicine
  • T6 30184160 ↗Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints
  • T6 23840983 ↗A reversible cause of skin hyperpigmentation and postural hypotension
  • T6INDIRECT 37770163 ↗Challenges and controversies in adrenal surgery: A practical approach
  • T6 PMC2219573 ↗Abtracts from the 30th Annual Meeting of the Society of General Internal Medicine
  • T6 42181213 ↗The cortisol stress response following surgery for proximal femur fractures in geriatric patients -
Counterpressure Maneuvers
T2
T2 — RCT in related condition
RegisteredPOTS
23 sources
  • T2REGISTERED-ONLY NCT05633693 ↗Postural Sway and Counterpressure Maneuvers for Pediatric Syncope
  • T2REGISTERED-ONLY NCT05555771 ↗Paediatric Syncope in the Emergency Department
  • T6INDIRECT 32151742 ↗Pharmacological norepinephrine transporter inhibition for the prevention of vasovagal syncope in you
  • T6INDIRECT 36195683 ↗Effects of short-term hypercaloric nutrition on orthostatic tolerance in healthy individuals: a rand
  • T6 35212554 ↗Orthostatic Hypotension: Management of a Complex, But Common, Medical Problem
  • T6 23472781 ↗Medical therapy and physical maneuvers in the treatment of the vasovagal syncope and orthostatic hyp
  • T6 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6 36169154 ↗Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of aut
  • T6 27637670 ↗Initial orthostatic hypotension in teenagers and young adults
  • T6INDIRECT 37226313 ↗Association between vitamin D deficiency and vasovagal syncope: A systematic review and meta-analysi
  • T2 17045903 ↗Effectiveness of physical counterpressure maneuvers in preventing vasovagal syncope: the Physical Co
  • T6INDIRECT 29381726 ↗A single-center randomized controlled trial observing the safety and efficacy of modified step-up gr
  • T6 35963508 ↗American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Me
  • T6 34386109 ↗JCS/JHRS 2019 guideline on non-pharmacotherapy of cardiac arrhythmias
  • T6INDIRECT 35462637 ↗COVID-19 and Cardiac Arrhythmias: a Contemporary Review
  • T6INDIRECT 33792518 ↗Dyspnea in Chronic Low Ventricular Preload States
  • T6INDIRECT 41089328 ↗Immunotherapies for postural orthostatic tachycardia syndrome, other common autonomic disorders, and
  • T6INDIRECT 37167358 ↗A Post-Pandemic Enigma: The Cardiovascular Impact of Post-Acute Sequelae of SARS-CoV-2
  • T6INDIRECT 37654428 ↗Postural orthostatic tachycardia syndrome and other related dysautonomic disorders after SARS-CoV-2
  • T6 38827268 ↗Cardioneuroablation for Drug Refractory Vasovagal Syncope After COVID-19 Infection
  • T6 36675975 ↗Transcutaneous Spinal Cord Stimulation Attenuates Blood Pressure Drops in Orthostasis
  • T6 32637542 ↗Video education to improve clinical skills in the prevention of and response to vasovagal syncopal e
  • T6 31456212 ↗Neurogenic Orthostatic Hypotension in Parkinson Disease: A Primer
Cyclophosphamide
T2
T2 — RCT in related condition
RegisteredME/CFSMCASPOTS
70 sources
  • T2 NCT02444091 ↗Cyclophosphamide in Myalgic Encephalopathy/ Chronic Fatigue Syndrome (ME/CFS)
  • T6 NCT01384513 ↗A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Mali
  • T6REGISTERED-ONLY NCT03779854 ↗Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults
  • T6INDIRECT 21491378 ↗Interventions for preventing oral mucositis for patients with cancer receiving treatment
  • T6INDIRECT 20687070 ↗Interventions for treating oral mucositis for patients with cancer receiving treatment
  • T6INDIRECT 36103991 ↗Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 d
  • T6INDIRECT 36228963 ↗Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline patho
  • T6INDIRECT 23599118 ↗Topical interleukin 1 receptor antagonist for treatment of dry eye disease: a randomized clinical tr
  • T6INDIRECT 15471655 ↗Course of fatigue in women receiving chemotherapy and/or radiotherapy for early stage breast cancer
  • T6INDIRECT 26844275 ↗Radiation-induced CD8 T-lymphocyte Apoptosis as a Predictor of Breast Fibrosis After Radiotherapy: R
  • T6 2683611 ↗Biology of natural killer cells
  • T6 10515901 ↗Q fever
  • T6 32762681 ↗Natural killer cells in cancer biology and therapy
  • T6 19375665 ↗Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity
  • T6 9560217 ↗Bax directly induces release of cytochrome c from isolated mitochondria
  • T6INDIRECT 20548096 ↗Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-
  • T6INDIRECT 34904799 ↗Polatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma
  • T2 30901302 ↗Randomized Phase III Trial of Ibrutinib and Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristin
  • T6INDIRECT 36542826 ↗Lisocabtagene maraleucel as second-line therapy for large B-cell lymphoma: primary analysis of the p
  • T6INDIRECT 30184451 ↗Rituximab plus Lenalidomide in Advanced Untreated Follicular Lymphoma
  • T6INDIRECT 25046337 ↗Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who rema
  • T6INDIRECT 30811293 ↗First-Line Treatment of Patients With Indolent Non-Hodgkin Lymphoma or Mantle-Cell Lymphoma With Ben
  • T6INDIRECT 20431041 ↗Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and l
  • T6INDIRECT 25154820 ↗Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effect
  • T6INDIRECT 25842160 ↗Circulating tumour DNA and CT monitoring in patients with untreated diffuse large B-cell lymphoma: a
  • T6INDIRECT 34542573 ↗Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephaliti
  • T6INDIRECT 26561338 ↗Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy
  • T6INDIRECT 29217664 ↗Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Re
  • T6INDIRECT 29271481 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 30361325 ↗DUET: A Phase 2 Study Evaluating the Efficacy and Safety of Sparsentan in Patients with FSGS
  • T6INDIRECT 32244252 ↗Daratumumab plus CyBorD for patients with newly diagnosed AL amyloidosis: safety run-in results of A
  • T6INDIRECT 1739631 ↗Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)
  • T6INDIRECT 8774401 ↗Intravenous immunoglobulin treatment in paraneoplastic neurological syndromes with antineuronal auto
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 17655751 ↗Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis
  • T6INDIRECT 24247168 ↗Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer
  • T6INDIRECT 29523094 ↗Pediatric multiple sclerosis: a review
  • T6INDIRECT 29186062 ↗Viral Oncology: Molecular Biology and Pathogenesis
  • T6INDIRECT 23452057 ↗Characterization of different courses of atopic dermatitis in adolescent and adult patients
  • T6 34630027 ↗Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy
  • T6 22544865 ↗Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action,
  • T6 25315420 ↗Autoimmune encephalopathies
  • T6 29344421 ↗Anti-Aging Implications of <i>Astragalus Membranaceus</i> (Huangqi): A Well-Known Chinese Tonic
  • T6INDIRECT 28242845 ↗Focal Segmental Glomerulosclerosis
  • T6INDIRECT 33649022 ↗Autoimmune encephalitis: proposed best practice recommendations for diagnosis and acute management
  • T6INDIRECT 32106302 ↗Overview of Castleman disease
  • T6INDIRECT 28213891 ↗Opioids and the immune system - friend or foe
  • T6INDIRECT 35215786 ↗<i>Herpes zoster</i>: A Review of Clinical Manifestations and Management
  • T6INDIRECT 29915719 ↗Past, Present, and Future of Rituximab-The World's First Oncology Monoclonal Antibody Therapy
  • T6INDIRECT 27777266 ↗A Proposal for a Serology-Based Approach to Membranous Nephropathy
  • T6 32433595 ↗Interaction between microbiota and immunity in health and disease
  • T6 32934330 ↗Exploring the NK cell platform for cancer immunotherapy
  • T6 37169756 ↗Angiogenic signaling pathways and anti-angiogenic therapy for cancer
  • T6 19597008 ↗Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis
  • T6 26228647 ↗Colchicine--Update on mechanisms of action and therapeutic uses
  • T6 32376392 ↗Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventio
  • T6 28550082 ↗Primary Membranous Nephropathy
  • T6 33657296 ↗Diffuse Large B-Cell Lymphoma
  • T6INDIRECT 30049614 ↗Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex ence
  • T6INDIRECT 24462240 ↗Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a c
  • T6INDIRECT 24703753 ↗A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder assoc
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 24423978 ↗Adrenocortical carcinoma
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 32792490 ↗Podocytopathies
  • T6 34988090 ↗Treatment of Inflammatory Bowel Disease: A Comprehensive Review
  • T6 24323045 ↗Autophagy and human diseases
Deep Brain Stimulation
T2
T2 — RCT in related condition
POTS
24 sources
  • T6INDIRECT 24018704 ↗Physiotherapy versus placebo or no intervention in Parkinson's disease
  • T6INDIRECT 15846598 ↗Electroconvulsive therapy for schizophrenia
  • T6INDIRECT 27863901 ↗A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease f
  • T6INDIRECT 19205066 ↗Dysautonomia rating scales in Parkinson's disease: sialorrhea, dysphagia, and constipation--critique
  • T6INDIRECT 36602886 ↗Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis
  • T6INDIRECT 24361112 ↗Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Par
  • T6INDIRECT 23128427 ↗Randomized clinical trial of 3 types of physical exercise for patients with Parkinson disease
  • T6INDIRECT 20679638 ↗Atomoxetine for depression and other neuropsychiatric symptoms in Parkinson disease
  • T6INDIRECT 12023411 ↗Pramipexole in patients with Parkinson's disease and marked drug resistant tremor: a randomised, dou
  • T2 17823535 ↗Motor and nonmotor symptom follow-up in parkinsonian patients after deep brain stimulation of the su
  • T6INDIRECT 32402162 ↗Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease
  • T6INDIRECT 33243615 ↗Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on
  • T6INDIRECT 25496901 ↗Wilson's disease and other neurological copper disorders
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 23225012 ↗Parkinson's disease
  • T6INDIRECT 34942142 ↗The neuropsychiatry of Parkinson's disease: advances and challenges
  • T6INDIRECT 23359374 ↗Criteria for the diagnosis of corticobasal degeneration
  • T6 28716886 ↗Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases
  • T6 28887905 ↗Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Sh
  • T6 20060022 ↗The cholinergic system and Parkinson disease
  • T6 27125836 ↗Technology in Parkinson's disease: Challenges and opportunities
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 28653647 ↗Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic app
Dexmedetomidine Sublingual
T2
T2 — RCT in related condition
POTS
3 sources
  • T2 36630319 ↗Sublingual dexmedetomidine (BXCL501) reduces opioid withdrawal symptoms: findings from a multi-site,
  • T2 36002761 ↗Sublingual Dexmedetomidine for Agitation Associated with Schizophrenia or Bipolar Disorder: A Post H
  • T6 40654581 ↗Schizophrenia management: Systematic review of current medications and Phase-3 agents (2008-2024)
Digoxin
T2
T2 — RCT in related condition
POTS
30 sources
  • T2 NCT03261570 ↗Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTS
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30019766 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30521670 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 34883203 ↗Heart rate variability in relation to cognition and behavior in neurodegenerative diseases: A system
  • T6INDIRECT 27388039 ↗Pharmacological interventions for treating heart failure in patients with Chagas cardiomyopathy
  • T6INDIRECT 31473866 ↗Characteristics and natural history of autonomic involvement in hereditary ATTR amyloidosis: a syste
  • T6INDIRECT 35498768 ↗Pediatric Intestinal Pseudo-Obstruction: Progress and Challenges
  • T6INDIRECT 32923331 ↗A Systematic Review of the Spectrum of Cardiac Arrhythmias in Sub-Saharan Africa
  • T6INDIRECT 33125753 ↗Endothelial-protective effects of a G-protein-biased sphingosine-1 phosphate receptor-1 agonist, SAR
  • T6 21321035 ↗Health effects of energy drinks on children, adolescents, and young adults
  • T6 28428055 ↗Sex differences in cardiovascular disease - Impact on care and outcomes
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 33624299 ↗Chloroquine or hydroxychloroquine for prevention and treatment of COVID-19
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 29916559 ↗Features of atrial fibrillation in wild-type transthyretin cardiac amyloidosis: a systematic review
  • T2 16864724 ↗Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis in
  • T6INDIRECT 8198938 ↗Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients wit
  • T6INDIRECT 24567799 ↗Cardiac autonomic neuropathy in patients with diabetes mellitus
  • T6INDIRECT 25408161 ↗Natural history and therapy of TTR-cardiac amyloidosis: emerging disease-modifying therapies from or
  • T6INDIRECT 24090418 ↗Life-threatening outcomes associated with autonomic dysreflexia: a clinical review
  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 27660695 ↗Update on the treatment of type 2 diabetes mellitus
  • T6 21483018 ↗Amyloidosis: pathogenesis and new therapeutic options
  • T6 30975301 ↗Screening and Management of Depression in Patients With Cardiovascular Disease: JACC State-of-the-Ar
  • T6 11751653 ↗Cirrhotic cardiomyopathy: a pathophysiological review of circulatory dysfunction in liver disease
  • T6 31196984 ↗Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
  • T6 25514304 ↗The diagnosis and management of mild cognitive impairment: a clinical review
Diltiazem
T2
T2 — RCT in related condition
POTS
25 sources
  • T6INDIRECT 24158454 ↗Blood pressure control and primary prevention of stroke: summary of the recent clinical trial data a
  • T6INDIRECT 24869750 ↗Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension
  • T6INDIRECT 32519776 ↗Withdrawal of antihypertensive drugs in older people
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 31917972 ↗Towards chamber specific heart-on-a-chip for drug testing applications
  • T6INDIRECT 31167038 ↗Pharmacotherapy for hypertension in adults 60 years or older
  • T6INDIRECT 24902920 ↗The design and rationale of a multicenter clinical trial comparing two strategies for control of sys
  • T6INDIRECT 30962677 ↗Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual e
  • T2 25377242 ↗Effect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa i
  • T6INDIRECT 10577041 ↗Botulinum toxin is a useful treatment in excessive drooling in saliva
  • T6INDIRECT 22187469 ↗Standards of medical care in diabetes--2012
  • T6INDIRECT 25408161 ↗Natural history and therapy of TTR-cardiac amyloidosis: emerging disease-modifying therapies from or
  • T6INDIRECT 23264422 ↗Standards of medical care in diabetes--2013
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 21193625 ↗Standards of medical care in diabetes--2011
  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6INDIRECT 19118286 ↗Standards of medical care in diabetes--2009
  • T6INDIRECT 37139824 ↗American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medicatio
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 9723817 ↗Grapefruit juice-drug interactions
  • T6 23850704 ↗Phenotypic screens as a renewed approach for drug discovery
  • T6 30354828 ↗Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the Ameri
  • T6 33895845 ↗2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral A
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
  • T6 16365341 ↗JBS 2: Joint British Societies' guidelines on prevention of cardiovascular disease in clinical pract
Domperidone
T2
T2 — RCT in related condition
POTS
28 sources
  • T6INDIRECT 26561338 ↗Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy
  • T6INDIRECT 27863901 ↗A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease f
  • T6INDIRECT 29217664 ↗Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Re
  • T6INDIRECT 15548480 ↗Mucuna pruriens in Parkinson's disease: a double blind clinical and pharmacological study
  • T6INDIRECT 27956826 ↗Nonmotor gastrointestinal disorders in older patients with Parkinson's disease: is there hope?
  • T6INDIRECT 9343116 ↗Catechol-O-methyltransferase inhibition with tolcapone reduces the "wearing off" phenomenon and levo
  • T2 17557339 ↗Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkin
  • T6INDIRECT 28202786 ↗Dopamine Modulates Adaptive Prediction Error Coding in the Human Midbrain and Striatum
  • T6INDIRECT 7608665 ↗Pen injected apomorphine against off phenomena in late Parkinson's disease: a double blind, placebo
  • T6INDIRECT 9810943 ↗Subcutaneous apomorphine in late stage Parkinson's disease: a long term follow up
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 26514824 ↗Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for
  • T6INDIRECT 2666581 ↗Multiple system atrophy--the nature of the beast
  • T6INDIRECT 31519472 ↗New evidence on the management of Lewy body dementia
  • T6INDIRECT 28100251 ↗Consensus guideline for the diagnosis and treatment of aromatic l-amino acid decarboxylase (AADC) de
  • T6INDIRECT 29508455 ↗Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
  • T6INDIRECT 23184849 ↗Grapefruit-medication interactions: forbidden fruit or avoidable consequences?
  • T6 29315692 ↗Comprehensive review of cardiovascular toxicity of drugs and related agents
  • T6 24699931 ↗Non-motor Parkinson's: integral to motor Parkinson's, yet often neglected
  • T6 33586685 ↗Gastrointestinal motility disorders in neurologic disease
  • T6 31473980 ↗Apomorphine for Parkinson's Disease: Efficacy and Safety of Current and New Formulations
  • T6 27505015 ↗Side effects of a dopamine agonist therapy for Parkinson's disease: a mini-review of clinical pharma
  • T6 26366103 ↗An update of clinical management of acute intermittent porphyria
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 16678566 ↗Childhood functional gastrointestinal disorders: child/adolescent
  • T6 23147521 ↗Clinical guideline: management of gastroparesis
Droxidopa
T2
T2 — RCT in related condition
WithdrawnME/CFSPOTS
57 sources
  • T2WITHDRAWN NCT00977171 ↗Study To Assess The Clinical Benefit Of Droxidopa In Subjects With Chronic Fatigue Syndrome
  • T2WITHDRAWN NCT03070730 ↗Hemodynamic Response of Neuropathic And Non-Neuropathic POTS Patients To Adrenoreceptor Agonist And
  • T6INDIRECT 41225175 ↗Systematic literature review: treatment of postural orthostatic tachycardia syndrome (POTS)
  • T6 29222399 ↗Pediatric Disorders of Orthostatic Intolerance
  • T6 23569093 ↗Common syndromes of orthostatic intolerance
  • T6 34821709 ↗Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?
  • T6 24819031 ↗Adolescent fatigue, POTS, and recovery: a guide for clinicians
  • T6INDIRECT 33723532 ↗Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrom
  • T6INDIRECT 28885363 ↗Prevalence, risk factors, and prognosis of orthostatic hypotension in diabetic patients: A systemati
  • T6INDIRECT 34000076 ↗Fludrocortisone for orthostatic hypotension
  • T2 24944260 ↗Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial
  • T6INDIRECT 10599797 ↗The treatment of neurogenic orthostatic hypotension with 3,4-DL-threo-dihydroxyphenylserine: a rando
  • T2 28494751 ↗Integrated analysis of droxidopa trials for neurogenic orthostatic hypotension
  • T6INDIRECT 23616163 ↗Low-dose propranolol and exercise capacity in postural tachycardia syndrome: a randomized study
  • T6INDIRECT 27372462 ↗Clinical benefit of midodrine hydrochloride in symptomatic orthostatic hypotension: a phase 4, doubl
  • T6INDIRECT 32986682 ↗The D1/D5 Dopamine Partial Agonist PF-06412562 in Advanced-Stage Parkinson's Disease: A Feasibility
  • T6INDIRECT 34657222 ↗Safety and efficacy of ampreloxetine in symptomatic neurogenic orthostatic hypotension: a phase 2 tr
  • T6INDIRECT 28967294 ↗An Autonomic Neuroprosthesis: Noninvasive Electrical Spinal Cord Stimulation Restores Autonomic Card
  • T6 27999003 ↗Diabetic Neuropathy: A Position Statement by the American Diabetes Association
  • T6 31519472 ↗New evidence on the management of Lewy body dementia
  • T6INDIRECT 34752479 ↗Drug-induced orthostatic hypotension: A systematic review and meta-analysis of randomised controlled
  • T2 25350981 ↗Randomized withdrawal study of patients with symptomatic neurogenic orthostatic hypotension responsi
  • T2 25487613 ↗Droxidopa for the short-term treatment of symptomatic neurogenic orthostatic hypotension in Parkinso
  • T6INDIRECT 25185131 ↗Efficacy of atomoxetine versus midodrine for the treatment of orthostatic hypotension in autonomic f
  • T2 24326693 ↗Droxidopa in patients with neurogenic orthostatic hypotension associated with Parkinson's disease (N
  • T6INDIRECT 12885750 ↗Norepinephrine precursor therapy in neurogenic orthostatic hypotension
  • T6INDIRECT 2890806 ↗Endogenous restoration of noradrenaline by precursor therapy in dopamine-beta-hydroxylase deficiency
  • T2 11710796 ↗L-threo-dihydroxyphenylserine (L-threo-DOPS; droxidopa) in the management of neurogenic orthostatic
  • T6INDIRECT 29326369 ↗Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using na
  • T6INDIRECT 34403043 ↗Autonomic dysfunction in SARS-COV-2 infection acute and long-term implications COVID-19 editor's pag
  • T6INDIRECT 38390594 ↗Dysautonomia following Lyme disease: a key component of post-treatment Lyme disease syndrome?
  • T6INDIRECT 37204997 ↗Postural Orthostatic Tachycardia Syndrome in COVID-19: A Contemporary Review of Mechanisms, Clinical
  • T6INDIRECT 41089328 ↗Immunotherapies for postural orthostatic tachycardia syndrome, other common autonomic disorders, and
  • T6INDIRECT 37654428 ↗Postural orthostatic tachycardia syndrome and other related dysautonomic disorders after SARS-CoV-2
  • T6 33786405 ↗Recent advances in carbon nanomaterials for biomedical applications: A review
  • T6 33886735 ↗Dysautonomia: A Forgotten Condition - Part 1
  • T6 37764145 ↗Comparison of the Efficacy of Longer versus Shorter Pulsed High Dose Dapsone Combination Therapy in
  • T6 32949293 ↗Program and Abstracts of the 31st International Symposium on the Autonomic Nervous System
  • T6 PMC11231130 ↗Abstracts from the 2024 Annual Meeting of the Society of General Internal Medicine
  • T6 35212554 ↗Orthostatic Hypotension: Management of a Complex, But Common, Medical Problem
  • T6 32222376 ↗Postural Orthostatic Tachycardia Syndrome (POTS): A critical assessment
  • T6 35720084 ↗Dysautonomia in COVID-19 Patients: A Narrative Review on Clinical Course, Diagnostic and Therapeutic
  • T6INDIRECT 32402162 ↗Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease
  • T6INDIRECT 29508455 ↗Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
  • T6INDIRECT 35841911 ↗Diagnosis and treatment of orthostatic hypotension
  • T6INDIRECT 24433463 ↗Review of pharmacological therapies in fibromyalgia syndrome
  • T6INDIRECT 33649021 ↗Autoimmune encephalitis: proposed recommendations for symptomatic and long-term management
  • T6 29075003 ↗Trends in GPCR drug discovery: new agents, targets and indications
  • T6 39353925 ↗Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy
  • T6 36810524 ↗Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions
  • T6 30793549 ↗Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: W
  • T6 26729077 ↗The Prodrug Approach: A Successful Tool for Improving Drug Solubility
  • T6 33924103 ↗Treatment Options for Motor and Non-Motor Symptoms of Parkinson's Disease
  • T6 33427939 ↗The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 23425518 ↗Guideline of transthyretin-related hereditary amyloidosis for clinicians
  • T6 28050656 ↗The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic o
Entacapone
T2
T2 — RCT in related condition
RegisteredPOTS
28 sources
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T6INDIRECT 33674954 ↗Overall Efficacy and Safety of Safinamide in Parkinson's Disease: A Systematic Review and a Meta-ana
  • T6INDIRECT 34964392 ↗Orthostatic Hypotension and Antiparkinsonian Drugs: A Systematic Review and Meta-analysis
  • T6 28716886 ↗Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases
  • T6HARM 28273839 ↗Parkinson's Disease: From Pathogenesis to Pharmacogenomics
  • T6 23225012 ↗Parkinson's disease
  • T6 34942142 ↗The neuropsychiatry of Parkinson's disease: advances and challenges
  • T6 22675666 ↗Clinical approach to Parkinson's disease: features, diagnosis, and principles of management
  • T6 35279112 ↗Opicapone versus placebo in the treatment of Parkinson's disease patients with end-of-dose motor flu
  • T6INDIRECT 27863901 ↗A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease f
  • T6INDIRECT 35010624 ↗Systematic Review on Parkinson's Disease Medications, Emphasizing on Three Recently Approved Drugs t
  • T6INDIRECT 9343116 ↗Catechol-O-methyltransferase inhibition with tolcapone reduces the "wearing off" phenomenon and levo
  • T2 8558148 ↗Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients wit
  • T6INDIRECT 8527287 ↗Pharmacokinetic-pharmacodynamic interaction between the COMT inhibitor tolcapone and single-dose lev
  • T6INDIRECT 23336248 ↗Opicapone: a short lived and very long acting novel catechol-O-methyltransferase inhibitor following
  • T6INDIRECT 27332626 ↗Droxidopa and Reduced Falls in a Trial of Parkinson Disease Patients With Neurogenic Orthostatic Hyp
  • T6INDIRECT 33164945 ↗Continuous Subcutaneous Levodopa Delivery for Parkinson's Disease: A Randomized Study
  • T6INDIRECT 32345378 ↗Effectiveness and safety of opicapone in Parkinson's disease patients with motor fluctuations: the O
  • T6INDIRECT 17894650 ↗Catechol-O-methyltransferase and its inhibitors in Parkinson's disease
  • T6INDIRECT 32456656 ↗Consensus guideline for the diagnosis and treatment of tetrahydrobiopterin (BH&lt;sub&gt;4&lt;/sub&g
  • T6INDIRECT 32373652 ↗Management of Advanced Therapies in Parkinson's Disease Patients in Times of Humanitarian Crisis: Th
  • T6INDIRECT 28261151 ↗The Treatment of Sleep Disorders in Parkinson's Disease: From Research to Clinical Practice
  • T6INDIRECT 32484584 ↗COVID-19 in Parkinson's Disease Patients Living in Lombardy, Italy
  • T6 28887905 ↗Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Sh
  • T6 29090092 ↗Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential trea
  • T6 36810524 ↗Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions
  • T6 27803666 ↗Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology
  • T6 26324905 ↗Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism
Entacapone & Propranolol
T2
T2 — RCT in related condition
RegisteredPOTS
1 source
Exposure therapy
T2
T2 — RCT in related condition
POTS
18 sources
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T2 31628568 ↗A Meta-analysis to Guide the Enhancement of CBT for Childhood Anxiety: Exposure Over Anxiety Managem
  • T6INDIRECT 36602886 ↗Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis
  • T6INDIRECT 35234292 ↗Pharmacotherapy for post traumatic stress disorder (PTSD)
  • T6INDIRECT 26352916 ↗Interventions for Individuals With High Levels of Needle Fear: Systematic Review of Randomized Contr
  • T6INDIRECT 38588457 ↗Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis
  • T6INDIRECT 25457929 ↗Tic-related obsessive-compulsive disorder (OCD): phenomenology and treatment outcome in the Pediatri
  • T2 29939055 ↗Measuring fear change within exposures: Functionally-defined habituation predicts outcome in three r
  • T6INDIRECT 30852257 ↗Fear extinction learning as a predictor of response to cognitive behavioral therapy for pediatric ob
  • T6 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 35430029 ↗Functional neurological disorder: new subtypes and shared mechanisms
  • T6INDIRECT 37436070 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 25138725 ↗The diagnosis of and treatment recommendations for anxiety disorders
  • T6INDIRECT 20726290 ↗Best practice guide for the treatment of nightmare disorder in adults
  • T6 26062169 ↗Fear and the Defense Cascade: Clinical Implications and Management
  • T6 21440852 ↗Cognitive-behavioral therapy for anxiety disorders in youth
  • T6 25936504 ↗Brains in the city: Neurobiological effects of urbanization
  • T6 22259614 ↗Vestibular rehabilitation therapy: review of indications, mechanisms, and key exercises
External automated abdominal binder
T2
T2 — RCT in related condition
WithdrawnPOTS
1 source
  • T2WITHDRAWN NCT01771484 ↗High Sodium Diet and External Abdominal Compression in POTS
Fludarabine
T2
T2 — RCT in related condition
RegisteredWithdrawnMCASPOTS
42 sources
  • T6WITHDRAWN NCT01773395 ↗GVAX vs. Placebo for MDS/AML After Allo HSCT
  • T6 NCT01384513 ↗A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Mali
  • T6REGISTERED-ONLY NCT03779854 ↗Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults
  • T6INDIRECT 36542826 ↗Lisocabtagene maraleucel as second-line therapy for large B-cell lymphoma: primary analysis of the p
  • T2 12393618 ↗Fludarabine, mitoxantrone, dexamethasone (FND) compared with an alternating triple therapy (ATT) reg
  • T6INDIRECT 25154820 ↗Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effect
  • T2 8648382 ↗Fludarabine, mitoxantrone, and dexamethasone: an effective new regimen for indolent lymphoma
  • T6INDIRECT 38659046 ↗Long-term remission and survival in patients with relapsed or refractory multiple myeloma after trea
  • T2 15741224 ↗Myelodysplasia and acute myeloid leukemia following therapy for indolent lymphoma with fludarabine,
  • T6 32934330 ↗Exploring the NK cell platform for cancer immunotherapy
  • T6 11229815 ↗The CD40/CD154 receptor/ligand dyad
  • T6 29915719 ↗Past, Present, and Future of Rituximab-The World's First Oncology Monoclonal Antibody Therapy
  • T6 24859366 ↗Activity of SL-401, a targeted therapy directed to interleukin-3 receptor, in blastic plasmacytoid d
  • T6INDIRECT 37756687 ↗Toxicity profiles of antibody-drug conjugates for anticancer treatment: a systematic review and meta
  • T6INDIRECT 28971751 ↗Anti-CD 19 and anti-CD 20 CAR-modified T cells for B-cell malignancies: a systematic review and meta
  • T6INDIRECT 29217664 ↗Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Re
  • T6INDIRECT 19263294 ↗Prolonged myelosuppression with clofarabine in the treatment of patients with relapsed or refractory
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6 33895845 ↗2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral A
  • T6 31210940 ↗European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gl
  • T6 22308288 ↗CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 a
  • T6 22762314 ↗Eltrombopag and improved hematopoiesis in refractory aplastic anemia
  • T6INDIRECT 30705099 ↗IgG4-related disease: what a hematologist needs to know
  • T6INDIRECT 34774343 ↗A review of FLT3 inhibitors in acute myeloid leukemia
  • T6INDIRECT 29844705 ↗Severe cutaneous adverse reactions induced by targeted anticancer therapies and immunotherapies
  • T6INDIRECT 32522746 ↗Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies
  • T6INDIRECT 33875812 ↗Transplant-associated thrombotic microangiopathy: theoretical considerations and a practical approac
  • T6INDIRECT 29475724 ↗A gene-expression profiling score for prediction of outcome in patients with follicular lymphoma: a
  • T6 19099185 ↗Mcl-1 is a potential therapeutic target in multiple types of cancer
  • T6 22075983 ↗BCL2A1: the underdog in the BCL2 family
  • T6 24975478 ↗Getting Syk: spleen tyrosine kinase as a therapeutic target
  • T6 23060872 ↗Immune dysregulation, polyendocrinopathy, enteropathy, x-linked syndrome: a paradigm of immunodefici
  • T6INDIRECT 30348186 ↗Anti-BCMA CAR-T cells for treatment of plasma cell dyscrasia: case report on POEMS syndrome and mult
  • T6INDIRECT 34134525 ↗Recognition, Prevention, and Management of Arrhythmias and Autonomic Disorders in Cardio-Oncology: A
  • T6INDIRECT 37345050 ↗The Black Hole: CAR T Cell Therapy in AML
  • T6INDIRECT 25124015 ↗Noninvasive imaging of cardiovascular injury related to the treatment of cancer
  • T6 30130469 ↗Iron and Cancer
  • T6 28174091 ↗Inhibitors of cyclin-dependent kinases as cancer therapeutics
  • T6 25561510 ↗Advances in anticancer immunotoxin therapy
  • T6 26566663 ↗The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel th
  • T6 26391778 ↗Cancer-treatment-induced neurotoxicity--focus on newer treatments
GIPR antagonist
T2
T2 — RCT in related condition
RegisteredPOTS
4 sources
  • T2REGISTERED-ONLY NCT07019519 ↗POTS-FLOW: Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patien
  • T6 35232225 ↗Worsening Postural Tachycardia Syndrome Is Associated With Increased Glucose-Dependent Insulinotropi
  • T6 28795195 ↗53 &lt;sup&gt;rd&lt;/sup&gt; EASD Annual Meeting of the European Association for the Study of Diabet
  • T6 32840677 ↗56<sup>th</sup> EASD Annual Meeting of the European Association for the Study of Diabetes : 21-25 Se
GLP-1R antagonist
T2
T2 — RCT in related condition
RegisteredPOTS
11 sources
  • T2REGISTERED-ONLY NCT07019519 ↗POTS-FLOW: Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patien
  • T6 41096559 ↗Gut Microbiome as a Source of Probiotic Drugs for Parkinson's Disease
  • T6 19898904 ↗High-affinity alphavbeta3 integrin targeted optical probe as a new imaging biomarker for early ather
  • T6 19018511 ↗Diet, delusion and diabetes
  • T6 28795195 ↗53 &lt;sup&gt;rd&lt;/sup&gt; EASD Annual Meeting of the European Association for the Study of Diabet
  • T6 27539147 ↗Abstracts of 52nd EASD Annual Meeting
  • T6 32840677 ↗56<sup>th</sup> EASD Annual Meeting of the European Association for the Study of Diabetes : 21-25 Se
  • T6INDIRECT 34559267 ↗European Association of Nuclear Medicine October 20-23, 2021 Virtual
  • T4 PMC6907427 ↗Clinical Diabetes/Therapeutics
  • T6INDIRECT 23949610 ↗Abstracts of the 49th EASD (European Association for the Study of Diabetes) Annual Meeting. Septembe
  • T6 41465588 ↗GLP-1 Signalling as a Therapeutic Avenue in Parkinson's Disease: A Comprehensive Review
Gabapentin
T2
T2 — RCT in related condition
POTS
32 sources
  • T2 NCT04345432 ↗Gabapentin Treatment of Postural Tachycardia Syndrome (PoTS)
  • T6INDIRECT 35182760 ↗ESCMID rapid guidelines for assessment and management of long COVID
  • T6INDIRECT 32840686 ↗Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cas
  • T6INDIRECT 24920437 ↗Central changes associated with chronic pelvic pain and endometriosis
  • T6INDIRECT 37189381 ↗Dupilumab in Inflammatory Skin Diseases: A Systematic Review
  • T6INDIRECT 36349400 ↗Clinical trials on the pharmacological treatment of long COVID: A systematic review
  • T6INDIRECT 19029129 ↗Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study
  • T6INDIRECT 18281407 ↗Systems Training for Emotional Predictability and Problem Solving (STEPPS) for outpatients with bord
  • T6INDIRECT 34444817 ↗Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Qu
  • T6INDIRECT 33662112 ↗Overminus Lens Therapy for Children 3 to 10 Years of Age With Intermittent Exotropia: A Randomized C
  • T6INDIRECT 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
  • T6 27999003 ↗Diabetic Neuropathy: A Position Statement by the American Diabetes Association
  • T6 31663402 ↗Consensus statement for perioperative care in total hip replacement and total knee replacement surge
  • T6INDIRECT 17943857 ↗Antidepressants for neuropathic pain
  • T6INDIRECT 30673120 ↗Pregabalin for neuropathic pain in adults
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 22281448 ↗Placebo-controlled comparison of prazosin and cognitive-behavioral treatments for sleep disturbances
  • T6INDIRECT 26902950 ↗Efficacy and Safety of Paliperidone Palmitate 3-Month Formulation for Patients with Schizophrenia: A
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 26514824 ↗Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for
  • T6INDIRECT 26084539 ↗International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 19118286 ↗Standards of medical care in diabetes--2009
  • T6 21092187 ↗Fabry disease
  • T6 20194146 ↗Recommendations for the pharmacological management of neuropathic pain: an overview and literature u
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 28620280 ↗Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy
  • T6 39353925 ↗Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy
  • T6 20876709 ↗Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treat
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 23425518 ↗Guideline of transthyretin-related hereditary amyloidosis for clinicians
  • T6 36178003 ↗World guidelines for falls prevention and management for older adults: a global initiative
Galantamine Pill
T2
T2 — RCT in related condition
RegisteredPOTS
1 source
GammaCore intervention
T2
T2 — RCT in related condition
POTS
1 source
  • T2 NCT06268288 ↗Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Synd
Guanfacine
T2
T2 — RCT in related condition
POTS
23 sources
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 24869750 ↗Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension
  • T6INDIRECT 23450540 ↗Methadone at tapered doses for the management of opioid withdrawal
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 35234292 ↗Pharmacotherapy for post traumatic stress disorder (PTSD)
  • T6INDIRECT 28486271 ↗Withdrawal of antihypertensive medication: a systematic review
  • T6INDIRECT 37818791 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 24902920 ↗The design and rationale of a multicenter clinical trial comparing two strategies for control of sys
  • T2 19877974 ↗Safety and effectiveness of coadministration of guanfacine extended release and psychostimulants in
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 34204991 ↗A Comprehensive Review of Tic Disorders in Children
  • T6INDIRECT 29335879 ↗Current Approaches and New Developments in the Pharmacological Management of Tourette Syndrome
  • T6INDIRECT 37139824 ↗American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medicatio
  • T6INDIRECT 30192094 ↗Management of common adverse effects of antipsychotic medications
  • T6INDIRECT 21445724 ↗European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological
  • T6 29315692 ↗Comprehensive review of cardiovascular toxicity of drugs and related agents
  • T6 16554257 ↗Contemporary assessment and pharmacotherapy of Tourette syndrome
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
  • T6 28050656 ↗The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic o
  • T6 30354828 ↗Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the Ameri
Home transcutaneous vagal nerve stimulation
T2
T2 — RCT in related condition
POTS
1 source
  • T2 NCT04632134 ↗Long-term Effects of Transcutaneous Vagal Nerve Stimulation on Postural Orthostatic Tachycardia Synd
Hybrid Exercise Training
T2
T2 — RCT in related condition
POTS
1 source
  • T2 NCT04603157 ↗Remote Self-training Program for Patients With Postural Orthostatic Tachycardia Syndrome
I-blocker
T2
T2 — RCT in related condition
POTS
32 sources
  • T2 NCT00865917 ↗Cardiovascular Effects of Selective I(f)-Channel Blockade
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30019766 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30521670 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 19687359 ↗Propranolol decreases tachycardia and improves symptoms in the postural tachycardia syndrome: less i
  • T6INDIRECT 28893208 ↗Trial design and rationale for APOLLO, a Phase 3, placebo-controlled study of patisiran in patients
  • T6INDIRECT 36723919 ↗Effect of Personalized Accelerated Pacing on Quality of Life, Physical Activity, and Atrial Fibrilla
  • T6INDIRECT 11804991 ↗Selective norepinephrine reuptake inhibition as a human model of orthostatic intolerance
  • T6INDIRECT 33602468 ↗Randomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syn
  • T6INDIRECT 23266540 ↗Angiotensin II, independent of plasma renin activity, contributes to the hypertension of autonomic f
  • T6 22258608 ↗The promise of induced pluripotent stem cells in research and therapy
  • T6HARM 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 30673120 ↗Pregabalin for neuropathic pain in adults
  • T6INDIRECT 26551272 ↗A Randomized Trial of Intensive versus Standard Blood-Pressure Control
  • T6INDIRECT 24902920 ↗The design and rationale of a multicenter clinical trial comparing two strategies for control of sys
  • T6INDIRECT 28642330 ↗Effects of Intensive BP Control in CKD
  • T6INDIRECT 22573363 ↗Catheter-based renal denervation for resistant hypertension: rationale and design of the SYMPLICITY
  • T6INDIRECT 29133606 ↗Effects of Bariatric Surgery in Obese Patients With Hypertension: The GATEWAY Randomized Trial (Gast
  • T6INDIRECT 24126931 ↗Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with mini
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 33243615 ↗Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 23264422 ↗Standards of medical care in diabetes--2013
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6 36148880 ↗Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes As
  • T6 19118286 ↗Standards of medical care in diabetes--2009
  • T6 20663977 ↗Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and
  • T6 29565029 ↗Hypertension
Individual tailored exercise
T2
T2 — RCT in related condition
POTS
1 source
  • T2 NCT05877534 ↗Effects of Individual Tailored Physical Exercise in Patients With POTS After COVID-19 - a Randomized
Indomethacin
T2
T2 — RCT in related condition
RegisteredPOTS
31 sources
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T6INDIRECT 37189381 ↗Dupilumab in Inflammatory Skin Diseases: A Systematic Review
  • T6INDIRECT 37147116 ↗Multidisciplinary consensus guideline for the diagnosis and management of spontaneous intracranial h
  • T6INDIRECT 34000076 ↗Fludrocortisone for orthostatic hypotension
  • T6INDIRECT 34143333 ↗The effects of caffeine in adults with neurogenic orthostatic hypotension: a systematic review
  • T6INDIRECT 27372462 ↗Clinical benefit of midodrine hydrochloride in symptomatic orthostatic hypotension: a phase 4, doubl
  • T6INDIRECT 40747556 ↗Altered Blood Pressure Reflexes in Women With Endometriosis
  • T6INDIRECT 30466384 ↗Lifestyle modifications as therapy for medication refractory post-traumatic headache (PTHA) in the m
  • T6 21749363 ↗Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects
  • T6 2666581 ↗Multiple system atrophy--the nature of the beast
  • T6 22500859 ↗What have we learned from brucellosis in the mouse model?
  • T6 4758519 ↗Cardiac denervation in diabetes
  • T6 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 27419911 ↗Epidural local anaesthetics versus opioid-based analgesic regimens for postoperative gastrointestina
  • T6INDIRECT 23076930 ↗Local anaesthetics and regional anaesthesia for preventing chronic pain after surgery
  • T6INDIRECT 29926477 ↗Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent
  • T6INDIRECT 22591985 ↗Efficacy of treatments for orthostatic hypotension: a systematic review
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 2875321 ↗Treatment of autonomic neuropathy with a somatostatin analogue SMS-201-995
  • T6INDIRECT 9727818 ↗Contrasting actions of pressor agents in severe autonomic failure
  • T6INDIRECT 20396637 ↗Inappropriate prescribing in the hospitalized elderly patient: defining the problem, evaluation tool
  • T6INDIRECT 37139824 ↗American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medicatio
  • T6INDIRECT 28262641 ↗Vestibular paroxysmia: Diagnostic criteria
  • T6INDIRECT 18488078 ↗Current aproach to cancer pain management: Availability and implications of different treatment opti
  • T6 28986925 ↗Cerebral blood flow in normal aging adults: cardiovascular determinants, clinical implications, and
  • T6 23588782 ↗Applications of CYP450 testing in the clinical setting
  • T6 16461471 ↗Diabetic neuropathy
  • T6 30033869 ↗A Summary of Electrospun Nanofibers as Drug Delivery System: Drugs Loaded and Biopolymers Used as Ma
  • T6 6811067 ↗Diagnosis and management of diabetic autonomic neuropathy
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
Inspiratory Threshold Device
T2
T2 — RCT in related condition
RegisteredPOTS
7 sources
  • T2REGISTERED-ONLY NCT00962728 ↗Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS)
  • T2 32705393 ↗Inspiratory muscle training improves cerebrovascular and postural control responses during orthostat
  • T6 24778619 ↗Arterial pressure and cerebral blood flow variability: friend or foe? A review
  • T6 34992796 ↗Anaesthesia after neoadjuvant chemotherapy, immunotherapy or radiotherapy
  • T6 23932268 ↗[Improving vital organs perfusion by the respiratory pump: physiology and clinical use]
  • T6 24078670 ↗Postexercise syncope: Wingate syncope test and effective countermeasure
  • T6 PMC2845228 ↗Commentary on Current Literature
Intrinsic Heart Rate
T2
T2 — RCT in related condition
RegisteredPOTS
23 sources
  • T2REGISTERED-ONLY NCT00608725 ↗Pathophysiology of Orthostatic Intolerance
  • T6INDIRECT 10190880 ↗Abnormal norepinephrine clearance and adrenergic receptor sensitivity in idiopathic orthostatic into
  • T6 20497993 ↗Sympathetic nervous system and blood pressure in humans: individualized patterns of regulation and t
  • T6 25589269 ↗Neural control of the circulation: how sex and age differences interact in humans
  • T6 35307156 ↗2022 ACC Expert Consensus Decision Pathway on Cardiovascular Sequelae of COVID-19 in Adults: Myocard
  • T6 21098405 ↗Afferent baroreflex failure in familial dysautonomia
  • T6INDIRECT 31391000 ↗Swallow syncope: a case report and review of literature
  • T6INDIRECT 33279955 ↗Cardiac pacing in severe recurrent reflex syncope and tilt-induced asystole
  • T6INDIRECT 27736760 ↗Randomized, Open-Label Study of the Pharmacokinetics and Safety of Oral and Intravenous Administrati
  • T6INDIRECT 32817835 ↗Cardioneuroablation for management of cardioinhibitory vasovagal syncope and pacemaker complications
  • T6INDIRECT 33918562 ↗Inappropriate Sinus Tachycardia Following Viral Illness
  • T6INDIRECT 42028077 ↗Extracardiac vagal nerve stimulation-guided cardioneuroablation in patients with interrupted superio
  • T6INDIRECT 36074973 ↗Sinus Tachycardia: a Multidisciplinary Expert Focused Review
  • T6INDIRECT 35106176 ↗Cardiac Pacing in Cardioinhibitory Reflex Syncope: Clinical Use of Closed-loop Stimulation
  • T6INDIRECT 40725699 ↗Neural Correlates of Huntington's Disease Based on Electroencephalography (EEG): A Mechanistic Revie
  • T6INDIRECT 24913692 ↗Ongoing clinical trials for Vasovagal Syncope: where are we in 2014?
  • T6 24844457 ↗Beneficial effects of physical activity on baroreflex control in the elderly
  • T6 31863250 ↗State of the art: leadless ventricular pacing : A national expert consensus of the Austrian Society
  • T6 33204081 ↗Falls Risk, Circadian Rhythms and Melatonin: Current Perspectives
  • T6 20123977 ↗Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failur
  • T6 22883907 ↗Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant α-synuclein
  • T6 27042032 ↗Impact of aging on cardiac function in a female rat model of menopause: role of autonomic control, i
  • T6 29470149 ↗Chronic, complete cervical<sub>6-7</sub> cord transection: distinct autonomic and cardiac deficits
Iron infusion
T2
T2 — RCT in related condition
WithdrawnPOTS
14 sources
  • T2WITHDRAWN NCT01978535 ↗Iron Sucrose in Adolescents With Iron Deficiency and Postural Orthostatic Tachycardia Syndrome (POTS
  • T6 30569038 ↗A novel nano-iron supplement to safely combat iron deficiency and anaemia in young children: The IHA
  • T6 37051178 ↗Effects of vitamin and mineral supplementation during pregnancy on maternal, birth, child health and
  • T6 32213001 ↗UEG Week 2019 Poster Presentations
  • T6 28608429 ↗27th Regional Congress of the ISBT, Copenhagen, Denmark, June 17-21, 2017
  • T6 24737224 ↗Abstracts from the 37th Annual Meeting of the Society of General Internal Medicine, 2014, San Diego,
  • T6INDIRECT 27140401 ↗Clinical iron deficiency disturbs normal human responses to hypoxia
  • T6 34684433 ↗Iron Deficiency in Celiac Disease: Prevalence, Health Impact, and Clinical Management
  • T6INDIRECT 38532802 ↗Patisiran exposure in early pregnancy: a case report
  • T6INDIRECT 41906589 ↗Nonanemic Iron Deficiency: Exercise Performance Recovery After Iron Repletion in Collegiate Athlete
  • T6INDIRECT 40832691 ↗The Management of Parkinson's Disease Before, during and after Pregnancy-an MDS Scientific Issues Co
  • T6INDIRECT 31173375 ↗29th Regional Congress of the ISBT, Basel, Switzerland, 22-26 June 2019
  • T6INDIRECT 32745265 ↗35th International Congress of the ISBT, Toronto, Canada, June 2-6, 2018
  • T6 36186804 ↗Indications and hemoglobin thresholds for red blood cell transfusion and iron replacement in adults
Isosorbide Dinitrate
T2
T2 — RCT in related condition
RegisteredPOTS
29 sources
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T6INDIRECT 27388039 ↗Pharmacological interventions for treating heart failure in patients with Chagas cardiomyopathy
  • T2 35299288 ↗Vericiguat in combination with isosorbide mononitrate in patients with chronic coronary syndromes: T
  • T6 1423218 ↗Chagas' disease
  • T6 27672286 ↗New insights into the pathophysiology of achalasia and implications for future treatment
  • T6 26676662 ↗Treating Diabetic Neuropathy: Present Strategies and Emerging Solutions
  • T6 36228868 ↗Glutamatergic systems in neuropathic pain and emerging non-opioid therapies
  • T6 35386135 ↗The Canadian Women's Heart Health Alliance Atlas on the Epidemiology, Diagnosis, and Management of C
  • T6INDIRECT 32103487 ↗Pharmacological interventions for heart failure in people with chronic kidney disease
  • T2 28219917 ↗Isosorbide Dinitrate, With or Without Hydralazine, Does Not Reduce Wave Reflections, Left Ventricula
  • T6INDIRECT 25300460 ↗NILVAD protocol: a European multicentre double-blind placebo-controlled trial of nilvadipine in mild
  • T6INDIRECT 3314956 ↗Efficacy of felodipine in chronic congestive heart failure: a placebo controlled haemodynamic study
  • T6INDIRECT 20632059 ↗Optimal treatment duration of glyceryl trinitrate for chronic anal fissure: results of a prospective
  • T6INDIRECT 9808874 ↗[Evaluation of the effects of diverse therapeutic treatments versus no treatment of patients with ne
  • T6INDIRECT 33387632 ↗Effects of Low-Level Tragus Stimulation on Endothelial Function in Heart Failure With Reduced Ejecti
  • T6INDIRECT 2515254 ↗Source of pain and primitive dysfunction in migraine: an identical site?
  • T6INDIRECT 31236077 ↗Pheochromocytoma-Induced Takotsubo Cardiomyopathy
  • T6INDIRECT 8364814 ↗Report of the Canadian Hypertension Society Consensus Conference: 3. Pharmacologic treatment of esse
  • T6INDIRECT 24701420 ↗Therapeutic approaches for renal colic in the emergency department: a review article
  • T6INDIRECT 2491825 ↗Effect of prostaglandin inhibitors on bile salt-induced mucosal damage of porcine colon
  • T6INDIRECT 25869016 ↗Abstracts from the 38th annual meeting of the society of general internal medicine
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 16461471 ↗Diabetic neuropathy
  • T6 34948113 ↗Genophenotypic Factors and Pharmacogenomics in Adverse Drug Reactions
  • T6 21620994 ↗Acute retinal arterial occlusive disorders
  • T6 28050656 ↗The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic o
  • T6 27311574 ↗Vasodilator Therapy: Nitrates and Nicorandil
  • T6 16450016 ↗Canadian Cardiovascular Society consensus conference recommendations on heart failure 2006: diagnosi
  • T6 10890797 ↗Alcohol and medication interactions
Kansas City Cardiac Dysautonomia Questionnaire
T2
T2 — RCT in related condition
RegisteredPOTS
1 source
  • T2REGISTERED-ONLY NCT06672861 ↗Development and Validation of the Kansas City Cardiac Dysautonomia Questionnaire (KCDysQ)
L-NMMA trimethaphan
T2
T2 — RCT in related condition
POTS
1 source
  • T2 NCT00580619 ↗Autonomic Nervous System and Chronic Fatigue Syndrome
L-Threo DOPS
T2
T2 — RCT in related condition
POTS
17 sources
  • T2 11710796 ↗L-threo-dihydroxyphenylserine (L-threo-DOPS; droxidopa) in the management of neurogenic orthostatic
  • T2 15666063 ↗Clinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic
  • T6 28357055 ↗Recent advances in treating Parkinson's disease
  • T6 26090077 ↗(123)I-Metaiodobenzylguanidine Myocardial Scintigraphy in Lewy Body-Related Disorders: A Literature
  • T6 10406987 ↗(123)I-metaiodobenzylguanidine myocardial scintigraphy in Parkinson's disease
  • T6 22883210 ↗Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP
  • T6INDIRECT 9221984 ↗Neuroleptic malignant syndrome-like condition in multiple system atrophy
  • T6INDIRECT 9221985 ↗Non-Hodgkin's lymphoma as a new cause of non-thrombotic superior sagittal sinus occlusion
  • T6INDIRECT 34703451 ↗Elderly-Onset Multiple System Atrophy with Lewy Body Pathology: A Case Report
  • T5 8676171 ↗Acute pandysautonomia: mass spectrometric and histopathological studies of the sympathetic nervous s
  • T6INDIRECT 32436100 ↗An update on MSA: premotor and non-motor features open a window of opportunities for early diagnosis
  • T6INDIRECT 32316335 ↗Current Symptomatic and Disease-Modifying Treatments in Multiple System Atrophy
  • T6INDIRECT 10824045 ↗Progressive supranuclear palsy
  • T6INDIRECT 39751950 ↗Diagnosis and treatment of autonomic failure, pain and sleep disturbances in Parkinson's disease: gu
  • T6 24634790 ↗Orthostatic hypotension in patients with Parkinson's disease and atypical parkinsonism
  • T6 21577106 ↗New insights into atypical parkinsonism
  • T6 25309444 ↗Role of sympathetic nerve activity in the process of fainting
LDN
T2
T2 — RCT in related condition
POTS
21 sources
  • T2 25739474 ↗Prevalence of REM sleep behavior disorder in multiple system atrophy: a multicenter study and meta-a
  • T2 39940333 ↗Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (
  • T2 40071727 ↗A systematic review and embryological perspective of pluripotent stem cell-derived autonomic postgan
  • T2 28445783 ↗Jump starting shared medical appointments for diabetes with weight management: Rationale and design
  • T6 31337484 ↗Chronic Pain Management in the Elderly
  • T6 23583175 ↗Modeling neural crest induction, melanocyte specification, and disease-related pigmentation defects
  • T6 22280551 ↗Combining SNP discovery from next-generation sequencing data with bulked segregant analysis (BSA) to
  • T6 30795902 ↗Defining the Functional Role of Na&lt;sub&gt;V&lt;/sub&gt;1.7 in Human Nociception
  • T6 20975614 ↗Energy imbalance and the risk of overfeeding in critically ill children
  • T6 38740499 ↗Low-dose naltrexone for post-COVID fatigue syndrome: a study protocol for a double-blind, randomised
  • T5 31911410 ↗Low-dose naltrexone as a treatment for chronic fatigue syndrome
  • T5 23546884 ↗Treatment of Complex Regional Pain Syndrome (CRPS) using low dose naltrexone (LDN)
  • T4 36969241 ↗Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOV
  • T4 30248938 ↗Low-Dose Naltrexone (LDN)-Review of Therapeutic Utilization
  • T4 32950543 ↗Pain management in hidradenitis suppurativa and a proposed treatment algorithm
  • T4 26387020 ↗Invited review: Recommendations for reporting intervention studies on reproductive performance in da
  • T6 32204380 ↗The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases
  • T6 23285249 ↗Human sensory neurons derived from induced pluripotent stem cells support varicella-zoster virus inf
  • T6 35025863 ↗WAPO-A1 is the causal gene of the 7AL QTL for spikelet number per spike in wheat
  • T6 27480492 ↗Stem cell-derived interneuron transplants as a treatment for schizophrenia: preclinical validation i
  • T6 24285961 ↗Bedside evaluation of dizzy patients
Lenalidomide
T2
T2 — RCT in related condition
POTS
21 sources
  • T6INDIRECT 37189381 ↗Dupilumab in Inflammatory Skin Diseases: A Systematic Review
  • T6INDIRECT 27884691 ↗AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions
  • T2 33763699 ↗Oral ixazomib, lenalidomide, and dexamethasone for transplant-ineligible patients with newly diagnos
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 21483018 ↗Amyloidosis: pathogenesis and new therapeutic options
  • T6 23095830 ↗Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and preven
  • T6 22184404 ↗A phase 1, multicenter, open-label, dose escalation study of elotuzumab in patients with advanced mu
  • T6 26561559 ↗Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924)
  • T6 24920586 ↗Phase 1 study of twice-weekly ixazomib, an oral proteasome inhibitor, in relapsed/refractory multipl
  • T6INDIRECT 30348186 ↗Anti-BCMA CAR-T cells for treatment of plasma cell dyscrasia: case report on POEMS syndrome and mult
  • T6INDIRECT 34655433 ↗Chemotherapy-Induced Peripheral Neuropathy: Epidemiology, Pathomechanisms and Treatment
  • T6INDIRECT 24672257 ↗Chemotherapy-induced peripheral neuropathy in adults: a comprehensive update of the literature
  • T6INDIRECT 29222231 ↗AL amyloidosis: from molecular mechanisms to targeted therapies
  • T6INDIRECT 34134525 ↗Recognition, Prevention, and Management of Arrhythmias and Autonomic Disorders in Cardio-Oncology: A
  • T6INDIRECT 34729520 ↗AL Amyloidosis: Current Chemotherapy and Immune Therapy Treatment Strategies: <i>JACC: CardioOncolog
  • T6INDIRECT 32906684 ↗Non-Hematologic Toxicity of Bortezomib in Multiple Myeloma: The Neuromuscular and Cardiovascular Adv
  • T6 34236546 ↗Inhibitors of immune checkpoints-PD-1, PD-L1, CTLA-4-new opportunities for cancer patients and a new
  • T6 32708302 ↗Small Molecule NF-κB Pathway Inhibitors in Clinic
  • T6 19528374 ↗Single-agent bortezomib in previously untreated multiple myeloma: efficacy, characterization of peri
  • T6 26391778 ↗Cancer-treatment-induced neurotoxicity--focus on newer treatments
LifeWrap Compression Garment
T2
T2 — RCT in related condition
POTS
1 source
Low sodium oxybate
T2
T2 — RCT in related condition
RegisteredPOTS
11 sources
  • T2REGISTERED-ONLY NCT07077278 ↗Effect of Low Sodium Oxybate (LXB) on Autonomic Symptom Burden in Idiopathic Hypersomnia Patients Wi
  • T6 38217475 ↗Brain fog in central disorders of hypersomnolence: a review
  • T6 39912238 ↗Current knowledge on the pathophysiology of idiopathic hypersomnia and potential mechanisms of actio
  • T6 38662324 ↗Dosing Optimization of Low-Sodium Oxybate in Narcolepsy and Idiopathic Hypersomnia in Adults: Consen
  • T6 40489042 ↗A Patient-centric Clinical Trial Design to Comprehensively Evaluate Low-Sodium Oxybate in People wit
  • T6 40472564 ↗Idiopathic hypersomnia symptoms over Time: Longitudinal follow up from the Hypersomnia Foundation re
  • T6 41831073 ↗Effectiveness and Safety of Low-Sodium Oxybate in Participants with Idiopathic Hypersomnia: Primary
  • T6 37621721 ↗Long-Term Treatment of Narcolepsy and Idiopathic Hypersomnia with Low-Sodium Oxybate
  • T6INDIRECT 42006054 ↗Narcolepsy as an immune-associated hypothalamic encephalopathy: orexin dysfunction and implications
  • T6 41375746 ↗A Comprehensive Review of Current and Emerging Treatments for Narcolepsy Type 1
  • T6 41678063 ↗Idiopathic hypersomnia is a 24-hour disorder
Mecamylamine
T2
T2 — RCT in related condition
RegisteredPOTS
21 sources
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T6 22192366 ↗Olfaction in Parkinson's disease and related disorders
  • T6HARM 16554257 ↗Contemporary assessment and pharmacotherapy of Tourette syndrome
  • T6 28725692 ↗Deficits in cholinergic neurotransmission and their clinical correlates in Parkinson's disease
  • T6 36496996 ↗Levodopa-Induced Dyskinesia in Parkinson's Disease: Pathogenesis and Emerging Treatment Strategies
  • T6 20945818 ↗Vascular dysfunctions following spinal cord injury
  • T6INDIRECT 18480694 ↗Nicotinic antagonist augmentation of selective serotonin reuptake inhibitor-refractory major depress
  • T2 24114425 ↗Acute effects of mecamylamine and varenicline on cognitive performance in non-smokers with and witho
  • T2 29319910 ↗Reversal of mecamylamine-induced effects in healthy subjects by nicotine receptor agonists: Cognitiv
  • T6 17227286 ↗Review of the pharmacology and clinical profile of bupropion, an antidepressant and tobacco use cess
  • T6 11212590 ↗Antidepressants as analgesics: an overview of central and peripheral mechanisms of action
  • T6 20189159 ↗Topical mecamylamine for diabetic macular edema
  • T6INDIRECT 27590099 ↗Cardiac sympatho-vagal balance and ventricular arrhythmia
  • T6INDIRECT 30643668 ↗Merging the Pathophysiology and Pharmacotherapy of Tics
  • T6INDIRECT 23861643 ↗Evidence-based pharmacotherapy for pediatric obsessive-compulsive disorder and chronic tic disorders
  • T6INDIRECT 36456693 ↗ACNP 61<sup>st</sup> Annual Meeting: Poster Abstracts P1 - P270
  • T6INDIRECT 16858760 ↗Abstracts of the 29th Annual Meeting of the Japan Neuroscience Society, July 19-21, 2006
  • T4 PMC7172550 ↗Subject Index
  • T6 21256603 ↗Treatment of nicotine addiction: present therapeutic options and pipeline developments
  • T6 19232953 ↗Endothelial nicotinic acetylcholine receptors and angiogenesis
  • T6 25878903 ↗Clinical and biochemical manifestations of depression: relation to the neurobiology of stress
Medications that modulate heart rate and blood pressure
T2
T2 — RCT in related condition
RegisteredPOTS
2 sources
  • T2REGISTERED-ONLY NCT04881318 ↗Compression Garments in the Community With POTS
  • T6 39297140 ↗Reduced Stroke Volume and Brain Perfusion Drive Postural Hyperventilation in Postural Orthostatic Ta
Methotrexate
T2
T2 — RCT in related condition
RegisteredWithdrawnMCASPOTS
51 sources
  • T6WITHDRAWN NCT01773395 ↗GVAX vs. Placebo for MDS/AML After Allo HSCT
  • T6REGISTERED-ONLY NCT03779854 ↗Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults
  • T2 21855836 ↗Systematic review and meta-analysis of methotrexate use and risk of cardiovascular disease
  • T6INDIRECT 31046809 ↗Long-term safety of secukinumab in patients with moderate-to-severe plaque psoriasis, psoriatic arth
  • T6INDIRECT 25046337 ↗Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who rema
  • T6INDIRECT 30943337 ↗Benralizumab for &lt;i&gt;PDGFRA&lt;/i&gt;-Negative Hypereosinophilic Syndrome
  • T6INDIRECT 30343531 ↗Efficacy and Safety of Ixekizumab in the Treatment of Radiographic Axial Spondyloarthritis: Sixteen-
  • T6INDIRECT 35671774 ↗Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor
  • T6INDIRECT 28435464 ↗Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of F
  • T6INDIRECT 25154820 ↗Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effect
  • T6INDIRECT 25789989 ↗A pilot study of omalizumab in eosinophilic esophagitis
  • T6 35732831 ↗The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 34542573 ↗Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephaliti
  • T6INDIRECT 28816346 ↗Homocysteine-lowering interventions for preventing cardiovascular events
  • T6INDIRECT 30019766 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30521670 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 26561338 ↗Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy
  • T6INDIRECT 27382171 ↗Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid a
  • T6INDIRECT 1739631 ↗Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)
  • T6INDIRECT 17965121 ↗Synovial tissue response to rituximab: mechanism of action and identification of biomarkers of respo
  • T6INDIRECT 17655751 ↗Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis
  • T6INDIRECT 24275598 ↗Treating inflammation by blocking interleukin-1 in humans
  • T6INDIRECT 32107531 ↗Pediatric hemophagocytic lymphohistiocytosis
  • T6INDIRECT 33077936 ↗Kinase inhibition in autoimmunity and inflammation
  • T6INDIRECT 35215786 ↗<i>Herpes zoster</i>: A Review of Clinical Manifestations and Management
  • T6INDIRECT 29915719 ↗Past, Present, and Future of Rituximab-The World's First Oncology Monoclonal Antibody Therapy
  • T6INDIRECT 24366648 ↗Diagnosis and management of Neuro-Behçet's disease: international consensus recommendations
  • T6INDIRECT 23109216 ↗Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for p
  • T6 34824210 ↗The JAK/STAT signaling pathway: from bench to clinic
  • T6 21303899 ↗International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of ad
  • T6 18758473 ↗Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
  • T6 25287861 ↗Calcitonin gene-related peptide: physiology and pathophysiology
  • T6 24587990 ↗Oxidative stress, prooxidants, and antioxidants: the interplay
  • T6 38311623 ↗Extracellular vesicles as tools and targets in therapy for diseases
  • T6 37169756 ↗Angiogenic signaling pathways and anti-angiogenic therapy for cancer
  • T6INDIRECT 30218025 ↗Mechanisms, biomarkers and targets for adult-onset Still's disease
  • T6INDIRECT 35655306 ↗Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine
  • T6INDIRECT 31954495 ↗Diagnosis and management of toxicities of immune checkpoint inhibitors in hepatocellular carcinoma
  • T6INDIRECT 34655433 ↗Chemotherapy-Induced Peripheral Neuropathy: Epidemiology, Pathomechanisms and Treatment
  • T6INDIRECT 24672257 ↗Chemotherapy-induced peripheral neuropathy in adults: a comprehensive update of the literature
  • T6INDIRECT 31485575 ↗Clinical Manifestations, Diagnosis, and Treatment of Sarcoidosis
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6 37919282 ↗Smart nanoparticles for cancer therapy
  • T6 34988090 ↗Treatment of Inflammatory Bowel Disease: A Comprehensive Review
  • T6 32213941 ↗Chemical Constituents and Pharmacological Activities of Garlic (<i>Allium sativum</i> L.): A Review
  • T6 29163522 ↗The Vagus Nerve in the Neuro-Immune Axis: Implications in the Pathology of the Gastrointestinal Trac
  • T6 31633216 ↗Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
  • T6 25182228 ↗Clinician's Guide to Prevention and Treatment of Osteoporosis
  • T6 35478046 ↗The clinician's guide to prevention and treatment of osteoporosis
Microcrystalline cellulose
T2
T2 — RCT in related condition
RegisteredPOTS
21 sources
  • T2REGISTERED-ONLY NCT05363514 ↗Low Dose Naltrexone Use in Patients With POTS
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30019766 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30521670 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30556597 ↗Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people
  • T6INDIRECT 36103313 ↗Fluvoxamine for the treatment of COVID-19
  • T6INDIRECT 35174663 ↗Effect of perindopril or leucine on physical performance in older people with sarcopenia: the LACE r
  • T6INDIRECT 33408364 ↗Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overwei
  • T6INDIRECT 32676977 ↗A Phase I, Randomized, Single‑Blind, Placebo‑Controlled, Single Ascending Dose Study of the Safety,
  • T6INDIRECT 39294522 ↗Atomoxetine on neurogenic orthostatic hypotension: a randomized, double-blind, placebo-controlled cr
  • T6 22547984 ↗Technologies for beneficial microorganisms inocula used as biofertilizers
  • T6 21690484 ↗Exercise training versus propranolol in the treatment of the postural orthostatic tachycardia syndro
  • T6INDIRECT 36971690 ↗Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
  • T6INDIRECT 34739197 ↗Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease
  • T6INDIRECT 24968000 ↗A randomized, single-ascending-dose, ivermectin-controlled, double-blind study of moxidectin in Onch
  • T6INDIRECT 35126309 ↗Efficacy and Safety of <i>Lactobacillus plantarum</i> K50 on Lipids in Koreans With Obesity: A Rando
  • T6INDIRECT 37651553 ↗Interventions for fatigue in people with kidney failure requiring dialysis
  • T6INDIRECT 36686404 ↗FDM-based additive manufacturing of recycled thermoplastics and associated composites
  • T6INDIRECT 34683875 ↗Understanding Direct Powder Extrusion for Fabrication of 3D Printed Personalised Medicines: A Case S
  • T6INDIRECT 36677490 ↗Domiciliation of <i>Trichoderma asperellum</i> Suppresses <i>Globiosporangium ultimum</i> and Promot
  • T6 35516564 ↗Widely used catalysts in biodiesel production: a review
Microcystalline Cellulose Capsules
T2
T2 — RCT in related condition
RegisteredPOTS
1 source
Mirabegron
T2
T2 — RCT in related condition
RegisteredPOTS
28 sources
  • T2REGISTERED-ONLY NCT07585513 ↗Beta-3 Enhanced Autonomic Therapy for POTS
  • T2 NCT06133075 ↗Using Mirabegron to Increase BP in Patients With POTS
  • T6 31519472 ↗New evidence on the management of Lewy body dementia
  • T6 29508455 ↗Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
  • T6 33593479 ↗Current Treatment for Benign Prostatic Hyperplasia
  • T6 33065745 ↗Neurogenic Bladder: Epidemiology, Diagnosis, and Management
  • T6 33999297 ↗The autonomic nervous system in septic shock and its role as a future therapeutic target: a narrativ
  • T2 39729463 ↗Evaluating the safety and effectiveness of α-blockers versus mirabegron for medical expulsive therap
  • T6INDIRECT 27863901 ↗A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease f
  • T2 41255616 ↗A systematic review and meta-analysis of the efficacy and safety of mirabegron vs. tamsulosin in all
  • T2 40176903 ↗The efficacy and safety of mirabegron and α-adrenergic receptor antagonist in the treatment of dista
  • T6INDIRECT 39139772 ↗How Can We Treat If We Do Not Measure: A Systematic Review of Neurogenic Bowel Objective Measures
  • T2 38178860 ↗Efficacy of mirabegron for ureteral stones: a systematic review with meta-analysis of randomized con
  • T2 38041752 ↗Evaluation of the efficacy and safety of either or both mirabegron and silodosin, as a medical expul
  • T6INDIRECT 35297106 ↗Combination therapy with tamsulosin and traditional herbal medicine for lower urinary tract symptoms
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6INDIRECT 33029723 ↗Sleep Issues in Parkinson's Disease and Their Management
  • T6INDIRECT 32789741 ↗Autonomic Dysfunction in Parkinson's Disease
  • T6INDIRECT 33205381 ↗Approach to Cognitive Impairment in Parkinson's Disease
  • T6INDIRECT 31434341 ↗A Stage-Based Approach to Therapy in Parkinson's Disease
  • T6INDIRECT 32676851 ↗Four-Repeat Tauopathies: Current Management and Future Treatments
  • T6INDIRECT 36927875 ↗Multiple system atrophy
  • T6 29315692 ↗Comprehensive review of cardiovascular toxicity of drugs and related agents
  • T6 33924103 ↗Treatment Options for Motor and Non-Motor Symptoms of Parkinson's Disease
  • T6 36986631 ↗Current Treatments and New, Tentative Therapies for Parkinson's Disease
  • T6 40274830 ↗Diabetic neuropathy: cutting-edge research and future directions
  • T6 34885733 ↗Treatment of Benign Prostatic Hyperplasia by Natural Drugs
Modafinil & Propranolol
T2
T2 — RCT in related condition
RegisteredPOTS
1 source
Moxonidine
T2
T2 — RCT in related condition
RegisteredPOTS
29 sources
  • T2REGISTERED-ONLY NCT04050410 ↗Autonomic Determinants of POTS - Pilot1
  • T6 30875083 ↗Human pluripotent stem cell-derived models and drug screening in CNS precision medicine
  • T6 12933912 ↗Autonomic diseases: clinical features and laboratory evaluation
  • T6 20304932 ↗Therapeutic strategies for targeting excessive central sympathetic activation in human hypertension
  • T6 34979961 ↗Management of hypertension and renin-angiotensin-aldosterone system blockade in adults with diabetic
  • T6 33577130 ↗Baroreceptor Modulation of the Cardiovascular System, Pain, Consciousness, and Cognition
  • T6INDIRECT 24869750 ↗Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension
  • T6INDIRECT 31841279 ↗Central blood pressure for the management of hypertension: Is it a practical clinical tool in curren
  • T2 1576046 ↗A comparison of the haemodynamic and behavioural effects of moxonidine and clonidine in normotensive
  • T6INDIRECT 30302936 ↗Efficacy and safety of azilsartan medoxomil/chlortalidone fixed-dose combination in hypertensive pat
  • T6 31710717 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
  • T6 20827352 ↗Potentially inappropriate medications in the elderly: the PRISCUS list
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 38807350 ↗Not first-line antihypertensive agents, but still effective-The efficacy and safety of imidazoline r
  • T6INDIRECT 39258018 ↗Accelerated hypertension following mavacamten introduction in severe obstructive hypertrophic cardio
  • T6INDIRECT 41227153 ↗Early Diagnostic Markers in Crisponi Syndrome: Two Cases and Review
  • T6INDIRECT 26298728 ↗Parkinson's disease between internal medicine and neurology
  • T6INDIRECT 25018961 ↗Chapter 2: Lifestyle and pharmacological treatments for lowering blood pressure in CKD ND patients
  • T6INDIRECT 34280980 ↗Prescription Habits Related to Chronic Pathologies of Elderly People in Primary Care in the Western
  • T6INDIRECT 32745277 ↗Abstracts of the Heart Failure 2019 and the World Congress on Acute Heart Failure, 25-28 May 2019, M
  • T6INDIRECT 41413609 ↗Effect of tofogliflozin on cardiac sympathetic nerve activity in type 2 diabetes mellitus patients w
  • T6 22048570 ↗Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications
  • T6 30728760 ↗Sympathetic Nervous System Activation and Its Modulation: Role in Atrial Fibrillation
  • T6 35411324 ↗Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From t
  • T6 30639431 ↗Sympathetic nervous system in age-related cardiovascular dysfunction: Pathophysiology and therapeuti
  • T6 25767284 ↗The sympathetic nervous system alterations in human hypertension
  • T6 17485976 ↗Centrally acting antihypertensive agents: an update
Moxonidine Pill
T2
T2 — RCT in related condition
RegisteredPOTS
1 source
  • T2REGISTERED-ONLY NCT04140721 ↗Autonomic Determinants of POTS - Pilot 2
NO Drug
T2
T2 — RCT in related condition
RegisteredPOTS
34 sources
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 23013600 ↗Associations of kidney disease measures with mortality and end-stage renal disease in individuals wi
  • T6INDIRECT 21571570 ↗Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis
  • T6INDIRECT 28854296 ↗Efficacy and Safety of Selective Serotonin Reuptake Inhibitors, Serotonin-Norepinephrine Reuptake In
  • T6INDIRECT 35445419 ↗The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy
  • T6INDIRECT 29740819 ↗Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursor
  • T6INDIRECT 25233067 ↗Systematic review of potential health risks posed by pharmaceutical, occupational and consumer expos
  • T6INDIRECT 19029129 ↗Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study
  • T6INDIRECT 1739631 ↗Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)
  • T6INDIRECT 17965121 ↗Synovial tissue response to rituximab: mechanism of action and identification of biomarkers of respo
  • T6 33753937 ↗Post-acute COVID-19 syndrome
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6INDIRECT 32541925 ↗Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million p
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 26551272 ↗A Randomized Trial of Intensive versus Standard Blood-Pressure Control
  • T6INDIRECT 20228401 ↗Effects of intensive blood-pressure control in type 2 diabetes mellitus
  • T6INDIRECT 20427088 ↗Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt l
  • T6INDIRECT 27195814 ↗Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75
  • T6INDIRECT 32409561 ↗Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, ra
  • T6INDIRECT 19114612 ↗Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
  • T6INDIRECT 27382171 ↗Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid a
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 27999003 ↗Diabetic Neuropathy: A Position Statement by the American Diabetes Association
  • T6INDIRECT 22187469 ↗Standards of medical care in diabetes--2012
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 23264422 ↗Standards of medical care in diabetes--2013
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6 29075003 ↗Trends in GPCR drug discovery: new agents, targets and indications
  • T6 22160349 ↗The novel object recognition memory: neurobiology, test procedure, and its modifications
  • T6 28585944 ↗Cellular uptake of nanoparticles: journey inside the cell
  • T6 20876709 ↗Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treat
  • T6 25182228 ↗Clinician's Guide to Prevention and Treatment of Osteoporosis
Non-invasive Neuromodulation
T2
T2 — RCT in related condition
POTS
23 sources
  • T6 NCT05648695 ↗Efficacy of Non-invasive NESA Neuromodulation in Fibromyalgia
  • T6INDIRECT 30560316 ↗Autonomic Neuromodulation Acutely Ameliorates Left Ventricular Strain in Humans
  • T6INDIRECT 33085647 ↗Repetitive transcranial magnetic stimulation of the cerebellum improves ataxia and cerebello-fronto
  • T6INDIRECT 36041704 ↗Transcutaneous cervical vagus nerve stimulation reduces behavioral and physiological manifestations
  • T6INDIRECT 37451734 ↗Motor and autonomic concomitant health improvements with neuromodulation and exercise (MACHINE) trai
  • T6INDIRECT 41003459 ↗Noninvasive Vagus Nerve Stimulation Reduces Withdrawal-Related Affective Distress and Improves Funct
  • T2 29649928 ↗Non-Invasive Activation of Cervical Spinal Networks after Severe Paralysis
  • T6 38129427 ↗Central neuropathic pain
  • T6 34989884 ↗The role of electrical stimulation for rehabilitation and regeneration after spinal cord injury
  • T6 35720084 ↗Dysautonomia in COVID-19 Patients: A Narrative Review on Clinical Course, Diagnostic and Therapeutic
  • T6 36397122 ↗Infraslow closed-loop brain training for anxiety and depression (ISAD): a protocol for a randomized,
  • T6INDIRECT 30813143 ↗The role of robotic gait training and tDCS in Friedrich ataxia rehabilitation: A case report
  • T6INDIRECT 26627895 ↗Case report of vasovagal syncope associated with single pulse transcranial magnetic stimulation in a
  • T6INDIRECT 34403043 ↗Autonomic dysfunction in SARS-COV-2 infection acute and long-term implications COVID-19 editor's pag
  • T6INDIRECT 34248714 ↗Developmental Considerations in Obsessive Compulsive Disorder: Comparing Pediatric and Adult-Onset C
  • T6INDIRECT 28208601 ↗Surgical Neurostimulation for Spinal Cord Injury
  • T6INDIRECT 37654428 ↗Postural orthostatic tachycardia syndrome and other related dysautonomic disorders after SARS-CoV-2
  • T6 33807256 ↗Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives
  • T6 39443513 ↗A review of temporal interference, nanoparticles, ultrasound, gene therapy, and designer receptors f
  • T6 39587517 ↗Potential hypothalamic mechanisms in trigeminal neuropathic pain: a comparative analysis with migrai
  • T6 39997046 ↗The Spectrum of Cognitive Impairment in Atypical Parkinsonism Syndromes: A Comprehensive Review of C
  • T6 33760875 ↗Is the heart rate variability monitoring using the analgesia nociception index a predictor of illnes
  • T6 30828289 ↗Evolution in the Treatment of Psychiatric Disorders: From Psychosurgery to Psychopharmacology to Neu
Non-invasive transcutaneous vagus nerve stimulation
T2
T2 — RCT in related condition
POTS
7 sources
  • T2 39969124 ↗Non-invasive vagus nerve stimulation and exercise capacity in healthy volunteers: a randomized trial
  • T6INDIRECT 41068419 ↗Feasibility, safety and efficacy of multi-dose vagus nerve stimulation in Parkinson's disease: a dou
  • T6 32435491 ↗Altered cardiorespiratory regulation during exercise in patients with Parkinson's disease: A challen
  • T6 38173801 ↗Non-invasive Vagus Nerve Simulation in Postural Orthostatic Tachycardia Syndrome
  • T6 40701604 ↗Non-invasive neuromodulation for alleviating dyspnoea: protocol for a feasibility sham-controlled ra
  • T6 41938682 ↗Novel Ultrasound-Guided Bilateral Simultaneous Hydrodissection of the Cervical Sympathetic Chain and
  • T6INDIRECT 41016890 ↗Short and long term effects of a two-week transcutaneous vagus nerve stimulation in hyperadrenergic
Octreotide
T2
T2 — RCT in related condition
RegisteredPOTS
32 sources
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T6INDIRECT 32826308 ↗The management of adult patients with severe chronic small intestinal dysmotility
  • T6INDIRECT 34000076 ↗Fludrocortisone for orthostatic hypotension
  • T6INDIRECT 35498768 ↗Pediatric Intestinal Pseudo-Obstruction: Progress and Challenges
  • T6INDIRECT 35280448 ↗Therapeutic Upper Gastrointestinal Endoscopy in Pediatric Gastroenterology
  • T6INDIRECT 39908479 ↗Novel Approaches to Treatment of Immune-Mediated Chronic Intestinal Pseudo-Obstruction
  • T6INDIRECT 41225175 ↗Systematic literature review: treatment of postural orthostatic tachycardia syndrome (POTS)
  • T6INDIRECT 22345429 ↗A somatostatin analog improves tilt table tolerance by decreasing splanchnic vascular conductance
  • T6INDIRECT 26387781 ↗Effect of neostigmine on gastroduodenal motility in patients with suspected gastrointestinal motilit
  • T2 17036177 ↗Treatment of postural tachycardia syndrome: a comparison of octreotide and midodrine
  • T6 25378951 ↗Systemic AA amyloidosis: epidemiology, diagnosis, and management
  • T6 26900156 ↗The Differential Diagnosis and Treatment of Atypical Parkinsonism
  • T6 29222399 ↗Pediatric Disorders of Orthostatic Intolerance
  • T6INDIRECT 23990266 ↗Antipsychotics for acute and chronic pain in adults
  • T6INDIRECT 23758443 ↗A systematic review of the pharmacological management of orthostatic hypotension
  • T6INDIRECT 34932836 ↗Transfusion thresholds for guiding red blood cell transfusion
  • T6INDIRECT 26366058 ↗Phase III study of pasireotide long-acting release in patients with metastatic neuroendocrine tumors
  • T6INDIRECT 2875321 ↗Treatment of autonomic neuropathy with a somatostatin analogue SMS-201-995
  • T2 8665540 ↗Octreotide effects on orthostatic hypotension in patients with multiple system atrophy: a controlled
  • T6 22187469 ↗Standards of medical care in diabetes--2012
  • T6INDIRECT 24567799 ↗Cardiac autonomic neuropathy in patients with diabetes mellitus
  • T6INDIRECT 23264422 ↗Standards of medical care in diabetes--2013
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 21193625 ↗Standards of medical care in diabetes--2011
  • T6 31710717 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 19118286 ↗Standards of medical care in diabetes--2009
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 7825766 ↗Postprandial hypotension: epidemiology, pathophysiology, and clinical management
  • T6 11751653 ↗Cirrhotic cardiomyopathy: a pathophysiological review of circulatory dysfunction in liver disease
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
POTSapp
T2
T2 — RCT in related condition
POTS
1 source
Parasym Transcutaneous Electrical Nerve Stimulation Device
T2
T2 — RCT in related condition
POTS
1 source
  • T2 NCT03930914 ↗Vagus Nerve Stimulation in Treatment of Postural Orthostatic Tachycardia Syndrome
Part
T2
T2 — RCT in related condition
POTS
34 sources
  • T6 34144933 ↗Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 35739136 ↗Long-COVID in children and adolescents: a systematic review and meta-analyses
  • T6INDIRECT 23013600 ↗Associations of kidney disease measures with mortality and end-stage renal disease in individuals wi
  • T6INDIRECT 35445419 ↗The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy
  • T6INDIRECT 29740819 ↗Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursor
  • T6INDIRECT 33925784 ↗Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systemic Review and Com
  • T6INDIRECT 32840686 ↗Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cas
  • T6INDIRECT 1739631 ↗Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)
  • T6INDIRECT 20856865 ↗Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with sympt
  • T6INDIRECT 33831043 ↗Post-COVID-19 syndrome among symptomatic COVID-19 patients: A prospective cohort study in a tertiary
  • T6 33753937 ↗Post-acute COVID-19 syndrome
  • T6 6326753 ↗Oxygen toxicity, oxygen radicals, transition metals and disease
  • T2 32541925 ↗Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million p
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 26551272 ↗A Randomized Trial of Intensive versus Standard Blood-Pressure Control
  • T6INDIRECT 20228401 ↗Effects of intensive blood-pressure control in type 2 diabetes mellitus
  • T6INDIRECT 30688979 ↗Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical T
  • T6INDIRECT 27195814 ↗Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75
  • T6INDIRECT 20566676 ↗Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and e
  • T6INDIRECT 19114612 ↗Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
  • T6INDIRECT 27382171 ↗Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid a
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 27999003 ↗Diabetic Neuropathy: A Position Statement by the American Diabetes Association
  • T6INDIRECT 22187469 ↗Standards of medical care in diabetes--2012
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 23264422 ↗Standards of medical care in diabetes--2013
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6 29075003 ↗Trends in GPCR drug discovery: new agents, targets and indications
  • T6 22160349 ↗The novel object recognition memory: neurobiology, test procedure, and its modifications
  • T6 28585944 ↗Cellular uptake of nanoparticles: journey inside the cell
  • T6 20876709 ↗Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treat
Patient and Healthy Volunteers training protocol
T2
T2 — RCT in related condition
POTS
1 source
Patisiran
T2
T2 — RCT in related condition
POTS
24 sources
  • T6INDIRECT 31473866 ↗Characteristics and natural history of autonomic involvement in hereditary ATTR amyloidosis: a syste
  • T6INDIRECT 32311072 ↗Pharmacological treatment for familial amyloid polyneuropathy
  • T2 39286810 ↗Assessing the effectiveness and safety of Patisiran and Vutrisiran in ATTRv amyloidosis with polyneu
  • T6INDIRECT 32587078 ↗Overview of treatments used in transthyretin-related hereditary amyloidosis: a systematic review
  • T6INDIRECT 42266139 ↗Pharmacological Interventions for Hereditary Transthyretin-Related Amyloidosis With Polyneuropathy:
  • T2 28893208 ↗Trial design and rationale for APOLLO, a Phase 3, placebo-controlled study of patisiran in patients
  • T2 31728713 ↗Analysis of autonomic outcomes in APOLLO, a phase III trial of the RNAi therapeutic patisiran in pat
  • T6 28739313 ↗Cardiac amyloidosis: An update on pathophysiology, diagnosis, and treatment
  • T6 31607664 ↗How to Image Cardiac Amyloidosis: A Practical Approach
  • T6 26611723 ↗Evolving landscape in the management of transthyretin amyloidosis
  • T6INDIRECT 38441582 ↗Cardiac Amyloidosis Due to Transthyretin Protein: A Review
  • T6INDIRECT 30829617 ↗Clinical Presentation, Diagnosis and Treatment of TTR Amyloidosis
  • T6INDIRECT 32328845 ↗Advances in the Treatment of Cardiac Amyloidosis
  • T6INDIRECT 35884871 ↗Re-Definition of the Epidemiology of Cardiac Amyloidosis
  • T6INDIRECT 31706583 ↗New developments in diagnosis, risk assessment and management in systemic amyloidosis
  • T6INDIRECT 36094752 ↗Targeting Amyloid Fibrils by Passive Immunotherapy in Systemic Amyloidosis
  • T6INDIRECT 31498378 ↗Scientific Advances in and Clinical Approaches to Small-Fiber Polyneuropathy: A Review
  • T6 36625940 ↗Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic target
  • T6 32110029 ↗Diagnosis and Treatment of Hereditary Transthyretin Amyloidosis (hATTR) Polyneuropathy: Current Pers
  • T6 35256455 ↗Novel approaches to diagnosis and management of hereditary transthyretin amyloidosis
  • T6 31368669 ↗Advances in the treatment of hereditary transthyretin amyloidosis: A review
  • T6 31118583 ↗Inotersen: new promise for the treatment of hereditary transthyretin amyloidosis
  • T6 33825853 ↗Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myo
  • T6 32785879 ↗A Review of Patisiran (ONPATTRO®) for the Treatment of Polyneuropathy in People with Hereditary Tran
Percutaneous electrical nerve field stimulation
T2
T2 — RCT in related condition
POTS
10 sources
  • T2 39888101 ↗Cardiac Vagal Efficiency Is Enhanced by Percutaneous Auricular Neurostimulation in Adolescents With
  • T6 39867596 ↗Efficacy of vagus nerve stimulation in gastrointestinal disorders: a systematic review
  • T6 41553718 ↗Overlap of Structural Gastrointestinal Disorders in Children With Disorders of Gut-Brain Interaction
  • T6INDIRECT 35616609 ↗Neuromodulation Using Computer-Altered Music to Treat a Ten-Year-Old Child Unresponsive to Standard
  • T6 40544377 ↗The prevalence and predictive factors of overlapping disorders of gut-brain interaction and celiac d
  • T4 PMC12463576 ↗Abstract
  • T4 PMC11493558 ↗Abstract
  • T4 PMC11094350 ↗ESPGHAN 56th Annual Meeting Abstracts
  • T6 40208134 ↗Auricular Allodynia is Associated With Worse Outcomes in Children With Functional Abdominal Pain Dis
  • T6 41735242 ↗Percutaneous Electrical Nerve Field Stimulation Improves Weight and Other Anthropometric Outcomes in
Percutaneous vagal nerve stimulation device
T2
T2 — RCT in related condition
RegisteredPOTS
1 source
  • T2REGISTERED-ONLY NCT05212129 ↗Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome
Physical exercise program
T2
T2 — RCT in related condition
RegisteredPOTS
24 sources
  • T2REGISTERED-ONLY NCT05094622 ↗Physical Training in Patients With POTS After Covid-19
  • T6INDIRECT 33428616 ↗Mindfulness-based programmes for mental health promotion in adults in nonclinical settings: A system
  • T6INDIRECT 38375882 ↗Mobile health (m-health) smartphone interventions for adolescents and adults with overweight or obes
  • T6INDIRECT 38995808 ↗Telerehabilitation - Historical Perspectives and Conceptual Framework in Reference to Neurological D
  • T6 37990730 ↗Thirty Obesity Myths, Misunderstandings, and/or Oversimplifications: An Obesity Medicine Association
  • T6 32823577 ↗Time Course of Autonomic Symptoms in Postural Orthostatic Tachycardia Syndrome (POTS) Patients: Two-
  • T6 39198662 ↗Individually tailored exercise in patients with postural orthostatic tachycardia syndrome related to
  • T6 33823928 ↗Effect of the combination of automated peripheral mechanical stimulation and physical exercise on ae
  • T6INDIRECT 24018704 ↗Physiotherapy versus placebo or no intervention in Parkinson's disease
  • T6INDIRECT 33999947 ↗Effect of exercise training on heart rate variability in type 2 diabetes mellitus patients: A system
  • T2 36602886 ↗Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis
  • T2 38588457 ↗Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis
  • T2 29721504 ↗Multicomponent Exercise Improves Physical Functioning but Not Cognition and Hemodynamic Parameters i
  • T6 39743381 ↗Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults
  • T6 34409961 ↗International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines
  • T6INDIRECT 34108836 ↗Management of Mental Health Disorders, Substance Use Disorders, and Suicide in Adults with Spinal Co
  • T6INDIRECT 33630722 ↗Management of Mental Health Disorders, Substance Use Disorders, and Suicide in Adults with Spinal Co
  • T6INDIRECT 32150216 ↗Abstract: Symposia, Conferences, Oral communications: 10th International Conference on Frailty, Sarc
  • T6INDIRECT 30583728 ↗Abstracts from hydrocephalus 2018: the tenth meeting of the International Society for Hydrocephalus
  • T6INDIRECT 40986224 ↗World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2025)
  • T6 37358956 ↗Differences in fall-related characteristics across cognitive disorders
  • T6 32290164 ↗Autonomic and Cognitive Function Response to Normobaric Hyperoxia Exposure in Healthy Subjects. Prel
  • T6 32218879 ↗Abstracts of the 14th International Congress of the European Geriatric Medicine Society: 10-12 Octob
  • T6 PMC9735049 ↗Abstracts of the 18th Congress of the European Geriatric Medicine Society : Live from London and Onl
Physical training program
T2
T2 — RCT in related condition
POTS
15 sources
  • T6INDIRECT 32103487 ↗Pharmacological interventions for heart failure in people with chronic kidney disease
  • T2 24714795 ↗Physical training as non-pharmacological treatment of neurocardiogenic syncope
  • T6 39458423 ↗Acute Sarcopenia: Mechanisms and Management
  • T6 22738091 ↗Exercise in multiple sclerosis -- an integral component of disease management
  • T6 24278164 ↗Oxygen and ventilatory output during several activities of daily living performed by COPD patients s
  • T6 24278871 ↗Effect of long-term resistance exercise on body composition, blood lipid factors, and vascular compl
  • T6INDIRECT 37623481 ↗Feasibility of a Virtual-Reality-Enabled At-Home Telerehabilitation Program for Stroke Survivors: A
  • T6INDIRECT 31204865 ↗Supplement
  • T4 PMC8487351 ↗UEG Week 2021 Poster Presentations
  • T4 PMC7103906 ↗Posters
  • T4 PMC3459571 ↗POSTER AWARD WINNER EDUCATION : SCI-U: AN INNOVATIVE APPROACH TO ONLINE PATIENT EDUCATION IN SPINAL
  • T6 PMC1876334 ↗Abstracts
  • T6 38792307 ↗Multi-Modal Prehabilitation in Thoracic Surgery: From Basic Concepts to Practical Modalities
  • T6 35034521 ↗Pathophysiology and clinical evaluation of the patient with unexplained persistent dyspnea
  • T6 40318694 ↗Multimorbidity, Muscle Strength, and Falls among Older Mexican Americans
Postural orthostatic tachycardia syndrome
T2
T2 — RCT in related condition
POTS
29 sources
  • T6 34144933 ↗Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019
  • T6INDIRECT 34509649 ↗Post-COVID syndrome. A case series and comprehensive review
  • T6INDIRECT 36223120 ↗Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults: A Systematic R
  • T6INDIRECT 31755549 ↗Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention o
  • T6INDIRECT 29740819 ↗Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursor
  • T6INDIRECT 34017846 ↗Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic
  • T2 19687359 ↗Propranolol decreases tachycardia and improves symptoms in the postural tachycardia syndrome: less i
  • T6INDIRECT 26690066 ↗The international POTS registry: Evaluating the efficacy of an exercise training intervention in a c
  • T6INDIRECT 25304766 ↗The impact of chronic migraine: The Chronic Migraine Epidemiology and Outcomes (CaMEO) Study methods
  • T2 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
  • T6 33753937 ↗Post-acute COVID-19 syndrome
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6 34308300 ↗Characterizing long COVID in an international cohort: 7 months of symptoms and their impact
  • T6INDIRECT 34024217 ↗Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments
  • T6INDIRECT 35594336 ↗Pathophysiology and mechanism of long COVID: a comprehensive review
  • T6INDIRECT 29503439 ↗Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T4 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6INDIRECT 37748514 ↗Distinguishing features of long COVID identified through immune profiling
  • T4 29036855 ↗Diagnostic criteria for persistent postural-perceptual dizziness (PPPD): Consensus document of the c
  • T6 35105985 ↗Pathological sequelae of long-haul COVID
  • T6 37919282 ↗Smart nanoparticles for cancer therapy
  • T6 33856918 ↗COVID-19 and Cardiovascular Disease: From Bench to Bedside
  • T6 30871703 ↗Autonomic Nervous System Dysfunction: JACC Focus Seminar
  • T6 39326415 ↗Mechanisms of long COVID and the path toward therapeutics
  • T6 25420112 ↗Pulmonary arteriovenous malformations
  • T6 31447842 ↗Fatigue, Sleep, and Autoimmune and Related Disorders
  • T6 26275795 ↗Vaccines, adjuvants and autoimmunity
  • T6 21777306 ↗Myalgic encephalomyelitis: International Consensus Criteria
REGN7544
T2
T2 — RCT in related condition
RegisteredPOTS
2 sources
  • T2REGISTERED-ONLY NCT06593600 ↗Study of Natriuretic Peptide Receptor 1 (NPR1) Antagonist in Adult Patients With Postural Orthostati
  • T6 41703216 ↗Natriuretic peptide signaling as a therapeutic target in POTS: physiological opportunities and cavea
Rebreathing test
T2
T2 — RCT in related condition
POTS
6 sources
  • T2 NCT02725060 ↗Autoimmune Basis for Postural Tachycardia Syndrome
  • T6 36399385 ↗Cardiac function, structural, and electrical remodeling by microgravity exposure
  • T6INDIRECT 40944681 ↗Exacerbation of Postural Orthostatic Tachycardia Syndrome With Tirzepatide Prescribed for Weight Los
  • T6 25059240 ↗Acute volume loading and exercise capacity in postural tachycardia syndrome
  • T6 31633009 ↗Inflight leg cuff test does not identify the risk for orthostatic hypotension after long-duration sp
  • T6 35547180 ↗The Elevated Central Chemosensitivity in Obstructive Sleep Apnea Patients with Hypertension
Rehydration Solution
T2
T2 — RCT in related condition
POTS
30 sources
  • T2 NCT02854683 ↗Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue
  • T6INDIRECT 36697370 ↗Interventions to improve sanitation for preventing diarrhoea
  • T6INDIRECT 31549742 ↗Interventions to improve disposal of child faeces for preventing diarrhoea and soil-transmitted helm
  • T6INDIRECT 33832950 ↗Delivering nutrition interventions to women and children in conflict settings: a systematic review
  • T6INDIRECT 39882369 ↗Oral medications for the treatment of postural orthostatic tachycardia syndrome; a systematic review
  • T6INDIRECT 40859389 ↗Mapping cerebral blood flow in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and ortho
  • T6INDIRECT 31973701 ↗The value of monitoring data in a process evaluation of hygiene behaviour change in Community Health
  • T2 31405524 ↗The Benefits of Oral Rehydration on Orthostatic Intolerance in Children with Postural Tachycardia Sy
  • T6HARM 30001836 ↗Exercise and non-pharmacological treatment of POTS
  • T6 25475887 ↗Severe acute malnutrition and infection
  • T6 20388747 ↗Proteomic analysis of the effects of ABA treatments on ripening Vitis vinifera berries
  • T6 25887480 ↗Proteomic analysis of Citrus sinensis roots and leaves in response to long-term magnesium-deficiency
  • T6 26975701 ↗Physiological and proteomic responses to salt stress in chloroplasts of diploid and tetraploid black
  • T6INDIRECT 29198916 ↗Anxiety-related adverse events following immunization (AEFI): A systematic review of published clust
  • T6INDIRECT 25928418 ↗Travellers' diarrhoea
  • T6INDIRECT 23869185 ↗The effect of intraoperative use of high-dose remifentanil on postoperative insulin resistance and m
  • T6INDIRECT 34885995 ↗Narrative Review of Primary Preventive Interventions against Water-Borne Diseases: Scientific Eviden
  • T6INDIRECT 40059405 ↗International society of sports nutrition position stand: nutrition and weight cut strategies for mi
  • T6INDIRECT 26079713 ↗Valuing and Sustaining (or Not) the Ability of Volunteer Community Health Workers to Deliver Integra
  • T6 21723922 ↗Calpain inhibition protected spinal cord motoneurons against 1-methyl-4-phenylpyridinium ion and rot
  • T6 33604464 ↗A comparative proteomic study of cold responses in potato leaves
  • T6 31640549 ↗2-DE-based proteomic analysis of protein changes associated with etiolated mesocotyl growth in Zea m
  • T6 30745707 ↗Clinical Practice Guidelines on Assessment and Management of Substance Abuse Disorder in Children an
  • T6 29682691 ↗Abstracts of the MASCC/ISOO Annual Meeting 2018
  • T6 3595395 ↗Prospects for effective non-antimicrobial antidiarrheal agents. Conference on Non-antimicrobial Anti
  • T6 PMC7166990 ↗Research Abstract Program of the 20th Annual ACVIM Forum Dallas, TX, May 29‐June 1, 2002
  • T6 24194646 ↗Management strategies in the treatment of neonatal and pediatric gastroenteritis
  • T6 21694853 ↗Acute gastroenteritis: from guidelines to real life
  • T6 23443111 ↗Wheat drought-responsive grain proteome analysis by linear and nonlinear 2-DE and MALDI-TOF mass spe
  • T6 27350278 ↗Body Mass Index (BMI) is Associated with the Therapeutic Response to Oral Rehydration Solution in Ch
RespirAct™ system
T2
T2 — RCT in related condition
RegisteredPOTS
2 sources
  • T2REGISTERED-ONLY NCT04271878 ↗Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome
  • T6 37157056 ↗Reduced and Delayed Cerebrovascular Reactivity in Patients with Parkinson's Disease
STEPS management protocol
T2
T2 — RCT in related condition
POTS
1 source
  • T2 NCT06268288 ↗Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Synd
Safinamide Methanesulfonate
T2
T2 — RCT in related condition
POTS
1 source
  • T2 33674954 ↗Overall Efficacy and Safety of Safinamide in Parkinson's Disease: A Systematic Review and a Meta-ana
Sertraline
T2
T2 — RCT in related condition
RegisteredPOTS
30 sources
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T6INDIRECT 28854296 ↗Efficacy and Safety of Selective Serotonin Reuptake Inhibitors, Serotonin-Norepinephrine Reuptake In
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 26130211 ↗A META-ANALYSIS OF COGNITIVE BEHAVIOR THERAPY AND MEDICATION FOR CHILD OBSESSIVE-COMPULSIVE DISORDER
  • T6INDIRECT 33687070 ↗Smoking cessation for improving mental health
  • T6INDIRECT 30019766 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30521670 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T2 15507582 ↗Cognitive-behavior therapy, sertraline, and their combination for children and adolescents with obse
  • T6INDIRECT 20855047 ↗Predictors and moderators of treatment outcome in the Pediatric Obsessive Compulsive Treatment Study
  • T6INDIRECT 22024003 ↗Controlled comparison of family cognitive behavioral therapy and psychoeducation/relaxation training
  • T6INDIRECT 21934055 ↗Cognitive behavior therapy augmentation of pharmacotherapy in pediatric obsessive-compulsive disorde
  • T6 26111766 ↗SLC transporters as therapeutic targets: emerging opportunities
  • T6 35430029 ↗Functional neurological disorder: new subtypes and shared mechanisms
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 17943857 ↗Antidepressants for neuropathic pain
  • T6INDIRECT 28178949 ↗Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 19092112 ↗A controlled trial of antidepressants in patients with Parkinson disease and depression
  • T6INDIRECT 12388617 ↗Dopamine modulates the response of the human amygdala: a study in Parkinson's disease
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 24229653 ↗What are the causes of late-life depression?
  • T6INDIRECT 33243615 ↗Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6 10379421 ↗Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines an
  • T6 22407614 ↗Serotonin and blood pressure regulation
  • T6 15320756 ↗Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?
  • T6 30975301 ↗Screening and Management of Depression in Patients With Cardiovascular Disease: JACC State-of-the-Ar
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 29975336 ↗Depression and Anxiety in Heart Failure: A Review
Shared medical appointment
T2
T2 — RCT in related condition
POTS
11 sources
  • T2 NCT05454137 ↗A Shared Medical Appointment Intervention for Quality of Life Improvement in POTS
  • T6 32725471 ↗Abstracts from the 2020 Annual Meeting of the Society of General Internal Medicine
  • T6 24737224 ↗Abstracts from the 37th Annual Meeting of the Society of General Internal Medicine, 2014, San Diego,
  • T6 PMC6796246 ↗UEG Week 2018 Poster Presentations
  • T6 17703327 ↗Abstracts of the Society of General Internal Medicine 29th Annual Meeting, April 26-29, 2006, Los An
  • T6 PMC13111897 ↗2026 International Congress Abstract Supplement
  • T2 28445783 ↗Jump starting shared medical appointments for diabetes with weight management: Rationale and design
  • T6 30972554 ↗Assessing an Interprofessional Polypharmacy and Deprescribing Educational Intervention for Primary C
  • T6 23625304 ↗Abstracts of the 36th Annual Meeting of the Society of General Internal Medicine. April 24-27, 2013.
  • T4 PMC9471381 ↗ICIMH 2022 Abstracts
  • T6INDIRECT 31123663 ↗CPNP 2019 Annual Meeting Poster Abstracts
Sildenafil
T2
T2 — RCT in related condition
POTS
24 sources
  • T6INDIRECT 30701543 ↗Phosphodiesterase 5 inhibitors for pulmonary hypertension
  • T2 20484178 ↗A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis
  • T6INDIRECT 31841599 ↗Nilotinib Effects on Safety, Tolerability, and Potential Biomarkers in Parkinson Disease: A Phase 2
  • T2 10930961 ↗Pharmacokinetic interactions between sildenafil and saquinavir/ritonavir
  • T2 11511713 ↗Treatment of erectile dysfunction with sildenafil citrate (Viagra) in parkinsonism due to Parkinson'
  • T6INDIRECT 15540759 ↗Interaction between the phosphodiesterase 5 inhibitor, tadalafil and 2 alpha-blockers, doxazosin and
  • T6INDIRECT 24316514 ↗Serelaxin in acute heart failure patients with preserved left ventricular ejection fraction: results
  • T6INDIRECT 23266540 ↗Angiotensin II, independent of plasma renin activity, contributes to the hypertension of autonomic f
  • T6INDIRECT 27113485 ↗Phosphodiesterase Type 5 Inhibition Reduces Albuminuria in Subjects with Overt Diabetic Nephropathy
  • T6INDIRECT 22857780 ↗Avanafil for the treatment of erectile dysfunction: a multicenter, randomized, double-blind study in
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 30218025 ↗Mechanisms, biomarkers and targets for adult-onset Still's disease
  • T6INDIRECT 29508455 ↗Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
  • T6INDIRECT 23186897 ↗Transverse myelitis
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6 28716886 ↗Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 16461471 ↗Diabetic neuropathy
  • T6 29315692 ↗Comprehensive review of cardiovascular toxicity of drugs and related agents
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 25621208 ↗Chronic complications of spinal cord injury
Sodium Chloride Capsules
T2
T2 — RCT in related condition
POTS
2 sources
  • T2 33926653 ↗Effect of High Dietary Sodium Intake in Patients With Postural Tachycardia Syndrome
  • T6INDIRECT 30298552 ↗Efficacy of fluid loading as a countermeasure to the hemodynamic and hormonal changes of 28-h head-d
Standing
T2
T2 — RCT in related condition
POTS
32 sources
  • T2 NCT03602482 ↗Standing Cognition and Co-morbidities of POTS Evaluation
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 21571570 ↗Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis
  • T6INDIRECT 30873598 ↗Multiple-micronutrient supplementation for women during pregnancy
  • T6INDIRECT 35445419 ↗The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy
  • T6INDIRECT 24944260 ↗Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial
  • T6INDIRECT 8673750 ↗Salt supplement increases plasma volume and orthostatic tolerance in patients with unexplained synco
  • T6INDIRECT 8828642 ↗Orthostatic intolerance after spaceflight
  • T6INDIRECT 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
  • T6INDIRECT 8941538 ↗Subnormal norepinephrine release relates to presyncope in astronauts after spaceflight
  • T6INDIRECT 29649928 ↗Non-Invasive Activation of Cervical Spinal Networks after Severe Paralysis
  • T6 27999003 ↗Diabetic Neuropathy: A Position Statement by the American Diabetes Association
  • T6HARM 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 26551272 ↗A Randomized Trial of Intensive versus Standard Blood-Pressure Control
  • T6INDIRECT 20228401 ↗Effects of intensive blood-pressure control in type 2 diabetes mellitus
  • T6INDIRECT 27195814 ↗Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75
  • T6INDIRECT 19114612 ↗Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
  • T6INDIRECT 24067431 ↗Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflo
  • T6INDIRECT 24902920 ↗The design and rationale of a multicenter clinical trial comparing two strategies for control of sys
  • T6INDIRECT 28642330 ↗Effects of Intensive BP Control in CKD
  • T6INDIRECT 16505299 ↗Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 22187469 ↗Standards of medical care in diabetes--2012
  • T6INDIRECT 23264422 ↗Standards of medical care in diabetes--2013
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 28467028 ↗Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria
  • T6 29075003 ↗Trends in GPCR drug discovery: new agents, targets and indications
  • T6 33894193 ↗Challenges in the diagnosis of Parkinson's disease
  • T6 20876709 ↗Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treat
  • T6 34308300 ↗Characterizing long COVID in an international cohort: 7 months of symptoms and their impact
  • T6 25182228 ↗Clinician's Guide to Prevention and Treatment of Osteoporosis
Stellate Ganglion Block
T2
T2 — RCT in related condition
POTS
22 sources
  • T6INDIRECT 23633371 ↗Interventions for treating pain and disability in adults with complex regional pain syndrome
  • T6INDIRECT 36375174 ↗Pharmacological interventions for people with borderline personality disorder
  • T6INDIRECT 34291816 ↗Interventions for the management of abdominal pain in ulcerative colitis
  • T2 41973314 ↗Stellate Ganglion Block in the Treatment of Long COVID: A Systematic Review
  • T2 24496086 ↗Effects of stellate ganglion block on vasomotor symptoms: findings from a randomized controlled clin
  • T2 40504522 ↗Stellate Ganglion Block for the Treatment of COVID-19-Induced Parosmia: A Randomized Clinical Trial
  • T2 40739539 ↗A prospective randomized clinical trial on the differential effect of left versus right stellate gan
  • T6INDIRECT 8792601 ↗Intravenous regional anesthesia with ketorolac-lidocaine for the management of sympathetically-media
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6 29276402 ↗Ganglion blocks as a treatment of pain: current perspectives
  • T5 34922127 ↗Stellate ganglion block reduces symptoms of Long COVID: A case series
  • T5 36106285 ↗Stellate Ganglion Block for Anosmia and Dysgeusia Due to Long COVID
  • T6INDIRECT 25584767 ↗Basic science and clinical management of painful and non-painful chemotherapy-related neuropathy
  • T4 36949968 ↗A Review of Stellate Ganglion Block as an Adjunctive Treatment Modality
  • T6INDIRECT 37166736 ↗Autonomic control of ventricular function in health and disease: current state of the art
  • T6INDIRECT 36074973 ↗Sinus Tachycardia: a Multidisciplinary Expert Focused Review
  • T6 34603069 ↗Asymmetry and Heterogeneity: Part and Parcel in Cardiac Autonomic Innervation and Function
  • T6 35411324 ↗Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From t
  • T6 40046430 ↗Neurological sequelae of long COVID: a comprehensive review of diagnostic imaging, underlying mechan
  • T6 39340173 ↗Neurocardiology: translational advancements and potential
  • T6 35811701 ↗The Mechanism of Cardiac Sympathetic Activity Assessment Methods: Current Knowledge
  • T6 34386109 ↗JCS/JHRS 2019 guideline on non-pharmacotherapy of cardiac arrhythmias
Stimulation
T2
T2 — RCT in related condition
RegisteredPOTS
32 sources
  • T2REGISTERED-ONLY NCT02281097 ↗Transdermal Vagal Stimulation for POTS
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 16614072 ↗Element interactions limit soil carbon storage
  • T6INDIRECT 30019766 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30521670 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 36915214 ↗Roles of neuropathology-associated reactive astrocytes: a systematic review
  • T6INDIRECT 25233067 ↗Systematic review of potential health risks posed by pharmaceutical, occupational and consumer expos
  • T6INDIRECT 24920437 ↗Central changes associated with chronic pelvic pain and endometriosis
  • T6INDIRECT 19205066 ↗Dysautonomia rating scales in Parkinson's disease: sialorrhea, dysphagia, and constipation--critique
  • T6INDIRECT 29649928 ↗Non-Invasive Activation of Cervical Spinal Networks after Severe Paralysis
  • T6INDIRECT 31830003 ↗Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cy
  • T6 33753937 ↗Post-acute COVID-19 syndrome
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6INDIRECT 26447819 ↗Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medicat
  • T6INDIRECT 30191554 ↗Interventions for preventing falls in older people in care facilities and hospitals
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 24361112 ↗Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Par
  • T6INDIRECT 16505299 ↗Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI
  • T2 27382171 ↗Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid a
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 33243615 ↗Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on
  • T6INDIRECT 21749363 ↗Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 23359374 ↗Criteria for the diagnosis of corticobasal degeneration
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6 29075003 ↗Trends in GPCR drug discovery: new agents, targets and indications
  • T6 23968694 ↗Sugar for the brain: the role of glucose in physiological and pathological brain function
  • T6 36148880 ↗Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes As
  • T6 27980341 ↗Induced pluripotent stem cell technology: a decade of progress
  • T6 17273548 ↗Physiology and immunology of the cholinergic antiinflammatory pathway
  • T6 20876709 ↗Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treat
Sucrose
T2
T2 — RCT in related condition
WithdrawnPOTS
26 sources
  • T2WITHDRAWN NCT04855266 ↗Iron Sucrose in Patients With Iron Deficiency and POTS
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30019766 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30521670 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30556597 ↗Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people
  • T6INDIRECT 25233067 ↗Systematic review of potential health risks posed by pharmaceutical, occupational and consumer expos
  • T6INDIRECT 34564844 ↗Nutrition-specific interventions for preventing and controlling anaemia throughout the life cycle: a
  • T6INDIRECT 30635141 ↗Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial
  • T6INDIRECT 26275453 ↗Effect of fortified complementary food supplementation on child growth in rural Bangladesh: a cluste
  • T6INDIRECT 25029210 ↗Metabolic fate of fructose ingested with and without glucose in a mixed meal
  • T6INDIRECT 24878745 ↗Learning to eat vegetables in early life: the role of timing, age and individual eating traits
  • T6 22859206 ↗Defining the core Arabidopsis thaliana root microbiome
  • T6 17406292 ↗Agrobacterium-mediated transformation of Arabidopsis thaliana using the floral dip method
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 22937145 ↗Oxytocin increases heart rate variability in humans at rest: implications for social approach-relate
  • T6INDIRECT 23642721 ↗Guillain-Barré syndrome and variants
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 18085482 ↗Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide
  • T6INDIRECT 32039382 ↗From NASH to diabetes and from diabetes to NASH: Mechanisms and treatment options
  • T6 31633216 ↗Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
  • T6 12034882 ↗Regulation of SOS1, a plasma membrane Na+/H+ exchanger in Arabidopsis thaliana, by SOS2 and SOS3
  • T6 24274116 ↗Enhancement of oxidative and drought tolerance in Arabidopsis by overaccumulation of antioxidant fla
  • T6 30013066 ↗Root exudate metabolites drive plant-soil feedbacks on growth and defense by shaping the rhizosphere
  • T6 24196324 ↗Rhizosphere microbiome assemblage is affected by plant development
Supine
T2
T2 — RCT in related condition
POTS
33 sources
  • T2 NCT03602482 ↗Standing Cognition and Co-morbidities of POTS Evaluation
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 21571570 ↗Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 35445419 ↗The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy
  • T6INDIRECT 26607938 ↗Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, doub
  • T6INDIRECT 24944260 ↗Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial
  • T6INDIRECT 8673750 ↗Salt supplement increases plasma volume and orthostatic tolerance in patients with unexplained synco
  • T6INDIRECT 8828642 ↗Orthostatic intolerance after spaceflight
  • T6INDIRECT 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
  • T6INDIRECT 8941538 ↗Subnormal norepinephrine release relates to presyncope in astronauts after spaceflight
  • T6 27999003 ↗Diabetic Neuropathy: A Position Statement by the American Diabetes Association
  • T6 21890520 ↗Low-frequency power of heart rate variability is not a measure of cardiac sympathetic tone but may b
  • T6INDIRECT 26447819 ↗Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medicat
  • T6INDIRECT 19114612 ↗Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
  • T6INDIRECT 24067431 ↗Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflo
  • T6INDIRECT 9091692 ↗Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind m
  • T6INDIRECT 22446170 ↗Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycemia risk in pati
  • T6INDIRECT 1540729 ↗Renal protective effect of enalapril in diabetic nephropathy
  • T6INDIRECT 33243615 ↗Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on
  • T6INDIRECT 2666581 ↗Multiple system atrophy--the nature of the beast
  • T6INDIRECT 29503439 ↗Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6 33769101 ↗Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
  • T6 25834232 ↗Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 26595642 ↗Lewy body dementias
  • T6 24713270 ↗Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in hu
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 36178003 ↗World guidelines for falls prevention and management for older adults: a global initiative
  • T6 35478046 ↗The clinician's guide to prevention and treatment of osteoporosis
  • T6 30354828 ↗Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the Ameri
TVNS + Slow-Paced Breathing
T2
T2 — RCT in related condition
RegisteredPOTS
1 source
  • T2REGISTERED-ONLY NCT06996314 ↗Effects of Auricular Vagus Nerve Stimulation Combined With Slow-paced Breathing on Individuals With
TVNS without Breathing Training
T2
T2 — RCT in related condition
RegisteredPOTS
1 source
  • T2REGISTERED-ONLY NCT06996314 ↗Effects of Auricular Vagus Nerve Stimulation Combined With Slow-paced Breathing on Individuals With
Tamsulosin Hydrochloride
T2
T2 — RCT in related condition
POTS
18 sources
  • T6INDIRECT 29620795 ↗Alpha-blockers as medical expulsive therapy for ureteral stones
  • T6INDIRECT 29161773 ↗Silodosin for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia
  • T2 21745239 ↗Tamsulosin shows a higher unbound drug fraction in human prostate than in plasma: a basis for urosel
  • T6 21753871 ↗Safety and efficacy of silodosin for the treatment of benign prostatic hyperplasia
  • T6 37415648 ↗Prostatic artery embolisation versus medical treatment in patients with benign prostatic hyperplasia
  • T6 21455413 ↗Benign prostatic hyperplasia: An overview of existing treatment
  • T6 34876420 ↗Randomised, quadruple blinded, placebo controlled, multicentre trial investigating prophylactic tams
  • T6INDIRECT 42015293 ↗Overflow urinary incontinence as an early manifestation of neuronal intranuclear inclusion disease (
  • T6INDIRECT 40433175 ↗Case report: Case series of urinary retention in young adults with severe autism hospitalized for be
  • T6INDIRECT 32607315 ↗Sacral Neuromodulation in a Patient with Wolff-Parkinson-White Syndrome: A Case Report
  • T6INDIRECT 38805053 ↗Non-motor symptoms in patients with amyotrophic lateral sclerosis: current state and future directio
  • T6INDIRECT 41393662 ↗The Comparative Effectiveness of PDE5 Inhibitors and β3 Agonists Versus α-Blockers in Medical Expuls
  • T6INDIRECT 38217372 ↗ACVIM consensus statement on diagnosis and management of urinary incontinence in dogs
  • T6 36051157 ↗Evolving Role of Silodosin for the Treatment of Urological Disorders - A Narrative Review
  • T6 8531059 ↗[Discovery and development of tamsulosin hydrochloride, a new alpha 1-adrenoceptor antagonist]
  • T6 25328864 ↗Silodosin for the treatment of clinical benign prostatic hyperplasia: safety, efficacy, and patient
  • T6 24198606 ↗Management of benign prostatic hyperplasia with silodosin
  • T6 33678164 ↗Evaluation of static and dynamic Pupillometry changes in men using Silodosin for benign prostatic hy
Terazosin therapy
T2
T2 — RCT in related condition
POTS
7 sources
  • T2 1375659 ↗The safety, efficacy and compliance of terazosin therapy for benign prostatic hyperplasia
  • T2 18159592 ↗High-dose terazosin therapy (5mg) in Korean patients with lower urinary tract symptoms with or witho
  • T6 15860960 ↗Treatment of benign prostatic hyperplasia in hypertensive men
  • T6 21455413 ↗Benign prostatic hyperplasia: An overview of existing treatment
  • T6 39044238 ↗Effect of low-dose terazosin on arterial stiffness improvement: A pilot study
  • T6 15369424 ↗Cost-effectiveness of tamsulosin, doxazosin, and terazosin in the treatment of benign prostatic hype
  • T6INDIRECT 28100576 ↗Perioperative management of a large, late presenting phaeochromocytoma
Time restricted eating
T2
T2 — RCT in related condition
RegisteredPOTS
22 sources
  • T2REGISTERED-ONLY NCT05409651 ↗Phenotyping Mitochondrial and Immune Dysfunction in POTS With Targeted Clinical Intervention.
  • T6INDIRECT 38375882 ↗Mobile health (m-health) smartphone interventions for adolescents and adults with overweight or obes
  • T2 36839342 ↗An Intervention of Four Weeks of Time-Restricted Eating (16/8) in Male Long-Distance Runners Does No
  • T6 35465246 ↗Circadian rhythm disruption in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for
  • T6 37990730 ↗Thirty Obesity Myths, Misunderstandings, and/or Oversimplifications: An Obesity Medicine Association
  • T6 34468792 ↗57<sup>th</sup> EASD Annual Meeting of the European Association for the Study of Diabetes
  • T6INDIRECT 42124054 ↗Intermittent Fasting and Healthy Aging in Older Adults: A Systematic Review of Cardiometabolic, Ment
  • T2 41859904 ↗Effect of 2 Weeks of Time-Restricted Eating on Innate Immunity and Systemic Inflammation in Patients
  • T6 36148880 ↗Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes As
  • T6 36151309 ↗Management of hyperglycaemia in type 2 diabetes, 2022. A consensus report by the American Diabetes A
  • T6 39353925 ↗Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy
  • T6 34327491 ↗Ten things to know about ten cardiovascular disease risk factors
  • T6 39651983 ↗5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes: Standards of Ca
  • T6INDIRECT 39334239 ↗Cardiovascular adaptations and pathological changes induced by spaceflight: from cellular mechanisms
  • T6INDIRECT 38731912 ↗Brain-Periphery Interactions in Huntington's Disease: Mediators and Lifestyle Interventions
  • T6INDIRECT 41470894 ↗Endocrine Adaptations to Prolonged Fasting: From Physiology, Clinical Uncertainties, Translational C
  • T6INDIRECT 39091005 ↗2023 Clinical Practice Guidelines for Diabetes Management in Korea: Full Version Recommendation of t
  • T6INDIRECT 40631460 ↗2025 Clinical Practice Guidelines for Diabetes Management in Korea: Recommendation of the Korean Dia
  • T6INDIRECT 35500564 ↗ZoomForward2022: European Congress on Obesity
  • T6 40492113 ↗Linking oxidative stress biomarkers to disease progression and antioxidant therapy in hypertension a
  • T6 41500519 ↗Unlocking the potential of circadian biology for cardiovascular health
  • T6 35517870 ↗Ten things to know about ten cardiovascular disease risk factors - 2022
Training program
T2
T2 — RCT in related condition
RegisteredWithdrawnPOTS
33 sources
  • T2REGISTERED-ONLY NCT05554107 ↗The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome
  • T2WITHDRAWN NCT04702217 ↗Physical Activity as a Complementary Treatment in POTS
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T2 29939051 ↗Brief mindfulness training for negative affectivity: A systematic review and meta-analysis
  • T6INDIRECT 33428616 ↗Mindfulness-based programmes for mental health promotion in adults in nonclinical settings: A system
  • T2 36497565 ↗The Effect of Resistance Training on the Rehabilitation of Elderly Patients with Sarcopenia: A Meta-
  • T6INDIRECT 36282618 ↗Support for healthy breastfeeding mothers with healthy term babies
  • T6INDIRECT 20223994 ↗Supine cycling plus volume loading prevent cardiovascular deconditioning during bed rest
  • T6INDIRECT 22345434 ↗Effect of rowing ergometry and oral volume loading on cardiovascular structure and function during b
  • T6INDIRECT 31685792 ↗Effect of dapagliflozin on obstructive sleep apnea in patients with type 2 diabetes: a preliminary s
  • T6 31633216 ↗Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
  • T6 14711655 ↗Census of the bacterial community of the gypsy moth larval midgut by using culturing and culture-ind
  • T6 16537132 ↗Costs and benefits of symbiont infection in aphids: variation among symbionts and across temperature
  • T6 19363018 ↗The Alzheimer's Disease Knowledge Scale: development and psychometric properties
  • T6INDIRECT 24018704 ↗Physiotherapy versus placebo or no intervention in Parkinson's disease
  • T6INDIRECT 24748784 ↗Physical activity and cognitive function in individuals over 60 years of age: a systematic review
  • T6INDIRECT 36602886 ↗Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis
  • T6INDIRECT 22807627 ↗A randomized controlled trial of Tai chi for balance, sleep quality and cognitive performance in eld
  • T6INDIRECT 25229735 ↗A randomized trial of functional electrical stimulation for walking in incomplete spinal cord injury
  • T6INDIRECT 35679471 ↗Human temperature regulation under heat stress in health, disease, and injury
  • T6INDIRECT 18665659 ↗Pathophysiology and treatment of psychosis in Parkinson's disease: a review
  • T6INDIRECT 26198889 ↗Postural Tachycardia Syndrome: Beyond Orthostatic Intolerance
  • T6INDIRECT 24093767 ↗Genotype- and phenotype-guided management of congenital long QT syndrome
  • T6INDIRECT 30001836 ↗Exercise and non-pharmacological treatment of POTS
  • T6INDIRECT 26715466 ↗The Therapeutic Potential of Exercise to Improve Mood, Cognition, and Sleep in Parkinson's Disease
  • T6INDIRECT 25274845 ↗Cerebrovascular regulation, exercise, and mild traumatic brain injury
  • T6 18054395 ↗Treatment of Argentine hemorrhagic fever
  • T6 20852669 ↗Optimal management of sarcopenia
  • T6 39743381 ↗Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults
  • T6 30786722 ↗Cardio-Oncology: Vascular and Metabolic Perspectives: A Scientific Statement From the American Heart
  • T6 19207771 ↗Postural tachycardia syndrome (POTS)
  • T6 22012131 ↗A practical approach to the treatment of depression in patients with chronic kidney disease and end-
  • T6 34409961 ↗International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines
Transcutaneous Vagus Nerve Stimulation
T2
T2 — RCT in related condition
POTS
24 sources
  • T6INDIRECT 40857067 ↗Phenotype characterization of heart failure with preserved ejection fraction in medical device and s
  • T6INDIRECT 35023349 ↗Neuromodulation of Inflammation to Treat Heart Failure With Preserved Ejection Fraction: A Pilot Ran
  • T6INDIRECT 30560316 ↗Autonomic Neuromodulation Acutely Ameliorates Left Ventricular Strain in Humans
  • T6INDIRECT 37999672 ↗Noninvasive Vagus Nerve Stimulation in Postural Tachycardia Syndrome: A Randomized Clinical Trial
  • T6INDIRECT 39969124 ↗Non-invasive vagus nerve stimulation and exercise capacity in healthy volunteers: a randomized trial
  • T2 39402309 ↗Acute right-sided transcutaneous vagus nerve stimulation improves cardio-vagal baroreflex gain in pa
  • T6INDIRECT 39969545 ↗Feasibility and acceptance of transdermal auricular vagus nerve stimulation using a TENS device in f
  • T6INDIRECT 41068419 ↗Feasibility, safety and efficacy of multi-dose vagus nerve stimulation in Parkinson's disease: a dou
  • T6 35269591 ↗The Interplay between Autonomic Nervous System and Inflammation across Systemic Autoimmune Diseases
  • T6 33999297 ↗The autonomic nervous system in septic shock and its role as a future therapeutic target: a narrativ
  • T6INDIRECT 35616609 ↗Neuromodulation Using Computer-Altered Music to Treat a Ten-Year-Old Child Unresponsive to Standard
  • T5 38110825 ↗Transcutaneous vagus nerve stimulation as a potential novel treatment for cyclic vomiting syndrome:
  • T6INDIRECT 40056025 ↗Clinical neurocardiology: defining the value of neuroscience-based cardiovascular therapeutics - 202
  • T6INDIRECT 39319097 ↗Effect of neuromodulation for chronic pain on the autonomic nervous system: a systematic review
  • T6INDIRECT 36169154 ↗Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of aut
  • T6INDIRECT 39896735 ↗Feasibility of trancutaneous auricular vagus nerve stimulation in Black and Hispanic/Latino people w
  • T4 37532979 ↗Safety and feasibility of transcutaneous vagus nerve stimulation in mild cognitive impairment: VINCI
  • T4 35318234 ↗Transcutaneous vagus nerve stimulation in erosive hand osteoarthritis: protocol for the randomised,
  • T6 31083399 ↗Inflammatory and Molecular Pathways in Heart Failure-Ischemia, HFpEF and Transthyretin Cardiac Amylo
  • T6 33532701 ↗The Vagal Autonomic Pathway of COVID-19 at the Crossroad of Alzheimer's Disease and Aging: A Review
  • T6 33807256 ↗Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives
  • T6 32435491 ↗Altered cardiorespiratory regulation during exercise in patients with Parkinson's disease: A challen
  • T6 34159566 ↗Current Insights into Treating Vertigo in Older Adults
  • T6 30623126 ↗A unifying conceptual framework of factors associated to cardiac vagal control
Transcutaneous auricular vagus nerve stimulation
T2
T2 — RCT in related condition
RegisteredPOTS
26 sources
  • T2REGISTERED-ONLY NCT07163130 ↗Tragus Stimulation for POTS Treatment
  • T6INDIRECT 40356702 ↗The developments and emerging trends of Autonomic Nervous System Research in Arrhythmia: a bibliomet
  • T6INDIRECT 39969545 ↗Feasibility and acceptance of transdermal auricular vagus nerve stimulation using a TENS device in f
  • T6INDIRECT 36940750 ↗Prefrontal tDCS modulates autonomic responses in COVID-19 inpatients
  • T6INDIRECT 41927730 ↗Post-exercise auricular vagus nerve stimulation modulates autonomic and recovery responses in physic
  • T6INDIRECT 40908377 ↗Effects of taVNS on physiological responses and cognitive performance during a mental stressor
  • T2 41345210 ↗Bilateral transcutaneous auricular vagus nerve stimulation for the treatment of insomnia in breast c
  • T6 33828455 ↗Therapeutic Potential of Vagus Nerve Stimulation for Inflammatory Bowel Diseases
  • T6 35784842 ↗"The Wandering Nerve Linking Heart and Mind" - The Complementary Role of Transcutaneous Vagus Nerve
  • T6 37388279 ↗Long COVID: Complications, Underlying Mechanisms, and Treatment Strategies
  • T6 34446089 ↗A method to quantify autonomic nervous system function in healthy, able-bodied individuals
  • T6 39448636 ↗Vagus nerve stimulation in Parkinson's disease: a scoping review of animal studies and human subject
  • T6INDIRECT 40995146 ↗Non-invasive brain stimulation for stroke-related motor impairment and disability: an umbrella revie
  • T2 41549029 ↗Home-based transcutaneous auricular vagus nerve stimulation (taVNS) improves motor and non-motor sym
  • T5 38110825 ↗Transcutaneous vagus nerve stimulation as a potential novel treatment for cyclic vomiting syndrome:
  • T6INDIRECT 39867596 ↗Efficacy of vagus nerve stimulation in gastrointestinal disorders: a systematic review
  • T6INDIRECT 40279198 ↗Gut neuropeptide involvement in Parkinson's disease
  • T6INDIRECT 39967766 ↗A Review of Advances in Multimodal Treatment Strategies for Chronic Disorders of Consciousness Follo
  • T6INDIRECT 41781173 ↗A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of
  • T6INDIRECT 40218285 ↗Current Concepts in Gastroparesis and Gastric Neuromuscular Disorders-Pathophysiology, Diagnosis, an
  • T6INDIRECT 39896735 ↗Feasibility of trancutaneous auricular vagus nerve stimulation in Black and Hispanic/Latino people w
  • T6 40305215 ↗Heart Rate Variability, Microvascular Dysfunction, and Inflammation: Exploring the Potential of taVN
  • T6 37554394 ↗Multi-session transcutaneous auricular vagus nerve stimulation for Parkinson's disease: evaluating f
  • T6 36873318 ↗Low-level tragus stimulation improves autoantibody-induced hyperadrenergic postural tachycardia synd
  • T6 39648211 ↗Exploring the efficacy of Transcutaneous Auricular Vagus nerve stimulation (taVNS) in modulating loc
  • T6 37374012 ↗Social Isolation: A Narrative Review on the Dangerous Liaison between the Autonomic Nervous System a
Transcutaneous vagal nerve stimulation
T2
T2 — RCT in related condition
POTS
17 sources
  • T2 NCT04632134 ↗Long-term Effects of Transcutaneous Vagal Nerve Stimulation on Postural Orthostatic Tachycardia Synd
  • T6 33586685 ↗Gastrointestinal motility disorders in neurologic disease
  • T6 34692718 ↗Immunopathophysiology of Juvenile Spondyloarthritis (jSpA): The "Out of the Box" View on Epigenetics
  • T6 37771451 ↗Treatment of non-epileptic episodes of anxious, fearful behavior in adolescent juvenile neuronal cer
  • T6 35959570 ↗Association of Autonomic Activation with traumatic reminder challenges in posttraumatic stress disor
  • T6 33043826 ↗<b>UEG</b> Week 2020 Poster Presentations
  • T2 34925341 ↗Transcutaneous Vagal Nerve Stimulation Alone or in Combination With Radiotherapy Stimulates Lung Tum
  • T6 27330903 ↗Recent advances in migraine therapy
  • T6 37416924 ↗When blood pressure refuses to budge: exploring the complexity of resistant hypertension
  • T6 36845167 ↗Ganglionic Plexus Ablation: A Step-by-step Guide for Electrophysiologists and Review of Modalities f
  • T6 37532979 ↗Safety and feasibility of transcutaneous vagus nerve stimulation in mild cognitive impairment: VINCI
  • T6INDIRECT 38586798 ↗Refractory Autonomic Instability in Mild Traumatic Brain Injury: A Case Report
  • T6INDIRECT 41134786 ↗Case-control study of autonomic symptoms in the setting of Long COVID with tilt table testing
  • T6INDIRECT 32949293 ↗Program and Abstracts of the 31st International Symposium on the Autonomic Nervous System
  • T4 PMC8317256 ↗BNA 2021 Festival of Neuroscience Poster abstracts
  • T6 35024055 ↗Neuromodulatory Approaches for Atrial Fibrillation Ablation
  • T6 41359106 ↗Peripheral Parasympathetic Networks in Pain: A Systems-Level Review of Mechanisms and Modulations
Transdiagnostic Group-Based Treatment
T2
T2 — RCT in related condition
POTS
1 source
Vagal stimulation
T2
T2 — RCT in related condition
RegisteredPOTS
32 sources
  • T2REGISTERED-ONLY NCT03124355 ↗Vagal Stimulation in POTS
  • T6REGISTERED-ONLY NCT05043051 ↗Autoimmune Basis for Postural Tachycardia Syndrome
  • T6INDIRECT 41668172 ↗Potential application of brain-gut axis-based treatments in Long COVID and ME/CFS: a case-based syst
  • T6INDIRECT 18240245 ↗A six-month randomized controlled trial of exercise and pyridostigmine in the treatment of fibromyal
  • T6INDIRECT 39969124 ↗Non-invasive vagus nerve stimulation and exercise capacity in healthy volunteers: a randomized trial
  • T6INDIRECT 34582903 ↗Effects of lidocaine and esmolol on hemodynamic response to tracheal intubation: a randomized clinic
  • T6INDIRECT 41927730 ↗Post-exercise auricular vagus nerve stimulation modulates autonomic and recovery responses in physic
  • T6INDIRECT 26387781 ↗Effect of neostigmine on gastroduodenal motility in patients with suspected gastrointestinal motilit
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6 29467611 ↗The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis
  • T6 33243837 ↗Autonomic dysfunction in 'long COVID': rationale, physiology and management strategies
  • T6 30871703 ↗Autonomic Nervous System Dysfunction: JACC Focus Seminar
  • T6 34128471 ↗Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury
  • T6 42342403 ↗Effects of auricular vagal neuromodulation therapy combined with slow-paced diaphragmatic breathing
  • T6INDIRECT 31391000 ↗Swallow syncope: a case report and review of literature
  • T6INDIRECT 30560316 ↗Autonomic Neuromodulation Acutely Ameliorates Left Ventricular Strain in Humans
  • T2 974610 ↗Observations on electrocardiogram and plasma catecholamines during dental procedures: the forgotten
  • T6INDIRECT 27736760 ↗Randomized, Open-Label Study of the Pharmacokinetics and Safety of Oral and Intravenous Administrati
  • T6INDIRECT 33387632 ↗Effects of Low-Level Tragus Stimulation on Endothelial Function in Heart Failure With Reduced Ejecti
  • T6INDIRECT 21263060 ↗Swallow syncope: a case report and review of the literature
  • T6INDIRECT 24567799 ↗Cardiac autonomic neuropathy in patients with diabetes mellitus
  • T6INDIRECT 30961531 ↗Primary headaches during lifespan
  • T6INDIRECT 39082698 ↗Cardioneuroablation for the treatment of reflex syncope and functional bradyarrhythmias: A Scientifi
  • T6INDIRECT 35449490 ↗Association of mast-cell-related conditions with hypermobile syndromes: a review of the literature
  • T6INDIRECT 16632674 ↗Cardiac disease and Rett syndrome
  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6 22331383 ↗Autonomic neural regulation of the immune system: implications for hypertension and cardiovascular d
  • T6 33828455 ↗Therapeutic Potential of Vagus Nerve Stimulation for Inflammatory Bowel Diseases
  • T6 10814617 ↗Recreational drug misuse: issues for the cardiologist
  • T6 32700055 ↗The extended autonomic system, dyshomeostasis, and COVID-19
  • T6 35269591 ↗The Interplay between Autonomic Nervous System and Inflammation across Systemic Autoimmune Diseases
  • T6 25621208 ↗Chronic complications of spinal cord injury
Waist-High Compression Tights
T2
T2 — RCT in related condition
RegisteredPOTS
2 sources
  • T2REGISTERED-ONLY NCT04881318 ↗Compression Garments in the Community With POTS
  • T6 39582711 ↗One Size Does Not Fit All: An Exploration of Compression Garment Use in Patients With Postural Ortho
Whole-body Electrical Muscle Stimulation Exercise
T2
T2 — RCT in related condition
RegisteredPOTS
1 source
  • T2REGISTERED-ONLY NCT07478172 ↗Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease
Yoga
T2
T2 — RCT in related condition
POTS
25 sources
  • T6INDIRECT 30191554 ↗Interventions for preventing falls in older people in care facilities and hospitals
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 25432016 ↗Exercise for reducing fear of falling in older people living in the community
  • T6INDIRECT 33687070 ↗Smoking cessation for improving mental health
  • T6INDIRECT 33428616 ↗Mindfulness-based programmes for mental health promotion in adults in nonclinical settings: A system
  • T6INDIRECT 24595586 ↗Non-surgical interventions for the management of chronic pelvic pain
  • T6INDIRECT 35056352 ↗Cognitive Behavioral Therapy for Migraine Headache: A Systematic Review and Meta-Analysis
  • T6INDIRECT 24748784 ↗Physical activity and cognitive function in individuals over 60 years of age: a systematic review
  • T6INDIRECT 36602886 ↗Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis
  • T2 20946990 ↗A pilot randomized controlled trial of the Yoga of Awareness program in the management of fibromyalg
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 34942142 ↗The neuropsychiatry of Parkinson's disease: advances and challenges
  • T6INDIRECT 25420112 ↗Pulmonary arteriovenous malformations
  • T6INDIRECT 25309504 ↗Management of fatigue in persons with multiple sclerosis
  • T6INDIRECT 29628432 ↗Cognitive and psychological issues in postural tachycardia syndrome
  • T6INDIRECT 21115758 ↗Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Asso
  • T6 29090092 ↗Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential trea
  • T6 29163522 ↗The Vagus Nerve in the Neuro-Immune Axis: Implications in the Pathology of the Gastrointestinal Trac
  • T6 26062169 ↗Fear and the Defense Cascade: Clinical Implications and Management
  • T6 25182228 ↗Clinician's Guide to Prevention and Treatment of Osteoporosis
  • T6 30291106 ↗Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes As
  • T6 36178003 ↗World guidelines for falls prevention and management for older adults: a global initiative
  • T6 35478046 ↗The clinician's guide to prevention and treatment of osteoporosis
  • T6 34409961 ↗International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines
Yohimbine
T2
T2 — RCT in related condition
POTS
26 sources
  • T6INDIRECT 31511863 ↗Opioids and Their Endocrine Effects: A Systematic Review and Meta-analysis
  • T6INDIRECT 22591985 ↗Efficacy of treatments for orthostatic hypotension: a systematic review
  • T6INDIRECT 35234292 ↗Pharmacotherapy for post traumatic stress disorder (PTSD)
  • T6INDIRECT 8080348 ↗Noradrenergic dysregulation during discontinuation of cocaine use in addicts
  • T2 20837887 ↗Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotensio
  • T6INDIRECT 30153753 ↗Double-Blind Randomized Clinical Trial of Prazosin for Alcohol Use Disorder
  • T6INDIRECT 22311903 ↗Synergistic effect of norepinephrine transporter blockade and α-2 antagonism on blood pressure in au
  • T6INDIRECT 10662747 ↗The pressor response to water drinking in humans : a sympathetic reflex?
  • T6INDIRECT 9727818 ↗Contrasting actions of pressor agents in severe autonomic failure
  • T6INDIRECT 12403667 ↗Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 17227286 ↗Review of the pharmacology and clinical profile of bupropion, an antidepressant and tobacco use cess
  • T6INDIRECT 25200111 ↗Drooling in Parkinson's disease: a review
  • T6INDIRECT 31031694 ↗Autonomic Dysfunction in α-Synucleinopathies
  • T6INDIRECT 28050310 ↗Gastrointestinal Dysfunctions in Parkinson's Disease: Symptoms and Treatments
  • T6INDIRECT 25589266 ↗Sympathoneural and adrenomedullary responses to mental stress
  • T6 22192366 ↗Olfaction in Parkinson's disease and related disorders
  • T6 29315692 ↗Comprehensive review of cardiovascular toxicity of drugs and related agents
  • T6 18308299 ↗Sympathetic modulation of immunity: relevance to disease
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 21890520 ↗Low-frequency power of heart rate variability is not a measure of cardiac sympathetic tone but may b
  • T6 22094370 ↗Cardiovascular dysautonomia in Parkinson disease: from pathophysiology to pathogenesis
Zoex compression garment
T2
T2 — RCT in related condition
POTS
1 source
  • T2 NCT01795469 ↗Abdominal and Lower Extremity Compression During Tilt Table Testing in Adolescent POTS Patients
alpha-lipoic acid (ALA)
T2
T2 — RCT in related condition
POTS
28 sources
  • T6INDIRECT 36349400 ↗Clinical trials on the pharmacological treatment of long COVID: A systematic review
  • T6INDIRECT 31076938 ↗Physical activity and dietary interventions in diabetic neuropathy: a systematic review
  • T6INDIRECT 35767077 ↗Systematic review about complementary medical hyperthermia in oncology
  • T6INDIRECT 39940333 ↗Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (
  • T6INDIRECT 33513879 ↗Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Cont
  • T6INDIRECT 27869661 ↗An Exploratory Investigation of Endotoxin Levels in Novice Long Distance Triathletes, and the Effect
  • T6INDIRECT 33114210 ↗Efficacy and Safety of the Combination of Superoxide Dismutase, Alpha Lipoic Acid, Vitamin B12, and
  • T6INDIRECT 27283929 ↗Effects of hemin on heme oxygenase-1, gastric emptying, and symptoms in diabetic gastroparesis
  • T6INDIRECT 39339645 ↗Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic
  • T2 37944311 ↗Alpha-lipoic acid does not improve olfactory training results in olfactory loss due to COVID-19: a d
  • T6INDIRECT 10219752 ↗Diabetic neuropathies: features and mechanisms
  • T6INDIRECT 30236383 ↗Peripheral neuropathy in children and adolescents treated for cancer
  • T6INDIRECT 32950543 ↗Pain management in hidradenitis suppurativa and a proposed treatment algorithm
  • T4 36615676 ↗Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Feat
  • T6INDIRECT 37054777 ↗Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequela
  • T6INDIRECT 36148558 ↗Neurological post-acute sequelae of SARS-CoV-2 infection
  • T6INDIRECT 27665271 ↗Nutritional interventions in primary mitochondrial disorders: Developing an evidence base
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 28620280 ↗Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy
  • T6 16461471 ↗Diabetic neuropathy
  • T6 29056658 ↗Mitochondrial Dysfunction in Chemotherapy-Induced Peripheral Neuropathy (CIPN)
  • T6 33924103 ↗Treatment Options for Motor and Non-Motor Symptoms of Parkinson's Disease
  • T6 33101584 ↗Oxidative Stress in Parkinson's Disease: Potential Benefits of Antioxidant Supplementation
  • T6 30136449 ↗Diagnosing Diabetic Neuropathy: Something Old, Something New
  • T6 18194747 ↗The spectrum of diabetic neuropathies
  • T6 23385875 ↗Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and ther
  • T6 35198136 ↗Neurological manifestations of long-COVID syndrome: a narrative review
  • T6 34181102 ↗The Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 infection
atenolol (beta-blocker)
T2
T2 — RCT in related condition
POTS
23 sources
  • T6INDIRECT 19821318 ↗Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitiv
  • T6INDIRECT 24158454 ↗Blood pressure control and primary prevention of stroke: summary of the recent clinical trial data a
  • T6INDIRECT 24869750 ↗Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension
  • T6INDIRECT 24902920 ↗The design and rationale of a multicenter clinical trial comparing two strategies for control of sys
  • T6INDIRECT 34739197 ↗Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease
  • T6INDIRECT 11435337 ↗Permanent cardiac pacing versus medical treatment for the prevention of recurrent vasovagal syncope:
  • T2 11216978 ↗Lack of efficacy of atenolol for the prevention of neurally mediated syncope in a highly symptomatic
  • T2 7484777 ↗Randomized double-blind, placebo-controlled trial of oral atenolol in patients with unexplained sync
  • T6INDIRECT 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
  • T6 33769101 ↗Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 30184160 ↗Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints
  • T6INDIRECT 31954495 ↗Diagnosis and management of toxicities of immune checkpoint inhibitors in hepatocellular carcinoma
  • T6INDIRECT 24636754 ↗Pheochromocytoma and paraganglioma: diagnosis, genetics, management, and treatment
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
  • T6 33909761 ↗Brazilian Guidelines of Hypertension - 2020
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
atomoxetine
T2
T2 — RCT in related condition
POTS
24 sources
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 22071859 ↗Antidepressants for pain management in rheumatoid arthritis
  • T6INDIRECT 27863901 ↗A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease f
  • T2 20679638 ↗Atomoxetine for depression and other neuropsychiatric symptoms in Parkinson disease
  • T6INDIRECT 31853557 ↗Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide
  • T2 25185131 ↗Efficacy of atomoxetine versus midodrine for the treatment of orthostatic hypotension in autonomic f
  • T2 34919634 ↗A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment
  • T6INDIRECT 22311903 ↗Synergistic effect of norepinephrine transporter blockade and α-2 antagonism on blood pressure in au
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 31519472 ↗New evidence on the management of Lewy body dementia
  • T6INDIRECT 29508455 ↗Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
  • T6INDIRECT 35841911 ↗Diagnosis and treatment of orthostatic hypotension
  • T6INDIRECT 31031694 ↗Autonomic Dysfunction in α-Synucleinopathies
  • T6INDIRECT 21445724 ↗European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological
  • T6 37230968 ↗Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
  • T6 28837986 ↗Sleep Disturbance, Cognitive Decline, and Dementia: A Review
  • T6 29315692 ↗Comprehensive review of cardiovascular toxicity of drugs and related agents
  • T6 21956442 ↗Parkinson's disease therapeutics: new developments and challenges since the introduction of levodopa
  • T6 16554257 ↗Contemporary assessment and pharmacotherapy of Tourette syndrome
  • T6 29523389 ↗Postural tachycardia syndrome - Diagnosis, physiology, and prognosis
  • T6 23753844 ↗Postural tachycardia syndrome (POTS)
  • T6 22519513 ↗The solute carrier 6 family of transporters
beta-blocker
T2
T2 — RCT in related condition
POTS
30 sources
  • T2 NCT00865917 ↗Cardiovascular Effects of Selective I(f)-Channel Blockade
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30019766 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30521670 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 36349400 ↗Clinical trials on the pharmacological treatment of long COVID: A systematic review
  • T6INDIRECT 26607938 ↗Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, doub
  • T6INDIRECT 19687359 ↗Propranolol decreases tachycardia and improves symptoms in the postural tachycardia syndrome: less i
  • T6INDIRECT 27665708 ↗Orthostatic changes in systolic blood pressure among SPRINT participants at baseline
  • T6INDIRECT 11198485 ↗Clinical improvement in patients with orthostatic intolerance after treatment with bisoprolol and fl
  • T6 33753937 ↗Post-acute COVID-19 syndrome
  • T6HARM 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6 31633216 ↗Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
  • T6INDIRECT 28816346 ↗Homocysteine-lowering interventions for preventing cardiovascular events
  • T6INDIRECT 26551272 ↗A Randomized Trial of Intensive versus Standard Blood-Pressure Control
  • T6INDIRECT 24902920 ↗The design and rationale of a multicenter clinical trial comparing two strategies for control of sys
  • T6INDIRECT 24126931 ↗Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with mini
  • T6INDIRECT 27170530 ↗Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double-blind, ran
  • T6INDIRECT 34739197 ↗Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease
  • T6INDIRECT 19470886 ↗Effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 di
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 18085482 ↗Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide
  • T6INDIRECT 26084539 ↗International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors
  • T6 29565029 ↗Hypertension
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 26468341 ↗Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations
  • T6 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
bisoprolol (beta-blocker)
T2
T2 — RCT in related condition
POTS
27 sources
  • T6INDIRECT 24869750 ↗Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension
  • T6INDIRECT 32519776 ↗Withdrawal of antihypertensive drugs in older people
  • T6INDIRECT 29059199 ↗Effectiveness of beta-blockers depending on the genotype of congenital long-QT syndrome: A meta-anal
  • T6INDIRECT 23796325 ↗Systematic review of genuine versus spurious side-effects of beta-blockers in heart failure using pl
  • T6INDIRECT 31167038 ↗Pharmacotherapy for hypertension in adults 60 years or older
  • T6INDIRECT 23730991 ↗Effects of intensive antihypertensive treatment on Chinese hypertensive patients older than 70 years
  • T6INDIRECT 28655357 ↗Drug-related problems and medication reviews among old people with dementia
  • T6INDIRECT 17786067 ↗A randomized, double-blind, placebo-controlled parallel-group study to assess the efficacy and safet
  • T6INDIRECT 24650926 ↗A randomized pilot study of aortic waveform guided therapy in chronic heart failure
  • T2 11198485 ↗Clinical improvement in patients with orthostatic intolerance after treatment with bisoprolol and fl
  • T6INDIRECT 24567799 ↗Cardiac autonomic neuropathy in patients with diabetes mellitus
  • T6INDIRECT 38441582 ↗Cardiac Amyloidosis Due to Transthyretin Protein: A Review
  • T6INDIRECT 35830976 ↗Incidence, risk factors, natural history, and hypothesised mechanisms of myocarditis and pericarditi
  • T6INDIRECT 28261151 ↗The Treatment of Sleep Disorders in Parkinson's Disease: From Research to Clinical Practice
  • T6INDIRECT 35853576 ↗Postural orthostatic tachycardia syndrome as a sequela of COVID-19
  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6INDIRECT 35307156 ↗2022 ACC Expert Consensus Decision Pathway on Cardiovascular Sequelae of COVID-19 in Adults: Myocard
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 31710717 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors
  • T6 11129673 ↗Chagas' heart disease
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
  • T6 33909761 ↗Brazilian Guidelines of Hypertension - 2020
  • T6 28050656 ↗The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic o
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
clonidine
T2
T2 — RCT in related condition
RegisteredME/CFSPOTS
61 sources
  • T2 NCT01507701 ↗Pilot Study for the NorCAPITAL Trial
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T6INDIRECT 23076904 ↗Printed educational materials: effects on professional practice and healthcare outcomes
  • T6INDIRECT 25379990 ↗Pharmacological interventions for somatoform disorders in adults
  • T6INDIRECT 17021301 ↗Interventions for the treatment, management and rehabilitation of patients with chronic fatigue synd
  • T6INDIRECT 31906979 ↗Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyel
  • T6INDIRECT 31478755 ↗Probiotics for Gastrointestinal Symptoms and Quality of Life in Autism: A Placebo-Controlled Pilot T
  • T6INDIRECT 22824921 ↗The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spin
  • T2 24493300 ↗Disease mechanisms and clonidine treatment in adolescent chronic fatigue syndrome: a combined cross-
  • T2 37296432 ↗Effect of propranolol and clonidine after severe traumatic brain injury: a pilot randomized clinical
  • T2 27457818 ↗Genetic variation in catechol-O-methyltransferase modifies effects of clonidine treatment in chronic
  • T2 25887557 ↗The protocol of the Oslo Study of Clonidine in Elderly Patients with Delirium; LUCID: a randomised p
  • T6 35176758 ↗Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus
  • T6 19207771 ↗Postural tachycardia syndrome (POTS)
  • T6INDIRECT 19406310 ↗A systematic review of the management of orthostatic hypotension after spinal cord injury
  • T6INDIRECT 28852322 ↗Acute colonic pseudo-obstruction: A systematic review of aetiology and mechanisms
  • T6INDIRECT 37189381 ↗Dupilumab in Inflammatory Skin Diseases: A Systematic Review
  • T6INDIRECT 23266540 ↗Angiotensin II, independent of plasma renin activity, contributes to the hypertension of autonomic f
  • T6INDIRECT 14695722 ↗Nefopam, a nonsedative benzoxazocine analgesic, selectively reduces the shivering threshold in unane
  • T6INDIRECT 24002370 ↗Effects of norepinephrine reuptake inhibition on postural tachycardia syndrome
  • T6INDIRECT 9819368 ↗Yohimbine in neurally mediated syncope. Pathophysiological implications
  • T6INDIRECT 21876972 ↗Dexmedetomidine for the prevention of shivering during spinal anesthesia
  • T6INDIRECT 33926653 ↗Effect of High Dietary Sodium Intake in Patients With Postural Tachycardia Syndrome
  • T6INDIRECT 9244228 ↗Effects of volume loading and pressor agents in idiopathic orthostatic tachycardia
  • T6 33243837 ↗Autonomic dysfunction in 'long COVID': rationale, physiology and management strategies
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T2 19602964 ↗Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysi
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 26355598 ↗Local Anesthetic Peripheral Nerve Block Adjuvants for Prolongation of Analgesia: A Systematic Qualit
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 24902920 ↗The design and rationale of a multicenter clinical trial comparing two strategies for control of sys
  • T6INDIRECT 16864724 ↗Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis in
  • T6INDIRECT 29133606 ↗Effects of Bariatric Surgery in Obese Patients With Hypertension: The GATEWAY Randomized Trial (Gast
  • T6INDIRECT 18161012 ↗Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse
  • T6INDIRECT 33723532 ↗Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrom
  • T6INDIRECT 26198889 ↗Postural Tachycardia Syndrome: Beyond Orthostatic Intolerance
  • T6INDIRECT 34821709 ↗Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6INDIRECT 32787804 ↗Females with ADHD: An expert consensus statement taking a lifespan approach providing guidance for t
  • T6 21575632 ↗Stress and visceral pain: from animal models to clinical therapies
  • T6 29867317 ↗Current Enlightenment About Etiology and Pharmacological Treatment of Autism Spectrum Disorder
  • T6 33936095 ↗Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity
  • T6 34414219 ↗Antidepressant Drugs Effects on Blood Pressure
  • T6 19789072 ↗Targeting voltage-gated calcium channels for neuropathic pain management
  • T6 38123150 ↗The Concise Guide to PHARMACOLOGY 2023/24: Ion channels
  • T6 22593735 ↗Synaptic regulation of the hypothalamic-pituitary-adrenal axis and its modulation by glucocorticoids
  • T6 29222399 ↗Pediatric Disorders of Orthostatic Intolerance
  • T6 15298528 ↗The burden of illness of irritable bowel syndrome: current challenges and hope for the future
  • T6INDIRECT 22187469 ↗Standards of medical care in diabetes--2012
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 26514824 ↗Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for
  • T6INDIRECT 23264422 ↗Standards of medical care in diabetes--2013
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 21193625 ↗Standards of medical care in diabetes--2011
  • T6INDIRECT 19118286 ↗Standards of medical care in diabetes--2009
  • T6 33769101 ↗Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 30354828 ↗Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the Ameri
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
clonidine (alpha-2 agonist)
T2
T2 — RCT in related condition
POTS
24 sources
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T2 19602964 ↗Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysi
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 26355598 ↗Local Anesthetic Peripheral Nerve Block Adjuvants for Prolongation of Analgesia: A Systematic Qualit
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 24902920 ↗The design and rationale of a multicenter clinical trial comparing two strategies for control of sys
  • T6INDIRECT 16864724 ↗Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis in
  • T6INDIRECT 29133606 ↗Effects of Bariatric Surgery in Obese Patients With Hypertension: The GATEWAY Randomized Trial (Gast
  • T6INDIRECT 18161012 ↗Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse
  • T6INDIRECT 9244228 ↗Effects of volume loading and pressor agents in idiopathic orthostatic tachycardia
  • T6INDIRECT 22187469 ↗Standards of medical care in diabetes--2012
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 26514824 ↗Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for
  • T6INDIRECT 23264422 ↗Standards of medical care in diabetes--2013
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 21193625 ↗Standards of medical care in diabetes--2011
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6INDIRECT 19118286 ↗Standards of medical care in diabetes--2009
  • T6 33769101 ↗Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 30354828 ↗Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the Ameri
  • T6 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
compression garments (POTS)
T2
T2 — RCT in related condition
POTS
30 sources
  • T6INDIRECT 9091692 ↗Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind m
  • T6INDIRECT 25350981 ↗Randomized withdrawal study of patients with symptomatic neurogenic orthostatic hypotension responsi
  • T6INDIRECT 25185131 ↗Efficacy of atomoxetine versus midodrine for the treatment of orthostatic hypotension in autonomic f
  • T6INDIRECT 28494751 ↗Integrated analysis of droxidopa trials for neurogenic orthostatic hypotension
  • T2 27271310 ↗Efficacy of Servo-Controlled Splanchnic Venous Compression in the Treatment of Orthostatic Hypotensi
  • T2 33478652 ↗Compression Garment Reduces Orthostatic Tachycardia and Symptoms in Patients With Postural Orthostat
  • T2 19456003 ↗Compression garments as countermeasures to orthostatic intolerance
  • T2 25448247 ↗Effects of patient-controlled abdominal compression on standing systolic blood pressure in adults wi
  • T2 22194814 ↗Are compression stockings an effective treatment for orthostatic presyncope?
  • T6 34024217 ↗Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments
  • T6INDIRECT 33723532 ↗Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrom
  • T6INDIRECT 32880754 ↗A case report of postural tachycardia syndrome after COVID-19
  • T6INDIRECT 30001836 ↗Exercise and non-pharmacological treatment of POTS
  • T6INDIRECT 34821709 ↗Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know?
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6INDIRECT 34144933 ↗Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019
  • T6INDIRECT 34218857 ↗Post-COVID-19 Syndrome (Long Haul Syndrome): Description of a Multidisciplinary Clinic at Mayo Clini
  • T6 19541551 ↗Association of N-type calcium channel autoimmunity in patients with autoimmune autonomic ganglionopa
  • T6 33271870 ↗The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders
  • T6 36444232 ↗AL Amyloidosis for Cardiologists: Awareness, Diagnosis, and Future Prospects: &lt;i&gt;JACC: CardioO
  • T6 22678960 ↗Mechanisms of sympathetic regulation in orthostatic intolerance
  • T6 40274830 ↗Diabetic neuropathy: cutting-edge research and future directions
  • T6 23472781 ↗Medical therapy and physical maneuvers in the treatment of the vasovagal syncope and orthostatic hyp
  • T6 33806183 ↗Biology of Lymphedema
  • T6 32974246 ↗Postural Tachycardia Syndrome in Children and Adolescents: Pathophysiology and Clinical Management
  • T6 33243837 ↗Autonomic dysfunction in 'long COVID': rationale, physiology and management strategies
  • T6 28050656 ↗The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic o
  • T6 19207771 ↗Postural tachycardia syndrome (POTS)
  • T6 18420158 ↗Management of neurogenic orthostatic hypotension: an update
  • T6 36178003 ↗World guidelines for falls prevention and management for older adults: a global initiative
desmopressin (DDAVP)
T2
T2 — RCT in related condition
POTS
25 sources
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 29161773 ↗Silodosin for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia
  • T6INDIRECT 30306544 ↗Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperp
  • T6INDIRECT 29953167 ↗Interventions for chronic non-hypovolaemic hypotonic hyponatraemia
  • T6INDIRECT 30584530 ↗Rapid-Onset Obesity with Hypoventilation, Hypothalamic, Autonomic Dysregulation, and Neuroendocrine
  • T6INDIRECT 36525900 ↗Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review
  • T6INDIRECT 20552588 ↗Clinostatic hypertension and orthostatic hypotension
  • T6INDIRECT 39882369 ↗Oral medications for the treatment of postural orthostatic tachycardia syndrome; a systematic review
  • T2 22561596 ↗Desmopressin acutely decreases tachycardia and improves symptoms in the postural tachycardia syndrom
  • T2 3089519 ↗The effect of desmopressin on nocturnal polyuria, overnight weight loss, and morning postural hypote
  • T6INDIRECT 33723532 ↗Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrom
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 30184160 ↗Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints
  • T6INDIRECT 24567799 ↗Cardiac autonomic neuropathy in patients with diabetes mellitus
  • T6INDIRECT 29508455 ↗Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
  • T6INDIRECT 26900156 ↗The Differential Diagnosis and Treatment of Atypical Parkinsonism
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6 24699931 ↗Non-motor Parkinson's: integral to motor Parkinson's, yet often neglected
  • T6 30793549 ↗Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: W
  • T6 29486781 ↗Vasoplegia treatments: the past, the present, and the future
  • T6 19124673 ↗Neurogenic orthostatic hypotension: a pathophysiological approach
  • T6 29523389 ↗Postural tachycardia syndrome - Diagnosis, physiology, and prognosis
  • T6 27495201 ↗Diagnostic Approach to Atypical Parkinsonian Syndromes
  • T6 23753844 ↗Postural tachycardia syndrome (POTS)
  • T6 26742931 ↗Wolfram Syndrome: Diagnosis, Management, and Treatment
diaphragmatic breathing exercise
T2
T2 — RCT in related condition
RegisteredPOTS
6 sources
  • T2REGISTERED-ONLY NCT07579026 ↗Effects of Breathing Retraining Exercises in Pregnant Females With Postural Orthostatic Tachycardia
  • T6 38298551 ↗HEART Rate Variability Biofeedback for LOng COVID Dysautonomia (HEARTLOC): Results of a Feasibility
  • T6 36410797 ↗HEART rate variability biofeedback for long COVID symptoms (HEARTLOC): protocol for a feasibility st
  • T6 PPR723180 ↗HEART rate variability biofeedback breathing programme for LOng Covid dysautonomia (HEARTLOC): resul
  • T6 PMC9204751 ↗Supplement
  • T6 PPR513768 ↗HEART rate variability biofeedback for LOng Covid symptoms (HEARTLOC): protocol for a feasibility st
droxidopa (norepinephrine precursor)
T2
T2 — RCT in related condition
POTS
28 sources
  • T6INDIRECT 34752479 ↗Drug-induced orthostatic hypotension: A systematic review and meta-analysis of randomised controlled
  • T2 24944260 ↗Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial
  • T2 25350981 ↗Randomized withdrawal study of patients with symptomatic neurogenic orthostatic hypotension responsi
  • T2 25487613 ↗Droxidopa for the short-term treatment of symptomatic neurogenic orthostatic hypotension in Parkinso
  • T6INDIRECT 25185131 ↗Efficacy of atomoxetine versus midodrine for the treatment of orthostatic hypotension in autonomic f
  • T2 24326693 ↗Droxidopa in patients with neurogenic orthostatic hypotension associated with Parkinson's disease (N
  • T6INDIRECT 12885750 ↗Norepinephrine precursor therapy in neurogenic orthostatic hypotension
  • T6INDIRECT 28967294 ↗An Autonomic Neuroprosthesis: Noninvasive Electrical Spinal Cord Stimulation Restores Autonomic Card
  • T6INDIRECT 2890806 ↗Endogenous restoration of noradrenaline by precursor therapy in dopamine-beta-hydroxylase deficiency
  • T2 11710796 ↗L-threo-dihydroxyphenylserine (L-threo-DOPS; droxidopa) in the management of neurogenic orthostatic
  • T6INDIRECT 32402162 ↗Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease
  • T6INDIRECT 33723532 ↗Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrom
  • T6INDIRECT 27999003 ↗Diabetic Neuropathy: A Position Statement by the American Diabetes Association
  • T6INDIRECT 31519472 ↗New evidence on the management of Lewy body dementia
  • T6INDIRECT 29508455 ↗Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
  • T6INDIRECT 35841911 ↗Diagnosis and treatment of orthostatic hypotension
  • T6INDIRECT 24433463 ↗Review of pharmacological therapies in fibromyalgia syndrome
  • T6INDIRECT 33649021 ↗Autoimmune encephalitis: proposed recommendations for symptomatic and long-term management
  • T6 29075003 ↗Trends in GPCR drug discovery: new agents, targets and indications
  • T6 39353925 ↗Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy
  • T6 36810524 ↗Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions
  • T6 30793549 ↗Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: W
  • T6 26729077 ↗The Prodrug Approach: A Successful Tool for Improving Drug Solubility
  • T6 33924103 ↗Treatment Options for Motor and Non-Motor Symptoms of Parkinson's Disease
  • T6 33427939 ↗The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 23425518 ↗Guideline of transthyretin-related hereditary amyloidosis for clinicians
  • T6 28050656 ↗The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic o
duloxetine (SNRI)
T2
T2 — RCT in related condition
POTS
23 sources
  • T6INDIRECT 28854296 ↗Efficacy and Safety of Selective Serotonin Reuptake Inhibitors, Serotonin-Norepinephrine Reuptake In
  • T6INDIRECT 30673120 ↗Pregabalin for neuropathic pain in adults
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T2 17472422 ↗An evaluation of the cardiovascular safety profile of duloxetine: findings from 42 placebo-controlle
  • T6INDIRECT 18253994 ↗Antidepressants for non-specific low back pain
  • T6INDIRECT 24920437 ↗Central changes associated with chronic pelvic pain and endometriosis
  • T6INDIRECT 19092112 ↗A controlled trial of antidepressants in patients with Parkinson disease and depression
  • T6INDIRECT 29243164 ↗Effects of exercise during chemotherapy on chemotherapy-induced peripheral neuropathy: a multicenter
  • T6INDIRECT 34919634 ↗A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment
  • T6 20876709 ↗Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treat
  • T6INDIRECT 27999003 ↗Diabetic Neuropathy: A Position Statement by the American Diabetes Association
  • T6INDIRECT 33243615 ↗Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 34655433 ↗Chemotherapy-Induced Peripheral Neuropathy: Epidemiology, Pathomechanisms and Treatment
  • T6INDIRECT 24672257 ↗Chemotherapy-induced peripheral neuropathy in adults: a comprehensive update of the literature
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6 20194146 ↗Recommendations for the pharmacological management of neuropathic pain: an overview and literature u
  • T6 26111766 ↗SLC transporters as therapeutic targets: emerging opportunities
  • T6 30190489 ↗Wilson disease
  • T6 30909387 ↗Mechanisms of Chemotherapy-Induced Peripheral Neuropathy
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 19118286 ↗Standards of medical care in diabetes--2009
ear blood pressure monitor
T2
T2 — RCT in related condition
RegisteredPOTS
1 source
educational retraining
T2
T2 — RCT in related condition
RegisteredPOTS
1 source
  • T2REGISTERED-ONLY NCT07579026 ↗Effects of Breathing Retraining Exercises in Pregnant Females With Postural Orthostatic Tachycardia
intravenous immunoglobulin (IVIg)
T2
T2 — RCT in related condition
RegisteredLong COVIDPOTS
45 sources
  • T6 NCT05350774 ↗Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2
  • T6 32744608 ↗Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplast
  • T6 29661905 ↗Randomized study of adjunctive belimumab in participants with generalized myasthenia gravis.
  • T6 22561833 ↗IgE and mast cells in allergic disease.
  • T6 25517090 ↗Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions.
  • T6 31676858 ↗TIM3 comes of age as an inhibitory receptor.
  • T6INDIRECT 33837630 ↗Prevalence, clinical characteristics and outcomes of Guillain-Barré syndrome spectrum associated wit
  • T6INDIRECT 35660931 ↗Global reports of myocarditis following COVID-19 vaccination: A systematic review and meta-analysis
  • T6INDIRECT 34365148 ↗Vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis post COVID-1
  • T6INDIRECT 34386902 ↗Association of CNS demyelination and COVID-19 infection: an updated systematic review
  • T6INDIRECT 33036570 ↗Implications of COVID-19 in high burden countries for HIV/TB: A systematic review of evidence
  • T6INDIRECT 32454187 ↗Review of trials currently testing treatment and prevention of COVID-19
  • T6INDIRECT 35316551 ↗A systematic review on mucocutaneous presentations after COVID-19 vaccination and expert recommendat
  • T6INDIRECT 35752132 ↗Acute ischemic stroke and vaccine-induced immune thrombotic thrombocytopenia post COVID-19 vaccinati
  • T6INDIRECT 36098903 ↗Guillain-Barré syndrome in association with COVID-19 vaccination: a systematic review
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6 33753937 ↗Post-acute COVID-19 syndrome
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6INDIRECT 34542573 ↗Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephaliti
  • T6INDIRECT 32840686 ↗Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cas
  • T6INDIRECT 32855289 ↗Guillain-Barré syndrome in SARS-CoV-2 infection: an instant systematic review of the first six month
  • T6INDIRECT 33949300 ↗Guillain Barre Syndrome as a Complication of COVID-19: A Systematic Review
  • T2 31782181 ↗Randomized Placebo-Controlled Trial of Intravenous Immunoglobulin in Autoimmune LGI1/CASPR2 Epilepsy
  • T6INDIRECT 23168581 ↗Safety and efficacy of ARA 290 in sarcoidosis patients with symptoms of small fiber neuropathy: a ra
  • T2 21745374 ↗Comparison of intravenous immunoglobulin and plasma exchange in treatment of mechanically ventilated
  • T2 8774401 ↗Intravenous immunoglobulin treatment in paraneoplastic neurological syndromes with antineuronal auto
  • T6 31541214 ↗Diagnosis and management of Guillain-Barré syndrome in ten steps
  • T6INDIRECT 23633371 ↗Interventions for treating pain and disability in adults with complex regional pain syndrome
  • T6INDIRECT 32653054 ↗Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally a
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 32201335 ↗Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 34281357 ↗Myocarditis With COVID-19 mRNA Vaccines
  • T6INDIRECT 33903743 ↗Systemic and organ-specific immune-related manifestations of COVID-19
  • T6 36707719 ↗The role of platelets in immune-mediated inflammatory diseases
  • T6 39326415 ↗Mechanisms of long COVID and the path toward therapeutics
  • T6 33219837 ↗Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological
  • T6 34716418 ↗Multisystem inflammatory syndrome in children and Kawasaki disease: a critical comparison
  • T6 34454673 ↗1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study
  • T6INDIRECT 24462240 ↗Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a c
  • T6INDIRECT 30218025 ↗Mechanisms, biomarkers and targets for adult-onset Still's disease
  • T6 23642721 ↗Guillain-Barré syndrome and variants
  • T6 33894193 ↗Challenges in the diagnosis of Parkinson's disease
  • T6 26659576 ↗Neurotropic virus infections as the cause of immediate and delayed neuropathology
  • T6 30285773 ↗Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
iron
T2
T2 — RCT in related condition
RegisteredPOTS
27 sources
  • T2REGISTERED-ONLY NCT07197905 ↗Restoring Iron Deficiency in POTS
  • T6INDIRECT 30873598 ↗Multiple-micronutrient supplementation for women during pregnancy
  • T6INDIRECT 33687070 ↗Smoking cessation for improving mental health
  • T6INDIRECT 26488938 ↗Interventions to improve water quality for preventing diarrhoea
  • T6INDIRECT 35445419 ↗The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy
  • T6INDIRECT 36915214 ↗Roles of neuropathology-associated reactive astrocytes: a systematic review
  • T6INDIRECT 25233067 ↗Systematic review of potential health risks posed by pharmaceutical, occupational and consumer expos
  • T6INDIRECT 34017846 ↗Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic
  • T6INDIRECT 26607938 ↗Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, doub
  • T6INDIRECT 30635141 ↗Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial
  • T6INDIRECT 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
  • T6 6326753 ↗Oxygen toxicity, oxygen radicals, transition metals and disease
  • T6 28585944 ↗Cellular uptake of nanoparticles: journey inside the cell
  • T6INDIRECT 27731885 ↗Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion
  • T6INDIRECT 27863901 ↗A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease f
  • T6INDIRECT 20427088 ↗Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt l
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 22187469 ↗Standards of medical care in diabetes--2012
  • T6INDIRECT 33243615 ↗Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 23264422 ↗Standards of medical care in diabetes--2013
  • T6 33894193 ↗Challenges in the diagnosis of Parkinson's disease
  • T6 20042772 ↗Standards of medical care in diabetes--2010
  • T6 25182228 ↗Clinician's Guide to Prevention and Treatment of Osteoporosis
  • T6 30291106 ↗Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes As
isoproterenol
T2
T2 — RCT in related condition
POTS
31 sources
  • T2 NCT02725060 ↗Autoimmune Basis for Postural Tachycardia Syndrome
  • T6INDIRECT 31888497 ↗Heart rate and heart rate variability comparison between postural orthostatic tachycardia syndrome v
  • T6INDIRECT 8673750 ↗Salt supplement increases plasma volume and orthostatic tolerance in patients with unexplained synco
  • T6INDIRECT 9505918 ↗Midodrine: a role in the management of neurocardiogenic syncope
  • T6INDIRECT 11804991 ↗Selective norepinephrine reuptake inhibition as a human model of orthostatic intolerance
  • T6INDIRECT 35107563 ↗Association of Generalized Anxiety Disorder With Autonomic Hypersensitivity and Blunted Ventromedial
  • T6INDIRECT 37999672 ↗Noninvasive Vagus Nerve Stimulation in Postural Tachycardia Syndrome: A Randomized Clinical Trial
  • T6INDIRECT 9819368 ↗Yohimbine in neurally mediated syncope. Pathophysiological implications
  • T6INDIRECT 10190880 ↗Abnormal norepinephrine clearance and adrenergic receptor sensitivity in idiopathic orthostatic into
  • T6INDIRECT 11914255 ↗Baroreflex buffering and susceptibility to vasoactive drugs
  • T6INDIRECT 10065030 ↗Increased orthostatic tolerance following moderate exercise training in patients with unexplained sy
  • T6 21890520 ↗Low-frequency power of heart rate variability is not a measure of cardiac sympathetic tone but may b
  • T6 19207771 ↗Postural tachycardia syndrome (POTS)
  • T6INDIRECT 23041006 ↗Head-up tilt testing for diagnosing vasovagal syncope: a meta-analysis
  • T6INDIRECT 29217664 ↗Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Re
  • T6INDIRECT 16505178 ↗Prevention of Syncope Trial (POST): a randomized, placebo-controlled study of metoprolol in the prev
  • T6INDIRECT 1670907 ↗Utility of upright tilt-table testing in the evaluation and management of syncope of unknown origin
  • T6INDIRECT 4612057 ↗The cardiovascular effects of morphine. The peripheral capacitance and resistance vessels in human s
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 17894650 ↗Catechol-O-methyltransferase and its inhibitors in Parkinson's disease
  • T6INDIRECT 34134525 ↗Recognition, Prevention, and Management of Arrhythmias and Autonomic Disorders in Cardio-Oncology: A
  • T6INDIRECT 29628432 ↗Cognitive and psychological issues in postural tachycardia syndrome
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6 32213941 ↗Chemical Constituents and Pharmacological Activities of Garlic (<i>Allium sativum</i> L.): A Review
  • T6 19639282 ↗Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophys
  • T6 29315692 ↗Comprehensive review of cardiovascular toxicity of drugs and related agents
  • T6 18308299 ↗Sympathetic modulation of immunity: relevance to disease
  • T6 29717928 ↗Impact of the Autonomic Nervous System on the Skeleton
  • T6 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
ivabradine (If channel blocker)
T2
T2 — RCT in related condition
POTS
26 sources
  • T6INDIRECT 29217664 ↗Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Re
  • T6INDIRECT 36349400 ↗Clinical trials on the pharmacological treatment of long COVID: A systematic review
  • T6INDIRECT 29759520 ↗Ablation of Inappropriate Sinus Tachycardia: A Systematic Review of the Literature
  • T2 29330767 ↗Ivabradine for the Treatment of Postural Orthostatic Tachycardia Syndrome: A Systematic Review
  • T6INDIRECT 38673384 ↗Pathophysiological Mechanisms in Long COVID: A Mixed Method Systematic Review
  • T6INDIRECT 36723919 ↗Effect of Personalized Accelerated Pacing on Quality of Life, Physical Activity, and Atrial Fibrilla
  • T2 33602468 ↗Randomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syn
  • T6INDIRECT 37999672 ↗Noninvasive Vagus Nerve Stimulation in Postural Tachycardia Syndrome: A Randomized Clinical Trial
  • T6INDIRECT 31841279 ↗Central blood pressure for the management of hypertension: Is it a practical clinical tool in curren
  • T6INDIRECT 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
  • T6INDIRECT 33723532 ↗Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrom
  • T6INDIRECT 34024217 ↗Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments
  • T6INDIRECT 32117030 ↗Posterior Reversible Encephalopathy Syndrome: Clinical Features and Outcome
  • T6INDIRECT 26198889 ↗Postural Tachycardia Syndrome: Beyond Orthostatic Intolerance
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6INDIRECT 35307156 ↗2022 ACC Expert Consensus Decision Pathway on Cardiovascular Sequelae of COVID-19 in Adults: Myocard
  • T6 39326415 ↗Mechanisms of long COVID and the path toward therapeutics
  • T6 29359025 ↗Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment
  • T6 34134525 ↗Recognition, Prevention, and Management of Arrhythmias and Autonomic Disorders in Cardio-Oncology: A
  • T6 37907497 ↗The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of lon
  • T6 33999297 ↗The autonomic nervous system in septic shock and its role as a future therapeutic target: a narrativ
  • T6 36969241 ↗Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOV
  • T6 39125722 ↗Comprehensive Review of COVID-19: Epidemiology, Pathogenesis, Advancement in Diagnostic and Detectio
  • T6 35176758 ↗Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus
  • T6 28428055 ↗Sex differences in cardiovascular disease - Impact on care and outcomes
  • T6 29222399 ↗Pediatric Disorders of Orthostatic Intolerance
memantine
T2
T2 — RCT in related condition
RegisteredPOTS
33 sources
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T6INDIRECT 30556597 ↗Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people
  • T6INDIRECT 34883203 ↗Heart rate variability in relation to cognition and behavior in neurodegenerative diseases: A system
  • T6INDIRECT 25791142 ↗Assessment and management of treatment-refractory obsessive-compulsive disorder in children
  • T6INDIRECT 30294976 ↗Available and future treatments for atypical parkinsonism. A systematic review
  • T6INDIRECT 34472659 ↗Movement disorders in patients with Rett syndrome: A systematic review of evidence and associated cl
  • T6INDIRECT 31853557 ↗Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide
  • T6INDIRECT 34919634 ↗A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment
  • T6INDIRECT 32986682 ↗The D1/D5 Dopamine Partial Agonist PF-06412562 in Advanced-Stage Parkinson's Disease: A Feasibility
  • T6INDIRECT 41416579 ↗Phase 2 study of zervimesine (CT1812) in participants with mild-to-moderate dementia with Lewy bodie
  • T6INDIRECT 28707277 ↗Open-Label Allopregnanolone Treatment of Men with Fragile X-Associated Tremor/Ataxia Syndrome
  • T6 28716886 ↗Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases
  • T6 31866818 ↗ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?
  • T6INDIRECT 30191554 ↗Interventions for preventing falls in older people in care facilities and hospitals
  • T6INDIRECT 22419314 ↗Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive
  • T6INDIRECT 23633371 ↗Interventions for treating pain and disability in adults with complex regional pain syndrome
  • T6INDIRECT 21649634 ↗Dementia medications and risk of falls, syncope, and related adverse events: meta-analysis of random
  • T6INDIRECT 27863901 ↗A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease f
  • T6INDIRECT 19700947 ↗Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation
  • T6INDIRECT 28604926 ↗ADS-5102 (Amantadine) Extended-Release Capsules for Levodopa-Induced Dyskinesia in Parkinson Disease
  • T6INDIRECT 28833562 ↗Randomized, placebo-controlled trial of ADS-5102 (amantadine) extended-release capsules for levodopa
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 23225012 ↗Parkinson's disease
  • T6INDIRECT 28106066 ↗The psychosis spectrum in Parkinson disease
  • T6INDIRECT 31519472 ↗New evidence on the management of Lewy body dementia
  • T6INDIRECT 28781611 ↗Best practice in the management of behavioural and psychological symptoms of dementia
  • T6INDIRECT 23186897 ↗Transverse myelitis
  • T6 20194146 ↗Recommendations for the pharmacological management of neuropathic pain: an overview and literature u
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 26595642 ↗Lewy body dementias
  • T6 21875407 ↗N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, va
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
methyldopa
T2
T2 — RCT in related condition
POTS
31 sources
  • T2 NCT00580619 ↗Autonomic Nervous System and Chronic Fatigue Syndrome
  • T6INDIRECT 36268467 ↗Clinical Features in Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency: A Systematic Review
  • T6INDIRECT 39538129 ↗Postural orthostatic tachycardia syndrome after COVID-19 vaccination: A systematic review
  • T6INDIRECT 8443479 ↗Double blind clinical and laboratory study of hypoglycaemia with human and porcine insulin in diabet
  • T6 33243837 ↗Autonomic dysfunction in 'long COVID': rationale, physiology and management strategies
  • T6 23225012 ↗Parkinson's disease
  • T6 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6 33909761 ↗Brazilian Guidelines of Hypertension - 2020
  • T6 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 32519776 ↗Withdrawal of antihypertensive drugs in older people
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 37818791 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 28834483 ↗Effect of Intensive Blood-Pressure Treatment on Patient-Reported Outcomes
  • T6INDIRECT 12023411 ↗Pramipexole in patients with Parkinson's disease and marked drug resistant tremor: a randomised, dou
  • T6INDIRECT 9343116 ↗Catechol-O-methyltransferase inhibition with tolcapone reduces the "wearing off" phenomenon and levo
  • T6INDIRECT 8558148 ↗Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients wit
  • T6INDIRECT 8527287 ↗Pharmacokinetic-pharmacodynamic interaction between the COMT inhibitor tolcapone and single-dose lev
  • T6INDIRECT 23336248 ↗Opicapone: a short lived and very long acting novel catechol-O-methyltransferase inhibitor following
  • T6INDIRECT 22187469 ↗Standards of medical care in diabetes--2012
  • T6INDIRECT 23264422 ↗Standards of medical care in diabetes--2013
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 21193625 ↗Standards of medical care in diabetes--2011
  • T6INDIRECT 19118286 ↗Standards of medical care in diabetes--2009
  • T6INDIRECT 37139824 ↗American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medicatio
  • T6 29565029 ↗Hypertension
  • T6 36507632 ↗10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2023
  • T6 38078592 ↗10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2024
  • T6 25767284 ↗The sympathetic nervous system alterations in human hypertension
  • T6 17308214 ↗Blood pressure and ageing
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
methylphenidate
T2
T2 — RCT in related condition
POTS
24 sources
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T2 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 33687070 ↗Smoking cessation for improving mental health
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 23233021 ↗A randomised controlled trial of bumetanide in the treatment of autism in children
  • T6INDIRECT 22024003 ↗Controlled comparison of family cognitive behavioral therapy and psychoeducation/relaxation training
  • T6INDIRECT 34743319 ↗Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double-Blind
  • T6INDIRECT 12023411 ↗Pramipexole in patients with Parkinson's disease and marked drug resistant tremor: a randomised, dou
  • T6INDIRECT 9727818 ↗Contrasting actions of pressor agents in severe autonomic failure
  • T6 21777306 ↗Myalgic encephalomyelitis: International Consensus Criteria
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 26084539 ↗International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors
  • T6INDIRECT 34942142 ↗The neuropsychiatry of Parkinson's disease: advances and challenges
  • T6INDIRECT 19484833 ↗Evidence-based recommendations for the assessment and management of sleep disorders in older persons
  • T6INDIRECT 31519472 ↗New evidence on the management of Lewy body dementia
  • T6INDIRECT 30192094 ↗Management of common adverse effects of antipsychotic medications
  • T6 26595642 ↗Lewy body dementias
  • T6 27803666 ↗Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology
  • T6 23506866 ↗SLC6 transporters: structure, function, regulation, disease association and therapeutics
  • T6 29315692 ↗Comprehensive review of cardiovascular toxicity of drugs and related agents
  • T6 29717928 ↗Impact of the Autonomic Nervous System on the Skeleton
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 19847337 ↗The economies of synthesis
  • T6 30354828 ↗Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the Ameri
metoprolol (beta-blocker)
T2
T2 — RCT in related condition
POTS
27 sources
  • T6INDIRECT 24869750 ↗Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension
  • T6INDIRECT 23796325 ↗Systematic review of genuine versus spurious side-effects of beta-blockers in heart failure using pl
  • T6INDIRECT 32409561 ↗Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, ra
  • T6INDIRECT 24902920 ↗The design and rationale of a multicenter clinical trial comparing two strategies for control of sys
  • T6INDIRECT 1540729 ↗Renal protective effect of enalapril in diabetic nephropathy
  • T2 16505178 ↗Prevention of Syncope Trial (POST): a randomized, placebo-controlled study of metoprolol in the prev
  • T6INDIRECT 31618127 ↗Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis D
  • T2 2337713 ↗Contrasting effects of enalapril and metoprolol on proteinuria in diabetic nephropathy
  • T6INDIRECT 23730991 ↗Effects of intensive antihypertensive treatment on Chinese hypertensive patients older than 70 years
  • T6INDIRECT 21301135 ↗Midodrine hydrochloride is effective in the treatment of children with postural orthostatic tachycar
  • T6INDIRECT 23094876 ↗Brugada phenocopy: new terminology and proposed classification
  • T6INDIRECT 28862947 ↗Role of Volume Redistribution in the Congestion of Heart Failure
  • T6INDIRECT 24636754 ↗Pheochromocytoma and paraganglioma: diagnosis, genetics, management, and treatment
  • T6INDIRECT 24093767 ↗Genotype- and phenotype-guided management of congenital long QT syndrome
  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6INDIRECT 35307156 ↗2022 ACC Expert Consensus Decision Pathway on Cardiovascular Sequelae of COVID-19 in Adults: Myocard
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 38078592 ↗10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2024
  • T6 27671918 ↗Anxiety Disorders and Cardiovascular Disease
  • T6 23588782 ↗Applications of CYP450 testing in the clinical setting
  • T6 11129673 ↗Chagas' heart disease
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
midodrine
T2
T2 — RCT in related condition
RegisteredPOTS
36 sources
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T6INDIRECT 19406310 ↗A systematic review of the management of orthostatic hypotension after spinal cord injury
  • T6INDIRECT 24944260 ↗Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial
  • T6INDIRECT 28893208 ↗Trial design and rationale for APOLLO, a Phase 3, placebo-controlled study of patisiran in patients
  • T2 9505918 ↗Midodrine: a role in the management of neurocardiogenic syncope
  • T6INDIRECT 28494751 ↗Integrated analysis of droxidopa trials for neurogenic orthostatic hypotension
  • T2 23978222 ↗A double-blind placebo-controlled cross-over study of the vascular effects of midodrine in neuropath
  • T6INDIRECT 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
  • T6INDIRECT 9244228 ↗Effects of volume loading and pressor agents in idiopathic orthostatic tachycardia
  • T6INDIRECT 28967294 ↗An Autonomic Neuroprosthesis: Noninvasive Electrical Spinal Cord Stimulation Restores Autonomic Card
  • T2 21301135 ↗Midodrine hydrochloride is effective in the treatment of children with postural orthostatic tachycar
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6 27999003 ↗Diabetic Neuropathy: A Position Statement by the American Diabetes Association
  • T2 9091692 ↗Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind m
  • T2 7687093 ↗Neurogenic orthostatic hypotension: a double-blind, placebo-controlled study with midodrine
  • T6INDIRECT 12521968 ↗Multifactorial intervention after a fall in older people with cognitive impairment and dementia pres
  • T6INDIRECT 22045363 ↗The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale
  • T6INDIRECT 16476804 ↗Pyridostigmine treatment trial in neurogenic orthostatic hypotension
  • T6INDIRECT 32244252 ↗Daratumumab plus CyBorD for patients with newly diagnosed AL amyloidosis: safety run-in results of A
  • T2 9674789 ↗A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension
  • T6INDIRECT 34024217 ↗Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 31519472 ↗New evidence on the management of Lewy body dementia
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6INDIRECT 30192094 ↗Management of common adverse effects of antipsychotic medications
  • T6 28571527 ↗Assessment and management of acute spinal cord injury: From point of injury to rehabilitation
  • T6 28716886 ↗Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 21483018 ↗Amyloidosis: pathogenesis and new therapeutic options
  • T6 39353925 ↗Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy
  • T6 36810524 ↗Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions
  • T6 35963508 ↗American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Me
  • T6 26138942 ↗When DLB, PD, and PSP masquerade as MSA: an autopsy study of 134 patients
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 23425518 ↗Guideline of transthyretin-related hereditary amyloidosis for clinicians
midodrine (alpha-1 agonist)
T2
T2 — RCT in related condition
POTS
27 sources
  • T2 9091692 ↗Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind m
  • T2 7687093 ↗Neurogenic orthostatic hypotension: a double-blind, placebo-controlled study with midodrine
  • T6INDIRECT 12521968 ↗Multifactorial intervention after a fall in older people with cognitive impairment and dementia pres
  • T6INDIRECT 24944260 ↗Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial
  • T6INDIRECT 22045363 ↗The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale
  • T6INDIRECT 16476804 ↗Pyridostigmine treatment trial in neurogenic orthostatic hypotension
  • T6INDIRECT 32244252 ↗Daratumumab plus CyBorD for patients with newly diagnosed AL amyloidosis: safety run-in results of A
  • T6INDIRECT 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
  • T2 9674789 ↗A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6INDIRECT 27999003 ↗Diabetic Neuropathy: A Position Statement by the American Diabetes Association
  • T6INDIRECT 34024217 ↗Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 31519472 ↗New evidence on the management of Lewy body dementia
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6INDIRECT 30192094 ↗Management of common adverse effects of antipsychotic medications
  • T6 28571527 ↗Assessment and management of acute spinal cord injury: From point of injury to rehabilitation
  • T6 28716886 ↗Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 21483018 ↗Amyloidosis: pathogenesis and new therapeutic options
  • T6 39353925 ↗Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy
  • T6 36810524 ↗Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions
  • T6 35963508 ↗American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Me
  • T6 26138942 ↗When DLB, PD, and PSP masquerade as MSA: an autopsy study of 134 patients
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octreotide
T2
T2 — RCT in related condition
POTS
24 sources
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omega-3 fatty acids
T2
T2 — RCT in related condition
WithdrawnPOTS
23 sources
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phenylephrine
T2
T2 — RCT in related condition
POTS
31 sources
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  • T6 29565029 ↗Hypertension
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  • T6 33909761 ↗Brazilian Guidelines of Hypertension - 2020
  • T6 32412940 ↗Genetics, diagnosis, management and future directions of research of phaeochromocytoma and paragangl
pregabalin
T2
T2 — RCT in related condition
POTS
24 sources
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  • T6INDIRECT 31519472 ↗New evidence on the management of Lewy body dementia
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 19118286 ↗Standards of medical care in diabetes--2009
  • T6 21092187 ↗Fabry disease
  • T6 20194146 ↗Recommendations for the pharmacological management of neuropathic pain: an overview and literature u
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 28620280 ↗Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy
  • T6 23970715 ↗Mechanisms and management of diabetic painful distal symmetrical polyneuropathy
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 23425518 ↗Guideline of transthyretin-related hereditary amyloidosis for clinicians
propranolol
T2
T2 — RCT in related condition
RegisteredPOTS
33 sources
  • T2REGISTERED-ONLY NCT04186286 ↗Crossover Study of Propranolol vs Ivabradine in POTS
  • T2REGISTERED-ONLY NCT00262470 ↗Treatment of Orthostatic Intolerance
  • T2REGISTERED-ONLY NCT01988883 ↗Modafinil and Cognitive Function in POTS
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  • T6INDIRECT 35056352 ↗Cognitive Behavioral Therapy for Migraine Headache: A Systematic Review and Meta-Analysis
  • T6INDIRECT 37189381 ↗Dupilumab in Inflammatory Skin Diseases: A Systematic Review
  • T6INDIRECT 29759520 ↗Ablation of Inappropriate Sinus Tachycardia: A Systematic Review of the Literature
  • T6INDIRECT 33224097 ↗Cyclic Vomiting Syndrome in Children
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  • T6INDIRECT 37999672 ↗Noninvasive Vagus Nerve Stimulation in Postural Tachycardia Syndrome: A Randomized Clinical Trial
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  • T6HARM 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
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  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 28834483 ↗Effect of Intensive Blood-Pressure Treatment on Patient-Reported Outcomes
  • T2 8198938 ↗Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients wit
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  • T6INDIRECT 26902950 ↗Efficacy and Safety of Paliperidone Palmitate 3-Month Formulation for Patients with Schizophrenia: A
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  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
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  • T6 32213941 ↗Chemical Constituents and Pharmacological Activities of Garlic (<i>Allium sativum</i> L.): A Review
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  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 6811067 ↗Diagnosis and management of diabetic autonomic neuropathy
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
propranolol (beta-blocker)
T2
T2 — RCT in related condition
POTS
23 sources
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 28834483 ↗Effect of Intensive Blood-Pressure Treatment on Patient-Reported Outcomes
  • T2 19687359 ↗Propranolol decreases tachycardia and improves symptoms in the postural tachycardia syndrome: less i
  • T2 8198938 ↗Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients wit
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  • T6INDIRECT 26902950 ↗Efficacy and Safety of Paliperidone Palmitate 3-Month Formulation for Patients with Schizophrenia: A
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  • T6INDIRECT 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
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  • T6 33243615 ↗Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on
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  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 30184160 ↗Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6 32213941 ↗Chemical Constituents and Pharmacological Activities of Garlic (<i>Allium sativum</i> L.): A Review
  • T6 30018614 ↗Immune System Dysregulation During Spaceflight: Potential Countermeasures for Deep Space Exploration
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  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 6811067 ↗Diagnosis and management of diabetic autonomic neuropathy
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  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
pyridostigmine (acetylcholinesterase inhibitor)
T2
T2 — RCT in related condition
POTS
30 sources
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  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6 26493934 ↗Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effe
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  • T6 29717928 ↗Impact of the Autonomic Nervous System on the Skeleton
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  • T6 29359025 ↗Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment
  • T6 21962754 ↗Multiple system atrophy: a clinical and neuropathological perspective
  • T6 34134525 ↗Recognition, Prevention, and Management of Arrhythmias and Autonomic Disorders in Cardio-Oncology: A
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  • T6 28050656 ↗The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic o
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  • T6 19207771 ↗Postural tachycardia syndrome (POTS)
ranitidine (H2 antihistamine)
T2
T2 — RCT in related condition
MCASPOTS
46 sources
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  • T6INDIRECT 29694674 ↗Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent
  • T6INDIRECT 36190739 ↗Pharmacological interventions for prevention of weight gain in people with schizophrenia
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  • T6 37139824 ↗American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medicatio
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  • T6 23476052 ↗Idiosyncratic adverse drug reactions: current concepts
  • T6 27620496 ↗Opportunities for new CT contrast agents to maximize the diagnostic potential of emerging spectral C
  • T6 21134576 ↗Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAI
  • T6 23268454 ↗World allergy organization guidelines for the assessment and management of anaphylaxis
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  • T6 32872533 ↗Ionic Liquids Toxicity-Benefits and Threats
  • T6 30884251 ↗Recent advances in our understanding of mast cell activation - or should it be mast cell mediator di
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  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
  • T6 17608249 ↗Risks of combined alcohol/medication use in older adults
  • T6 32785879 ↗A Review of Patisiran (ONPATTRO®) for the Treatment of Polyneuropathy in People with Hereditary Tran
sertraline (SSRI)
T2
T2 — RCT in related condition
POTS
23 sources
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 28854296 ↗Efficacy and Safety of Selective Serotonin Reuptake Inhibitors, Serotonin-Norepinephrine Reuptake In
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  • T6INDIRECT 28178949 ↗Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A
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  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T2 15507582 ↗Cognitive-behavior therapy, sertraline, and their combination for children and adolescents with obse
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  • T6INDIRECT 20855047 ↗Predictors and moderators of treatment outcome in the Pediatric Obsessive Compulsive Treatment Study
  • T6INDIRECT 12388617 ↗Dopamine modulates the response of the human amygdala: a study in Parkinson's disease
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 24229653 ↗What are the causes of late-life depression?
  • T6INDIRECT 33243615 ↗Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 35430029 ↗Functional neurological disorder: new subtypes and shared mechanisms
  • T6 26111766 ↗SLC transporters as therapeutic targets: emerging opportunities
  • T6 10379421 ↗Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines an
  • T6 22407614 ↗Serotonin and blood pressure regulation
  • T6 15320756 ↗Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?
  • T6 30975301 ↗Screening and Management of Depression in Patients With Cardiovascular Disease: JACC State-of-the-Ar
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 29975336 ↗Depression and Anxiety in Heart Failure: A Review
triamcinolone
T2
T2 — RCT in related condition
POTS
22 sources
  • T6INDIRECT 23633371 ↗Interventions for treating pain and disability in adults with complex regional pain syndrome
  • T6INDIRECT 27115217 ↗Intranasal steroids versus placebo or no intervention for chronic rhinosinusitis
  • T6INDIRECT 23710959 ↗Sinus surgery and delivery method influence the effectiveness of topical corticosteroids for chronic
  • T6INDIRECT 25919144 ↗Interventions for rosacea
  • T6INDIRECT 29932206 ↗Saline irrigation for allergic rhinitis
  • T6INDIRECT 28614232 ↗The efficiency and safety of dexamethasone for pain control in total joint arthroplasty: A meta-anal
  • T6INDIRECT 37496207 ↗Efficacy of hydrodilatation in frozen shoulder: a systematic review and meta-analysis
  • T6INDIRECT 27115215 ↗Different types of intranasal steroids for chronic rhinosinusitis
  • T2 20427088 ↗Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt l
  • T6INDIRECT 17088333 ↗Treatment of shoulder pain in spastic hemiplegia by reducing spasticity of the subscapular muscle: a
  • T6INDIRECT 30184160 ↗Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints
  • T6INDIRECT 31954495 ↗Diagnosis and management of toxicities of immune checkpoint inhibitors in hepatocellular carcinoma
  • T6INDIRECT 31871494 ↗Therapeutic Approaches for Peripheral and Central Neuropathic Pain
  • T6INDIRECT 24436882 ↗Oropharyngeal Dysphagia after anterior cervical spine surgery: a review
  • T6INDIRECT 33586020 ↗Peripheral Nervous System Manifestations Associated with COVID-19
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6 27551328 ↗The use of inhaled corticosteroids in pediatric asthma: update
  • T6 34948113 ↗Genophenotypic Factors and Pharmacogenomics in Adverse Drug Reactions
  • T6 31506830 ↗Emerging Insights and Interventions for Diabetic Retinopathy
  • T6 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6 28632002 ↗Management of prostacyclin side effects in adult patients with pulmonary arterial hypertension
  • T6 24940130 ↗Steroids: pharmacology, complications, and practice delivery issues
Albuterol-sulphate
T4
T4 — Case series
POTS
10 sources
  • T6 35379908 ↗Halotolerant biofilm-producing rhizobacteria mitigate seawater-induced salt stress and promote growt
  • T6 31090026 ↗Abstracts from the 2019 Annual Meeting of the Society of General Internal Medicine
  • T6 22696014 ↗Guidelines for status epilepticus: are we there yet?
  • T6 23625304 ↗Abstracts of the 36th Annual Meeting of the Society of General Internal Medicine. April 24-27, 2013.
  • T6 PMC7159487 ↗Poster Sessions
  • T4 PMC6661815 ↗Intensive Care Society State of the Art 2018 Abstracts
  • T6INDIRECT 37650038 ↗PROCEEDINGS OF THE XXIII CONGRESS OF THE ITALIAN ASSOCIATION OF MYOLOGY: PadovaJune 8-10, 2023
  • T4 PMC7167762 ↗III. Abstracts
  • T4 PMC4587627 ↗Abstracts of Scientific Presentations : 2015 AALAS National Meeting Phoenix, Arizona
  • T6 32226274 ↗The Use of Antiallergic and Antiasthmatic Drugs in Viral Infections of the Upper Respiratory Tract
Alpelisib
T4
T4 — Case series
POTS
9 sources
  • T6 32708302 ↗Small Molecule NF-κB Pathway Inhibitors in Clinic
  • T6 39185033 ↗Paraneoplastic hypoglycemia: An overview for optimal clinical guidance
  • T6 41465487 ↗iNOS in Macrophage Polarization: Pharmacological and Regulatory Insights
  • T6 31612778 ↗Meeting Abstracts - Academy of Managed Care Pharmacy Nexus 2019
  • T6 PMC11635028 ↗Index
  • T6INDIRECT 40498965 ↗EACR 2025 Congress: Innovative Cancer Science, 16-19 June 2025
  • T4 PMC11231130 ↗Abstracts from the 2024 Annual Meeting of the Society of General Internal Medicine
  • T4 PMC9205280 ↗Abstracts from the 2022 Annual Meeting of the Society of General Internal Medicine
  • T6 41048472 ↗Assessing the Impact of Antidepressants on Cancer Treatment: A Retrospective Analysis of 14 Antineop
Cardiac sympathetic denervation
T4
T4 — Case series
POTS
26 sources
  • T6INDIRECT 35694936 ↗Association Between Parkinson's Disease and Coronary Artery Disease: A Systematic Review and Meta-An
  • T6INDIRECT 34964392 ↗Orthostatic Hypotension and Antiparkinsonian Drugs: A Systematic Review and Meta-analysis
  • T6INDIRECT 40406920 ↗Prevalence of Supine Hypertension in Alpha-Synucleinopathies: A Systematic Review and Meta-Analysis
  • T6INDIRECT 20837887 ↗Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotensio
  • T6INDIRECT 37993489 ↗Relationship between Parkinson's disease and cardio-cerebrovascular diseases: a Mendelian randomized
  • T6INDIRECT 11971094 ↗Orthostatic hypotension from sympathetic denervation in Parkinson's disease
  • T6INDIRECT 31407088 ↗Autonomic cardiovascular control changes in recent heart transplant recipients lead to physiological
  • T6 21890520 ↗Low-frequency power of heart rate variability is not a measure of cardiac sympathetic tone but may b
  • T6 29971039 ↗On Cell Loss and Selective Vulnerability of Neuronal Populations in Parkinson's Disease
  • T6 20103559 ↗Cardiac autonomic neuropathy in diabetes: a clinical perspective
  • T6INDIRECT 26350119 ↗Autosomal dominant Parkinson's disease caused by SNCA duplications
  • T4 24567799 ↗Cardiac autonomic neuropathy in patients with diabetes mellitus
  • T6INDIRECT 25484925 ↗The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis
  • T6INDIRECT 24093767 ↗Genotype- and phenotype-guided management of congenital long QT syndrome
  • T6INDIRECT 24262198 ↗Autonomic disorders predicting Parkinson's disease
  • T6INDIRECT 24715569 ↗Dysautonomia in Parkinson disease
  • T6INDIRECT 26869865 ↗A systematic review of the cardiotoxicity of methadone
  • T6INDIRECT 32789741 ↗Autonomic Dysfunction in Parkinson's Disease
  • T6 31498132 ↗Brain-First versus Gut-First Parkinson's Disease: A Hypothesis
  • T6 30871703 ↗Autonomic Nervous System Dysfunction: JACC Focus Seminar
  • T6 29628907 ↗Diagnostic Criteria for Parkinson's Disease: From James Parkinson to the Concept of Prodromal Diseas
  • T6 19124673 ↗Neurogenic orthostatic hypotension: a pathophysiological approach
  • T6 29523389 ↗Postural tachycardia syndrome - Diagnosis, physiology, and prognosis
  • T6 22033559 ↗Biology of Parkinson's disease: pathogenesis and pathophysiology of a multisystem neurodegenerative
  • T6 22094370 ↗Cardiovascular dysautonomia in Parkinson disease: from pathophysiology to pathogenesis
  • T6 18606002 ↗Congenital long QT syndrome
Cerebrolysin®
T4
T4 — Case series
POTS
11 sources
  • T6INDIRECT 32365943 ↗Current Synthesis and Systematic Review of Main Effects of Calf Blood Deproteinized Medicine (Actove
  • T6 27429559 ↗Neuropeptide Treatment with Cerebrolysin Enhances the Survival of Grafted Neural Stem Cell in an α-S
  • T6 33168048 ↗10th European Conference on Rare Diseases & Orphan Products (ECRD 2020)
  • T6 PMC6643206 ↗E-Poster Viewing
  • T6 40986224 ↗World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2025)
  • T6INDIRECT 37874422 ↗ESICM LIVES 2023
  • T6INDIRECT 22977921 ↗Abstracts of the 10th Congress of the European Association of NeuroOncology. Marseille, France. Sept
  • T4 PMC10643713 ↗The 7th Congress of Biophysicists of Russia - conference proceedings : Abstracts
  • T4 PMC11391898 ↗ESOC 2023 Abstract Book
  • T4 PMC7103906 ↗Posters
  • T6 26858901 ↗Disease and Stem Cell-Based Analysis of the 2014 ASNTR Meeting
Contrast Bath
T4
T4 — Case series
POTS
7 sources
  • T6 26232394 ↗Modulatory influences of estradiol and other anorexigenic hormones on metabotropic, Gi/o-coupled rec
  • T6 22566994 ↗The influence of autonomic dysfunction associated with aging and type 2 diabetes on daily life activ
  • T6 35295500 ↗Complex Regional Pain Syndrome. A Comprehensive Review on Neuroplastic Changes Supporting the Use of
  • T6 27742893 ↗Dopaminergic inhibition of gonadotropin-releasing hormone neurons in the cichlid fish Astatotilapia
  • T6 40827134 ↗Supplement
  • T4 PMC7745344 ↗Supplement
  • T6 PMC10722647 ↗Abstract
Counseling Psychology
T4
T4 — Case series
POTS
11 sources
  • T6INDIRECT 33593124 ↗The Empirical Status of Mindfulness-Based Interventions: A Systematic Review of 44 Meta-Analyses of
  • T6 24978634 ↗Treatment of advanced Parkinson's disease
  • T6INDIRECT 33669438 ↗Three Cases of Severe ME/CFS in Adults
  • T6 33831812 ↗Associations between weight-based teasing and disordered eating behaviors among youth
  • T6 37693239 ↗Classic psychedelic use and current meditation practice
  • T6INDIRECT 34926835 ↗Program Abstracts from The GSA 2021 Annual Scientific Meeting, "Disruption to Transformation: Aging
  • T4 PMC11688754 ↗Full GSA 2024 Abstract Book PDF
  • T4 PMC9009819 ↗CPNP 2022 Annual Meeting Poster Abstracts
  • T4 PMC8922672 ↗Oral and Poster abstracts
  • T4 PMC7741497 ↗Program Abstracts from The GSA 2020 Annual Scientific Meeting “Turning 75: Why Age Matters”
  • T6 33059389 ↗Weight-based teasing in youth: Associations with metabolic and inflammatory markers
Ergotamine/ Caffeine
T4
T4 — Case series
POTS
9 sources
  • T6INDIRECT 34143333 ↗The effects of caffeine in adults with neurogenic orthostatic hypotension: a systematic review
  • T6 23472781 ↗Medical therapy and physical maneuvers in the treatment of the vasovagal syncope and orthostatic hyp
  • T6 21664375 ↗Pharmacotherapy of autonomic failure
  • T6 22581120 ↗Italian guidelines for primary headaches: 2012 revised version
  • T6 25104940 ↗Combination ergotamine and caffeine improves seated blood pressure and presyncopal symptoms in auton
  • T6 10210895 ↗Ergotamine/caffeine treatment of orthostatic hypotension in parkinsonism with autonomic failure
  • T6INDIRECT 29076058 ↗Pharmacotherapy of Cardiovascular Autonomic Dysfunction in Parkinson Disease
  • T6INDIRECT 31123663 ↗CPNP 2019 Annual Meeting Poster Abstracts
  • T4 PMC12978741 ↗Abstracts - IANCON 2025
Fulvestrant
T4
T4 — Case series
POTS
16 sources
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
  • T6INDIRECT 35207228 ↗Current and Emerging Medical Therapies in Pituitary Tumors
  • T6INDIRECT 36835974 ↗The Role of Aromatase Inhibitors in Male Prolactinoma
  • T6INDIRECT 34843036 ↗49th ESCP virtual symposium on clinical pharmacy 19.10.2021-21.10.2021 Clinical pharmacy, working co
  • T6INDIRECT 31612778 ↗Meeting Abstracts - Academy of Managed Care Pharmacy Nexus 2019
  • T6INDIRECT 31639031 ↗Meeting abstracts from the 5th International Clinical Trials Methodology Conference (ICTMC 2019) : B
  • T6INDIRECT 27650181 ↗EANM'16
  • T4 PMC4212304 ↗UEG Week 2014 Oral Presentations
  • T6INDIRECT 40767450 ↗SEDCYDO - SEGER - SEMO CONGRESS MADRID 2025, 8-10 MAY. Proceedings and Abstract
  • T6 28174091 ↗Inhibitors of cyclin-dependent kinases as cancer therapeutics
  • T6 41461581 ↗The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors
  • T6 29607374 ↗Targeted Therapy: Attacking Cancer with Molecular and Immunological Targeted Agents
Imaginal exposure
T4
T4 — Case series
POTS
12 sources
  • T6INDIRECT 34747131 ↗Is weight stigma associated with physical activity? A systematic review
  • T6INDIRECT 26352916 ↗Interventions for Individuals With High Levels of Needle Fear: Systematic Review of Randomized Contr
  • T6INDIRECT 21934055 ↗Cognitive behavior therapy augmentation of pharmacotherapy in pediatric obsessive-compulsive disorde
  • T6INDIRECT 28412602 ↗Secondary outcomes from the pediatric obsessive compulsive disorder treatment study II
  • T6 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6 26062169 ↗Fear and the Defense Cascade: Clinical Implications and Management
  • T6 27007463 ↗Exposure-based Interventions for the management of individuals with high levels of needle fear acros
  • T6INDIRECT 32206586 ↗Obsessive-compulsive disorder in children and adolescents: epidemiology, diagnosis and management
  • T6INDIRECT 34111207 ↗The prevalence and evidence-based management of needle fear in adults with chronic disease: A scopin
  • T6INDIRECT 19183470 ↗The Pediatric Obsessive-Compulsive Disorder Treatment Study II: rationale, design and methods
  • T4 PMC11627190 ↗ACNP 63rd Annual Meeting: Poster Abstracts P609-P914
  • T6 22800994 ↗Obsessive-compulsive and tic-related disorders
In-lab polysomnography
T4
T4 — Case series
POTS
10 sources
  • T6INDIRECT 30053970 ↗Respiratory care in familial dysautonomia: Systematic review and expert consensus recommendations
  • T6INDIRECT 22348451 ↗Melatonin pharmacokinetics following two different oral surge-sustained release doses in older adult
  • T6INDIRECT 36823241 ↗Impact of reboxetine plus oxybutynin treatment for obstructive sleep apnea on cardiovascular autonom
  • T6 33295989 ↗Autonomic dysregulation and sleep homeostasis in insomnia
  • T6 33991086 ↗Association of Depressive Symptoms with Sleep Disturbance: A Co-twin Control Study
  • T6 29680425 ↗Prevalence and characteristics of sleep-disordered breathing in familial dysautonomia
  • T6INDIRECT 35251925 ↗Obstructive sleep apnea in a case of ehlers-danlos syndrome
  • T6INDIRECT 40723062 ↗Sleep Disorders in Children with Rett Syndrome
  • T4 PMC6935577 ↗Atrial Fibrillation
  • T6 41444346 ↗Obstructive sleep apnea increases heartbeat-evoked potentials and reorganizes Granger-causal couplin
Long-COVID postural tachycardia syndrome
T4
T4 — Case series
POTS
8 sources
  • T6 33740207 ↗Long-COVID postural tachycardia syndrome: an American Autonomic Society statement.
  • T6 36339677 ↗Postural orthostatic tachycardia syndrome and post-acute COVID-19
  • T5 40660536 ↗Successful treatment of long-COVID postural tachycardia syndrome with epipharyngeal abrasive therapy
  • T6 36169154 ↗Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of aut
  • T6 37388279 ↗Long COVID: Complications, Underlying Mechanisms, and Treatment Strategies
  • T6INDIRECT 36205820 ↗33RD International Symposium on the Autonomic Nervous System
  • T4 PMC9205280 ↗Abstracts from the 2022 Annual Meeting of the Society of General Internal Medicine
  • T6 39449566 ↗Much more than a biological phenomenon: A qualitative study of women's experiences of brain fog acro
NBMI
T4
T4 — Case series
POTS
7 sources
  • T6 35614479 ↗The role of basket trials in drug development for neurodegenerative disorders
  • T6 32316335 ↗Current Symptomatic and Disease-Modifying Treatments in Multiple System Atrophy
  • T6 34512258 ↗Novel Therapies for Parkinsonian Syndromes-Recent Progress and Future Perspectives
  • T6 23074460 ↗Bariatric surgery: an evidence-based analysis
  • T6 35393538 ↗Abstracts from the 54<sup>th</sup> European Society of Human Genetics (ESHG) Conference: e-Posters
  • T6INDIRECT 38743312 ↗Pharmacotherapies for the Treatment of Progressive Supranuclear Palsy: A Narrative Review
  • T4 PMC11470995 ↗UEG Week 2024 Poster Presentations
Neridronate
T4
T4 — Case series
POTS
8 sources
  • T6INDIRECT 37610446 ↗Sensory neuropathy in amyotrophic lateral sclerosis: a systematic review
  • T6 36096831 ↗Proceedings of the 28th European Paediatric Rheumatology Congress (PReS 2022) : Prague, Czech Republ
  • T6 39598411 ↗Benign Evolution of Complex Regional Pain Syndrome (CRPS) Type 1 in Patients Treated with Intravenou
  • T6 35212265 ↗Pseudo-pheochromocytoma due to obstructive sleep apnea: a case report
  • T6 40767450 ↗SEDCYDO - SEGER - SEMO CONGRESS MADRID 2025, 8-10 MAY. Proceedings and Abstract
  • T4 PMC6777611 ↗Abstracts from the 50th European Society of Human Genetics Conference: Posters
  • T4 PMC7103906 ↗Posters
  • T4 PMC7104471 ↗Physicians Poster Abstracts : EBMT 2012
Neural Therapy
T4
T4 — Case series
POTS
11 sources
  • T6 35526973 ↗Trigger Point Injections
  • T6 36641366 ↗The vagus nerve in cardiovascular physiology and pathophysiology: From evolutionary insights to clin
  • T6INDIRECT 35839020 ↗Local anesthetics as a therapeutic tool for post COVID-19 patients: A case report
  • T6INDIRECT 36714125 ↗Case report: Individualized pulsed electromagnetic field therapy in a Long COVID patient using the A
  • T6 29855197 ↗ASNTR 2018 Abstracts
  • T4 41564315 ↗Neuraltherapeutic Medicine in Post-Acute COVID-19 Vaccination Syndrome (PACVS): A Critical Review wi
  • T6 22179483 ↗The continued promise of stem cell therapy in regenerative medicine
  • T6 22125442 ↗A showcase of bench-to-bedside regenerative medicine at the 2010 ASNTR
  • T6 26858901 ↗Disease and Stem Cell-Based Analysis of the 2014 ASNTR Meeting
  • T6 28494821 ↗Abstracts for the 24th Annual Meeting of the American Society for Neural Therapy and Repair
  • T6 39070159 ↗Neurological symphony: post-acute COVID-19 syndrome, an innovative pathophysiological exploration fr
Niraparib
T4
T4 — Case series
POTS
13 sources
  • T6 32404379 ↗Clinical trials in REM sleep behavioural disorder: challenges and opportunities
  • T6 29607374 ↗Targeted Therapy: Attacking Cancer with Molecular and Immunological Targeted Agents
  • T6 35158955 ↗Existing Evidence for the Repurposing of PARP-1 Inhibitors in Rare Demyelinating Diseases
  • T6 38046043 ↗Management of hypertension in patients with cancer: challenges and considerations
  • T6 31189100 ↗Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization
  • T6INDIRECT 39186376 ↗Acute Kidney Injury Associated with Anticancer Therapies: Small Molecules and Targeted Therapies
  • T6INDIRECT 34559267 ↗European Association of Nuclear Medicine October 20-23, 2021 Virtual
  • T4 PMC10408386 ↗Poster Abstracts - Academy of Managed Care Pharmacy Nexus 2020
  • T6INDIRECT 34982365 ↗Proceedings of the World Molecular Imaging Congress 2021, October 5-8, 2021: General Abstracts
  • T6INDIRECT 40498965 ↗EACR 2025 Congress: Innovative Cancer Science, 16-19 June 2025
  • T4 PMC11177578 ↗EHA2024 Hybrid Congress
  • T4 PMC9260650 ↗Posters
  • T6 37312150 ↗Review of cancer therapies for the perioperative physician
Permanent pacemaker therapy
T4
T4 — Case series
POTS
15 sources
  • T6INDIRECT 17208080 ↗The expectation effect and cardiac pacing for refractory vasovagal syncope
  • T6INDIRECT 32151742 ↗Pharmacological norepinephrine transporter inhibition for the prevention of vasovagal syncope in you
  • T6 34455427 ↗2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy
  • T6 37754821 ↗Shared Decision Making and Cardioneuroablation Allow Discontinuation of Permanent Pacing in Patients
  • T6 15481606 ↗Clinical characteristics of hypervagotonic sinus node dysfunction
  • T5 34306697 ↗Avoidance and early diagnosis of erroneous permanent pacemaker placement into the left ventricle: A
  • T6INDIRECT 39544310 ↗Cardioneuroablation eliminating cardiac asystole associated with area postrema syndrome: a case repo
  • T6INDIRECT 42028077 ↗Extracardiac vagal nerve stimulation-guided cardioneuroablation in patients with interrupted superio
  • T6INDIRECT 41798792 ↗Efficacy and safety of cardioneuroablation as a treatment for patients with functional bradyarrhythm
  • T6INDIRECT 25696046 ↗Implantable diagnostic and therapeutic devices in children
  • T4 PMC11907109 ↗Standard Poster Abstracts for the 17th Asia Pacific Heart Rhythm Society (APHRS) Scientific Sessions
  • T4 PMC7166401 ↗2012 ACVIM Forum Research Abstracts Program
  • T6 39106234 ↗The triggers of situational syncope do not influence the head-up tilt test response and prognosis
  • T6 25053240 ↗Highlights in clinical autonomic neurosciences: novel insights about vasovagal syncope and postural
  • T6 39712356 ↗Vasovagal Syncope: A Review of Current and Emerging Therapies for a Common Cardiology Condition
Prazosin Hydrochloride
T4
T4 — Case series
POTS
25 sources
  • T6INDIRECT 16864724 ↗Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis in
  • T6INDIRECT 19101235 ↗Effectiveness of digoxin in reducing one-year mortality in chronic heart failure in the Digitalis In
  • T6INDIRECT 16675509 ↗Ondansetron does not reduce the shivering threshold in healthy volunteers
  • T6 32848775 ↗Pharmacotherapy of Behavioral and Psychological Symptoms of Dementia: State of the Art and Future Pr
  • T6 26370 ↗The second Lilly Prize Lecture, University of Newcastle, July 1977. beta-Adrenergic receptor blockad
  • T6 21565668 ↗Hypertension in pheochromocytoma: characteristics and treatment
  • T6 24937433 ↗Netrin-1 controls sympathetic arterial innervation
  • T6INDIRECT 3176460 ↗Pheochromocytoma--recent advances in diagnosis and treatment
  • T6INDIRECT 31528576 ↗Pheochromocytoma-induced shock: a case report
  • T6INDIRECT 34353832 ↗Anaesthetic challenges in perioperative management of thoracic paraganglioma in an 8-year-old child
  • T4 PMC1737656 ↗Atlas of peripheral nerve surgery
  • T4 PMC1737653 ↗Diagnosis and management of Alzheimer's disease and other dementias
  • T4 PMC1737652 ↗Upper motor neurone syndrome and spasticity. Clinical management and neurophysiology
  • T4 PMC1737650 ↗Post traumatic stress disorder diagnosis, management and treatment
  • T4 PMC1737646 ↗Maudsley neuropsychiatry modules: a teaching package for self paced learning or small group seminars
  • T6 21753871 ↗Safety and efficacy of silodosin for the treatment of benign prostatic hyperplasia
  • T6 1742694 ↗Non-insulin-dependent (type II) diabetes mellitus
  • T6 1574883 ↗Pheochromocytoma
  • T6 36120615 ↗Autonomic Dysreflexia following Spinal Cord Injury
  • T6 8104650 ↗Alfuzosin, a selective alpha 1-adrenoceptor antagonist in the lower urinary tract
  • T6 6138365 ↗Acute reduction in human platelet alpha 2-adrenoreceptor affinity for agonist by endogenous and exog
  • T6 24246572 ↗The α1 adrenoceptor antagonist prazosin enhances sleep continuity in fear-conditioned Wistar-Kyoto r
  • T6 8401939 ↗Altered cardiac adrenergic neurotransmission in streptozotocin-induced diabetic rats
  • T6 6956401 ↗Hypertension secondary to pheochromocytoma
  • T6 1309183 ↗Medications in older patients
RAD001
T4
T4 — Case series
MCASPOTS
30 sources
  • T6 NCT00449748 ↗Everolimus (RAD001) as Therapy for Patients With Systemic Mastocytosis
  • T6INDIRECT 24407160 ↗Identification of Ponatinib as a potent inhibitor of growth, migration, and activation of neoplastic
  • T6 37169756 ↗Angiogenic signaling pathways and anti-angiogenic therapy for cancer
  • T6 21235428 ↗Mechanisms of drug resistance in kinases
  • T6 26654227 ↗Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell l
  • T6 27549339 ↗Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
  • T6 18559612 ↗Phase II study of dasatinib in Philadelphia chromosome-negative acute and chronic myeloid diseases,
  • T6 20038218 ↗Experience with everolimus (RAD001), an oral mammalian target of rapamycin inhibitor, in patients wi
  • T6 24323045 ↗Autophagy and human diseases
  • T6 31277291 ↗A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifesty
  • T6 20814256 ↗Emerging pharmacotherapies for neurodevelopmental disorders
  • T6 34944054 ↗Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson's Disease
  • T6 22695254 ↗Safety and preliminary efficacy analysis of the mTOR inhibitor ridaforolimus in patients with taxane
  • T6INDIRECT 20405294 ↗Total laparoscopic radical hysterectomy for cervical cancer in prolapsed uterus
  • T6INDIRECT 23258954 ↗Clinical application of development of nonantibiotic macrolides that correct inflammation-driven imm
  • T6INDIRECT 26062813 ↗Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloprol
  • T6INDIRECT 27507155 ↗IL-4 downregulates expression of the target receptor CD30 in neoplastic canine mast cells
  • T6INDIRECT 19259308 ↗Optimizing imatinib mesylate treatment in gastrointestinal stromal tumors
  • T6INDIRECT 21484580 ↗The 21st conference of the asian pacific association for the study of the liver : oral presentations
  • T6INDIRECT 30561866 ↗"Abstracts of the 77th Annual Meeting of the Japanese Cancer Association; 2018 Sept 27-29; Osaka, Ja
  • T4 PMC7163973 ↗Poster Presentations
  • T6 17934482 ↗Aberrant cytokine signaling in leukemia
  • T6 32435640 ↗Targeting the HGF/MET Axis in Cancer Therapy: Challenges in Resistance and Opportunities for Improve
  • T6 21372221 ↗Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a
  • T6INDIRECT 34559267 ↗European Association of Nuclear Medicine October 20-23, 2021 Virtual
  • T6INDIRECT 30480124 ↗Program Abstracts from the 21st International Association of Gerontology and Geriatrics (IAGG) World
  • T6INDIRECT 28894880 ↗EANM'17
  • T4 PMC6216117 ↗Abstracts from the 23rd Annual Scientific Meeting and Education Day of the Society for Neuro-Oncolog
  • T4 PMC4894295 ↗21st Congress of the European Hematology Association Copenhagen, Denmark, June 9–12, 2016
  • T4 PMC2888565 ↗15th Congress of the European Hematology Association, Spain, Barcelona, June 10–13, 2010
Rabbit Anti-Thymocyte Globulin
T4
T4 — Case series
POTS
15 sources
  • T6INDIRECT 39382091 ↗Interventions for BK virus infection in kidney transplant recipients
  • T6INDIRECT 30786841 ↗Concomitant use of blinatumomab and donor lymphocyte infusion for mixed-phenotype acute leukemia: a
  • T6 39200392 ↗Heart Transplant Rejection: From the Endomyocardial Biopsy to Gene Expression Profiling
  • T6 32785838 ↗Autologous haematopoietic stem cell transplantation for refractory stiff-person syndrome: the UK exp
  • T6 21720671 ↗The IKEM pancreas and islet transplant program as part of healthcare for type 1 diabetes patients: r
  • T6INDIRECT 25745552 ↗Clinical reversible myelopathy in T-cell lymphoblastic lymphoma treated with nelarabine and radiothe
  • T6INDIRECT 36876244 ↗Hypercholesterolemia due to lipoprotein-X manifesting as pseudohyponatremia in a patient with choles
  • T6INDIRECT 36323940 ↗The 48<sup>th</sup> Annual Meeting of the European Society for Blood and Marrow Transplantation: Phy
  • T6INDIRECT 27114361 ↗Abstracts from the 2016 Society of General Internal Medicine Annual Meeting
  • T6INDIRECT 21559853 ↗Building 21st Century medicine through education, research, policy and practice. Abstracts of the So
  • T4 PMC11177578 ↗EHA2024 Hybrid Congress
  • T6 PMC7104471 ↗Physicians Poster Abstracts : EBMT 2012
  • T6 PMC4894295 ↗21st Congress of the European Hematology Association Copenhagen, Denmark, June 9–12, 2016
  • T6 38500081 ↗Management of kidney transplant recipients for primary care practitioners
  • T6 34841047 ↗Neurogenic Orthostatic Hypotension: a Common Complication of Successful Pancreas Transplantation
Ribociclib
T4
T4 — Case series
POTS
17 sources
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 28174091 ↗Inhibitors of cyclin-dependent kinases as cancer therapeutics
  • T6 34604797 ↗Cardiovascular Manifestations From Therapeutic Radiation: A Multidisciplinary Expert Consensus State
  • T6 29607374 ↗Targeted Therapy: Attacking Cancer with Molecular and Immunological Targeted Agents
  • T6 32452701 ↗An up-to-date overview of computational polypharmacology in modern drug discovery
  • T6INDIRECT 39186376 ↗Acute Kidney Injury Associated with Anticancer Therapies: Small Molecules and Targeted Therapies
  • T6INDIRECT 31612778 ↗Meeting Abstracts - Academy of Managed Care Pharmacy Nexus 2019
  • T6INDIRECT 40584433 ↗Potential synergism of abemaciclib with chloroquine and disulfiram/copper in atypical meningioma: A
  • T4 PMC10408411 ↗Meeting Abstracts - AMCP Managed Care & Specialty Pharmacy Annual Meeting 2019
  • T4 PMC10408386 ↗Poster Abstracts - Academy of Managed Care Pharmacy Nexus 2020
  • T6INDIRECT 28397154 ↗Abstracts from the 2017 Society of General Internal Medicine Annual Meeting
  • T6INDIRECT 40767450 ↗SEDCYDO - SEGER - SEMO CONGRESS MADRID 2025, 8-10 MAY. Proceedings and Abstract
  • T6 39042344 ↗Cardiovascular Toxicity in Cancer Therapy: Protecting the Heart while Combating Cancer
  • T6 38543080 ↗A Drug Safety Briefing (II) in Transplantation from Real-World Individual Pharmacotherapy Management
  • T6 41810127 ↗Charting the Current Landscape and Future Prospects of Cancer Therapy-Related Cardiovascular Toxicit
  • T6 39352628 ↗Glucocorticoid treatment and adrenal suppression in children: current view and open issues
  • T6 37312150 ↗Review of cancer therapies for the perioperative physician
Ropivacaine 0.5%
T4
T4 — Case series
POTS
12 sources
  • T6INDIRECT 26355598 ↗Local Anesthetic Peripheral Nerve Block Adjuvants for Prolongation of Analgesia: A Systematic Qualit
  • T6INDIRECT 27419911 ↗Epidural local anaesthetics versus opioid-based analgesic regimens for postoperative gastrointestina
  • T6INDIRECT 23076930 ↗Local anaesthetics and regional anaesthesia for preventing chronic pain after surgery
  • T6INDIRECT 29926477 ↗Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent
  • T6INDIRECT 29694674 ↗Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent
  • T6INDIRECT 40689673 ↗Comparison of two peripheral regional analgesic techniques for primary elective total hip arthroplas
  • T6 33436442 ↗Pain management after open liver resection: Procedure-Specific Postoperative Pain Management (PROSPE
  • T6INDIRECT 34712535 ↗Tardive Dyskinesia in a Postoperative Gynecological Patient After Single Dose Administration of Meto
  • T6INDIRECT 41111139 ↗Abstracts of the ICARE 2025 79th SIAARTI National Congress
  • T4 PMC12975069 ↗Proceedings: National multidisciplinary conference on recent advances in medical specialities
  • T6 31020032 ↗Transition to outpatient total hip and knee arthroplasty: experience at an academic tertiary care ce
  • T6 36483978 ↗Nomogram for Prediction of Postoperative Delirium after Deep Brain Stimulation of Subthalamic Nucleu
Mirror Therapy
T5
T5 — Case report
POTS
18 sources
  • T6INDIRECT 23633371 ↗Interventions for treating pain and disability in adults with complex regional pain syndrome
  • T6INDIRECT 33175411 ↗Transcranial direct current stimulation (tDCS) for improving activities of daily living, and physica
  • T6INDIRECT 30050569 ↗Noninvasive Brain Stimulations for Unilateral Spatial Neglect after Stroke: A Systematic Review and
  • T6INDIRECT 40067404 ↗Efficacy of neuromodulation and rehabilitation approaches on pain relief in patients with spinal cor
  • T6INDIRECT 26544542 ↗Pharmacological interventions for unilateral spatial neglect after stroke
  • T6INDIRECT 40995146 ↗Non-invasive brain stimulation for stroke-related motor impairment and disability: an umbrella revie
  • T6INDIRECT 41683658 ↗Beyond the Pain: Rethinking Chronic Pain Management Through Integrated Therapeutic Approaches-A Syst
  • T6 31871494 ↗Therapeutic Approaches for Peripheral and Central Neuropathic Pain
  • T6 27317916 ↗Demystifying Poststroke Pain: From Etiology to Treatment
  • T5 19967390 ↗Derangement of body representation in complex regional pain syndrome: report of a case treated with
  • T6INDIRECT 37631018 ↗Stroke-Induced Central Pain: Overview of the Mechanisms, Management, and Emerging Targets of Central
  • T6INDIRECT 29973967 ↗Development of a Multimodal Analgesia Protocol for Perioperative Acute Pain Management for Lower Lim
  • T6INDIRECT 36320223 ↗An Algorithm Approach to Phantom Limb Pain
  • T6 41743427 ↗Current status and future prospects of brain-computer interfaces in the field of neurological diseas
  • T6 35195724 ↗Association of Chiropractic Colleges Research Agenda Conference 2022: Wellness and Health Promotion:
  • T6 40986224 ↗World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2025)
  • T6 34276544 ↗Best Practices in the Clinical Management of Progressive Supranuclear Palsy and Corticobasal Syndrom
  • T6 25411651 ↗Special Considerations for Multiple Limb Amputation
0.9% Sodium Chloride
T6
T6 — Mechanistic / preclinical
POTS
20 sources
  • T6INDIRECT 29926477 ↗Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent
  • T6INDIRECT 29932206 ↗Saline irrigation for allergic rhinitis
  • T6INDIRECT 29694674 ↗Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent
  • T6INDIRECT 37496207 ↗Efficacy of hydrodilatation in frozen shoulder: a systematic review and meta-analysis
  • T6INDIRECT 34122328 ↗Long-Term Results of Ultrasound-Guided Radiofrequency Ablation of Benign Thyroid Nodules: State of t
  • T6INDIRECT 22733065 ↗Safety, tolerability, and pharmacokinetics of intravenous oseltamivir: single- and multiple-dose pha
  • T6INDIRECT 34807760 ↗A Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of a Fir
  • T6INDIRECT 28707277 ↗Open-Label Allopregnanolone Treatment of Men with Fragile X-Associated Tremor/Ataxia Syndrome
  • T6 26514824 ↗Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for
  • T6 31642064 ↗Medical interventions for chronic rhinosinusitis in cystic fibrosis
  • T6INDIRECT 32784744 ↗Foodborne Botulism: Clinical Diagnosis and Medical Treatment
  • T6INDIRECT 31780881 ↗Inappropriate Antidiuretic Hormone Secretion and Cerebral Salt-Wasting Syndromes in Neurological Pat
  • T6INDIRECT 36532656 ↗The conundrum of COVID-19 mRNA vaccine-induced anaphylaxis
  • T6INDIRECT 19730409 ↗Guidelines for the Prevention and Treatment of Opportunistic Infections among HIV-exposed and HIV-in
  • T6INDIRECT 24569199 ↗Guidelines for the prevention and treatment of opportunistic infections in HIV-exposed and HIV-infec
  • T6 7049208 ↗Pindolol--the pharmacology of a partial agonist
  • T6 31633216 ↗Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
  • T6 2552038 ↗Localization and development of nerve growth factor-sensitive rat basal forebrain neurons and their
  • T6 31189100 ↗Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization
  • T6 30150361 ↗Dorsal BNST α<sub>2A</sub>-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initia
8-week CBT Program
T6
T6 — Mechanistic / preclinical
POTS
9-ING-41
T6
T6 — Mechanistic / preclinical
POTS
26 sources
  • T6INDIRECT 1540729 ↗Renal protective effect of enalapril in diabetic nephropathy
  • T6INDIRECT 8673750 ↗Salt supplement increases plasma volume and orthostatic tolerance in patients with unexplained synco
  • T6INDIRECT 9505918 ↗Midodrine: a role in the management of neurocardiogenic syncope
  • T6INDIRECT 11511713 ↗Treatment of erectile dysfunction with sildenafil citrate (Viagra) in parkinsonism due to Parkinson'
  • T6INDIRECT 12023411 ↗Pramipexole in patients with Parkinson's disease and marked drug resistant tremor: a randomised, dou
  • T6INDIRECT 9343116 ↗Catechol-O-methyltransferase inhibition with tolcapone reduces the "wearing off" phenomenon and levo
  • T6INDIRECT 9810943 ↗Subcutaneous apomorphine in late stage Parkinson's disease: a long term follow up
  • T6INDIRECT 4612057 ↗The cardiovascular effects of morphine. The peripheral capacitance and resistance vessels in human s
  • T6INDIRECT 16107351 ↗The role of levodopa in the management of dementia with Lewy bodies
  • T6INDIRECT 12397141 ↗Goal setting and attainment in Alzheimer's disease patients treated with donepezil
  • T6INDIRECT 2545827 ↗Diffuse Lewy body disease: clinical features in 15 cases
  • T6INDIRECT 11861698 ↗Positional down beating nystagmus in 50 patients: cerebellar disorders and possible anterior semicir
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 2666581 ↗Multiple system atrophy--the nature of the beast
  • T6INDIRECT 2940082 ↗Metabolism and possible health effects of aluminum
  • T6INDIRECT 35679471 ↗Human temperature regulation under heat stress in health, disease, and injury
  • T6INDIRECT 17227286 ↗Review of the pharmacology and clinical profile of bupropion, an antidepressant and tobacco use cess
  • T6INDIRECT 33895845 ↗2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral A
  • T6 6326753 ↗Oxygen toxicity, oxygen radicals, transition metals and disease
  • T6 11250812 ↗Climate change and mosquito-borne disease
  • T6 10379421 ↗Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines an
  • T6 11694544 ↗Hirschsprung disease, associated syndromes, and genetics: a review
  • T6 32287334 ↗Free radicals, oxidative stress, and antioxidants in human health and disease
  • T6 8177173 ↗Gas vesicles
  • T6 16678566 ↗Childhood functional gastrointestinal disorders: child/adolescent
  • T6 16365341 ↗JBS 2: Joint British Societies' guidelines on prevention of cardiovascular disease in clinical pract
A 24-hour ROC training program with a standing posture
T6
T6 — Mechanistic / preclinical
POTS
A 48-hour ROC training program with a standing posture
T6
T6 — Mechanistic / preclinical
POTS
A regular therapy program without receiving any ROC training
T6
T6 — Mechanistic / preclinical
POTS
AAV2-GDNF gene therapy
T6
T6 — Mechanistic / preclinical
POTS
4 sources
  • T6 32700249 ↗Neurotrophic factors for disease-modifying treatments of Parkinson's disease: gaps between basic sci
  • T6 34398313 ↗Current experimental disease-modifying therapeutics for multiple system atrophy
  • T6 38828714 ↗An update on multiple system atrophy
  • T6 40640529 ↗Investigational Gene Therapies for Parkinson's Disease
AFFITOPE® PD01A + Adjuvant
T6
T6 — Mechanistic / preclinical
POTS
AFFITOPE® PD03A + Adjuvant
T6
T6 — Mechanistic / preclinical
POTS
ARC-IM Investigational System
T6
T6 — Mechanistic / preclinical
POTS
ART0380
T6
T6 — Mechanistic / preclinical
POTS
1 source
  • T6 39853679 ↗A phase 2 basket study of talabostat, a small-molecule inhibitor of dipeptidyl peptidases, administe
AZD1390
T6
T6 — Mechanistic / preclinical
POTS
1 source
  • T6 40498965 ↗EACR 2025 Congress: Innovative Cancer Science, 16-19 June 2025
AZD5363
T6
T6 — Mechanistic / preclinical
POTS
2 sources
  • T6 26186558 ↗Targeting the Pim kinases in multiple myeloma
  • T6 31639031 ↗Meeting abstracts from the 5th International Clinical Trials Methodology Conference (ICTMC 2019) : B
AZD8154
T6
T6 — Mechanistic / preclinical
POTS
Acarbose
T6
T6 — Mechanistic / preclinical
POTS
21 sources
  • T6INDIRECT 31794067 ↗Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in pe
  • T6INDIRECT 35675216 ↗Systematic review and meta-analysis examining the relationship between postprandial hypotension, car
  • T6INDIRECT 28489279 ↗Dipeptidyl-peptidase (DPP)-4 inhibitors and glucagon-like peptide (GLP)-1 analogues for prevention o
  • T6INDIRECT 31349678 ↗Acute Effects of Nutritive and Non-Nutritive Sweeteners on Postprandial Blood Pressure
  • T6INDIRECT 35133603 ↗Hypoglycemia and Dysautonomia After Bariatric Surgery: a Systematic Review and Perspective
  • T6INDIRECT 25732215 ↗Effects of guar gum ingestion on postprandial blood pressure in older adults
  • T6INDIRECT 39064619 ↗Effect of Low-Dose Mulberry Fruit Extract on Postprandial Glucose and Insulin Responses: A Randomize
  • T6INDIRECT 32121016 ↗Sensory Acceptance, Appetite Control and Gastrointestinal Tolerance of Yogurts Containing Coffee-Cas
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 22187469 ↗Standards of medical care in diabetes--2012
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 24567799 ↗Cardiac autonomic neuropathy in patients with diabetes mellitus
  • T6INDIRECT 23264422 ↗Standards of medical care in diabetes--2013
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 21193625 ↗Standards of medical care in diabetes--2011
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 27660695 ↗Update on the treatment of type 2 diabetes mellitus
  • T6 30291106 ↗Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes As
  • T6 19118286 ↗Standards of medical care in diabetes--2009
  • T6 16365341 ↗JBS 2: Joint British Societies' guidelines on prevention of cardiovascular disease in clinical pract
Adenosine
T6
T6 — Mechanistic / preclinical
POTS
25 sources
  • T6INDIRECT 30556597 ↗Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people
  • T6INDIRECT 33441035 ↗Synonymous but Not Silent: The Codon Usage Code for Gene Expression and Protein Folding
  • T6INDIRECT 29271481 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 35603936 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 31917873 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 24944260 ↗Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial
  • T6INDIRECT 30635141 ↗Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial
  • T6INDIRECT 23806384 ↗Antiplatelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of
  • T6INDIRECT 15749735 ↗Magnesium sulphate only slightly reduces the shivering threshold in humans
  • T6 29075003 ↗Trends in GPCR drug discovery: new agents, targets and indications
  • T6INDIRECT 21749363 ↗Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects
  • T6INDIRECT 21221114 ↗ATP7A-related copper transport diseases-emerging concepts and future trends
  • T6INDIRECT 34942142 ↗The neuropsychiatry of Parkinson's disease: advances and challenges
  • T6INDIRECT 2940082 ↗Metabolism and possible health effects of aluminum
  • T6INDIRECT 35655306 ↗Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6INDIRECT 21115758 ↗Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Asso
  • T6 23968694 ↗Sugar for the brain: the role of glucose in physiological and pathological brain function
  • T6 26593421 ↗RNA mis-splicing in disease
  • T6 28689769 ↗Osteoporosis treatment: recent developments and ongoing challenges
  • T6 26111766 ↗SLC transporters as therapeutic targets: emerging opportunities
  • T6 20810645 ↗tRNA biology charges to the front
  • T6 33769101 ↗Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
  • T6 30324412 ↗European guidance for the diagnosis and management of osteoporosis in postmenopausal women
Adjuvant without active component
T6
T6 — Mechanistic / preclinical
POTS
Aleeto
T6
T6 — Mechanistic / preclinical
POTS
1 source
  • T6 40542573 ↗Special Issue: Abstracts of the 11<sup>th</sup> Congress of the European Academy of Neurology, Helsi
Alefacept
T6
T6 — Mechanistic / preclinical
POTS
10 sources
  • T6INDIRECT 39297531 ↗Interleukin-receptor antagonist and tumour necrosis factor inhibitors for the primary and secondary
  • T6INDIRECT 29271481 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 35603936 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 31917873 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 33871055 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6 37436070 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 32421085 ↗Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in
  • T6INDIRECT 32546899 ↗Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in
  • T6 38617189 ↗Structure and function of therapeutic antibodies approved by the US FDA in 2023
  • T6 39202335 ↗Simulated Microgravity Alters Gene Regulation Linked to Immunity and Cardiovascular Disease
American Autonomic Society statement
T6
T6 — Mechanistic / preclinical
POTS
3 sources
  • T6 33740207 ↗Long-COVID postural tachycardia syndrome: an American Autonomic Society statement.
  • T6 36169154 ↗Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of aut
  • T6 35470419 ↗Post-COVID-19 postural orthostatic tachycardia syndrome
Androgen receptor inhibitor
T6
T6 — Mechanistic / preclinical
POTS
7 sources
  • T6 34691199 ↗Dermatology: how to manage acne vulgaris
  • T6 40142611 ↗Characterization and Management of Adverse Events of Low-Dose Oral Minoxidil Treatment for Alopecia:
  • T6 38376087 ↗Low-Dose Oral Minoxidil for Alopecia: A Comprehensive Review
  • T6 32745289 ↗Research Communications of the 27<sup>th</sup> ECVIM-CA Congress. Intercontinental, Saint Julian's,
  • T6 PMC6876493 ↗Abstracts from the 52nd European Society of Human Genetics (ESHG) Conference: Posters
  • T6 23115463 ↗Pharmaceutical approval update
  • T6 40722209 ↗Arrhythmias, conduction disorders and sudden cardiac death in cancer patients and survivors: expert
Anodal cerebellar and cathodal spinal tDCS
T6
T6 — Mechanistic / preclinical
POTS
Art-therapy
T6
T6 — Mechanistic / preclinical
POTS
22 sources
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 30191554 ↗Interventions for preventing falls in older people in care facilities and hospitals
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 33428616 ↗Mindfulness-based programmes for mental health promotion in adults in nonclinical settings: A system
  • T6INDIRECT 23633371 ↗Interventions for treating pain and disability in adults with complex regional pain syndrome
  • T6INDIRECT 33957075 ↗Dismantling, optimising, and personalising internet cognitive behavioural therapy for depression: a
  • T6INDIRECT 36602886 ↗Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis
  • T6INDIRECT 18281407 ↗Systems Training for Emotional Predictability and Problem Solving (STEPPS) for outpatients with bord
  • T6INDIRECT 18398080 ↗Effect of lower targets for blood pressure and LDL cholesterol on atherosclerosis in diabetes: the S
  • T6INDIRECT 9570194 ↗Left ventricular structure and function in children infected with human immunodeficiency virus: the
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 23225012 ↗Parkinson's disease
  • T6INDIRECT 19337156 ↗The IC3D classification of the corneal dystrophies
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6 21976606 ↗Food animals and antimicrobials: impacts on human health
  • T6 22258608 ↗The promise of induced pluripotent stem cells in research and therapy
  • T6 28887905 ↗Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Sh
  • T6 27977393 ↗Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Associa
  • T6 25834232 ↗Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing
  • T6 36859484 ↗Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration bac
AtriCure Commercially Available Devices
T6
T6 — Mechanistic / preclinical
POTS
AtriCure ISOLATOR Synergy Surgical Ablation System
T6
T6 — Mechanistic / preclinical
POTS
1 source
  • T6 37124558 ↗Hybrid epicardial and endocardial sinus node-sparing ablation therapy for inappropriate sinus tachyc
Autologous Mesenchymal Stem Cells
T6
T6 — Mechanistic / preclinical
POTS
13 sources
  • T6INDIRECT 30294976 ↗Available and future treatments for atypical parkinsonism. A systematic review
  • T6 21962754 ↗Multiple system atrophy: a clinical and neuropathological perspective
  • T6 28803444 ↗Atypical parkinsonian syndromes: a general neurologist's perspective
  • T6 32095235 ↗Insights into the pathogenesis of multiple system atrophy: focus on glial cytoplasmic inclusions
  • T6 26749150 ↗Therapeutic approaches in Parkinson's disease and related disorders
  • T6 31152011 ↗Intrathecal administration of autologous mesenchymal stem cells in multiple system atrophy
  • T6INDIRECT 36660581 ↗Multiple system atrophy-cerebellar: A case report and literature review
  • T6INDIRECT 24598411 ↗Towards translational therapies for multiple system atrophy
  • T6INDIRECT 32436100 ↗An update on MSA: premotor and non-motor features open a window of opportunities for early diagnosis
  • T6INDIRECT 30363880 ↗Current Concepts in the Treatment of Multiple System Atrophy
  • T6INDIRECT 32767032 ↗Current Management and Emerging Therapies in Multiple System Atrophy
  • T6INDIRECT 38743312 ↗Pharmacotherapies for the Treatment of Progressive Supranuclear Palsy: A Narrative Review
  • T6INDIRECT 21179616 ↗Multiple system atrophy: current and future approaches to management
BOTOX
T6
T6 — Mechanistic / preclinical
POTS
23 sources
  • T6INDIRECT 33175411 ↗Transcranial direct current stimulation (tDCS) for improving activities of daily living, and physica
  • T6INDIRECT 25919144 ↗Interventions for rosacea
  • T6INDIRECT 27819409 ↗Interventions for chronic kidney disease-associated restless legs syndrome
  • T6INDIRECT 34318929 ↗Interventions for preventing falls and fall-related fractures in community-dwelling older adults: A
  • T6INDIRECT 34271512 ↗Neurocognitive impairments and brain abnormalities resulting from opioid-related overdoses: A system
  • T6INDIRECT 29549458 ↗Gastrointestinal symptoms in postural tachycardia syndrome: a systematic review
  • T6INDIRECT 35094007 ↗Walking improvement in chronic incomplete spinal cord injury with exoskeleton robotic training (WISE
  • T6INDIRECT 29649928 ↗Non-Invasive Activation of Cervical Spinal Networks after Severe Paralysis
  • T6INDIRECT 31802596 ↗Open-label pilot study: Non-invasive vagal nerve stimulation improves symptoms and gastric emptying
  • T6INDIRECT 28571527 ↗Assessment and management of acute spinal cord injury: From point of injury to rehabilitation
  • T6INDIRECT 29934758 ↗Diabetic Gastroparesis: Principles and Current Trends in Management
  • T6INDIRECT 25954496 ↗The diagnosis and treatment of chronic migraine
  • T6INDIRECT 18686748 ↗Treatment of fragile X-associated tremor ataxia syndrome (FXTAS) and related neurological problems
  • T6INDIRECT 29335879 ↗Current Approaches and New Developments in the Pharmacological Management of Tourette Syndrome
  • T6INDIRECT 24142590 ↗Treatment of dystonia
  • T6INDIRECT 23612753 ↗Hyperhidrosis: anatomy, pathophysiology and treatment with emphasis on the role of botulinum toxins
  • T6INDIRECT 17274492 ↗Bladder management for adults with spinal cord injury: a clinical practice guideline for health-care
  • T6 31387301 ↗Mechanisms of Botulinum Toxin Type A Action on Pain
  • T6 28778262 ↗Current Understanding of Neurodegenerative Diseases Associated With the Protein Tau
  • T6 20142810 ↗New treatments for chronic prostatitis/chronic pelvic pain syndrome
  • T6 35411324 ↗Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From t
  • T6 24713270 ↗Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in hu
  • T6 23550085 ↗Diabetic cardiac autonomic neuropathy, inflammation and cardiovascular disease
BRC-002
T6
T6 — Mechanistic / preclinical
POTS
16 sources
  • T6INDIRECT 33408364 ↗Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overwei
  • T6 31655889 ↗The autoantibody-mediated encephalitides: from clinical observations to molecular pathogenesis
  • T6 31633216 ↗Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
  • T6 36357675 ↗Rare and common genetic determinants of metabolic individuality and their effects on human health
  • T6 34693230 ↗Symptom Persistence Despite Improvement in Cardiopulmonary Health - Insights from longitudinal CMR,
  • T6 32144319 ↗A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli
  • T6INDIRECT 34468792 ↗57<sup>th</sup> EASD Annual Meeting of the European Association for the Study of Diabetes
  • T6INDIRECT 35393538 ↗Abstracts from the 54<sup>th</sup> European Society of Human Genetics (ESHG) Conference: e-Posters
  • T6INDIRECT 34559267 ↗European Association of Nuclear Medicine October 20-23, 2021 Virtual
  • T6INDIRECT 28608429 ↗27th Regional Congress of the ISBT, Copenhagen, Denmark, June 17-21, 2017
  • T6INDIRECT 39871188 ↗Falls and balance impairment; what and how has this been measured in adults with joint hypermobility
  • T6INDIRECT 28795195 ↗53 &lt;sup&gt;rd&lt;/sup&gt; EASD Annual Meeting of the European Association for the Study of Diabet
  • T6INDIRECT 32840677 ↗56<sup>th</sup> EASD Annual Meeting of the European Association for the Study of Diabetes : 21-25 Se
  • T6 38425314 ↗HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease
  • T6 38853153 ↗First-in-man study of the PSMA Minibody IR800-IAB2M for molecularly targeted intraoperative fluoresc
  • T6 28797221 ↗Use of genotyping-by-sequencing to determine the genetic structure in the medicinal plant chamomile,
Balance training by means of conventional rehabilitation
T6
T6 — Mechanistic / preclinical
POTS
Balance training over stabilometric platform
T6
T6 — Mechanistic / preclinical
POTS
Beach Tennis session
T6
T6 — Mechanistic / preclinical
POTS
Behavior Change Coaching
T6
T6 — Mechanistic / preclinical
POTS
Berzosertib
T6
T6 — Mechanistic / preclinical
POTS
2 sources
  • T6 37325475 ↗PI3K/Akt/Nrf2 mediated cellular signaling and virus-host interactions: latest updates on the potenti
  • T6 40498965 ↗EACR 2025 Congress: Innovative Cancer Science, 16-19 June 2025
Beta blocker
T6
T6 — Mechanistic / preclinical
POTS
23 sources
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30019766 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 24902920 ↗The design and rationale of a multicenter clinical trial comparing two strategies for control of sys
  • T6INDIRECT 27170530 ↗Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double-blind, ran
  • T6INDIRECT 34739197 ↗Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease
  • T6INDIRECT 22281448 ↗Placebo-controlled comparison of prazosin and cognitive-behavioral treatments for sleep disturbances
  • T6INDIRECT 11435337 ↗Permanent cardiac pacing versus medical treatment for the prevention of recurrent vasovagal syncope:
  • T6INDIRECT 19687359 ↗Propranolol decreases tachycardia and improves symptoms in the postural tachycardia syndrome: less i
  • T6INDIRECT 19470886 ↗Effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 di
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 26835847 ↗Hypertension and aging
  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6INDIRECT 30192094 ↗Management of common adverse effects of antipsychotic medications
  • T6INDIRECT 35307156 ↗2022 ACC Expert Consensus Decision Pathway on Cardiovascular Sequelae of COVID-19 in Adults: Myocard
  • T6 26062169 ↗Fear and the Defense Cascade: Clinical Implications and Management
  • T6 34236546 ↗Inhibitors of immune checkpoints-PD-1, PD-L1, CTLA-4-new opportunities for cancer patients and a new
  • T6 33909761 ↗Brazilian Guidelines of Hypertension - 2020
  • T6 35963508 ↗American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Me
  • T6 33753937 ↗Post-acute COVID-19 syndrome
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
Bovril
T6
T6 — Mechanistic / preclinical
POTS
7 sources
  • T6 9728937 ↗Treatment of postural hypotension
  • T6 35633931 ↗Treatment strategies for clozapine-induced hypotension: a systematic review
  • T6 37732384 ↗Emulsifiers in ultra-processed foods in the UK food supply
  • T6 21233984 ↗Monoamine oxidase inhibitors: clinical review
  • T6 4731440 ↗Amyloidosis complicated by intractable postural hypotension
  • T6 20755019 ↗Annual Museum
  • T6 29838764 ↗"The Hospital" Nursing Mirror
Bupivacaine
T6
T6 — Mechanistic / preclinical
POTS
25 sources
  • T6INDIRECT 26355598 ↗Local Anesthetic Peripheral Nerve Block Adjuvants for Prolongation of Analgesia: A Systematic Qualit
  • T6INDIRECT 23633371 ↗Interventions for treating pain and disability in adults with complex regional pain syndrome
  • T6INDIRECT 27419911 ↗Epidural local anaesthetics versus opioid-based analgesic regimens for postoperative gastrointestina
  • T6INDIRECT 23076930 ↗Local anaesthetics and regional anaesthesia for preventing chronic pain after surgery
  • T6INDIRECT 29926477 ↗Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent
  • T6INDIRECT 26861472 ↗Ziconotide Monotherapy: A Systematic Review of Randomised Controlled Trials
  • T6INDIRECT 7574055 ↗Effects of perioperative analgesic technique on rate of recovery after colon surgery
  • T6INDIRECT 8214727 ↗Epidural anesthesia for labor in an ambulatory patient
  • T6INDIRECT 24496086 ↗Effects of stellate ganglion block on vasomotor symptoms: findings from a randomized controlled clin
  • T6 31663402 ↗Consensus statement for perioperative care in total hip replacement and total knee replacement surge
  • T6INDIRECT 26514824 ↗Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for
  • T6INDIRECT 23094876 ↗Brugada phenocopy: new terminology and proposed classification
  • T6INDIRECT 29276402 ↗Ganglion blocks as a treatment of pain: current perspectives
  • T6INDIRECT 26869865 ↗A systematic review of the cardiotoxicity of methadone
  • T6INDIRECT 34295184 ↗The American Society of Pain and Neuroscience (ASPN) Best Practices and Guidelines for the Intervent
  • T6INDIRECT 32448142 ↗Persistent post-traumatic headache: a migrainous loop or not? The clinical evidence
  • T6INDIRECT 18488078 ↗Current aproach to cancer pain management: Availability and implications of different treatment opti
  • T6 29315692 ↗Comprehensive review of cardiovascular toxicity of drugs and related agents
  • T6 35215352 ↗Chiral Switch: Between Therapeutical Benefit and Marketing Strategy
  • T6 29262334 ↗Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotio
  • T6 34764220 ↗Consensus practice guidelines on interventions for cervical spine (facet) joint pain from a multispe
  • T6 25632113 ↗Designer receptors enhance memory in a mouse model of Down syndrome
  • T6 30090998 ↗Facet joint syndrome: from diagnosis to interventional management
  • T6 22066560 ↗Why still in hospital after fast-track hip and knee arthroplasty?
  • T6 19238499 ↗The feasibility and perioperative complications of outpatient knee arthroplasty
CBO standard
T6
T6 — Mechanistic / preclinical
POTS
CERE-110: Adeno-Associated Virus injection Surgery
T6
T6 — Mechanistic / preclinical
POTS
CIIIT
T6
T6 — Mechanistic / preclinical
POTS
CPAP
T6
T6 — Mechanistic / preclinical
POTS
22 sources
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 26671213 ↗Systematic Differences between Cochrane and Non-Cochrane Meta-Analyses on the Same Topic: A Matched
  • T6INDIRECT 38375882 ↗Mobile health (m-health) smartphone interventions for adolescents and adults with overweight or obes
  • T6INDIRECT 27863901 ↗A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease f
  • T6INDIRECT 31570638 ↗Stridor in multiple system atrophy: Consensus statement on diagnosis, prognosis, and treatment
  • T6INDIRECT 31129916 ↗Interventions for improving sleep quality in people with chronic kidney disease
  • T6INDIRECT 30584530 ↗Rapid-Onset Obesity with Hypoventilation, Hypothalamic, Autonomic Dysregulation, and Neuroendocrine
  • T6INDIRECT 28013207 ↗An investigation into the prevalence of sleep disturbances in primary Sjögren's syndrome: a systemat
  • T6INDIRECT 31685792 ↗Effect of dapagliflozin on obstructive sleep apnea in patients with type 2 diabetes: a preliminary s
  • T6INDIRECT 23116538 ↗Treatment of multiple system atrophy using intravenous immunoglobulin
  • T6INDIRECT 24703753 ↗A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder assoc
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 19484833 ↗Evidence-based recommendations for the assessment and management of sleep disorders in older persons
  • T6INDIRECT 30113864 ↗Obstructive Sleep Apnea and the Risk of Cognitive Decline in Older Adults
  • T6INDIRECT 33992686 ↗Epidemiology and organ specific sequelae of post-acute COVID19: A narrative review
  • T6 28716886 ↗Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases
  • T6 28298428 ↗Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of th
  • T6 37230968 ↗Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
  • T6 25514304 ↗The diagnosis and management of mild cognitive impairment: a clinical review
  • T6 30354828 ↗Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the Ameri
CV4 + RR
T6
T6 — Mechanistic / preclinical
POTS
Carbidopa High-Dose
T6
T6 — Mechanistic / preclinical
POTS
Carbidopa Low-Dose
T6
T6 — Mechanistic / preclinical
POTS
Carbidopa/levodopa
T6
T6 — Mechanistic / preclinical
POTS
23 sources
  • T6INDIRECT 27863901 ↗A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease f
  • T6INDIRECT 24361112 ↗Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Par
  • T6INDIRECT 15548480 ↗Mucuna pruriens in Parkinson's disease: a double blind clinical and pharmacological study
  • T6INDIRECT 9343116 ↗Catechol-O-methyltransferase inhibition with tolcapone reduces the "wearing off" phenomenon and levo
  • T6INDIRECT 8558148 ↗Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients wit
  • T6INDIRECT 8527287 ↗Pharmacokinetic-pharmacodynamic interaction between the COMT inhibitor tolcapone and single-dose lev
  • T6INDIRECT 23336248 ↗Opicapone: a short lived and very long acting novel catechol-O-methyltransferase inhibitor following
  • T6INDIRECT 12388617 ↗Dopamine modulates the response of the human amygdala: a study in Parkinson's disease
  • T6 28716886 ↗Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6INDIRECT 32402162 ↗Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease
  • T6INDIRECT 26350119 ↗Autosomal dominant Parkinson's disease caused by SNCA duplications
  • T6INDIRECT 2545827 ↗Diffuse Lewy body disease: clinical features in 15 cases
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 23225012 ↗Parkinson's disease
  • T6INDIRECT 19484833 ↗Evidence-based recommendations for the assessment and management of sleep disorders in older persons
  • T6INDIRECT 29508455 ↗Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
  • T6INDIRECT 19933976 ↗Medical records documentation of constipation preceding Parkinson disease: A case-control study
  • T6 28887905 ↗Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Sh
  • T6 29090092 ↗Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential trea
  • T6 28273839 ↗Parkinson's Disease: From Pathogenesis to Pharmacogenomics
  • T6 26324905 ↗Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism
  • T6 31196984 ↗Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
Carboplatin
T6
T6 — Mechanistic / preclinical
POTS
21 sources
  • T6INDIRECT 26836199 ↗Antiemetic medication for prevention and treatment of chemotherapy-induced nausea and vomiting in ch
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 29217664 ↗Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Re
  • T6INDIRECT 27884691 ↗AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions
  • T6INDIRECT 30200910 ↗CRITICS-II: a multicentre randomised phase II trial of neo-adjuvant chemotherapy followed by surgery
  • T6INDIRECT 36482103 ↗Atezolizumab plus anthracycline-based chemotherapy in metastatic triple-negative breast cancer: the
  • T6INDIRECT 31980913 ↗Autologous monocyte-derived DC vaccination combined with cisplatin in stage III and IV melanoma pati
  • T6INDIRECT 8774401 ↗Intravenous immunoglobulin treatment in paraneoplastic neurological syndromes with antineuronal auto
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6 24323045 ↗Autophagy and human diseases
  • T6INDIRECT 30184160 ↗Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints
  • T6INDIRECT 34655433 ↗Chemotherapy-Induced Peripheral Neuropathy: Epidemiology, Pathomechanisms and Treatment
  • T6INDIRECT 24672257 ↗Chemotherapy-induced peripheral neuropathy in adults: a comprehensive update of the literature
  • T6INDIRECT 24636754 ↗Pheochromocytoma and paraganglioma: diagnosis, genetics, management, and treatment
  • T6INDIRECT 25584767 ↗Basic science and clinical management of painful and non-painful chemotherapy-related neuropathy
  • T6 30909387 ↗Mechanisms of Chemotherapy-Induced Peripheral Neuropathy
  • T6 28620280 ↗Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy
  • T6 30130469 ↗Iron and Cancer
  • T6 28286483 ↗Long-Term Effects, Pathophysiological Mechanisms, and Risk Factors of Chemotherapy-Induced Periphera
  • T6 32114384 ↗Resistance to Checkpoint Inhibition in Cancer Immunotherapy
  • T6 23095830 ↗Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and preven
Cemiplimab
T6
T6 — Mechanistic / preclinical
POTS
16 sources
  • T6INDIRECT 36446613 ↗Anti-Hu Antibodies in Patients With Neurologic Side Effects of Immune Checkpoint Inhibitors
  • T6INDIRECT 34458371 ↗Guillain-Barré Syndrome-Like Polyneuropathy Associated with Immune Checkpoint Inhibitors: A Systemat
  • T6 34236546 ↗Inhibitors of immune checkpoints-PD-1, PD-L1, CTLA-4-new opportunities for cancer patients and a new
  • T6 31866206 ↗Hypophysitis: An update on the novel forms, diagnosis and management of disorders of pituitary infla
  • T6 35453977 ↗The Role and Potential of <sup>18</sup>F-FDG PET/CT in Malignant Melanoma: Prognostication, Monitori
  • T6 34281989 ↗Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhi
  • T6INDIRECT 36561623 ↗Diabetes insipidus: A rare endocrine complication of immune check point inhibitors: A case report an
  • T6INDIRECT 37700240 ↗Management of respiratory failure in immune checkpoint inhibitors-induced overlap syndrome: a case s
  • T6INDIRECT 34659082 ↗Paraneoplastic Neuropathies: What's New Since the 2004 Recommended Diagnostic Criteria
  • T6INDIRECT 40675801 ↗Neurological immune-related adverse events with checkpoint inhibitor therapy: challenges for the neu
  • T6INDIRECT 39170102 ↗Diagnostic and prognostic biomarkers in immune checkpoint inhibitor-related encephalitis: a retrospe
  • T6 33380303 ↗Immune Checkpoint Inhibitors and Neurotoxicity
  • T6 38617189 ↗Structure and function of therapeutic antibodies approved by the US FDA in 2023
  • T6 41810127 ↗Charting the Current Landscape and Future Prospects of Cancer Therapy-Related Cardiovascular Toxicit
  • T6 41440526 ↗COVID-19 and Lung Cancer Interactions: A Literature Review
  • T6 34559267 ↗European Association of Nuclear Medicine October 20-23, 2021 Virtual
Cerebellar repetitive transcranial magnetic stimulation
T6
T6 — Mechanistic / preclinical
POTS
2 sources
  • T6INDIRECT 40995146 ↗Non-invasive brain stimulation for stroke-related motor impairment and disability: an umbrella revie
  • T6 34276544 ↗Best Practices in the Clinical Management of Progressive Supranuclear Palsy and Corticobasal Syndrom
Cetuximab
T6
T6 — Mechanistic / preclinical
POTS
18 sources
  • T6INDIRECT 29217664 ↗Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Re
  • T6INDIRECT 35767077 ↗Systematic review about complementary medical hyperthermia in oncology
  • T6INDIRECT 23981966 ↗Phase 2 study of pemetrexed plus carboplatin, or pemetrexed plus cisplatin with concurrent radiation
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 37919282 ↗Smart nanoparticles for cancer therapy
  • T6 34236546 ↗Inhibitors of immune checkpoints-PD-1, PD-L1, CTLA-4-new opportunities for cancer patients and a new
  • T6 26391778 ↗Cancer-treatment-induced neurotoxicity--focus on newer treatments
  • T6 30503208 ↗NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines
  • T6 33833386 ↗Autologous CD33-CAR-T cells for treatment of relapsed/refractory acute myelogenous leukemia
  • T6 27044938 ↗Phase I Study of LY2606368, a Checkpoint Kinase 1 Inhibitor, in Patients With Advanced Cancer
  • T6INDIRECT 19417117 ↗Anaphylactic reaction to anakinra in a rheumatoid arthritis patient intolerant to multiple nonbiolog
  • T6INDIRECT 31130732 ↗Surgery of the lateral skull base: a 50-year endeavour
  • T6INDIRECT 28800865 ↗Anaphylaxis
  • T6INDIRECT 25124015 ↗Noninvasive imaging of cardiovascular injury related to the treatment of cancer
  • T6INDIRECT 32421085 ↗Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in
  • T6 35159802 ↗Review on Nanoparticles and Nanostructured Materials: Bioimaging, Biosensing, Drug Delivery, Tissue
  • T6 29950872 ↗Anaphylaxis in the 21st century: phenotypes, endotypes, and biomarkers
  • T6 28730291 ↗Electrolyte disorders with platinum-based chemotherapy: mechanisms, manifestations and management
Cognitive Multisensory Rehabilitation
T6
T6 — Mechanistic / preclinical
POTS
Conservative Measures for Orthostatic Hypotension
T6
T6 — Mechanistic / preclinical
POTS
Continuous Positive Airway Pressure
T6
T6 — Mechanistic / preclinical
POTS
22 sources
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 34969689 ↗Cardiac autonomic neuropathy and risk of cardiovascular disease and mortality in type 1 and type 2 d
  • T6INDIRECT 26671213 ↗Systematic Differences between Cochrane and Non-Cochrane Meta-Analyses on the Same Topic: A Matched
  • T6INDIRECT 31570638 ↗Stridor in multiple system atrophy: Consensus statement on diagnosis, prognosis, and treatment
  • T6INDIRECT 31129916 ↗Interventions for improving sleep quality in people with chronic kidney disease
  • T6INDIRECT 30584530 ↗Rapid-Onset Obesity with Hypoventilation, Hypothalamic, Autonomic Dysregulation, and Neuroendocrine
  • T6INDIRECT 28489279 ↗Dipeptidyl-peptidase (DPP)-4 inhibitors and glucagon-like peptide (GLP)-1 analogues for prevention o
  • T6INDIRECT 21745374 ↗Comparison of intravenous immunoglobulin and plasma exchange in treatment of mechanically ventilated
  • T6INDIRECT 31685792 ↗Effect of dapagliflozin on obstructive sleep apnea in patients with type 2 diabetes: a preliminary s
  • T6INDIRECT 23116538 ↗Treatment of multiple system atrophy using intravenous immunoglobulin
  • T6INDIRECT 24703753 ↗A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder assoc
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 19484833 ↗Evidence-based recommendations for the assessment and management of sleep disorders in older persons
  • T6INDIRECT 29101940 ↗REM Sleep Behavior Disorder: Diagnosis, Clinical Implications, and Future Directions
  • T6INDIRECT 36782262 ↗Circadian disruption and sleep disorders in neurodegeneration
  • T6 28716886 ↗Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases
  • T6 26595642 ↗Lewy body dementias
  • T6 28298428 ↗Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of th
  • T6 33753937 ↗Post-acute COVID-19 syndrome
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
Continuous positive airway pressure
T6
T6 — Mechanistic / preclinical
POTS
22 sources
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 34969689 ↗Cardiac autonomic neuropathy and risk of cardiovascular disease and mortality in type 1 and type 2 d
  • T6INDIRECT 26671213 ↗Systematic Differences between Cochrane and Non-Cochrane Meta-Analyses on the Same Topic: A Matched
  • T6INDIRECT 31570638 ↗Stridor in multiple system atrophy: Consensus statement on diagnosis, prognosis, and treatment
  • T6INDIRECT 31129916 ↗Interventions for improving sleep quality in people with chronic kidney disease
  • T6INDIRECT 30584530 ↗Rapid-Onset Obesity with Hypoventilation, Hypothalamic, Autonomic Dysregulation, and Neuroendocrine
  • T6INDIRECT 28489279 ↗Dipeptidyl-peptidase (DPP)-4 inhibitors and glucagon-like peptide (GLP)-1 analogues for prevention o
  • T6INDIRECT 21745374 ↗Comparison of intravenous immunoglobulin and plasma exchange in treatment of mechanically ventilated
  • T6INDIRECT 31685792 ↗Effect of dapagliflozin on obstructive sleep apnea in patients with type 2 diabetes: a preliminary s
  • T6INDIRECT 23116538 ↗Treatment of multiple system atrophy using intravenous immunoglobulin
  • T6INDIRECT 24703753 ↗A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder assoc
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 19484833 ↗Evidence-based recommendations for the assessment and management of sleep disorders in older persons
  • T6INDIRECT 29101940 ↗REM Sleep Behavior Disorder: Diagnosis, Clinical Implications, and Future Directions
  • T6INDIRECT 36782262 ↗Circadian disruption and sleep disorders in neurodegeneration
  • T6 28716886 ↗Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases
  • T6 26595642 ↗Lewy body dementias
  • T6 28298428 ↗Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of th
  • T6 33753937 ↗Post-acute COVID-19 syndrome
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
Contrast Compression Therapy
T6
T6 — Mechanistic / preclinical
POTS
Conventional rehabilitation, the Erigo®Pro table, motor imagery
T6
T6 — Mechanistic / preclinical
POTS
Conventional rehabilitation, the Erigo®Pro table, motor imagery on gait parameters.
T6
T6 — Mechanistic / preclinical
POTS
Conventional rehabilitation, the Erigo®Pro table, motor imagery on gait.
T6
T6 — Mechanistic / preclinical
POTS
Cycloset
T6
T6 — Mechanistic / preclinical
POTS
11 sources
  • T6 28273839 ↗Parkinson's Disease: From Pathogenesis to Pharmacogenomics
  • T6 27660695 ↗Update on the treatment of type 2 diabetes mellitus
  • T6 23241069 ↗A review of the efficacy and safety of oral antidiabetic drugs
  • T6 27505015 ↗Side effects of a dopamine agonist therapy for Parkinson's disease: a mini-review of clinical pharma
  • T6 17592632 ↗A randomized, double-blind, placebo-controlled trial to assess safety and tolerability during treatm
  • T6INDIRECT 23792716 ↗Clinical Diabetes/Therapeutics
  • T6 31442412 ↗Dopaminergic impact of cART and anti-depressants on HIV neuropathogenesis in older adults
  • T6 27994440 ↗Use of bedaquiline and delamanid in diabetes patients: clinical and pharmacological considerations
  • T6 20523873 ↗Bromocriptine mesylate: FDA-approved novel treatment for type-2 diabetes
  • T6 36012132 ↗Bromocriptine-QR Therapy Reduces Sympathetic Tone and Ameliorates a Pro-Oxidative/Pro-Inflammatory P
  • T6 21847449 ↗Bromocriptine in type 2 diabetes mellitus
DRG stimulation 20 Hz 30/90
T6
T6 — Mechanistic / preclinical
POTS
DRG stimulation 5 Hz 30/90
T6
T6 — Mechanistic / preclinical
POTS
DaTSCAN™ Ioflupane Injection
T6
T6 — Mechanistic / preclinical
POTS
Dance-therapy
T6
T6 — Mechanistic / preclinical
POTS
22 sources
  • T6INDIRECT 30191554 ↗Interventions for preventing falls in older people in care facilities and hospitals
  • T6INDIRECT 25432016 ↗Exercise for reducing fear of falling in older people living in the community
  • T6INDIRECT 24018704 ↗Physiotherapy versus placebo or no intervention in Parkinson's disease
  • T6INDIRECT 32449203 ↗Interventions for increasing fruit and vegetable consumption in children aged five years and under
  • T6INDIRECT 29770960 ↗Interventions for increasing fruit and vegetable consumption in children aged five years and under
  • T6INDIRECT 34318929 ↗Interventions for preventing falls and fall-related fractures in community-dwelling older adults: A
  • T6INDIRECT 36602886 ↗Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis
  • T6INDIRECT 35665915 ↗Interventions for preventing falls in Parkinson's disease
  • T6INDIRECT 29143692 ↗Non-pharmacological interventions for Lewy body dementia: a systematic review
  • T6INDIRECT 38588457 ↗Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis
  • T6INDIRECT 34942142 ↗The neuropsychiatry of Parkinson's disease: advances and challenges
  • T6INDIRECT 2940082 ↗Metabolism and possible health effects of aluminum
  • T6INDIRECT 17227286 ↗Review of the pharmacology and clinical profile of bupropion, an antidepressant and tobacco use cess
  • T6INDIRECT 18286801 ↗Cannabinoids in health and disease
  • T6INDIRECT 26387020 ↗Invited review: Recommendations for reporting intervention studies on reproductive performance in da
  • T6INDIRECT 25332912 ↗Effects of physical activity in Parkinson's disease: A new tool for rehabilitation
  • T6 28716886 ↗Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases
  • T6 27366343 ↗Pathophysiology of Motor Dysfunction in Parkinson's Disease as the Rationale for Drug Treatment and
  • T6 39743381 ↗Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults
  • T6 33924103 ↗Treatment Options for Motor and Non-Motor Symptoms of Parkinson's Disease
  • T6 35705848 ↗Depression in Patients with Parkinson's Disease: Current Understanding of its Neurobiology and Impli
  • T6 27770207 ↗Gait disorders in adults and the elderly : A clinical guide
Dipyridamole/ Aspirin
T6
T6 — Mechanistic / preclinical
POTS
2 sources
Dorsal Root Ganglion Stimulation Cessation
T6
T6 — Mechanistic / preclinical
POTS
Dose-attenuated IST and Hetrombopag
T6
T6 — Mechanistic / preclinical
POTS
Double blinded IVIg
T6
T6 — Mechanistic / preclinical
POTS
Dry Needling
T6
T6 — Mechanistic / preclinical
POTS
15 sources
  • T6INDIRECT 32290577 ↗Comparative Effectiveness of Botulinum Toxin Injection for Chronic Shoulder Pain: A Meta-Analysis of
  • T6INDIRECT 38900335 ↗Botulinum Toxin-A for the Treatment of Myogenous Temporomandibular Disorders: An Umbrella Review of
  • T6 32629534 ↗Hypermobile Ehlers-Danlos syndromes: Complex phenotypes, challenging diagnoses, and poorly understoo
  • T6 32279713 ↗Medical and Surgical Treatments for Dystonia
  • T6 35095742 ↗Pain in Multiple Sclerosis: Understanding Pathophysiology, Diagnosis, and Management Through Clinica
  • T6 35526973 ↗Trigger Point Injections
  • T6 24579044 ↗Effect of Platelet-Rich Plasma (PRP) versus Autologous Whole Blood on Pain and Function Improvement
  • T6INDIRECT 33467373 ↗TMJ Dysfunctions Systemic Implications and Postural Assessments: A Review of Recent Literature
  • T6INDIRECT 37830088 ↗Breaking the cycle: unraveling the diagnostic, pathophysiological and treatment challenges of refrac
  • T6INDIRECT 20820780 ↗Long-term safety and effectiveness of the "OptEase" vena cava filter
  • T6INDIRECT 37089610 ↗"Long COVID-19" and viral "fibromyalgia-ness": Suggesting a mechanistic role for fascial myofibrobla
  • T6 41221343 ↗Exploring fascia in myofascial pain syndrome: an integrative model of mechanisms
  • T6 42080121 ↗Myofascial pain in older adults: a geroscience-informed framework integrating precision geriatrics a
  • T6 32725471 ↗Abstracts from the 2020 Annual Meeting of the Society of General Internal Medicine
  • T6 35195724 ↗Association of Chiropractic Colleges Research Agenda Conference 2022: Wellness and Health Promotion:
Dual chamber pacemeker
T6
T6 — Mechanistic / preclinical
POTS
EEG/HRV/RSA Monitoring using Infiniti System
T6
T6 — Mechanistic / preclinical
POTS
ETX-636 dose escalation
T6
T6 — Mechanistic / preclinical
POTS
ETX-636 dose escalation in combination with fulvestrant
T6
T6 — Mechanistic / preclinical
POTS
ETX-636 dose expansion in combination with fulvestrant
T6
T6 — Mechanistic / preclinical
POTS
Elastic abdominal binder
T6
T6 — Mechanistic / preclinical
POTS
8 sources
  • T6INDIRECT 25448247 ↗Effects of patient-controlled abdominal compression on standing systolic blood pressure in adults wi
  • T6 20439562 ↗Preventing and treating orthostatic hypotension: As easy as A, B, C
  • T6 35293295 ↗Advances in the Pharmacological and Non-pharmacological Management of Non-motor Symptoms in Parkinso
  • T6 32938788 ↗Association of transient orthostatic hypotension with falls and syncope in patients with Parkinson d
  • T6 30363559 ↗Elastic Abdominal Binders Attenuate Orthostatic Hypotension in Parkinson's Disease
  • T6INDIRECT 39751950 ↗Diagnosis and treatment of autonomic failure, pain and sleep disturbances in Parkinson's disease: gu
  • T6INDIRECT 40192452 ↗Evaluation and management of autonomic functions in patients with spinal cord injury: A scoping revi
  • T6 33392545 ↗Initial assessment and management of respiratory infections in persons with spinal cord injuries and
Elimusertib
T6
T6 — Mechanistic / preclinical
POTS
3 sources
Eplerenone
T6
T6 — Mechanistic / preclinical
POTS
22 sources
  • T6INDIRECT 33107592 ↗Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progr
  • T6INDIRECT 32519776 ↗Withdrawal of antihypertensive drugs in older people
  • T6INDIRECT 31554937 ↗Long-term phase 3 study of esaxerenone as mono or combination therapy with other antihypertensive dr
  • T6INDIRECT 36266539 ↗Results from a phase 1, randomized, double-blind, multiple ascending dose study characterizing the p
  • T6INDIRECT 26644241 ↗Mineralocorticoid Receptor Activation Contributes to the Supine Hypertension of Autonomic Failure
  • T6INDIRECT 20368505 ↗Impact of aldosterone receptor blockade compared with thiazide therapy on sympathetic nervous system
  • T6INDIRECT 33739123 ↗Local Passive Heat for the Treatment of Hypertension in Autonomic Failure
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6 26760044 ↗Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Gui
  • T6 24423978 ↗Adrenocortical carcinoma
  • T6INDIRECT 38441582 ↗Cardiac Amyloidosis Due to Transthyretin Protein: A Review
  • T6INDIRECT 23184849 ↗Grapefruit-medication interactions: forbidden fruit or avoidable consequences?
  • T6INDIRECT 34403043 ↗Autonomic dysfunction in SARS-COV-2 infection acute and long-term implications COVID-19 editor's pag
  • T6INDIRECT 27406184 ↗Interventional procedures and future drug therapy for hypertension
  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6 36507632 ↗10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2023
  • T6 38078592 ↗10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2024
  • T6 39353925 ↗Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy
  • T6 39651970 ↗10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2025
  • T6 27471550 ↗Interactions between kidney disease and diabetes: dangerous liaisons
  • T6 30354828 ↗Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the Ameri
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
Everolimus
T6
T6 — Mechanistic / preclinical
POTS
16 sources
  • T6INDIRECT 36005278 ↗Hypoxia-inducible factor stabilisers for the anaemia of chronic kidney disease
  • T6INDIRECT 38299639 ↗Non-immunosuppressive treatment for IgA nephropathy
  • T6INDIRECT 29217664 ↗Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Re
  • T6INDIRECT 26366058 ↗Phase III study of pasireotide long-acting release in patients with metastatic neuroendocrine tumors
  • T6INDIRECT 31407088 ↗Autonomic cardiovascular control changes in recent heart transplant recipients lead to physiological
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6 24423978 ↗Adrenocortical carcinoma
  • T6INDIRECT 23184849 ↗Grapefruit-medication interactions: forbidden fruit or avoidable consequences?
  • T6INDIRECT 24636754 ↗Pheochromocytoma and paraganglioma: diagnosis, genetics, management, and treatment
  • T6INDIRECT 31130732 ↗Surgery of the lateral skull base: a 50-year endeavour
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 28174091 ↗Inhibitors of cyclin-dependent kinases as cancer therapeutics
  • T6 21092758 ↗CYP17 inhibitors for prostate cancer therapy
Exenatide Pen Injector [Bydureon]
T6
T6 — Mechanistic / preclinical
POTS
Exercise Self-Monitoring
T6
T6 — Mechanistic / preclinical
POTS
3 sources
  • T6 34295408 ↗Treatment burden and ability to work
  • T6 34632375 ↗Self-Monitoring of Balance Performance can Reduce the Rate of Falls Among Older Adults
  • T6 23949610 ↗Abstracts of the 49th EASD (European Association for the Study of Diabetes) Annual Meeting. Septembe
Expectation-Enhancing Informational Framing
T6
T6 — Mechanistic / preclinical
POTS
Fesoterodine
T6
T6 — Mechanistic / preclinical
POTS
20 sources
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 28655357 ↗Drug-related problems and medication reviews among old people with dementia
  • T6 29508455 ↗Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
  • T6 23186897 ↗Transverse myelitis
  • T6 23184849 ↗Grapefruit-medication interactions: forbidden fruit or avoidable consequences?
  • T6 37139824 ↗American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medicatio
  • T6 37465527 ↗Research on prescribing cascades: a scoping review
  • T6 34769943 ↗Evaluation of Silodosin and Pelvic Floor Muscle Training in Men with Benign Prostatic Hyperplasia an
  • T6INDIRECT 25125424 ↗Lower urinary tract symptoms in men
  • T6INDIRECT 32767032 ↗Current Management and Emerging Therapies in Multiple System Atrophy
  • T6INDIRECT 40507996 ↗Hazardous Interactions Between Food, Herbs, and Drugs in the First Stage of Biotransformation: Case
  • T6INDIRECT 28503229 ↗CUA guideline on adult overactive bladder
  • T6 33137942 ↗Prodrugs for Improved Drug Delivery: Lessons Learned from Recently Developed and Marketed Products
  • T6 34885733 ↗Treatment of Benign Prostatic Hyperplasia by Natural Drugs
  • T6 36051157 ↗Evolving Role of Silodosin for the Treatment of Urological Disorders - A Narrative Review
  • T6 27629059 ↗New medical treatments for lower urinary tract symptoms due to benign prostatic hyperplasia and futu
  • T6 34991304 ↗A Review of Aging and the Lower Urinary Tract: The Future of Urology
  • T6 36533160 ↗Subjective cognitive decline, mild cognitive impairment, and dementia - syndromic approach: recommen
  • T6 33065745 ↗Neurogenic Bladder: Epidemiology, Diagnosis, and Management
  • T6 34276544 ↗Best Practices in the Clinical Management of Progressive Supranuclear Palsy and Corticobasal Syndrom
Fu's needling
T6
T6 — Mechanistic / preclinical
POTS
Gemcitabine
T6
T6 — Mechanistic / preclinical
POTS
20 sources
  • T6INDIRECT 37756687 ↗Toxicity profiles of antibody-drug conjugates for anticancer treatment: a systematic review and meta
  • T6INDIRECT 36482103 ↗Atezolizumab plus anthracycline-based chemotherapy in metastatic triple-negative breast cancer: the
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6 24423978 ↗Adrenocortical carcinoma
  • T6 24323045 ↗Autophagy and human diseases
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 33895845 ↗2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral A
  • T6 26561559 ↗Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924)
  • T6 27044938 ↗Phase I Study of LY2606368, a Checkpoint Kinase 1 Inhibitor, in Patients With Advanced Cancer
  • T6 26377597 ↗Phase 2 study of frontline brentuximab vedotin monotherapy in Hodgkin lymphoma patients aged 60 year
  • T6INDIRECT 34655433 ↗Chemotherapy-Induced Peripheral Neuropathy: Epidemiology, Pathomechanisms and Treatment
  • T6INDIRECT 24672257 ↗Chemotherapy-induced peripheral neuropathy in adults: a comprehensive update of the literature
  • T6INDIRECT 23186897 ↗Transverse myelitis
  • T6INDIRECT 23594434 ↗A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival
  • T6INDIRECT 32117030 ↗Posterior Reversible Encephalopathy Syndrome: Clinical Features and Outcome
  • T6INDIRECT 34134525 ↗Recognition, Prevention, and Management of Arrhythmias and Autonomic Disorders in Cardio-Oncology: A
  • T6 37919282 ↗Smart nanoparticles for cancer therapy
  • T6 30130469 ↗Iron and Cancer
  • T6 23095830 ↗Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and preven
  • T6 26391778 ↗Cancer-treatment-induced neurotoxicity--focus on newer treatments
Gonadotropin Releasing Hormone Agonists
T6
T6 — Mechanistic / preclinical
POTS
11 sources
  • T6 28293453 ↗An overview and management of osteoporosis
  • T6 23470964 ↗Molecular pathways: Inhibiting steroid biosynthesis in prostate cancer
  • T6INDIRECT 16223449 ↗Familial clustering of Leiomyomatosis peritonealis disseminata: an unknown genetic syndrome?
  • T6 25182228 ↗Clinician's Guide to Prevention and Treatment of Osteoporosis
  • T6 35478046 ↗The clinician's guide to prevention and treatment of osteoporosis
  • T6INDIRECT 32028907 ↗Computed tomography evaluation of extensive intravenous angioleiomyoma: a case report
  • T6INDIRECT 40575073 ↗Primary hyperhidrosis: an updated review
  • T6INDIRECT 41438256 ↗Peritoneal Inclusion Cyst Mimicking Adrenal Pathology in a Young Man: A Rare Case Report
  • T6INDIRECT 19350330 ↗Abstracts of the Society of General Internal Medicine 32nd Annual Meeting. Miami Beach, Florida, USA
  • T6 38939420 ↗A Comprehensive Review of the Efficacy and Safety of Dopamine Agonists for Women with Endometriosis-
  • T6 40566700 ↗A Pragmatic Approach to Sexual Health in Movement Disorders
Goserelin
T6
T6 — Mechanistic / preclinical
POTS
17 sources
  • T6INDIRECT 24595586 ↗Non-surgical interventions for the management of chronic pelvic pain
  • T6INDIRECT 31727154 ↗Blood-derived dendritic cell vaccinations induce immune responses that correlate with clinical outco
  • T6INDIRECT 9810943 ↗Subcutaneous apomorphine in late stage Parkinson's disease: a long term follow up
  • T6INDIRECT 30580266 ↗Chemoprevention in BRCA1 mutation carriers (CIBRAC): protocol for an open allocation crossover feasi
  • T6 34451161 ↗Critical Review of Biodegradable and Bioactive Polymer Composites for Bone Tissue Engineering and Dr
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
  • T6INDIRECT 31960741 ↗Multimodality Cardiac Imaging in the Era of Emerging Cancer Therapies
  • T6INDIRECT 36811119 ↗Clozapine is the approved option in treatment-resistant schizophrenia and requires careful managemen
  • T6INDIRECT 34745786 ↗Treatment and Management of Sexual Disinhibition in Elderly Patients With Neurocognitive Disorders
  • T6INDIRECT 37685769 ↗Primary Hemostasis Disorders as a Cause of Heavy Menstrual Bleeding in Women of Reproductive Age
  • T6INDIRECT 32276665 ↗The French national protocol for Kennedy's disease (SBMA): consensus diagnostic and management recom
  • T6INDIRECT 37968732 ↗Symptomatic treatment options for Huntington's disease (guidelines of the German Neurological Societ
  • T6 41461581 ↗The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors
  • T6 25928806 ↗Proceedings of the fourth international conference on central hypoventilation
  • T6 33948343 ↗Prostate cancer racial, socioeconomic, geographic disparities: targeting the genomic landscape and s
Graded motor imagery
T6
T6 — Mechanistic / preclinical
POTS
16 sources
  • T6INDIRECT 23633371 ↗Interventions for treating pain and disability in adults with complex regional pain syndrome
  • T6INDIRECT 41683658 ↗Beyond the Pain: Rethinking Chronic Pain Management Through Integrated Therapeutic Approaches-A Syst
  • T6 31871494 ↗Therapeutic Approaches for Peripheral and Central Neuropathic Pain
  • T6 27973405 ↗Chronic Pain in Children and Adolescents: Diagnosis and Treatment of Primary Pain Disorders in Head,
  • T6 35295500 ↗Complex Regional Pain Syndrome. A Comprehensive Review on Neuroplastic Changes Supporting the Use of
  • T6 32802594 ↗Immersive Virtual Reality for Pain Relief in Upper Limb Complex Regional Pain Syndrome: A Pilot Stud
  • T6INDIRECT 35005361 ↗Evidence of motor system reorganization in complex regional pain syndrome type 1: A case report
  • T6INDIRECT 27582958 ↗The clinical physiotherapy assessment of non-traumatic shoulder instability
  • T6INDIRECT 36466621 ↗Altered bodily perceptions in chronic neuropathic pain conditions and implications for treatment usi
  • T6INDIRECT 41743427 ↗Current status and future prospects of brain-computer interfaces in the field of neurological diseas
  • T6 35195724 ↗Association of Chiropractic Colleges Research Agenda Conference 2022: Wellness and Health Promotion:
  • T6 40986224 ↗World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2025)
  • T6 PMC11235737 ↗ePresentations
  • T6 PMC10795779 ↗Book of Posters
  • T6 PMC9377251 ↗Symposia Abstracts
  • T6 33490941 ↗Complex regional pain syndrome - Autoimmune or functional neurologic syndrome
HZT-501
T6
T6 — Mechanistic / preclinical
POTS
Home sleep study device
T6
T6 — Mechanistic / preclinical
POTS
Horse Anti-Thymocyte Globulin
T6
T6 — Mechanistic / preclinical
POTS
Hybrid Cardiac Rehabilitation Program
T6
T6 — Mechanistic / preclinical
POTS
1 source
  • T6 40869705 ↗Implementation of a Hybrid Cardiac Rehabilitation and Symptom Scoring System in Patients with Inappr
Hydralazine
T6
T6 — Mechanistic / preclinical
POTS
23 sources
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 24158454 ↗Blood pressure control and primary prevention of stroke: summary of the recent clinical trial data a
  • T6INDIRECT 24869750 ↗Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension
  • T6INDIRECT 32519776 ↗Withdrawal of antihypertensive drugs in older people
  • T6INDIRECT 24902920 ↗The design and rationale of a multicenter clinical trial comparing two strategies for control of sys
  • T6INDIRECT 1540729 ↗Renal protective effect of enalapril in diabetic nephropathy
  • T6INDIRECT 26906034 ↗Interleukin-1 Blockade in Acute Decompensated Heart Failure: A Randomized, Double-Blinded, Placebo-C
  • T6INDIRECT 2337713 ↗Contrasting effects of enalapril and metoprolol on proteinuria in diabetic nephropathy
  • T6INDIRECT 28655357 ↗Drug-related problems and medication reviews among old people with dementia
  • T6INDIRECT 24650926 ↗A randomized pilot study of aortic waveform guided therapy in chronic heart failure
  • T6INDIRECT 24229653 ↗What are the causes of late-life depression?
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 29508455 ↗Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
  • T6INDIRECT 23186897 ↗Transverse myelitis
  • T6INDIRECT 28862947 ↗Role of Volume Redistribution in the Congestion of Heart Failure
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6 36507632 ↗10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2023
  • T6 38078592 ↗10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2024
  • T6 29315692 ↗Comprehensive review of cardiovascular toxicity of drugs and related agents
  • T6 25767284 ↗The sympathetic nervous system alterations in human hypertension
  • T6 30354828 ↗Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the Ameri
Hydrochlorothiazide
T6
T6 — Mechanistic / preclinical
POTS
25 sources
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 19821318 ↗Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitiv
  • T6INDIRECT 33107592 ↗Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progr
  • T6INDIRECT 24869750 ↗Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension
  • T6INDIRECT 1540729 ↗Renal protective effect of enalapril in diabetic nephropathy
  • T6INDIRECT 18398080 ↗Effect of lower targets for blood pressure and LDL cholesterol on atherosclerosis in diabetes: the S
  • T6INDIRECT 34739197 ↗Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease
  • T6INDIRECT 26936519 ↗Dapagliflozin reduces albuminuria in patients with diabetes and hypertension receiving renin-angiote
  • T6INDIRECT 18326958 ↗Efficacy of the combination of amlodipine and valsartan in patients with hypertension uncontrolled w
  • T6INDIRECT 22187469 ↗Standards of medical care in diabetes--2012
  • T6INDIRECT 23094876 ↗Brugada phenocopy: new terminology and proposed classification
  • T6INDIRECT 29508455 ↗Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
  • T6INDIRECT 20396637 ↗Inappropriate prescribing in the hospitalized elderly patient: defining the problem, evaluation tool
  • T6INDIRECT 23264422 ↗Standards of medical care in diabetes--2013
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 21193625 ↗Standards of medical care in diabetes--2011
  • T6 29565029 ↗Hypertension
  • T6 26111766 ↗SLC transporters as therapeutic targets: emerging opportunities
  • T6 33769101 ↗Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
  • T6 18266020 ↗European guidance for the diagnosis and management of osteoporosis in postmenopausal women
  • T6 32792490 ↗Podocytopathies
  • T6 32213941 ↗Chemical Constituents and Pharmacological Activities of Garlic (<i>Allium sativum</i> L.): A Review
  • T6 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6 30354828 ↗Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the Ameri
Hydrocodone ER
T6
T6 — Mechanistic / preclinical
POTS
1 source
  • T6INDIRECT 31073926 ↗Safety of Opioids in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis
Hypnotherapy
T6
T6 — Mechanistic / preclinical
POTS
23 sources
  • T6INDIRECT 24018704 ↗Physiotherapy versus placebo or no intervention in Parkinson's disease
  • T6INDIRECT 30578633 ↗Psychological therapies for anxiety and depression in children and adolescents with long-term physic
  • T6INDIRECT 36515150 ↗Management of REM sleep behavior disorder: an American Academy of Sleep Medicine systematic review,
  • T6INDIRECT 39607990 ↗Systematic review and meta-analysis of the effect of psychological interventions on anxiety in child
  • T6INDIRECT 31129916 ↗Interventions for improving sleep quality in people with chronic kidney disease
  • T6INDIRECT 34844288 ↗Interventions for the management of abdominal pain in Crohn's disease and inflammatory bowel disease
  • T6INDIRECT 34291816 ↗Interventions for the management of abdominal pain in ulcerative colitis
  • T6INDIRECT 37751413 ↗Experiences of people with long COVID: Symptoms, support strategies and the Long COVID Optimal Healt
  • T6 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6 35430029 ↗Functional neurological disorder: new subtypes and shared mechanisms
  • T6INDIRECT 30789419 ↗Diagnosis and Treatment of Rumination Syndrome: A Critical Review
  • T6INDIRECT 37496529 ↗Efficacy of Stellate Ganglion Block in Treating Long-Term COVID-19-Related Olfactory and Gustatory D
  • T6INDIRECT 28368365 ↗Mind-Body Interventions for Pediatric Inflammatory Bowel Disease
  • T6INDIRECT 27582958 ↗The clinical physiotherapy assessment of non-traumatic shoulder instability
  • T6INDIRECT 20726290 ↗Best practice guide for the treatment of nightmare disorder in adults
  • T6 29163522 ↗The Vagus Nerve in the Neuro-Immune Axis: Implications in the Pathology of the Gastrointestinal Trac
  • T6 37629273 ↗The Impact of Microbiota on the Gut-Brain Axis: Examining the Complex Interplay and Implications
  • T6 39319312 ↗Role of stress and early-life stress in the pathogeny of inflammatory bowel disease
  • T6 32213001 ↗UEG Week 2019 Poster Presentations
  • T6 39754724 ↗European Guideline on Chronic Nausea and Vomiting-A UEG and ESNM Consensus for Clinical Management
  • T6 PMC6643206 ↗E-Poster Viewing
  • T6 25973272 ↗Central sensitization syndrome and the initial evaluation of a patient with fibromyalgia: a review
  • T6 36467081 ↗Treatment of ADHD: Drugs, psychological therapies, devices, complementary and alternative methods as
IPTp-DP
T6
T6 — Mechanistic / preclinical
POTS
1 source
  • T6 26259941 ↗Urban Malaria: Understanding its Epidemiology, Ecology, and Transmission Across Seven Diverse ICEMR
ISTp-DP
T6
T6 — Mechanistic / preclinical
POTS
1 source
  • T6 34064288 ↗Discrimination of Genetically Very Close Accessions of Sweet Orange (<i>Citrus sinensis</i> L. Osbec
IV saline / fluid loading
T6
T6 — Mechanistic / preclinical
POTS
Immunoabsorption/plasmapheresis procedure
T6
T6 — Mechanistic / preclinical
POTS
In clinic VRpain reduction exercises + VR homeworks
T6
T6 — Mechanistic / preclinical
POTS
Inflatable abdominal binder
T6
T6 — Mechanistic / preclinical
POTS
9 sources
  • T6INDIRECT 27271310 ↗Efficacy of Servo-Controlled Splanchnic Venous Compression in the Treatment of Orthostatic Hypotensi
  • T6INDIRECT 32673517 ↗Splanchnic Venous Compression Enhances the Effects of ß-Blockade in the Treatment of Postural Tachyc
  • T6 28050656 ↗The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic o
  • T6 35230654 ↗Advances in the Pathophysiology and Management of Supine Hypertension in Patients with Neurogenic Or
  • T6 32943966 ↗Neurogenic Orthostatic Hypotension: State of the Art and Therapeutic Strategies
  • T6INDIRECT 32906173 ↗Clinical Trials for Neurogenic Orthostatic Hypotension: A Comprehensive Review of Endpoints, Pitfall
  • T6 35591450 ↗Assessment of Abdominal Constrictor's Forces for Informing Computational Models of Orthostatic Hypot
  • T6 32038283 ↗Intermittent Calf Compression Delays the Onset of Presyncope in Young Healthy Individuals
  • T6 41404536 ↗Update on the Treatment of Autonomic Disorders
Insulin
T6
T6 — Mechanistic / preclinical
POTS
24 sources
  • T6INDIRECT 32541925 ↗Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million p
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 20566676 ↗Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and e
  • T6INDIRECT 19114612 ↗Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
  • T6INDIRECT 23279307 ↗Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequat
  • T6INDIRECT 24067431 ↗Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflo
  • T6INDIRECT 24902920 ↗The design and rationale of a multicenter clinical trial comparing two strategies for control of sys
  • T6INDIRECT 24026211 ↗Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 d
  • T6INDIRECT 21816980 ↗Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequat
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 27999003 ↗Diabetic Neuropathy: A Position Statement by the American Diabetes Association
  • T6INDIRECT 22187469 ↗Standards of medical care in diabetes--2012
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 23264422 ↗Standards of medical care in diabetes--2013
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 21193625 ↗Standards of medical care in diabetes--2011
  • T6 29075003 ↗Trends in GPCR drug discovery: new agents, targets and indications
  • T6 28585944 ↗Cellular uptake of nanoparticles: journey inside the cell
  • T6 23968694 ↗Sugar for the brain: the role of glucose in physiological and pathological brain function
  • T6 36148880 ↗Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes As
  • T6 33753937 ↗Post-acute COVID-19 syndrome
  • T6 20876709 ↗Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treat
Ipratropium-bromide
T6
T6 — Mechanistic / preclinical
POTS
18 sources
  • T6INDIRECT 27115217 ↗Intranasal steroids versus placebo or no intervention for chronic rhinosinusitis
  • T6INDIRECT 27115215 ↗Different types of intranasal steroids for chronic rhinosinusitis
  • T6INDIRECT 23740736 ↗Metered dose inhalers versus nebulizers for aerosol bronchodilator delivery for adult patients recei
  • T6INDIRECT 35355450 ↗The impact of identifying laryngeal obstruction syndromes on reducing treatment of pediatric asthma:
  • T6INDIRECT 7742148 ↗The reproducibility and effect on non-specific airway responsiveness of inhaled prostaglandin D2 and
  • T6INDIRECT 29234869 ↗A Controlled Trial of Inhaled Bronchodilators in Familial Dysautonomia
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6 24699931 ↗Non-motor Parkinson's: integral to motor Parkinson's, yet often neglected
  • T6 25200111 ↗Drooling in Parkinson's disease: a review
  • T6INDIRECT 28050310 ↗Gastrointestinal Dysfunctions in Parkinson's Disease: Symptoms and Treatments
  • T6INDIRECT 32397615 ↗Future Trends in Nebulized Therapies for Pulmonary Disease
  • T6INDIRECT 36927875 ↗Multiple system atrophy
  • T6INDIRECT 36994117 ↗Second to none: rationale, timing, and clinical management of clozapine use in schizophrenia
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6 35453749 ↗Inflammation and Oxidative Stress as Common Mechanisms of Pulmonary, Autonomic and Musculoskeletal D
  • T6 31277288 ↗Effects of Water Availability in the Soil on Tropane Alkaloid Production in Cultivated <i>Datura str
  • T6 27433087 ↗Gut dysfunction in Parkinson's disease
Irinotecan
T6
T6 — Mechanistic / preclinical
POTS
18 sources
  • T6INDIRECT 27070085 ↗Wait-and-see treatment strategies for rectal cancer patients with clinical complete response after n
  • T6INDIRECT 37756687 ↗Toxicity profiles of antibody-drug conjugates for anticancer treatment: a systematic review and meta
  • T6INDIRECT 38478773 ↗Cannabis and Cannabinoids in Adults With Cancer: ASCO Guideline
  • T6INDIRECT 16940980 ↗CPT-11 and concomitant hyperfractionated accelerated radiotherapy induce efficient local control in
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6 24423978 ↗Adrenocortical carcinoma
  • T6 37919282 ↗Smart nanoparticles for cancer therapy
  • T6 23095830 ↗Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and preven
  • T6 35648703 ↗Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer
  • T6 27044938 ↗Phase I Study of LY2606368, a Checkpoint Kinase 1 Inhibitor, in Patients With Advanced Cancer
  • T6INDIRECT 24672257 ↗Chemotherapy-induced peripheral neuropathy in adults: a comprehensive update of the literature
  • T6INDIRECT 32880078 ↗Therapeutics for COVID-19: from computation to practices-where we are, where we are heading to
  • T6INDIRECT 38087070 ↗Gut Microbiota Modulation and Its Implications on Neuropathic Pain: A Comprehensive Literature Revie
  • T6INDIRECT 34094953 ↗The Use of Antihypertensive Drugs as Coadjuvant Therapy in Cancer
  • T6INDIRECT 35510137 ↗International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines
  • T6 35159802 ↗Review on Nanoparticles and Nanostructured Materials: Bioimaging, Biosensing, Drug Delivery, Tissue
  • T6 37124134 ↗Immunotherapy in glioblastoma treatment: Current state and future prospects
  • T6 34948113 ↗Genophenotypic Factors and Pharmacogenomics in Adverse Drug Reactions
Isometric Exercise Training
T6
T6 — Mechanistic / preclinical
POTS
4 sources
  • T6 38762832 ↗Isometric Exercise Training and Arterial Hypertension: An Updated Review
  • T6 37581135 ↗Evaluation of Cardiovascular Response to Isometric Handgrip Exercise in Obese Individuals
  • T6 39831301 ↗Physical function estimates change in pain following IIPT among children with chronic pain
  • T6 PMC8148279 ↗Neural Hormonal Mechanisms (Renin; Neural Control; Vasoactive Autacoids)
Kerendia
T6
T6 — Mechanistic / preclinical
POTS
1 source
  • T6 36345396 ↗Clinical Evaluation of Dapagliflozin in the Management of CKD: Focus on Patient Selection and Clinic
Ketamine
T6
T6 — Mechanistic / preclinical
POTS
25 sources
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 26355598 ↗Local Anesthetic Peripheral Nerve Block Adjuvants for Prolongation of Analgesia: A Systematic Qualit
  • T6INDIRECT 23633371 ↗Interventions for treating pain and disability in adults with complex regional pain syndrome
  • T6INDIRECT 15846598 ↗Electroconvulsive therapy for schizophrenia
  • T6INDIRECT 27419911 ↗Epidural local anaesthetics versus opioid-based analgesic regimens for postoperative gastrointestina
  • T6INDIRECT 25866139 ↗Warming of intravenous and irrigation fluids for preventing inadvertent perioperative hypothermia
  • T6INDIRECT 23076930 ↗Local anaesthetics and regional anaesthesia for preventing chronic pain after surgery
  • T6INDIRECT 35234292 ↗Pharmacotherapy for post traumatic stress disorder (PTSD)
  • T6INDIRECT 24126931 ↗Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with mini
  • T6INDIRECT 34743319 ↗Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double-Blind
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 31663402 ↗Consensus statement for perioperative care in total hip replacement and total knee replacement surge
  • T6INDIRECT 26514824 ↗Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for
  • T6INDIRECT 34655433 ↗Chemotherapy-Induced Peripheral Neuropathy: Epidemiology, Pathomechanisms and Treatment
  • T6INDIRECT 23094876 ↗Brugada phenocopy: new terminology and proposed classification
  • T6INDIRECT 31871494 ↗Therapeutic Approaches for Peripheral and Central Neuropathic Pain
  • T6INDIRECT 23184849 ↗Grapefruit-medication interactions: forbidden fruit or avoidable consequences?
  • T6 22160349 ↗The novel object recognition memory: neurobiology, test procedure, and its modifications
  • T6 33769101 ↗Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
  • T6 30909387 ↗Mechanisms of Chemotherapy-Induced Peripheral Neuropathy
  • T6 28298428 ↗Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of th
  • T6 30127324 ↗Current Concepts and Treatments of Schizophrenia
  • T6 31633216 ↗Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
  • T6 20511282 ↗N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observ
  • T6 33907312 ↗The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets
Kinesio Taping
T6
T6 — Mechanistic / preclinical
POTS
12 sources
  • T6INDIRECT 41683658 ↗Beyond the Pain: Rethinking Chronic Pain Management Through Integrated Therapeutic Approaches-A Syst
  • T6INDIRECT 30407326 ↗Management of chronic pain in Ehlers-Danlos syndrome: Two case reports and a review of literature
  • T6 36534007 ↗Dysphagia, dysphonia and olfactory disease: a map of Cochrane evidence relevant to rehabilitation fo
  • T6 34462917 ↗Research priorities for children with neurological impairment and medical complexity in high-income
  • T6 37653505 ↗Psychological interventions for individuals with Ehlers-Danlos syndrome and hypermobility spectrum d
  • T6 40986224 ↗World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2025)
  • T6INDIRECT 41287699 ↗Knee Osteoarthritis: Current Insights Into Pathophysiology and Non-surgical Management Options
  • T6INDIRECT 32119569 ↗Platform and poster presentation abstracts
  • T6INDIRECT 28277786 ↗Platform and poster presentation abstracts
  • T6INDIRECT 32218879 ↗Abstracts of the 14th International Congress of the European Geriatric Medicine Society: 10-12 Octob
  • T6 PMC12075107 ↗ESPGHAN 57th Annual Meeting Abstracts
  • T6 PMC8853075 ↗World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2021): Po
L-acetyl carnitine
T6
T6 — Mechanistic / preclinical
POTS
3 sources
  • T6 21321035 ↗Health effects of energy drinks on children, adolescents, and young adults
  • T6 32676851 ↗Four-Repeat Tauopathies: Current Management and Future Treatments
  • T6 34512258 ↗Novel Therapies for Parkinsonian Syndromes-Recent Progress and Future Perspectives
L-arginine
T6
T6 — Mechanistic / preclinical
POTS
26 sources
  • T6INDIRECT 25924806 ↗Clinical symptoms, signs and tests for identification of impending and current water-loss dehydratio
  • T6INDIRECT 30701543 ↗Phosphodiesterase 5 inhibitors for pulmonary hypertension
  • T6INDIRECT 26774659 ↗Childhood asthma exacerbations and the Arg16 β2-receptor polymorphism: A meta-analysis stratified by
  • T6INDIRECT 36602886 ↗Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis
  • T6INDIRECT 26607938 ↗Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, doub
  • T6INDIRECT 22561596 ↗Desmopressin acutely decreases tachycardia and improves symptoms in the postural tachycardia syndrom
  • T6INDIRECT 3089519 ↗The effect of desmopressin on nocturnal polyuria, overnight weight loss, and morning postural hypote
  • T6INDIRECT 14670816 ↗Mechanisms of postspaceflight orthostatic hypotension: low alpha1-adrenergic receptor responses befo
  • T6INDIRECT 24473484 ↗Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary
  • T6 21092187 ↗Fabry disease
  • T6INDIRECT 30184160 ↗Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints
  • T6INDIRECT 19337156 ↗The IC3D classification of the corneal dystrophies
  • T6INDIRECT 30039193 ↗Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder
  • T6INDIRECT 11179008 ↗Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia
  • T6INDIRECT 11179021 ↗Familial dysautonomia is caused by mutations of the IKAP gene
  • T6INDIRECT 35307156 ↗2022 ACC Expert Consensus Decision Pathway on Cardiovascular Sequelae of COVID-19 in Adults: Myocard
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6 31866818 ↗ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?
  • T6 31710717 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors
  • T6 31633216 ↗Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
  • T6 33907312 ↗The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets
  • T6 32287334 ↗Free radicals, oxidative stress, and antioxidants in human health and disease
  • T6 31196984 ↗Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
  • T6 20646222 ↗Water, hydration, and health
  • T6 20534464 ↗Resting-state functional MRI in depression unmasks increased connectivity between networks via the d
Lartesertib
T6
T6 — Mechanistic / preclinical
POTS
Lenalidamide
T6
T6 — Mechanistic / preclinical
POTS
Lesion-Specific Surgical Correction
T6
T6 — Mechanistic / preclinical
POTS
Letrozole
T6
T6 — Mechanistic / preclinical
POTS
16 sources
  • T6INDIRECT 32382043 ↗Pregnancy rates after slow-release insemination (SRI) and standard bolus intrauterine insemination (
  • T6 24423978 ↗Adrenocortical carcinoma
  • T6 28174091 ↗Inhibitors of cyclin-dependent kinases as cancer therapeutics
  • T6 31277273 ↗Nutrition and Breast Cancer: A Literature Review on Prevention, Treatment and Recurrence
  • T6 33295608 ↗Male infertility due to testicular disorders
  • T6 24131779 ↗A first-in-human, phase 1, dose-escalation study of dinaciclib, a novel cyclin-dependent kinase inhi
  • T6INDIRECT 32576952 ↗Diphthamide-deficiency syndrome: a novel human developmental disorder and ribosomopathy
  • T6INDIRECT 25232325 ↗Cyclophosphamide-induced severe acute hyponatremic encephalopathy in patients with breast cancer: re
  • T6INDIRECT 31818306 ↗Idiopathic mast cell activation syndrome and radiation therapy: a case study, literature review, and
  • T6INDIRECT 31960741 ↗Multimodality Cardiac Imaging in the Era of Emerging Cancer Therapies
  • T6INDIRECT 36835974 ↗The Role of Aromatase Inhibitors in Male Prolactinoma
  • T6INDIRECT 32881895 ↗COVID-19 prevention and treatment: A critical analysis of chloroquine and hydroxychloroquine clinica
  • T6INDIRECT 32086342 ↗RABL6A Is an Essential Driver of MPNSTs that Negatively Regulates the RB1 Pathway and Sensitizes Tum
  • T6 28173850 ↗New horizons in treatment of osteoporosis
  • T6 32452701 ↗An up-to-date overview of computational polypharmacology in modern drug discovery
  • T6 29607374 ↗Targeted Therapy: Attacking Cancer with Molecular and Immunological Targeted Agents
Leuprolide
T6
T6 — Mechanistic / preclinical
POTS
16 sources
  • T6INDIRECT 18509106 ↗Pharmacotherapy for inappropriate sexual behaviors in dementia: a systematic review of literature
  • T6 29075003 ↗Trends in GPCR drug discovery: new agents, targets and indications
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
  • T6INDIRECT 30789419 ↗Diagnosis and Treatment of Rumination Syndrome: A Critical Review
  • T6INDIRECT 31960741 ↗Multimodality Cardiac Imaging in the Era of Emerging Cancer Therapies
  • T6INDIRECT 23486794 ↗Approach to inappropriate sexual behaviour in people with dementia
  • T6INDIRECT 31341757 ↗Pharmacologic Management of Agitation in Patients with Dementia
  • T6INDIRECT 20820780 ↗Long-term safety and effectiveness of the "OptEase" vena cava filter
  • T6INDIRECT 39762640 ↗Impact of extended-course oral nirmatrelvir/ritonavir in established Long COVID: a case series
  • T6INDIRECT 32725471 ↗Abstracts from the 2020 Annual Meeting of the Society of General Internal Medicine
  • T6 41461581 ↗The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors
  • T6 24054763 ↗Differing leukocyte gene expression profiles associated with fatigue in patients with prostate cance
  • T6 18580296 ↗Sex hormone effects on body fluid regulation
Losartan
T6
T6 — Mechanistic / preclinical
POTS
27 sources
  • T6 NCT01210430 ↗Local Vasoconstriction in Postural Tachycardia Syndrome
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30019766 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 33624299 ↗Chloroquine or hydroxychloroquine for prevention and treatment of COVID-19
  • T6INDIRECT 30521670 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 33107592 ↗Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progr
  • T6INDIRECT 24869750 ↗Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension
  • T6INDIRECT 24902920 ↗The design and rationale of a multicenter clinical trial comparing two strategies for control of sys
  • T6INDIRECT 21993710 ↗Effects of olmesartan on renal and cardiovascular outcomes in type 2 diabetes with overt nephropathy
  • T6INDIRECT 34739197 ↗Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease
  • T6INDIRECT 22034636 ↗Sulodexide fails to demonstrate renoprotection in overt type 2 diabetic nephropathy
  • T6INDIRECT 29508455 ↗Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
  • T6INDIRECT 23594434 ↗A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival
  • T6INDIRECT 36787743 ↗Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic
  • T6INDIRECT 31031694 ↗Autonomic Dysfunction in α-Synucleinopathies
  • T6 33769101 ↗Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 34589395 ↗Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic n
  • T6 20978471 ↗The relationship between blood pressure and cognitive function
  • T6 23588782 ↗Applications of CYP450 testing in the clinical setting
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
  • T6 25514304 ↗The diagnosis and management of mild cognitive impairment: a clinical review
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
  • T6 31210940 ↗European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gl
  • T6 16365341 ↗JBS 2: Joint British Societies' guidelines on prevention of cardiovascular disease in clinical pract
Low-Dose Total Body Irradiation
T6
T6 — Mechanistic / preclinical
POTS
3 sources
  • T6 36323940 ↗The 48<sup>th</sup> Annual Meeting of the European Society for Blood and Marrow Transplantation: Phy
  • T6 PMC11177578 ↗EHA2024 Hybrid Congress
  • T6 PMC4894295 ↗21st Congress of the European Hematology Association Copenhagen, Denmark, June 9–12, 2016
M1774
T6
T6 — Mechanistic / preclinical
POTS
Maintenance:BEVACIZUMAB
T6
T6 — Mechanistic / preclinical
POTS
Maintenance:BEVACIZUMAB+CAPECITABINE+CYCLOPHOSPHAMIDE
T6
T6 — Mechanistic / preclinical
POTS
Massage
T6
T6 — Mechanistic / preclinical
POTS
28 sources
  • T6INDIRECT 30191554 ↗Interventions for preventing falls in older people in care facilities and hospitals
  • T6INDIRECT 33091160 ↗Electromechanical-assisted training for walking after stroke
  • T6INDIRECT 23633371 ↗Interventions for treating pain and disability in adults with complex regional pain syndrome
  • T6INDIRECT 20537128 ↗Post-injection delirium/sedation syndrome in patients with schizophrenia treated with olanzapine lon
  • T6INDIRECT 36602886 ↗Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis
  • T6INDIRECT 36282618 ↗Support for healthy breastfeeding mothers with healthy term babies
  • T6INDIRECT 12521968 ↗Multifactorial intervention after a fall in older people with cognitive impairment and dementia pres
  • T6INDIRECT 20946990 ↗A pilot randomized controlled trial of the Yoga of Awareness program in the management of fibromyalg
  • T6INDIRECT 30635141 ↗Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial
  • T6INDIRECT 25304766 ↗The impact of chronic migraine: The Chronic Migraine Epidemiology and Outcomes (CaMEO) Study methods
  • T6INDIRECT 19484833 ↗Evidence-based recommendations for the assessment and management of sleep disorders in older persons
  • T6INDIRECT 34741573 ↗Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considera
  • T6INDIRECT 34655433 ↗Chemotherapy-Induced Peripheral Neuropathy: Epidemiology, Pathomechanisms and Treatment
  • T6INDIRECT 23186897 ↗Transverse myelitis
  • T6INDIRECT 31871494 ↗Therapeutic Approaches for Peripheral and Central Neuropathic Pain
  • T6INDIRECT 32698400 ↗Current State of Knowledge on Primary Sjögren's Syndrome, an Autoimmune Exocrinopathy
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6INDIRECT 38748847 ↗Clinical practice guidelines for the care of girls and women with Turner syndrome
  • T6 26062169 ↗Fear and the Defense Cascade: Clinical Implications and Management
  • T6 26959131 ↗Understanding Neuropathic Corneal Pain--Gaps and Current Therapeutic Approaches
  • T6 33586685 ↗Gastrointestinal motility disorders in neurologic disease
  • T6 21620994 ↗Acute retinal arterial occlusive disorders
  • T6 22229124 ↗The history of Parkinson's disease: early clinical descriptions and neurological therapies
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 25621208 ↗Chronic complications of spinal cord injury
  • T6 36178003 ↗World guidelines for falls prevention and management for older adults: a global initiative
  • T6 16678566 ↗Childhood functional gastrointestinal disorders: child/adolescent
  • T6 35478046 ↗The clinician's guide to prevention and treatment of osteoporosis
Matched Unrelated Donor Hematopoetic Stem Cell Transplant
T6
T6 — Mechanistic / preclinical
POTS
Median Nerve Decompression
T6
T6 — Mechanistic / preclinical
POTS
5 sources
  • T6 1848299 ↗Inherited amyloidosis
  • T6 36387914 ↗New horizons of biomaterials in treatment of nerve damage in diabetes mellitus: A translational pros
  • T6 33203445 ↗Epigenetic profiling of Italian patients identified methylation sites associated with hereditary tra
  • T6 20676282 ↗Cardiac amyloidosis responding to bortezomib: case report and review of literature
  • T6 26087075 ↗Supplement
Memantine
T6
T6 — Mechanistic / preclinical
POTS
24 sources
  • T6INDIRECT 30191554 ↗Interventions for preventing falls in older people in care facilities and hospitals
  • T6INDIRECT 22419314 ↗Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive
  • T6INDIRECT 23633371 ↗Interventions for treating pain and disability in adults with complex regional pain syndrome
  • T6INDIRECT 30556597 ↗Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people
  • T6INDIRECT 21649634 ↗Dementia medications and risk of falls, syncope, and related adverse events: meta-analysis of random
  • T6INDIRECT 27863901 ↗A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease f
  • T6INDIRECT 19700947 ↗Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation
  • T6INDIRECT 28604926 ↗ADS-5102 (Amantadine) Extended-Release Capsules for Levodopa-Induced Dyskinesia in Parkinson Disease
  • T6INDIRECT 28833562 ↗Randomized, placebo-controlled trial of ADS-5102 (amantadine) extended-release capsules for levodopa
  • T6INDIRECT 31853557 ↗Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 23225012 ↗Parkinson's disease
  • T6INDIRECT 28106066 ↗The psychosis spectrum in Parkinson disease
  • T6INDIRECT 31519472 ↗New evidence on the management of Lewy body dementia
  • T6INDIRECT 28781611 ↗Best practice in the management of behavioural and psychological symptoms of dementia
  • T6INDIRECT 23186897 ↗Transverse myelitis
  • T6 20194146 ↗Recommendations for the pharmacological management of neuropathic pain: an overview and literature u
  • T6 28716886 ↗Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases
  • T6 31866818 ↗ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 26595642 ↗Lewy body dementias
  • T6 21875407 ↗N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, va
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
Miransertib
T6
T6 — Mechanistic / preclinical
POTS
1 source
Motor Representation Techniques
T6
T6 — Mechanistic / preclinical
POTS
NGF group
T6
T6 — Mechanistic / preclinical
POTS
1 source
National Institutes of Health Expert Consensus Meeting
T6
T6 — Mechanistic / preclinical
POTS
4 sources
  • T6 34144933 ↗Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019
  • T6 34246578 ↗Postural orthostatic tachycardia syndrome (POTS): Priorities for POTS care and research from a 2019
  • T6 36169159 ↗Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of pos
  • T6 35753858 ↗2022 AHA/ACC Key Data Elements and Definitions for Cardiovascular and Noncardiovascular Complication
Nebivolol Hydrochloride
T6
T6 — Mechanistic / preclinical
POTS
1 source
  • T6 36013259 ↗The Role of the Pharmacist in Selecting the Best Choice of Medication Formulation in Dysphagic Patie
Nicotinamide Riboside
T6
T6 — Mechanistic / preclinical
POTS
20 sources
  • T6INDIRECT 31076938 ↗Physical activity and dietary interventions in diabetic neuropathy: a systematic review
  • T6INDIRECT 40808332 ↗Levodopa and Plant-Derived Bioactive Compounds in Parkinson's Disease: Mechanisms, Efficacy, and Fut
  • T6 27491830 ↗Diabetes and Cognitive Impairment
  • T6 34400495 ↗Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome
  • T6 27797810 ↗Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice
  • T6 28351347 ↗Sporobolus stapfianus: Insights into desiccation tolerance in the resurrection grasses from linking
  • T6INDIRECT 39334239 ↗Cardiovascular adaptations and pathological changes induced by spaceflight: from cellular mechanisms
  • T6INDIRECT 41303689 ↗Neurodegeneration as Ecosystem Failure: A New Paradigm for Prevention and Treatment
  • T6INDIRECT 40598239 ↗Current strategies in the management of dementia with lewy bodies and future directions based on dis
  • T6INDIRECT 40498265 ↗Chronic Fatigue in Cancer Survivorship: Psychiatry Versus Oncology or Psychiatry with Oncology?
  • T6INDIRECT 39996855 ↗Mitochondrial Dysfunction and Its Potential Molecular Interplay in Hypermobile Ehlers-Danlos Syndrom
  • T6INDIRECT 30480150 ↗Program Abstracts from the GSA 2018 Annual Scientific Meeting "The Purposes of Longer Lives"
  • T6INDIRECT 32150216 ↗Abstract: Symposia, Conferences, Oral communications: 10th International Conference on Frailty, Sarc
  • T6INDIRECT 29032633 ↗2017 Annual Meetings
  • T6 38673885 ↗Emerging Therapeutic Strategies in Sarcopenia: An Updated Review on Pathogenesis and Treatment Advan
  • T6 35578945 ↗Physiological Systems in Promoting Frailty
  • T6 34944054 ↗Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson's Disease
  • T6 33129841 ↗Vincristine- and bortezomib-induced neuropathies - from bedside to bench and back
  • T6 34695606 ↗Role of senescence in the chronic health consequences of COVID-19
  • T6 38555403 ↗Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in
Nifedipine
T6
T6 — Mechanistic / preclinical
POTS
26 sources
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 30701543 ↗Phosphodiesterase 5 inhibitors for pulmonary hypertension
  • T6INDIRECT 24869750 ↗Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension
  • T6INDIRECT 32519776 ↗Withdrawal of antihypertensive drugs in older people
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 1540729 ↗Renal protective effect of enalapril in diabetic nephropathy
  • T6INDIRECT 8198938 ↗Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients wit
  • T6INDIRECT 2337713 ↗Contrasting effects of enalapril and metoprolol on proteinuria in diabetic nephropathy
  • T6INDIRECT 9890307 ↗Contrasting effects of vasodilators on blood pressure and sodium balance in the hypertension of auto
  • T6 22258608 ↗The promise of induced pluripotent stem cells in research and therapy
  • T6INDIRECT 23186897 ↗Transverse myelitis
  • T6INDIRECT 24090418 ↗Life-threatening outcomes associated with autonomic dysreflexia: a clinical review
  • T6INDIRECT 23184849 ↗Grapefruit-medication interactions: forbidden fruit or avoidable consequences?
  • T6INDIRECT 20396637 ↗Inappropriate prescribing in the hospitalized elderly patient: defining the problem, evaluation tool
  • T6INDIRECT 22126626 ↗Adverse interactions between antifungal azoles and vincristine: review and analysis of cases
  • T6INDIRECT 37139824 ↗American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medicatio
  • T6INDIRECT 26401246 ↗Statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute
  • T6 33769101 ↗Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 9723817 ↗Grapefruit juice-drug interactions
  • T6 36507632 ↗10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2023
  • T6 38078592 ↗10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2024
  • T6 23850704 ↗Phenotypic screens as a renewed approach for drug discovery
  • T6 25621208 ↗Chronic complications of spinal cord injury
  • T6 30354828 ↗Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the Ameri
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
NightWare
T6
T6 — Mechanistic / preclinical
POTS
Nitroglycerin transdermal
T6
T6 — Mechanistic / preclinical
POTS
5 sources
  • T6INDIRECT 16391172 ↗Clonidine for the treatment of supine hypertension and pressure natriuresis in autonomic failure
  • T6 37109736 ↗Recent Advancement of Medical Patch for Transdermal Drug Delivery
  • T6 34631214 ↗The Pathogenesis and Treatment of Cardiovascular Autonomic Dysfunction in Parkinson's Disease: What
  • T6 40006555 ↗AI-Driven Innovation in Skin Kinetics for Transdermal Drug Delivery: Overcoming Barriers and Enhanci
  • T6 29076058 ↗Pharmacotherapy of Cardiovascular Autonomic Dysfunction in Parkinson Disease
Nitrous Oxide
T6
T6 — Mechanistic / preclinical
POTS
28 sources
  • T6INDIRECT 15846598 ↗Electroconvulsive therapy for schizophrenia
  • T6INDIRECT 27419911 ↗Epidural local anaesthetics versus opioid-based analgesic regimens for postoperative gastrointestina
  • T6INDIRECT 29926477 ↗Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent
  • T6INDIRECT 26222246 ↗Interventions for pain with intrauterine device insertion
  • T6INDIRECT 29694674 ↗Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent
  • T6INDIRECT 34671311 ↗Visual Snow Syndrome as a Network Disorder: A Systematic Review
  • T6INDIRECT 34743319 ↗Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double-Blind
  • T6INDIRECT 14705689 ↗Effect of postoperative skin-surface warming on oxygen consumption and the shivering threshold
  • T6INDIRECT 16732081 ↗Fructose administration increases intraoperative core temperature by augmenting both metabolic rate
  • T6INDIRECT 22189652 ↗Core temperatures during major abdominal surgery in patients warmed with new circulating-water garme
  • T6INDIRECT 26514824 ↗Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for
  • T6INDIRECT 23186897 ↗Transverse myelitis
  • T6INDIRECT 35782167 ↗Biological nitrogen fixation and prospects for ecological intensification in cereal-based cropping s
  • T6INDIRECT 25053156 ↗Recommendations for anesthesia and perioperative management in patients with Ehlers-Danlos syndrome(
  • T6INDIRECT 26387020 ↗Invited review: Recommendations for reporting intervention studies on reproductive performance in da
  • T6INDIRECT 24032030 ↗Controls on soil microbial community stability under climate change
  • T6INDIRECT 26401246 ↗Statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute
  • T6 33769101 ↗Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
  • T6 27671918 ↗Anxiety Disorders and Cardiovascular Disease
  • T6 24248213 ↗Cobalamin deficiency: clinical picture and radiological findings
  • T6 31555890 ↗Doubled haploid technology for line development in maize: technical advances and prospects
  • T6 31141884 ↗Natural Antioxidant Anthocyanins-A Hidden Therapeutic Candidate in Metabolic Disorders with Major Fo
  • T6 27403447 ↗Cerebral blood flow and autoregulation: current measurement techniques and prospects for noninvasive
  • T6 29429934 ↗Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary
  • T6 34386109 ↗JCS/JHRS 2019 guideline on non-pharmacotherapy of cardiac arrhythmias
  • T6 14726459 ↗Global change and human vulnerability to vector-borne diseases
  • T6 30072764 ↗Soil bacterial networks are less stable under drought than fungal networks
  • T6 30587246 ↗Rhizosphere microorganisms can influence the timing of plant flowering
Nutrition
T6
T6 — Mechanistic / preclinical
POTS
21 sources
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 35739136 ↗Long-COVID in children and adolescents: a systematic review and meta-analyses
  • T6INDIRECT 32690803 ↗Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observa
  • T6INDIRECT 30191554 ↗Interventions for preventing falls in older people in care facilities and hospitals
  • T6INDIRECT 32840686 ↗Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cas
  • T6INDIRECT 20427088 ↗Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt l
  • T6INDIRECT 27195814 ↗Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75
  • T6INDIRECT 22492586 ↗Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metf
  • T6INDIRECT 22446170 ↗Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycemia risk in pati
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 22187469 ↗Standards of medical care in diabetes--2012
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 23264422 ↗Standards of medical care in diabetes--2013
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 21193625 ↗Standards of medical care in diabetes--2011
  • T6 36148880 ↗Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes As
  • T6 33753937 ↗Post-acute COVID-19 syndrome
  • T6 20876709 ↗Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treat
  • T6 25182228 ↗Clinician's Guide to Prevention and Treatment of Osteoporosis
  • T6 30291106 ↗Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes As
Olaparib
T6
T6 — Mechanistic / preclinical
POTS
14 sources
  • T6 32404379 ↗Clinical trials in REM sleep behavioural disorder: challenges and opportunities
  • T6 29607374 ↗Targeted Therapy: Attacking Cancer with Molecular and Immunological Targeted Agents
  • T6 32452701 ↗An up-to-date overview of computational polypharmacology in modern drug discovery
  • T6 33959901 ↗Multidisciplinary practice guidelines for the diagnosis, genetic counseling and treatment of pheochr
  • T6 31189100 ↗Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization
  • T6INDIRECT 40317194 ↗Approach to the Patient With Metastatic Pheochromocytoma and Paraganglioma
  • T6INDIRECT 38652045 ↗Approach to the Patient: Concept and Application of Targeted Radiotherapy in the Paraganglioma Patie
  • T6INDIRECT 32862332 ↗Emerging Treatments for Advanced/Metastatic Pheochromocytoma and Paraganglioma
  • T6INDIRECT 35903274 ↗Pediatric Metastatic Pheochromocytoma and Paraganglioma: Clinical Presentation and Diagnosis, Geneti
  • T6INDIRECT 37916027 ↗Pheochromocytoma: a changing perspective and current concepts
  • T6INDIRECT 38944505 ↗Management of Pheochromocytomas and Paragangliomas
  • T6INDIRECT 31564906 ↗Therapies targeting the signal pathways of pheochromocytoma and paraganglioma
  • T6 35158955 ↗Existing Evidence for the Repurposing of PARP-1 Inhibitors in Rare Demyelinating Diseases
  • T6 33810219 ↗MicroRNAs, Long Non-Coding RNAs, and Circular RNAs: Potential Biomarkers and Therapeutic Targets in
Optional lumbar puncture + blood sample
T6
T6 — Mechanistic / preclinical
POTS
OraVescent Fentanyl
T6
T6 — Mechanistic / preclinical
POTS
Oxygen
T6
T6 — Mechanistic / preclinical
POTS
24 sources
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 33925784 ↗Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systemic Review and Com
  • T6INDIRECT 32840686 ↗Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cas
  • T6INDIRECT 36915214 ↗Roles of neuropathology-associated reactive astrocytes: a systematic review
  • T6INDIRECT 25233067 ↗Systematic review of potential health risks posed by pharmaceutical, occupational and consumer expos
  • T6INDIRECT 32409561 ↗Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, ra
  • T6INDIRECT 20484178 ↗A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis
  • T6INDIRECT 33180097 ↗Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Random
  • T6INDIRECT 8828642 ↗Orthostatic intolerance after spaceflight
  • T6INDIRECT 33831043 ↗Post-COVID-19 syndrome among symptomatic COVID-19 patients: A prospective cohort study in a tertiary
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 27999003 ↗Diabetic Neuropathy: A Position Statement by the American Diabetes Association
  • T6INDIRECT 33243615 ↗Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on
  • T6INDIRECT 34024217 ↗Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6 6326753 ↗Oxygen toxicity, oxygen radicals, transition metals and disease
  • T6 23968694 ↗Sugar for the brain: the role of glucose in physiological and pathological brain function
  • T6 21092187 ↗Fabry disease
  • T6 29565029 ↗Hypertension
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6 33753937 ↗Post-acute COVID-19 syndrome
Oxymetazoline 0.05% nasal solution
T6
T6 — Mechanistic / preclinical
POTS
Pacemaker treatment, pacemaker programmed as active = CLS
T6
T6 — Mechanistic / preclinical
POTS
Pacemaker, programmed as passive = VVI 30 beats per minute
T6
T6 — Mechanistic / preclinical
POTS
Panzyga IVIG
T6
T6 — Mechanistic / preclinical
POTS
Pembrolizumab
T6
T6 — Mechanistic / preclinical
POTS
19 sources
  • T6INDIRECT 29217664 ↗Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Re
  • T6INDIRECT 29271481 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 31917873 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 37189381 ↗Dupilumab in Inflammatory Skin Diseases: A Systematic Review
  • T6INDIRECT 20427088 ↗Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt l
  • T6INDIRECT 27048170 ↗Safety and tolerability of BAN2401--a clinical study in Alzheimer's disease with a protofibril selec
  • T6INDIRECT 31727154 ↗Blood-derived dendritic cell vaccinations induce immune responses that correlate with clinical outco
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 34988090 ↗Treatment of Inflammatory Bowel Disease: A Comprehensive Review
  • T6INDIRECT 30184160 ↗Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints
  • T6INDIRECT 33856918 ↗COVID-19 and Cardiovascular Disease: From Bench to Bedside
  • T6INDIRECT 31954495 ↗Diagnosis and management of toxicities of immune checkpoint inhibitors in hepatocellular carcinoma
  • T6INDIRECT 29222231 ↗AL amyloidosis: from molecular mechanisms to targeted therapies
  • T6INDIRECT 33416999 ↗Rituximab for the treatment of multiple sclerosis: a review
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6 28174091 ↗Inhibitors of cyclin-dependent kinases as cancer therapeutics
  • T6 32114384 ↗Resistance to Checkpoint Inhibition in Cancer Immunotherapy
  • T6 33807303 ↗Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis
Precompression Defibrillation
T6
T6 — Mechanistic / preclinical
POTS
Prism Adaptation Therapy Group
T6
T6 — Mechanistic / preclinical
POTS
Pseudoephedrine
T6
T6 — Mechanistic / preclinical
POTS
24 sources
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 20927745 ↗Finasteride for benign prostatic hyperplasia
  • T6INDIRECT 29932206 ↗Saline irrigation for allergic rhinitis
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 37818791 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 36971690 ↗Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
  • T6INDIRECT 26306400 ↗Effects of hexanic extract of Serenoa repens (Permixon® 160 mg) on inflammation biomarkers in the tr
  • T6INDIRECT 15089807 ↗Modelling the cardiovascular effects of ephedrine
  • T6INDIRECT 23116538 ↗Treatment of multiple system atrophy using intravenous immunoglobulin
  • T6INDIRECT 15066944 ↗Water potentiates the pressor effect of ephedra alkaloids
  • T6INDIRECT 27999003 ↗Diabetic Neuropathy: A Position Statement by the American Diabetes Association
  • T6INDIRECT 19484833 ↗Evidence-based recommendations for the assessment and management of sleep disorders in older persons
  • T6INDIRECT 20396637 ↗Inappropriate prescribing in the hospitalized elderly patient: defining the problem, evaluation tool
  • T6INDIRECT 32117030 ↗Posterior Reversible Encephalopathy Syndrome: Clinical Features and Outcome
  • T6INDIRECT 29058089 ↗Evidence-based treatment of neurogenic orthostatic hypotension and related symptoms
  • T6INDIRECT 24385718 ↗Pharmacotherapy of essential tremor
  • T6 29315692 ↗Comprehensive review of cardiovascular toxicity of drugs and related agents
  • T6 34414219 ↗Antidepressant Drugs Effects on Blood Pressure
  • T6 18500382 ↗Pharmacology of stimulants prohibited by the World Anti-Doping Agency (WADA)
  • T6 23472781 ↗Medical therapy and physical maneuvers in the treatment of the vasovagal syncope and orthostatic hyp
  • T6 33909761 ↗Brazilian Guidelines of Hypertension - 2020
  • T6 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6 22110357 ↗MAO-inhibitors in Parkinson's Disease
  • T6 30354828 ↗Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the Ameri
Quinapril
T6
T6 — Mechanistic / preclinical
POTS
26 sources
  • T6INDIRECT 33107592 ↗Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progr
  • T6INDIRECT 24869750 ↗Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension
  • T6INDIRECT 32519776 ↗Withdrawal of antihypertensive drugs in older people
  • T6INDIRECT 35886227 ↗Adverse Effects of Angiotensin-Converting Enzyme Inhibitors in Humans: A Systematic Review and Meta-
  • T6INDIRECT 30480768 ↗First-line drugs inhibiting the renin angiotensin system versus other first-line antihypertensive dr
  • T6INDIRECT 31167038 ↗Pharmacotherapy for hypertension in adults 60 years or older
  • T6INDIRECT 30832759 ↗The Pharmacological Treatment of Arterial Hypertension in Frail, Older Patients—a Systematic Review
  • T6INDIRECT 24650926 ↗A randomized pilot study of aortic waveform guided therapy in chronic heart failure
  • T6INDIRECT 28373993 ↗Efficacy of Administration of an Angiotensin Converting Enzyme Inhibitor for Two Years on Autonomic
  • T6INDIRECT 31841279 ↗Central blood pressure for the management of hypertension: Is it a practical clinical tool in curren
  • T6INDIRECT 27388039 ↗Pharmacological interventions for treating heart failure in patients with Chagas cardiomyopathy
  • T6INDIRECT 40162571 ↗Withdrawal of antihypertensive drugs in older people
  • T6INDIRECT 29943271 ↗Long-term effects of device-guided slow breathing in stable heart failure patients with reduced ejec
  • T6INDIRECT 19222671 ↗Pheochromocytoma presenting with myocardial infarction, cardiomyopathy, renal failure, pulmonary hem
  • T6INDIRECT 33832606 ↗Management of Women With Acquired Cardiovascular Disease From Pre-Conception Through Pregnancy and P
  • T6INDIRECT 34094953 ↗The Use of Antihypertensive Drugs as Coadjuvant Therapy in Cancer
  • T6INDIRECT 8364814 ↗Report of the Canadian Hypertension Society Consensus Conference: 3. Pharmacologic treatment of esse
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 30793549 ↗Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: W
  • T6 31141884 ↗Natural Antioxidant Anthocyanins-A Hidden Therapeutic Candidate in Metabolic Disorders with Major Fo
  • T6 34948113 ↗Genophenotypic Factors and Pharmacogenomics in Adverse Drug Reactions
  • T6 36552014 ↗Diabetes-Induced Cardiac Autonomic Neuropathy: Impact on Heart Function and Prognosis
  • T6 19475778 ↗Choice of ACE inhibitor combinations in hypertensive patients with type 2 diabetes: update after rec
  • T6 29062239 ↗Cardiac autonomic neuropathy in patients with diabetes mellitus: current perspectives
  • T6 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6 32699774 ↗RSSDI-ESI Clinical Practice Recommendations for the Management of Type 2 Diabetes Mellitus 2020
RMC-4630
T6
T6 — Mechanistic / preclinical
POTS
Rapid Pulse Confirmation Device
T6
T6 — Mechanistic / preclinical
POTS
Rehabilitation
T6
T6 — Mechanistic / preclinical
POTS
22 sources
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 35739136 ↗Long-COVID in children and adolescents: a systematic review and meta-analyses
  • T6INDIRECT 30191554 ↗Interventions for preventing falls in older people in care facilities and hospitals
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 33925784 ↗Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systemic Review and Com
  • T6INDIRECT 32840686 ↗Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cas
  • T6INDIRECT 20484178 ↗A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis
  • T6INDIRECT 16505299 ↗Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI
  • T6INDIRECT 23128427 ↗Randomized clinical trial of 3 types of physical exercise for patients with Parkinson disease
  • T6INDIRECT 33831043 ↗Post-COVID-19 syndrome among symptomatic COVID-19 patients: A prospective cohort study in a tertiary
  • T6INDIRECT 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 22187469 ↗Standards of medical care in diabetes--2012
  • T6INDIRECT 33243615 ↗Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on
  • T6INDIRECT 23264422 ↗Standards of medical care in diabetes--2013
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 21193625 ↗Standards of medical care in diabetes--2011
  • T6 19118286 ↗Standards of medical care in diabetes--2009
  • T6 33753937 ↗Post-acute COVID-19 syndrome
  • T6 20876709 ↗Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treat
  • T6 25182228 ↗Clinician's Guide to Prevention and Treatment of Osteoporosis
Retifanlimab
T6
T6 — Mechanistic / preclinical
POTS
2 sources
  • T6 38617189 ↗Structure and function of therapeutic antibodies approved by the US FDA in 2023
  • T6 41097798 ↗Immune Checkpoint Inhibitors in Merkel Cell Carcinoma of the Skin: A 2025 Comprehensive Review
Rivastigmine tartrate
T6
T6 — Mechanistic / preclinical
POTS
3 sources
  • T6 32357528 ↗Pharmacogenomics of Cognitive Dysfunction and Neuropsychiatric Disorders in Dementia
  • T6 36830034 ↗Effect-Directed, Chemical and Taxonomic Profiling of Peppermint Proprietary Varieties and Correspond
  • T6 37396659 ↗Identifying potential drug-target interactions based on ensemble deep learning
Rosiglitazone
T6
T6 — Mechanistic / preclinical
POTS
25 sources
  • T6INDIRECT 31794067 ↗Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in pe
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 31167038 ↗Pharmacotherapy for hypertension in adults 60 years or older
  • T6INDIRECT 22895968 ↗Momordica charantia for type 2 diabetes mellitus
  • T6INDIRECT 28333365 ↗Clozapine combined with different antipsychotic drugs for treatment-resistant schizophrenia
  • T6INDIRECT 39464183 ↗Risk of bone fracture by using dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor a
  • T6INDIRECT 22446170 ↗Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycemia risk in pati
  • T6INDIRECT 19921145 ↗The gait and balance of patients with diabetes can be improved: a randomised controlled trial
  • T6INDIRECT 31501226 ↗Heart Rate Variability and Cardiac Autonomic Dysfunction: Prevalence, Risk Factors, and Relationship
  • T6INDIRECT 21722580 ↗The effect of type-2-diabetes-related vascular endothelial dysfunction on skin physiology and activi
  • T6INDIRECT 32039382 ↗From NASH to diabetes and from diabetes to NASH: Mechanisms and treatment options
  • T6INDIRECT 35033161 ↗Adherence and persistence rates of major antidiabetic medications: a review
  • T6INDIRECT 26387020 ↗Invited review: Recommendations for reporting intervention studies on reproductive performance in da
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 21193625 ↗Standards of medical care in diabetes--2011
  • T6INDIRECT 19118286 ↗Standards of medical care in diabetes--2009
  • T6INDIRECT 37139824 ↗American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medicatio
  • T6INDIRECT 32699774 ↗RSSDI-ESI Clinical Practice Recommendations for the Management of Type 2 Diabetes Mellitus 2020
  • T6 27491830 ↗Diabetes and Cognitive Impairment
  • T6 27660695 ↗Update on the treatment of type 2 diabetes mellitus
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
  • T6 30291106 ↗Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes As
  • T6 35478046 ↗The clinician's guide to prevention and treatment of osteoporosis
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
Routine physical therapy and exercise program
T6
T6 — Mechanistic / preclinical
POTS
ST-503
T6
T6 — Mechanistic / preclinical
POTS
19 sources
  • T6INDIRECT 30191554 ↗Interventions for preventing falls in older people in care facilities and hospitals
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 31755549 ↗Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention o
  • T6INDIRECT 37818791 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 20427088 ↗Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt l
  • T6INDIRECT 24902920 ↗The design and rationale of a multicenter clinical trial comparing two strategies for control of sys
  • T6INDIRECT 30200910 ↗CRITICS-II: a multicentre randomised phase II trial of neo-adjuvant chemotherapy followed by surgery
  • T6INDIRECT 9285463 ↗Autonomic effects of selegiline: possible cardiovascular toxicity in Parkinson's disease
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6INDIRECT 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 17227286 ↗Review of the pharmacology and clinical profile of bupropion, an antidepressant and tobacco use cess
  • T6 25834232 ↗Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing
  • T6 31633216 ↗Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 8177173 ↗Gas vesicles
  • T6 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
Salbutamol
T6
T6 — Mechanistic / preclinical
POTS
22 sources
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 38580972 ↗A systematic review and meta-analysis on sodium tanshinone IIA sulfonate injection for the adjunctiv
  • T6INDIRECT 25757188 ↗Equivalent Lung Dose and Systemic Exposure of Budesonide/Formoterol Combination via Easyhaler and Tu
  • T6INDIRECT 23179472 ↗Bioequivalence and tolerability assessment of a novel intravenous ciclosporin lipid emulsion compare
  • T6INDIRECT 8098220 ↗Beta adrenoreceptor subtype cross regulation in the human heart
  • T6INDIRECT 20565455 ↗Systemic bioavailability of hydrofluoroalkane (HFA) formulations of fluticasone/salmeterol in health
  • T6INDIRECT 7742148 ↗The reproducibility and effect on non-specific airway responsiveness of inhaled prostaglandin D2 and
  • T6INDIRECT 23589685 ↗Evaluation of effects of shoulder girdle training on strength and performance of activities of daily
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
  • T6INDIRECT 24093037 ↗Reducing pill burden and helping with medication awareness to improve adherence
  • T6INDIRECT 18286801 ↗Cannabinoids in health and disease
  • T6INDIRECT 27712641 ↗Anorectal and Pelvic Pain
  • T6INDIRECT 36868923 ↗Cutaneous lupus erythematosus: a review of etiopathogenic, clinical, diagnostic and therapeutic aspe
  • T6INDIRECT 22143168 ↗Dysautonomia: perioperative implications
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6 10379421 ↗Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines an
  • T6 33573164 ↗Magnesium in Aging, Health and Diseases
  • T6 29315692 ↗Comprehensive review of cardiovascular toxicity of drugs and related agents
  • T6 18308299 ↗Sympathetic modulation of immunity: relevance to disease
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
Sequential Gas Delivery
T6
T6 — Mechanistic / preclinical
POTS
1 source
  • T6 39297140 ↗Reduced Stroke Volume and Brain Perfusion Drive Postural Hyperventilation in Postural Orthostatic Ta
Silver hydroxyapatite
T6
T6 — Mechanistic / preclinical
POTS
1 source
  • T6 34584412 ↗Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Deliver
Single agent, adjuvant anti-PD1 therapy
T6
T6 — Mechanistic / preclinical
POTS
Soticlestat
T6
T6 — Mechanistic / preclinical
POTS
4 sources
  • T6 35483386 ↗CDKL5 deficiency disorder: clinical features, diagnosis, and management
  • T6 38203200 ↗Clinical and Genetic Features of Dravet Syndrome: A Prime Example of the Role of Precision Medicine
  • T6 36923331 ↗Dravet Syndrome as an Example of Precision Medicine in Epilepsy
  • T6 39196806 ↗Advancements in Dravet Syndrome Therapeutics: A Comprehensive Look at Present and Future Treatment H
Sotorasib
T6
T6 — Mechanistic / preclinical
POTS
4 sources
  • T6 37285026 ↗A review of the current state of single-cell proteomics and future perspective
  • T6 39042344 ↗Cardiovascular Toxicity in Cancer Therapy: Protecting the Heart while Combating Cancer
  • T6 41048472 ↗Assessing the Impact of Antidepressants on Cancer Treatment: A Retrospective Analysis of 14 Antineop
  • T6 40498965 ↗EACR 2025 Congress: Innovative Cancer Science, 16-19 June 2025
Standing Table Group
T6
T6 — Mechanistic / preclinical
POTS
State of the science and clinical care from a
T6
T6 — Mechanistic / preclinical
POTS
3 sources
  • T6 34144933 ↗Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019
  • T6 36169159 ↗Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of pos
  • T6 35753858 ↗2022 AHA/ACC Key Data Elements and Definitions for Cardiovascular and Noncardiovascular Complication
Structured Combined Exercise Program
T6
T6 — Mechanistic / preclinical
POTS
Supine/Standing Postural Change Test
T6
T6 — Mechanistic / preclinical
POTS
Suprascapular and median nerve blocks
T6
T6 — Mechanistic / preclinical
POTS
Sural Nerve Graft to the Substantia Nigra
T6
T6 — Mechanistic / preclinical
POTS
TAK-117
T6
T6 — Mechanistic / preclinical
POTS
16 sources
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30019766 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30521670 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 41057811 ↗Depressive disorders: systematic review of approved psychiatric medications (2009-April 2025) and pi
  • T6INDIRECT 38747749 ↗Effects of Vitamin D Supplementation on Central Hemodynamic Parameters and Autonomic Nervous System
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6INDIRECT 6758355 ↗Fasting: the history, pathophysiology and complications
  • T6INDIRECT 32925078 ↗COVID-19: Review of a 21st Century Pandemic from Etiology to Neuro-psychiatric Implications
  • T6INDIRECT 26387020 ↗Invited review: Recommendations for reporting intervention studies on reproductive performance in da
  • T6 27660695 ↗Update on the treatment of type 2 diabetes mellitus
  • T6 36810524 ↗Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions
  • T6 32708302 ↗Small Molecule NF-κB Pathway Inhibitors in Clinic
TAK-341
T6
T6 — Mechanistic / preclinical
POTS
12 sources
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6INDIRECT 32925078 ↗COVID-19: Review of a 21st Century Pandemic from Etiology to Neuro-psychiatric Implications
  • T6INDIRECT 26387020 ↗Invited review: Recommendations for reporting intervention studies on reproductive performance in da
  • T6INDIRECT 37147404 ↗Parkinson's disease therapy: what lies ahead?
  • T6INDIRECT 10490564 ↗Hypotension in patients with coronary disease: can profound hypotensive events cause myocardial isch
  • T6INDIRECT 27770180 ↗40<sup>th</sup> EASD Annual Meeting of the European Association for the Study of Diabetes : Munich,
  • T6 27660695 ↗Update on the treatment of type 2 diabetes mellitus
  • T6 36810524 ↗Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions
TAK-583
T6
T6 — Mechanistic / preclinical
POTS
11 sources
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6INDIRECT 6758355 ↗Fasting: the history, pathophysiology and complications
  • T6INDIRECT 26387020 ↗Invited review: Recommendations for reporting intervention studies on reproductive performance in da
  • T6INDIRECT 27770180 ↗40<sup>th</sup> EASD Annual Meeting of the European Association for the Study of Diabetes : Munich,
  • T6INDIRECT 20820780 ↗Long-term safety and effectiveness of the "OptEase" vena cava filter
  • T6INDIRECT 28795195 ↗53 &lt;sup&gt;rd&lt;/sup&gt; EASD Annual Meeting of the European Association for the Study of Diabet
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
TEV-56286
T6
T6 — Mechanistic / preclinical
POTS
3 sources
  • T6 41440056 ↗Alpha-Synuclein Neurobiology in Parkinson's Disease: A Comprehensive Review of Its Role, Mechanisms,
  • T6 42293144 ↗Multiple system atrophy: integrating clinical phenotypes and multimodal biomarkers for early diagnos
  • T6 41387161 ↗Treatment of primary adult-onset neurodegenerative cerebellar ataxias
Tilt table test
T6
T6 — Mechanistic / preclinical
POTS
25 sources
  • T6INDIRECT 9935002 ↗The North American Vasovagal Pacemaker Study (VPS). A randomized trial of permanent cardiac pacing f
  • T6INDIRECT 10899092 ↗Dual-chamber pacing in the treatment of neurally mediated tilt-positive cardioinhibitory syncope : p
  • T6INDIRECT 15451153 ↗A randomized, double-blind, placebo-controlled study of permanent cardiac pacing for the treatment o
  • T6INDIRECT 10193720 ↗Effects of paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on refractory vasovag
  • T6INDIRECT 16505178 ↗Prevention of Syncope Trial (POST): a randomized, placebo-controlled study of metoprolol in the prev
  • T6INDIRECT 11194602 ↗'The Italian Protocol': a simplified head-up tilt testing potentiated with oral nitroglycerin to ass
  • T6INDIRECT 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
  • T6INDIRECT 12270863 ↗Management of vasovagal syncope: controlling or aborting faints by leg crossing and muscle tensing
  • T6INDIRECT 8941538 ↗Subnormal norepinephrine release relates to presyncope in astronauts after spaceflight
  • T6 33243837 ↗Autonomic dysfunction in 'long COVID': rationale, physiology and management strategies
  • T6INDIRECT 28106066 ↗The psychosis spectrum in Parkinson disease
  • T6INDIRECT 9214258 ↗Diagnosing syncope. Part 2: Unexplained syncope. Clinical Efficacy Assessment Project of the America
  • T6INDIRECT 35841911 ↗Diagnosis and treatment of orthostatic hypotension
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6INDIRECT 27749843 ↗Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 cop
  • T6INDIRECT 11842064 ↗Computational modeling of cardiovascular response to orthostatic stress
  • T6 20668263 ↗REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century
  • T6 19639282 ↗Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophys
  • T6 19962493 ↗Pathophysiology of fibromyalgia
  • T6 17626613 ↗Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia
  • T6 30007465 ↗Hereditary Alpha Tryptasemia: Genotyping and Associated Clinical Features
  • T6 29523389 ↗Postural tachycardia syndrome - Diagnosis, physiology, and prognosis
  • T6 35176758 ↗Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
Tipifarnib
T6
T6 — Mechanistic / preclinical
POTS
9 sources
  • T6 24423978 ↗Adrenocortical carcinoma
  • T6 32862332 ↗Emerging Treatments for Advanced/Metastatic Pheochromocytoma and Paraganglioma
  • T6 35559257 ↗Selinexor and COVID-19: The Neglected Warden
  • T6 26890144 ↗Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new
  • T6 39735644 ↗Pheochromocytoma: an updated scoping review from clinical presentation to management and treatment
  • T6INDIRECT 35903274 ↗Pediatric Metastatic Pheochromocytoma and Paraganglioma: Clinical Presentation and Diagnosis, Geneti
  • T6INDIRECT 23788859 ↗Chemotherapy-induced polyneuropathy. Part I. Pathophysiology
  • T6 23738080 ↗Phase II Study of Bortezomib as a Single Agent in Patients with Previously Untreated or Relapsed/Ref
  • T6 30761065 ↗Role of Sonification and Rhythmic Auditory Cueing for Enhancing Gait Associated Deficits Induced by
Transcutaneous electrical nerve stimulation
T6
T6 — Mechanistic / preclinical
POTS
27 sources
  • T6INDIRECT 17943857 ↗Antidepressants for neuropathic pain
  • T6INDIRECT 23633371 ↗Interventions for treating pain and disability in adults with complex regional pain syndrome
  • T6INDIRECT 22336858 ↗Whole-body vibration training for patients with neurodegenerative disease
  • T6INDIRECT 30050569 ↗Noninvasive Brain Stimulations for Unilateral Spatial Neglect after Stroke: A Systematic Review and
  • T6INDIRECT 36282618 ↗Support for healthy breastfeeding mothers with healthy term babies
  • T6INDIRECT 34844288 ↗Interventions for the management of abdominal pain in Crohn's disease and inflammatory bowel disease
  • T6INDIRECT 21418678 ↗Low back pain (chronic)
  • T6INDIRECT 34291816 ↗Interventions for the management of abdominal pain in ulcerative colitis
  • T6INDIRECT 30560316 ↗Autonomic Neuromodulation Acutely Ameliorates Left Ventricular Strain in Humans
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6INDIRECT 23186897 ↗Transverse myelitis
  • T6INDIRECT 31871494 ↗Therapeutic Approaches for Peripheral and Central Neuropathic Pain
  • T6INDIRECT 25584767 ↗Basic science and clinical management of painful and non-painful chemotherapy-related neuropathy
  • T6INDIRECT 27130211 ↗Pediatric complex regional pain syndrome: a review
  • T6INDIRECT 24142590 ↗Treatment of dystonia
  • T6INDIRECT 36211804 ↗Tremor in Parkinson's Disease: From Pathophysiology to Advanced Therapies
  • T6INDIRECT 23227356 ↗Ehlers-danlos syndrome, hypermobility type: an underdiagnosed hereditary connective tissue disorder
  • T6 40274830 ↗Diabetic neuropathy: cutting-edge research and future directions
  • T6 26676662 ↗Treating Diabetic Neuropathy: Present Strategies and Emerging Solutions
  • T6 34671261 ↗Advances About Immunoinflammatory Pathogenesis and Treatment in Diabetic Peripheral Neuropathy
  • T6 34179101 ↗Review of the Role of the Brain in Chemotherapy-Induced Peripheral Neuropathy
  • T6 37670573 ↗Pharmacological and Nonpharmacological Treatments for Painful Diabetic Peripheral Neuropathy
  • T6 32856490 ↗Current Strategies for the Management of Painful Diabetic Neuropathy
  • T6 28085085 ↗Wearable Sensors for Remote Health Monitoring
  • T6 25621208 ↗Chronic complications of spinal cord injury
  • T6 16320031 ↗Outcome of non-invasive treatment modalities on back pain: an evidence-based review
  • T6 28674681 ↗Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Prime
Transcutaneous electrical nerve stimulation and hypnosis
T6
T6 — Mechanistic / preclinical
POTS
Tranylcypromine
T6
T6 — Mechanistic / preclinical
POTS
24 sources
  • T6INDIRECT 17943857 ↗Antidepressants for neuropathic pain
  • T6INDIRECT 22071859 ↗Antidepressants for pain management in rheumatoid arthritis
  • T6INDIRECT 32315333 ↗Pharmacological treatment of depression: A systematic review comparing clinical practice guideline r
  • T6INDIRECT 35234292 ↗Pharmacotherapy for post traumatic stress disorder (PTSD)
  • T6INDIRECT 32402075 ↗Pharmacological Augmentation in Unipolar Depression: A Guide to the Guidelines
  • T6INDIRECT 36375174 ↗Pharmacological interventions for people with borderline personality disorder
  • T6INDIRECT 36971690 ↗Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
  • T6INDIRECT 2915441 ↗Randomized double-blind trial of intravenous prochlorperazine for the treatment of acute headache
  • T6INDIRECT 1705137 ↗Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine
  • T6 31871779 ↗Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 28100251 ↗Consensus guideline for the diagnosis and treatment of aromatic l-amino acid decarboxylase (AADC) de
  • T6INDIRECT 32456656 ↗Consensus guideline for the diagnosis and treatment of tetrahydrobiopterin (BH&lt;sub&gt;4&lt;/sub&g
  • T6INDIRECT 34151765 ↗Depression and Pain: Use of Antidepressants
  • T6INDIRECT 31075831 ↗The Serotonin Syndrome: From Molecular Mechanisms to Clinical Practice
  • T6INDIRECT 16511612 ↗The pharmacotherapy of chronic pain: a review
  • T6 27222667 ↗Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy
  • T6 22407614 ↗Serotonin and blood pressure regulation
  • T6 27803666 ↗Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology
  • T6 29315692 ↗Comprehensive review of cardiovascular toxicity of drugs and related agents
  • T6 37841347 ↗Depletion of dopamine in Parkinson's disease and relevant therapeutic options: A review of the liter
  • T6 24905879 ↗Induced pluripotent stem cells for regenerative medicine
  • T6 17608249 ↗Risks of combined alcohol/medication use in older adults
  • T6 30354828 ↗Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the Ameri
Tuvusertib
T6
T6 — Mechanistic / preclinical
POTS
Upstroke Compression Defibrillation
T6
T6 — Mechanistic / preclinical
POTS
VX-150
T6
T6 — Mechanistic / preclinical
POTS
13 sources
  • T6INDIRECT 28922704 ↗Direct-acting antivirals for chronic hepatitis C
  • T6INDIRECT 28585310 ↗Direct-acting antivirals for chronic hepatitis C
  • T6 36695182 ↗Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association
  • T6 38264914 ↗2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6 39866113 ↗2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Ass
  • T6 27065172 ↗Hemodynamics
  • T6 31633216 ↗Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
  • T6INDIRECT 36696027 ↗Immune Mechanisms in Epileptogenesis: Update on Diagnosis and Treatment of Autoimmune Epilepsy Syndr
  • T6INDIRECT 32767032 ↗Current Management and Emerging Therapies in Multiple System Atrophy
  • T6INDIRECT 25465548 ↗Effect of blending Jersey and Holstein-Friesian milk on Cheddar cheese processing, composition, and
  • T6 37035422 ↗Advanced surface engineering of titanium materials for biomedical applications: From static modifica
  • T6 40274830 ↗Diabetic neuropathy: cutting-edge research and future directions
  • T6 20526857 ↗RNAi-mediated suppression of isoprene emission in poplar transiently impacts phenolic metabolism und
Vildagliptin
T6
T6 — Mechanistic / preclinical
POTS
20 sources
  • T6INDIRECT 34352984 ↗2021 Clinical Practice Guidelines for Diabetes Mellitus of the Korean Diabetes Association
  • T6INDIRECT 28489279 ↗Dipeptidyl-peptidase (DPP)-4 inhibitors and glucagon-like peptide (GLP)-1 analogues for prevention o
  • T6INDIRECT 39464183 ↗Risk of bone fracture by using dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor a
  • T6INDIRECT 31349678 ↗Acute Effects of Nutritive and Non-Nutritive Sweeteners on Postprandial Blood Pressure
  • T6INDIRECT 25336915 ↗Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl pept
  • T6INDIRECT 28109295 ↗A randomised, active- and placebo-controlled, three-period crossover trial to investigate short-term
  • T6 36148880 ↗Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes As
  • T6 29565029 ↗Hypertension
  • T6 36151309 ↗Management of hyperglycaemia in type 2 diabetes, 2022. A consensus report by the American Diabetes A
  • T6 27491830 ↗Diabetes and Cognitive Impairment
  • T6INDIRECT 29934758 ↗Diabetic Gastroparesis: Principles and Current Trends in Management
  • T6INDIRECT 35033161 ↗Adherence and persistence rates of major antidiabetic medications: a review
  • T6INDIRECT 29021829 ↗Review article: effects of type 2 diabetes therapies on bone metabolism
  • T6INDIRECT 23147521 ↗Clinical guideline: management of gastroparesis
  • T6INDIRECT 32699774 ↗RSSDI-ESI Clinical Practice Recommendations for the Management of Type 2 Diabetes Mellitus 2020
  • T6INDIRECT 39091005 ↗2023 Clinical Practice Guidelines for Diabetes Management in Korea: Full Version Recommendation of t
  • T6 27660695 ↗Update on the treatment of type 2 diabetes mellitus
  • T6 23241069 ↗A review of the efficacy and safety of oral antidiabetic drugs
  • T6 29748368 ↗Cardiovascular Effects of New Oral Glucose-Lowering Agents: DPP-4 and SGLT-2 Inhibitors
  • T6 38645427 ↗Endothelial dysfunction in vascular complications of diabetes: a comprehensive review of mechanisms
Whey protein powder and L-carnitine
T6
T6 — Mechanistic / preclinical
POTS
Whirlpool Bath
T6
T6 — Mechanistic / preclinical
POTS
4 sources
  • T6 35295500 ↗Complex Regional Pain Syndrome. A Comprehensive Review on Neuroplastic Changes Supporting the Use of
  • T6 32010039 ↗Effects of Exoskeleton Gait Training on Balance, Load Distribution, and Functional Status in Stroke:
  • T6 1571875 ↗New Brunswick's remarkable Dr. Roberts
  • T6 PMC7122588 ↗Abkürzungen
Zinc oxide
T6
T6 — Mechanistic / preclinical
POTS
17 sources
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30019766 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30521670 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 30556597 ↗Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people
  • T6INDIRECT 34564844 ↗Nutrition-specific interventions for preventing and controlling anaemia throughout the life cycle: a
  • T6 28585944 ↗Cellular uptake of nanoparticles: journey inside the cell
  • T6 35682631 ↗Neurotransmitters-Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous
  • T6 29075626 ↗Impact of Metal and Metal Oxide Nanoparticles on Plant: A Critical Review
  • T6 22229124 ↗The history of Parkinson's disease: early clinical descriptions and neurological therapies
  • T6 22908279 ↗Soybean susceptibility to manufactured nanomaterials with evidence for food quality and soil fertili
  • T6INDIRECT 29387043 ↗Strategies to Combat Antibiotic Resistance in the Wastewater Treatment Plants
  • T6INDIRECT 10931787 ↗Inorganic dust pneumonias: the metal-related parenchymal disorders
  • T6INDIRECT 25323828 ↗Current treatments in familial dysautonomia
  • T6INDIRECT 26387020 ↗Invited review: Recommendations for reporting intervention studies on reproductive performance in da
  • T6INDIRECT 36836486 ↗The Rationale for Vitamin, Mineral, and Cofactor Treatment in the Precision Medical Care of Autism S
  • T6INDIRECT 35480890 ↗Applications of Alginate-Based Nanomaterials in Enhancing the Therapeutic Effects of Bee Products
  • T6 35159802 ↗Review on Nanoparticles and Nanostructured Materials: Bioimaging, Biosensing, Drug Delivery, Tissue
carvedilol (beta-blocker)
T6
T6 — Mechanistic / preclinical
POTS
23 sources
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 24158454 ↗Blood pressure control and primary prevention of stroke: summary of the recent clinical trial data a
  • T6INDIRECT 32519776 ↗Withdrawal of antihypertensive drugs in older people
  • T6INDIRECT 30480768 ↗First-line drugs inhibiting the renin angiotensin system versus other first-line antihypertensive dr
  • T6INDIRECT 23796325 ↗Systematic review of genuine versus spurious side-effects of beta-blockers in heart failure using pl
  • T6INDIRECT 35234292 ↗Pharmacotherapy for post traumatic stress disorder (PTSD)
  • T6INDIRECT 36349400 ↗Clinical trials on the pharmacological treatment of long COVID: A systematic review
  • T6INDIRECT 31167038 ↗Pharmacotherapy for hypertension in adults 60 years or older
  • T6INDIRECT 24650926 ↗A randomized pilot study of aortic waveform guided therapy in chronic heart failure
  • T6INDIRECT 17094780 ↗The influence of CYP2D6 phenotype on the clinical response of nebivolol in patients with essential h
  • T6INDIRECT 34024217 ↗Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments
  • T6INDIRECT 28862947 ↗Role of Volume Redistribution in the Congestion of Heart Failure
  • T6INDIRECT 38441582 ↗Cardiac Amyloidosis Due to Transthyretin Protein: A Review
  • T6INDIRECT 34134525 ↗Recognition, Prevention, and Management of Arrhythmias and Autonomic Disorders in Cardio-Oncology: A
  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6 29565029 ↗Hypertension
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 31710717 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors
  • T6 38078592 ↗10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2024
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 24517644 ↗The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
cyclosporine
T6
T6 — Mechanistic / preclinical
MCASPOTS
51 sources
  • T6 NCT00006251 ↗Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by C
  • T6 NCT00014235 ↗Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transpla
  • T6 NCT00118352 ↗Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophen
  • T6 NCT00112593 ↗Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and M
  • T6INDIRECT 21497847 ↗AUA guideline for the diagnosis and treatment of interstitial cystitis/bladder pain syndrome
  • T6INDIRECT 37056675 ↗The crucial role and mechanism of insulin resistance in metabolic disease
  • T6INDIRECT 30968949 ↗Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlli
  • T6INDIRECT 26110030 ↗Clinical and diagnostic utility of saliva as a non-invasive diagnostic fluid: 
a systematic review
  • T6INDIRECT 10951147 ↗Randomized double-blind study of cyclosporin in chronic 'idiopathic' urticaria
  • T6INDIRECT 25046337 ↗Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who rema
  • T6INDIRECT 20431041 ↗Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and l
  • T6INDIRECT 29652551 ↗n-3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease
  • T6INDIRECT 30943337 ↗Benralizumab for &lt;i&gt;PDGFRA&lt;/i&gt;-Negative Hypereosinophilic Syndrome
  • T6 22878108 ↗Cell biology of ischemia/reperfusion injury
  • T6INDIRECT 32114706 ↗Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
  • T6INDIRECT 24554461 ↗Echinacea for preventing and treating the common cold
  • T6INDIRECT 25919144 ↗Interventions for rosacea
  • T6INDIRECT 29271481 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 35603936 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 31917873 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 22251436 ↗Maraviroc, a chemokine receptor-5 antagonist, fails to demonstrate efficacy in the treatment of pati
  • T6 28293453 ↗An overview and management of osteoporosis
  • T6 33243615 ↗Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on
  • T6 37436070 ↗Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis
  • T6INDIRECT 17655751 ↗Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis
  • T6INDIRECT 25686388 ↗The pathophysiology, diagnosis, and treatment of dry eye disease
  • T6INDIRECT 24275598 ↗Treating inflammation by blocking interleukin-1 in humans
  • T6INDIRECT 28242845 ↗Focal Segmental Glomerulosclerosis
  • T6INDIRECT 30558872 ↗Antibiotic allergy
  • T6INDIRECT 32106302 ↗Overview of Castleman disease
  • T6 26228647 ↗Colchicine--Update on mechanisms of action and therapeutic uses
  • T6 25861976 ↗Ion channels in innate and adaptive immunity
  • T6 28736339 ↗TFOS DEWS II pain and sensation report
  • T6 32376392 ↗Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventio
  • T6 30774631 ↗The Immunology of Macrophage Activation Syndrome
  • T6INDIRECT 31485575 ↗Clinical Manifestations, Diagnosis, and Treatment of Sarcoidosis
  • T6INDIRECT 29399043 ↗Treatment strategies for autoimmune encephalitis
  • T6INDIRECT 23184849 ↗Grapefruit-medication interactions: forbidden fruit or avoidable consequences?
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 23147521 ↗Clinical guideline: management of gastroparesis
  • T6INDIRECT 31210940 ↗European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gl
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6 29565029 ↗Hypertension
  • T6 34988090 ↗Treatment of Inflammatory Bowel Disease: A Comprehensive Review
  • T6 19165601 ↗Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps
  • T6 23241069 ↗A review of the efficacy and safety of oral antidiabetic drugs
  • T6 33909761 ↗Brazilian Guidelines of Hypertension - 2020
  • T6 25182228 ↗Clinician's Guide to Prevention and Treatment of Osteoporosis
  • T6 35478046 ↗The clinician's guide to prevention and treatment of osteoporosis
  • T6 30354828 ↗Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the Ameri
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
diphenhydramine (H1 antihistamine)
T6
T6 — Mechanistic / preclinical
MCASPOTS
43 sources
  • T6INDIRECT 25046337 ↗Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who rema
  • T6INDIRECT 29650949 ↗Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement
  • T6INDIRECT 20226302 ↗The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficu
  • T6INDIRECT 25200415 ↗Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-Ig
  • T6INDIRECT 12867500 ↗Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin
  • T6INDIRECT 10377184 ↗Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-indu
  • T6INDIRECT 24176117 ↗A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic pa
  • T6INDIRECT 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
  • T6INDIRECT 18774392 ↗Treatment of chronic autoimmune urticaria with omalizumab
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6INDIRECT 30175841 ↗Interventions to improve the appropriate use of polypharmacy for older people
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 23633371 ↗Interventions for treating pain and disability in adults with complex regional pain syndrome
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 18787227 ↗Antipsychotic therapy during early and late pregnancy. A systematic review
  • T6INDIRECT 28893208 ↗Trial design and rationale for APOLLO, a Phase 3, placebo-controlled study of patisiran in patients
  • T6 37160297 ↗Antidepressants for pain management in adults with chronic pain: a network meta-analysis
  • T6 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 15577865 ↗Rhinosinusitis: establishing definitions for clinical research and patient care
  • T6INDIRECT 15577816 ↗Rhinosinusitis: Establishing definitions for clinical research and patient care
  • T6INDIRECT 32436290 ↗EAACI Allergen Immunotherapy User's Guide
  • T6INDIRECT 24813302 ↗Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of a
  • T6INDIRECT 32128023 ↗IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position p
  • T6INDIRECT 26525001 ↗2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines
  • T6 27795547 ↗Food allergy: immune mechanisms, diagnosis and immunotherapy
  • T6 26869768 ↗Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chit
  • T6 37230968 ↗Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
  • T6 33204386 ↗World allergy organization anaphylaxis guidance 2020
  • T6 21460831 ↗TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch
  • T6 21134576 ↗Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAI
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 26084539 ↗International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors
  • T6INDIRECT 19484833 ↗Evidence-based recommendations for the assessment and management of sleep disorders in older persons
  • T6INDIRECT 37139824 ↗American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medicatio
  • T6INDIRECT 23147521 ↗Clinical guideline: management of gastroparesis
  • T6 21034217 ↗Orexin receptors: pharmacology and therapeutic opportunities
  • T6 30018614 ↗Immune System Dysregulation During Spaceflight: Potential Countermeasures for Deep Space Exploration
  • T6 34589395 ↗Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic n
  • T6 29055040 ↗THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors
  • T6 26650439 ↗The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors
  • T6 29852897 ↗Insomnia in the Elderly: A Review
  • T6 10457047 ↗Childhood functional gastrointestinal disorders
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
fludrocortisone
T6
T6 — Mechanistic / preclinical
POTS
25 sources
  • T6INDIRECT 19406310 ↗A systematic review of the management of orthostatic hypotension after spinal cord injury
  • T6INDIRECT 9091692 ↗Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind m
  • T6INDIRECT 12521968 ↗Multifactorial intervention after a fall in older people with cognitive impairment and dementia pres
  • T6INDIRECT 19687359 ↗Propranolol decreases tachycardia and improves symptoms in the postural tachycardia syndrome: less i
  • T6INDIRECT 28893208 ↗Trial design and rationale for APOLLO, a Phase 3, placebo-controlled study of patisiran in patients
  • T6INDIRECT 9505918 ↗Midodrine: a role in the management of neurocardiogenic syncope
  • T6INDIRECT 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
  • T6INDIRECT 9244228 ↗Effects of volume loading and pressor agents in idiopathic orthostatic tachycardia
  • T6INDIRECT 12933939 ↗Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic hypoten
  • T6 36639608 ↗Long COVID: major findings, mechanisms and recommendations
  • T6INDIRECT 27999003 ↗Diabetic Neuropathy: A Position Statement by the American Diabetes Association
  • T6INDIRECT 24423978 ↗Adrenocortical carcinoma
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 30184160 ↗Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints
  • T6INDIRECT 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 19713422 ↗Guidelines for the diagnosis and management of syncope (version 2009)
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6 29565029 ↗Hypertension
  • T6 28716886 ↗Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 26595642 ↗Lewy body dementias
  • T6 33909761 ↗Brazilian Guidelines of Hypertension - 2020
  • T6 35648703 ↗Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer
  • T6 6811067 ↗Diagnosis and management of diabetic autonomic neuropathy
  • T6 36178003 ↗World guidelines for falls prevention and management for older adults: a global initiative
gabapentin
T6
T6 — Mechanistic / preclinical
POTS
26 sources
  • T6INDIRECT 17943857 ↗Antidepressants for neuropathic pain
  • T6INDIRECT 30673120 ↗Pregabalin for neuropathic pain in adults
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 32840686 ↗Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cas
  • T6INDIRECT 24920437 ↗Central changes associated with chronic pelvic pain and endometriosis
  • T6INDIRECT 19029129 ↗Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study
  • T6INDIRECT 18281407 ↗Systems Training for Emotional Predictability and Problem Solving (STEPPS) for outpatients with bord
  • T6INDIRECT 22281448 ↗Placebo-controlled comparison of prazosin and cognitive-behavioral treatments for sleep disturbances
  • T6INDIRECT 26902950 ↗Efficacy and Safety of Paliperidone Palmitate 3-Month Formulation for Patients with Schizophrenia: A
  • T6INDIRECT 33786700 ↗Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infect
  • T6INDIRECT 27999003 ↗Diabetic Neuropathy: A Position Statement by the American Diabetes Association
  • T6INDIRECT 25081580 ↗Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsess
  • T6INDIRECT 31663402 ↗Consensus statement for perioperative care in total hip replacement and total knee replacement surge
  • T6INDIRECT 26514824 ↗Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for
  • T6INDIRECT 26084539 ↗International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors
  • T6INDIRECT 20042772 ↗Standards of medical care in diabetes--2010
  • T6INDIRECT 19118286 ↗Standards of medical care in diabetes--2009
  • T6 21092187 ↗Fabry disease
  • T6 20194146 ↗Recommendations for the pharmacological management of neuropathic pain: an overview and literature u
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 28620280 ↗Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy
  • T6 39353925 ↗Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy
  • T6 20876709 ↗Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treat
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6 23425518 ↗Guideline of transthyretin-related hereditary amyloidosis for clinicians
  • T6 36178003 ↗World guidelines for falls prevention and management for older adults: a global initiative
hOMSC300
T6
T6 — Mechanistic / preclinical
POTS
1 source
ibuprofen (NSAID)
T6
T6 — Mechanistic / preclinical
MCASPOTS
51 sources
  • T6INDIRECT 30327483 ↗Phenome-wide association studies across large population cohorts support drug target validation
  • T6INDIRECT 29861802 ↗Low-Level Laser Therapy for Temporomandibular Disorders: A Systematic Review with Meta-Analysis
  • T6INDIRECT 35361131 ↗Headache onset after vaccination against SARS-CoV-2: a systematic literature review and meta-analysi
  • T6INDIRECT 32176310 ↗A Systematic Review of Drug-Induced Pemphigoid
  • T6INDIRECT 31117264 ↗Herpes Virus, Oral Clinical Signs and QoL: Systematic Review of Recent Data
  • T6INDIRECT 28709457 ↗Tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review of its epidemiology, d
  • T6INDIRECT 28779491 ↗Antiepileptic drugs for chronic non-cancer pain in children and adolescents
  • T6INDIRECT 24085261 ↗Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers
  • T6INDIRECT 29856741 ↗Changes in the serum levels of inflammatory cytokines in antidepressant drug-naïve patients with maj
  • T6INDIRECT 21834936 ↗Response to a selective COX-2 inhibitor in patients with urticaria/angioedema induced by nonsteroida
  • T6INDIRECT 24554461 ↗Echinacea for preventing and treating the common cold
  • T6INDIRECT 23076930 ↗Local anaesthetics and regional anaesthesia for preventing chronic pain after surgery
  • T6INDIRECT 29926477 ↗Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent
  • T6INDIRECT 24595586 ↗Non-surgical interventions for the management of chronic pelvic pain
  • T6INDIRECT 22376048 ↗American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in o
  • T6INDIRECT 31132795 ↗Phase 3 randomized, placebo-controlled, double-blind study of lasmiditan for acute treatment of migr
  • T6INDIRECT 31207169 ↗The Efficacy, Tolerability, and Joint Safety of Fasinumab in Osteoarthritis Pain: A Phase IIb/III Do
  • T6INDIRECT 15345500 ↗A randomised, placebo controlled, comparative trial of the gastrointestinal safety and efficacy of A
  • T6INDIRECT 28655357 ↗Drug-related problems and medication reviews among old people with dementia
  • T6INDIRECT 9727818 ↗Contrasting actions of pressor agents in severe autonomic failure
  • T6INDIRECT 33723532 ↗Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrom
  • T6INDIRECT 32689643 ↗Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Pathophysiological Insights
  • T6INDIRECT 29844705 ↗Severe cutaneous adverse reactions induced by targeted anticancer therapies and immunotherapies
  • T6INDIRECT 27866580 ↗Eosinophilia
  • T6INDIRECT 24792340 ↗Migraine and estrogen
  • T6INDIRECT 26525001 ↗2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines
  • T6INDIRECT 29438602 ↗International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
  • T6INDIRECT 23452057 ↗Characterization of different courses of atopic dermatitis in adolescent and adult patients
  • T6 25287861 ↗Calcitonin gene-related peptide: physiology and pathophysiology
  • T6 39174535 ↗Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strateg
  • T6 32376392 ↗Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventio
  • T6 30874629 ↗Pain and immunity: implications for host defence
  • T6 31275462 ↗PEGylated liposomes: immunological responses
  • T6 19099185 ↗Mcl-1 is a potential therapeutic target in multiple types of cancer
  • T6 9092596 ↗Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage
  • T6INDIRECT 23094876 ↗Brugada phenocopy: new terminology and proposed classification
  • T6INDIRECT 17915006 ↗Hereditary sensory and autonomic neuropathies: types II, III, and IV
  • T6INDIRECT 24433463 ↗Review of pharmacological therapies in fibromyalgia syndrome
  • T6INDIRECT 37139824 ↗American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medicatio
  • T6INDIRECT 28541649 ↗Consensus Recommendations for the Clinical Application of Repetitive Transcranial Magnetic Stimulati
  • T6INDIRECT 19730409 ↗Guidelines for the Prevention and Treatment of Opportunistic Infections among HIV-exposed and HIV-in
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 23588782 ↗Applications of CYP450 testing in the clinical setting
  • T6 16461471 ↗Diabetic neuropathy
  • T6 29315692 ↗Comprehensive review of cardiovascular toxicity of drugs and related agents
  • T6 30033869 ↗A Summary of Electrospun Nanofibers as Drug Delivery System: Drugs Loaded and Biopolymers Used as Ma
  • T6 30712918 ↗Type 2 diabetes mellitus and osteoarthritis
  • T6 10457047 ↗Childhood functional gastrointestinal disorders
  • T6 26834959 ↗Predicting risk of adverse drug reactions in older adults
  • T6 31394725 ↗Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Comprehensive Review
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
in clinic pain VR reduction exercises
T6
T6 — Mechanistic / preclinical
POTS
increased dietary salt / fluid (POTS)
T6
T6 — Mechanistic / preclinical
POTS
modafinil
T6
T6 — Mechanistic / preclinical
POTS
24 sources
  • T6INDIRECT 29744873 ↗Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - as
  • T6INDIRECT 26447539 ↗Interventions for fatigue in Parkinson's disease
  • T6INDIRECT 36190739 ↗Pharmacological interventions for prevention of weight gain in people with schizophrenia
  • T6INDIRECT 27863901 ↗A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease f
  • T6INDIRECT 32402075 ↗Pharmacological Augmentation in Unipolar Depression: A Guide to the Guidelines
  • T6INDIRECT 36138129 ↗The impact of pharmacological and non-pharmacological interventions on physical health outcomes in p
  • T6INDIRECT 36971690 ↗Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
  • T6INDIRECT 20679638 ↗Atomoxetine for depression and other neuropsychiatric symptoms in Parkinson disease
  • T6INDIRECT 17134849 ↗Safety, tolerability and efficacy of levodopa-carbidopa treatment for cocaine dependence: two double
  • T6 30653247 ↗Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
  • T6INDIRECT 33723532 ↗Long-Haul Post-COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrom
  • T6INDIRECT 22021174 ↗The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor sy
  • T6INDIRECT 26084539 ↗International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors
  • T6INDIRECT 19484833 ↗Evidence-based recommendations for the assessment and management of sleep disorders in older persons
  • T6INDIRECT 25200111 ↗Drooling in Parkinson's disease: a review
  • T6INDIRECT 29101940 ↗REM Sleep Behavior Disorder: Diagnosis, Clinical Implications, and Future Directions
  • T6INDIRECT 25980576 ↗2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tach
  • T6 26595642 ↗Lewy body dementias
  • T6 28837986 ↗Sleep Disturbance, Cognitive Decline, and Dementia: A Review
  • T6 24699931 ↗Non-motor Parkinson's: integral to motor Parkinson's, yet often neglected
  • T6 33924103 ↗Treatment Options for Motor and Non-Motor Symptoms of Parkinson's Disease
  • T6 19603170 ↗Primary biliary cirrhosis
  • T6 23065655 ↗A practical guide to the therapy of narcolepsy and hypersomnia syndromes
  • T6 20815187 ↗Fatigue in multiple sclerosis: mechanisms, evaluation, and treatment
nrTMS and open phase
T6
T6 — Mechanistic / preclinical
POTS
prednisone
T6
T6 — Mechanistic / preclinical
RegisteredPOTS
25 sources
  • T6REGISTERED-ONLY NCT06597682 ↗Evaluating Immunomodulatory Interventions in Post-Acute Sequelae of SARS-CoV-2 InfEction
  • T6INDIRECT 26343551 ↗Interactive telemedicine: effects on professional practice and health care outcomes
  • T6INDIRECT 26561338 ↗Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy
  • T6INDIRECT 24067431 ↗Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflo
  • T6INDIRECT 33180097 ↗Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Random
  • T6INDIRECT 31782181 ↗Randomized Placebo-Controlled Trial of Intravenous Immunoglobulin in Autoimmune LGI1/CASPR2 Epilepsy
  • T6INDIRECT 27382171 ↗Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid a
  • T6INDIRECT 17965121 ↗Synovial tissue response to rituximab: mechanism of action and identification of biomarkers of respo
  • T6 28293453 ↗An overview and management of osteoporosis
  • T6 26760044 ↗Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Gui
  • T6 29442540 ↗Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor The
  • T6INDIRECT 24462240 ↗Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a c
  • T6INDIRECT 33649022 ↗Autoimmune encephalitis: proposed best practice recommendations for diagnosis and acute management
  • T6INDIRECT 30184160 ↗Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints
  • T6INDIRECT 30218025 ↗Mechanisms, biomarkers and targets for adult-onset Still's disease
  • T6INDIRECT 24682347 ↗2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the
  • T6INDIRECT 37748514 ↗Distinguishing features of long COVID identified through immune profiling
  • T6 17223625 ↗Histoplasmosis: a clinical and laboratory update
  • T6 32231332 ↗Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
  • T6 32792490 ↗Podocytopathies
  • T6 9723817 ↗Grapefruit juice-drug interactions
  • T6 34988090 ↗Treatment of Inflammatory Bowel Disease: A Comprehensive Review
  • T6 25182228 ↗Clinician's Guide to Prevention and Treatment of Osteoporosis
  • T6 35478046 ↗The clinician's guide to prevention and treatment of osteoporosis
  • T6 31080465 ↗2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Commit
Α-Lipoic Acid
T6
T6 — Mechanistic / preclinical
POTS
19 sources
  • T6INDIRECT 27869661 ↗An Exploratory Investigation of Endotoxin Levels in Novice Long Distance Triathletes, and the Effect
  • T6INDIRECT 33652910 ↗The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metaboli
  • T6 20876709 ↗Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treat
  • T6 18616962 ↗Diabetic neuropathy: mechanisms to management
  • T6 23970715 ↗Mechanisms and management of diabetic painful distal symmetrical polyneuropathy
  • T6 28824446 ↗Human Pathophysiological Adaptations to the Space Environment
  • T6 23550085 ↗Diabetic cardiac autonomic neuropathy, inflammation and cardiovascular disease
  • T6INDIRECT 34655433 ↗Chemotherapy-Induced Peripheral Neuropathy: Epidemiology, Pathomechanisms and Treatment
  • T6INDIRECT 24567799 ↗Cardiac autonomic neuropathy in patients with diabetes mellitus
  • T6INDIRECT 30039193 ↗Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder
  • T6INDIRECT 35373533 ↗International consensus statement on allergy and rhinology: Olfaction
  • T6INDIRECT 30248938 ↗Low-Dose Naltrexone (LDN)-Review of Therapeutic Utilization
  • T6INDIRECT 32950543 ↗Pain management in hidradenitis suppurativa and a proposed treatment algorithm
  • T6INDIRECT 32906684 ↗Non-Hematologic Toxicity of Bortezomib in Multiple Myeloma: The Neuromuscular and Cardiovascular Adv
  • T6INDIRECT 32676851 ↗Four-Repeat Tauopathies: Current Management and Future Treatments
  • T6 16461471 ↗Diabetic neuropathy
  • T6 30793549 ↗Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: W
  • T6 36412084 ↗Long COVID: mechanisms, risk factors and recovery
  • T6 24954624 ↗Diabetic neuropathy: mechanisms, emerging treatments, and subtypes